• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4875-4883
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• 2016

Background and objective: Breast cancer-related lymphoedema (BCRL) is a disabling complication with long term impact on quality on life after breast cancer treatment. Its management remains a major challenge for patients and health care professionals; the goal of this overview was to summarize effects of different treatment strategies for patients with BCRL. Methods: A thorough search was undertaken to allow a systematic review or meta-analysis of treatments for BCRL. Two investigators independently selected studies and abstracted the data. Results: Combined physical therapy (CPT) with different combinations of surgery, oral pharmaceuticals, low-level laser therapy, weight reduction, mesenchymal stem cell therapy, kinesio tex taping, and acupuncture might be effective in reducing lymphoedema, but exercise demonstrated no obvious benefit. The results of direct comparisons showed CPT might be more effective than standard physiotherapy (ST). Manual lymphatic drainage (MLD) may not offer additional benefits to ST for swelling reduction, but could facilitate compression bandaging. MLD seemed to have similar effects with self-administered simple lymphatic drainage (SLD) or using an intermittent pneumatic compression pump (IPC). IPC might also not be associated with additional effectiveness for CPT. Efficacy of stem cell therapy vs. compression sleeve or CPT, as well as the effects of daflon and coumarin could not be established. Conclusion: Although many treatments for BCRL might reduce lymphoedema volume, their effects were not well established. The quality of many of the original studies in the included reviews was not optimal, so that in future randomized control trials are a high priority.

• 한국치위생학회지
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• 제10권5호
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• pp.807-817
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• 2010

Objectives : The purpose of this study was to analyzes the job implementation of dental hygienist at dental hospital(university), dental clinic and general hospital in the city of Gwangju. Methods : The subjects in this study were dental hygienists who worked at dental hospital(university), dental clinic and general hospital in the city of Gwangju. A survey was conducted by post from June 10 to August 10. Out of the collected data, 204 answer sheets were analyzed. Results : 1. 'Medical & Dental history taking', 'Extra & Intra oral examination' and 'Dental hygiene care plane' in dental clinic were significantly higher than dental hospital(university) and general hospital(p<0.001). 'Remove of extrinsic stain' and 'Treatment of hypersensitivity tooth' in dental clinic and general hospital were significantly higher than dental hospital(university)(p<0.001). 'Preventive dental caries treatment' and 'Diet control' were shown the low frequency of job implementation. 2. Almost task elements of dental assistance duty shown that dental hygienists under the 24 years old were significantly higher dental hygienists over the 30 years old(p<0.05) and dental clinic and general hospital were significantly higher than dental hospital(university)(p<0.05) in frequency of job implementation. 3. 'Dental staff supervision', 'Patient management' and 'Dental chart arrangement' shown that dental hygienists over the 30 years old were significantly higher than dental hygienists under the 24 years old in frequency of job implementation(p<0.05). 'Infection control' of dental hygienists over 30 years old was significantly lower than dental hygienists under the 24 years old(p<0.001). Conclusions : The results of this study indicate that a scope of dental hygienists' job need to extend also in order to accomplish a job efficiently, is suggested that the effort is necessary to improve a quality of dental hygienist and to change of recognition of the dentist about dental hygienists' job.

• Environmental Analysis Health and Toxicology
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• 제20권1호
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• pp.29-37
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• 2005

Recently, significant contamination problems by residual chemicals have occasionally been occurred from major rivers and drinking water in Korea. Therefore, the management for use of them and risk assessment should be more strictly performed. In this study, we have analyzed trihalomethanes in treated water samples taken from water plants located in the region of four major rivers (i.e. Han river, Geum river, Youngsan river and Nakdong river) in Korea for eight years (1997～2004). From the data, we could assess the excess cancer risk by calculating the chronic daily intakes (CDI) multiplied by individual oral slope factors, Q₁＊, for the cancer suspected matters such as trihalomethanes, moreover the hazard index which is calculated by dividing the CDI by the acceptable daily reference dose (R/sub f/D) was determined for the risk assessment. As a result, in the case of 95 percentile excess cancer risk, it was shown that the excess cancer risk for dichlorobromomethane in the Nakdong river region is highest among the tested samples as 8.73 x 10/sup -6/. The 95 percentile total hazard index (the sum of individual hazard indices considering R/sub f/D), in addition, was below 1.0 for all samples, and therefore it was assessed that water samples taken from treatment plants of four major rivers are not harmful.

• 대한치과의사협회지
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• 제51권7호
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• pp.405-413
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• 2013

Pediatric and adolescent dental anxiety and fear have been researched in the connection with behavior modification for a long time and this dental anxiety can persist until the adult hoods resulting in extreme fear of and avoidance of dental treatments and causes oral health deterioration. However, the domestic researches regarding adolescent dental anxiety and fear are insufficient. For this reason, this study aims to examine the level of fear and the influential factors affecting their dental fear and to utilize the result as the basic materials in the dental management. The subjects were the students from a middle school located in Gyeonggi-Do. The school was selected by convenient sampling and self-answered questionnaire was filled in by the students. The distribution of responses in each category of fear was examined by frequency analysis. The analysis was conducted using cross tabulation in order to examine the difference between male students and female students and using independent sample t-test in order to compare the fear score of each category. The study results showed the fear score of female students for the category 'causing irritation during the dental treatments' was significantly higher in statistics(p<0.05). Therefore, these results should be reflected to the dental care environments in order for the adolescent to reduce the dental anxiety and fear.

• 디지털융복합연구
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• 제18권4호
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• pp.309-314
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• 2020

Polymethyl methacrylate (PMMA)는 치과 교정장치 재료로 사용해 왔다. 하지만 낮은 항균력으로 인한 구강감염을 촉진시킬 염려가 있다. 본 연구에서는 이를 극복하기 위하여 최근 발표된 Ag-MSN, graphene-oxide nanosheets(nGO), Cerium nanoparticle(CNP)의 나노입자를 교정레진인 Dentarum 회사의 Orthocryl를 사용하여 레진 파우더 대비 중량비 0, 0.25, 0.5, 1.0, 2.0%를 MMA 액에 혼합한 후 제조사의 지시에 따라 PMMA 분말: MMA 액 (1.2 : 1) 비율로 혼합하여 교정용 시편을 제작하였고 교정용 레진 항진균 실험, 통계분석을 하였다. 항균실험을 한 결과 교정용 PMMA레진이 Ag-MSN을 함유할 때 항(진)균적 성질이 증가하였다. nGO를 PM에 넣으면 표면이 거칠어지고 친수성을 높일 수 있었고 항균 접착제 효과가 표면 거칠기의 변화가 아닌 친수성이 증가하였다. CNP 농도가 높을수록 항부착 성질이 최대 60%까지 관찰되었다. 나노입자함유 교정용 레진은 항균효과가 나타남을 알 수 있었다. 이는 의치, 치열 교정 장치 및 임시 수복물에 대한 유망한 항균 치과 재료로서의 잠재적 유용성을 시사한다.

• 한국임상약학회지
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• 제30권4호
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• pp.243-249
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• 2020

Background: Despite the increased use of direct-acting oral anticoagulants, warfarin is still recommended as first-line therapy in patients with mechanical valves or moderate to severe mitral stenosis. Anticoagulation management services (AMSs) are warranted for patients receiving warfarin therapy due to the complexity of warfarin dosing and large interpatient variability. To overcome limited health care resources, we developed a messenger app-based chatbot that provides information to patients taking warfarin. Methods: We developed "WafarinTalk" as an add-on to the open-source messenger app KakaoTalk. We developed the prototype chatbot after building a database containing seven categories: 1) dosage and indications, 2) drug-drug interactions, 3) drug-food interactions, 4) drug-diet supplement interactions, 5) monitoring, 6) adverse events, and 7) precautions. We then surveyed 30 pharmacists and 10 patients on chatbot reliability and on participant satisfaction. Results: We found that 80% of the pharmacists agreed on the consistency of chatbot responses and 44% agreed on the appropriateness of chatbot. Furthermore, 47% of pharmacists said that they were willing to recommend the chatbot to patients. Of the seven categories, information on drug-food interaction was the most useful; 90% of patients said they were satisfied with the chatbot and 100% of patients said they were willing to use it when they were unable to see a pharmacist. We updated the prototype chatbot with feedback from the survey. Conclusion: This study showed that warfarin-related information could be provided to patients through a messenger application-based chatbot.

• Journal of Microbiology and Biotechnology
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• 제32권7호
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• pp.835-843
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• 2022

Deinococcus radiodurans is an extremophilic bacterium that can thrive in harsh environments. This property can be attributed to its unique metabolites that possess strong antioxidants and other pharmacological properties. To determine the potential of D. radiodurans R1 lysate (DeinoLys) as a pharmacological candidate for inflammatory bowel disease (IBD), we investigated the antiinflammatory activity of DeinoLys in bone marrow-derived dendritic cells (BMDCs) and a colitis mice model. Lipopolysaccharide (LPS)-stimulated BMDCs treated with DeinoLys exhibited alterations in their phenotypic and functional properties by changing into tolerogenic DCs, including strongly inhibited proinflammatory cytokines (TNF-α and IL-12p70) and surface molecule expression and activated DC-induced T cell proliferation/activation with high IL-10 production. These phenotypic and functional changes in BMDCs induced by DeinoLys in the presence of LPS were abrogated by IL-10 neutralization. Furthermore, oral administration of DeinoLys significantly reduced clinical symptoms against dextran sulfate sodium-induced colitis, including body weight loss, disease activity index, histological severity in colon tissue, and lower myeloperoxidase level in mice. Our results establish DeinoLys as a potential anti-inflammatory candidate for IBD therapy.

• 대한본초학회지
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• 제33권3호
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• pp.45-53
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• 2018

Objectives : In cases of osteoarthritis, the hypofunction of the cartilage and joint leads to a limited range of joint motion, swelling, and pain, which is generally treated using pharmaceutical drugs (e.g., anti-inflammatory agents, cartilage protectants, and nonsteroidal anti-inflammatory drugs) or replacement arthroplasty. However, long-term drug treatment is associated with adverse effects on the gastrointestinal systems. The present study aimed to evaluate the ability of Giheolsotong-hwan to treat of osteoarthritis symptoms in the MIA-induced rat model based on histological analysis, and factors that are associated with inflammation and bone mineral metabolism. Methods : Giheolsotong-hwan was administered orally at doses of 200 mg/kg/day or 400 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate ($3mg/50{\mu}{\ell}$ of 0.9% saline) into the intra-articular space of the rats' right knee. The rats subsequently received the same doses of oral Giheolsotong-hwan for another 4 weeks. We evaluated the treatment effects based on serum biomarkers and histopathological analysis of the knee joints. Results : Compared to those in control rats, the Giheolsotong-hwan treatments significantly decreased the serum concentration of inflammation factors (i.e., $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, $PGE_2$, and $LTB_4$), and bone degrade factors (i.e., MMP-9, CTX-II, and COMP). In addition, the Giheolsotong-hwan treatments significantly increased the concentration of glycosaminoglycans of bone defence factors, but no chage the TIMP-1. Furthermore, the Giheolsotong-hwan treatments effectively preserved the knee cartilage and proteoglycan. Conclusion : The results indicate that Giheolsotong-hwan treated osteoarthritis symptoms. Thus, Giheolsotong-hwan may be a novel oriental therapeutic option for the management of osteoarthritis.

• 대한치위생과학회지
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• 제5권2호
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• pp.35-44
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• 2022

Background: This study was aimed at investigating the perception of social network service (SNS) users regarding dental office visits and determining the proportion of dental SNS users among general SNS users. Methods: We surveyed 177 adults using SNSs. Dental SNS characteristics were classified into information provision, interaction, recency, reliability, and interest, and the recognition level of each area was surveyed on a 5-point scale. The total number of items was 17, including three information provision, three interaction, four recency, four reliability, and three interest items. Results: Among the five domains, the recognition level was the highest for reliability (3.51 points) and the lowest for interest (2.94 points). Among the 17 items, the recognition level was the highest for "Educational information provided by dental SNS is valuable" at 3.60 points, "Dental SNS educational video is useful for information sharing and dental knowledge improvement" at 3.53 points, and "The perceived educational information of dental SNS is reliable" at 3.51 points. Participants in their 20s and 30s had higher scores for being up-to-date (3.33 and 2.88 points, respectively) and reliability (3.59 and 3.09 points, respectively) than those in their 40s or older. The recognition level of all areas of dental SNS characteristics was significantly higher for experienced dental SNS users than for nonexperienced ones. Conclusions: The results of this study suggested that dental institutions should consider ways to utilize SNS for patient management and education and that dental SNS-related contents should contain educational and reliable information to help SNS users manage their oral health.

• Journal of Periodontal and Implant Science
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• 제53권2호
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• pp.145-156
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• 2023

Purpose: The significance of keratinized tissue for peri-implant health has been emphasized. However, there is an absence of clinical evidence for the use of a xenogeneic collagen matrix (XCM) to manage peri-implant mucositis and peri-implantitis. Therefore, the purpose of this study was to investigate outcomes after keratinized tissue augmentation using an XCM for the management of peri-implant diseases. Methods: Twelve implants (5 with peri-implant mucositis and 7 with peri-implantitis) in 10 patients were included in this study. Non-surgical treatments were first performed, but inflammation persisted in all implant sites. The implant sites all showed a lack of keratinized mucosa (KM) and vestibular depth (VD). Apically positioned flaps with XCM application were performed. Bone augmentation was simultaneously performed on peri-implantitis sites with an intrabony defect (>3 mm). The following clinical parameters were measured: the probing pocket depth (PPD), modified sulcular bleeding index (mSBI), suppuration (SUP), keratinized mucosal height (KMH), and VD. Results: There were no adverse healing events during the follow-up visits (18±4.6 months). The final KMHs and VDs were 4.34±0.86 mm and 8.0±4.05 mm, respectively, for the sites with peri-implant mucositis and 3.29±0.86 mm and 6.5±1.91 mm, respectively, for the sites with peri-implantitis. Additionally, the PPD and mSBI significantly decreased, and none of the implants presented with SUP. Conclusions: Keratinized tissue augmentation using an XCM for sites with peri-implant mucositis and peri-implantitis was effective for increasing the KMH and VD and decreasing peri-implant inflammation.