• Nutrition Research and Practice
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• v.8 no.4
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• pp.386-390
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• 2014

BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS: We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of ${\beta}$-amyloid peptide ($A{\beta}$) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice. RESULTS: Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of $A{\beta}1$-42 until evaluation) effectively blocked $A{\beta}1$-42-induced impairment in passive avoidance performance, and $A{\beta}1$-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-$1{\alpha}$ in the hippocampus. In addition, it alleviated the $A{\beta}1$-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-$1{\beta}$ in the brain. CONCLUSIONS: The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.

• Journal of dental hygiene science
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• v.18 no.6
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• pp.357-366
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• 2018

The purpose of this study was to evaluate the validity of dental hygienist job according to judgment standard of medical practice in medical law. In this study, we conducted a self-administered questionnaire survey to evaluate the validity of dental hygienist job for 12 professors of dental college in Gangneung-Wonju National University from November 10 to 20, 2017. We investigated whether the dental hygienist job conforms to the three criteria of medical practice such as disease prevention and treatment, patient care, and health hazard. The response rates were scored and classified into four categories according to the final score. As a result of this study, dental hygienist job are classified into four categories according to judgment standard of medical practice. The higher the level of the category, the higher the degree of difficulty, and the higher the level of expertise and skills required. More than 50% of respondents answered that measuring the gingival pocket, bleeding on probing, professional tooth cleaning, oral health education, counseling after dental treatment are all three criteria for medical treatment. And these were classified into Level 4 group which requires the difficulty and expertise in the final score 4.3. It is necessary to develop and utilize standardized guidelines on the level of knowledge, education, and qualification standards required for dental practice in order to effectively allocate work among the dental personnel while ensuring the health rights of patients in the dental clinic field in Korea. In addition, there is a need to evaluate the various aspects of cost effectiveness, dental health service productivity, and health promotion contribution to dental hygienist jobs, And based on this evidence, it is necessary to continue to expand and adjust the dental hygienist job and to reorganize the dental workforce system.

• Journal of dental hygiene science
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• v.2 no.1
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• pp.21-24
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• 2002

It is important to practice preventive method to control oral disease. Dental caries tendency has been decreased in developed countries, but early childhood caries(ECC, BBTD) became serious dental problems in many countries. To slove these problems, more positive and definite prenatal programs on infants and child are needed. Mostly the control of oral health was affected by a mother's knowledge and behavior in this stage. According to many studies, prenatal education is the most effective method to promote oral health in children. But in Korea, there is little oral health education programs for pregnant women, nursing mothers, infants and children. The purpose of this study was to access the knowledge and opinions of caries prevention among gravid women. 330 pregnant women(primiparae=181, multiparae=149), aged 23 to 39 years were randomly selected at prenatal health education courses in Seoul, Korea, 2000. Face-to-Face interviews were conducted by a trained interviewer using questionnaires included demographics, attitude toward children's dental cares, knowledge of early childhood caries, knowledge concerning pregnancy and oral health. The obtained results were as follows; (1) Most respondents were very concerned about their children's oral health. (2) 58% of the respondents were unaware of early childhood caries and the proportion was significantly higher among primipara (p<0.05). (3) Only 43% of the respondents believed that improper breast feeding could develop ECC, the proportion was significantly higher among primipara(p<0.05). (4) 82% of the respondents reportedly believed that the fetus takes away calcium from the mother's teeth during pregnancy. (5) 71% of the respondents believed that dental treatment during pregnancy was unsafe. There is a relatively low level of accurate knowledge regarding infant nutritions, maternal need for oral health and dental caries prevention among pregnant women. Oral health education and promotion programs that are science-based are needed for gravid women.

• The Journal of Korean Society for School & Community Health Education
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• v.15 no.2
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• pp.39-49
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• 2014

Objectives: University students's oral health care practice and oral health status are very important. Because its affect their systemic disease, so as to have confidence, and to be eager to study. However if they feel dental fear, they avoid dental treatment. It is miss opportunities of early treatment and prevention treatment and have little effect on dental treatment. The aim of this study was to investigate the factors influencing dental fear of university students to reduce their dental fear. Methods: A total of 366 self-administered questionnaires were collected from university student in Cheon-an. To investigate the factors influencing dental fear of university students, t-test, one-way ANOVA, correlation analysis, linear regression analysis were carried out by using SPSS ver. 18.0 Results: University students feel the most fear of specific dental stimuli. Especially, 'Feeling the needle injected'. University Students felt dental fear in order of 'fear of specific dental stimuli', 'physiologic arousal', 'avoidance fear'. 'Feeling the needle injected', they felt severe dental fear. 'My muscles become tense' of Symptoms they feel dental fear was the most frequent Sex affects avoidance fear, physiologic arousal, fear of specific dental stimuli and dental fear. Femal feel more its than male. The time since last dental clinic visit affects physiologic arousal, fear of specific dental stimuli and dental fear. Group do not visit the dental clinic within a year feel more its than others. Conclusions: To reduce dental fear in university students, it is necessary to make them visit dental clinics frequently and dental staffs consider their sex. Therefore, Department of dental hygiene and dentistry must be added the management of dental fear of the curriculum. In addition, it must be emphasized that to visit dental clinics frequently for university students.

• Journal of Korean society of Dental Hygiene
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• v.11 no.5
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• pp.791-799
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• 2011

Objectives : This study aimed at examining the aspects of utilization of the dental services in some regions and analyzing the related factors with a view to helping the old solve the dental problems and overcome the difficulties. Methods : This investigation was intended for 422 old people living in Jeon-ju city and Jang-su county from July 18, 2006 to August 25 by direct interviewing posing questions. The survey data sets were analyzed by chi-square, correlation, multiple regression and logistic regression. Results : 1. The average number of the existing teeth per an old person was 13.6 and the 28.8% of the old who didn't use denture called for dentures. 2. The annual coefficient of utilization in dental services for an old person was 52.3% and the annual average visits to dental clinics were 3.12 days while 38.6% of the old experienced illegal dental treatments. 3. The affecting factors on the dental utilization for treatment were as follows: family income, dental clinics available, the number of existing teeth, the days of dental trouble, the recognition of the prevention of the dental disease, the knowledge for the dental treatment and the oral health judged by himself. 4. The major variables influencing the utilization of dental services were spouse presence, form of family, income, having a regular dental care, denture presence and the experience of inconvenience in living. Conclusions : To conclude, the following suggestions could be made. First, It was necessary that enforcement practice of free dental prosthesis service and application to the national health insurance in old people's prosthetic therapy for government support because the economic factor was barrier to utilization of the dental services. Second, Dental clinic was required to the health center because availability of common dental services was big impact in utilization of the dental services.

• Journal of Korean society of Dental Hygiene
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• v.8 no.4
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• pp.127-139
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• 2008

The purpose of this study was to examine the awareness of people in general about halitosis. The subjects in this study were 184 people who visited the clinical practice lab at J health college to get their teeth scaled. After a survey was conducted from May 1 to June 3, 2008, the analyzable answer sheets from 178 respondents were analyzed after four different areas were selected, which included smoking/nonsmoking, scaling experience, toothbrushing frequency and the use of oral hygiene supplies. SPSSWIN 12.0 program was utilized to make a frequency analysis and crosstabs analysis. The findings of the study were as follows: 1. Concerning subjective feelings of halitosis, 55.3 percent(99 people) of the respondents found themselves to have a moderate level of bad breath. 28.5 percent(51) deemed themselves to have a little foul breath, and 14 percent(25) didn't feel they had any bad breath. 2. As to the subjective level of halitosis, 89.8 percent(168) thought that their bad breath was a little perceived only by themselves, regardless of smoking, scaling experience, toothbrushing frequency and the use of oral hygiene supplies. 3. In regard to the cause of halitosis, 31 percent(56) cited plaque in the mouth as the cause, and 28.5 percent(51) pointed out the other causes that weren't mentioned in the questionnaire. 18.4 percent(33) cited decayed tooth, and 11.2 percent(20) pointed out gastroenteric disorder. 10.6 percent(19) viewed diabetes as the cause. 4. As to the time when they had the subjective symptom of halitosis, 114 respondents(63.7%) felt their own bad breath the most immediately after they got up 21.8 percent(39 respondents) did it when they were hungry 5.5 percent(9) did that before breakfast, and 4.5 percent(8) did that after having breakfast. 5. Regarding view of how to prevent halitosis, 52.5 percent(94) brushed their teeth frequently 21.2 percent(38) got their teeth scaled on a regular basis at a dentist's office, and 17.9 percent(32) drank water often. The above-mentioned finding seemed to suggest that the respondents weren't well aware of the fact halitosis was a sort of oral and systemic disease. Therefore the development of halitosis prevention and care programs geared toward practice lab visions were required.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7331-7335
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• 2015

Background: Concurrent chemoradiation with three weekly high dose cisplatin is the non-surgical standard of care for the treatment of locally advanced head and neck cancers. Although this treatment regime is efficacious, it has high acute toxicity, which leads not only to increased treatment cost, but also to increased overall treatment time. Hence, the current study was undertaken to evaluate the acute toxicity and tumor response in head and neck cancer patients treated with concurrent chemoradiation using $40mg/m^2$ weekly cisplatin, which has been our institutional practice. Materials and Methods: This single institution retrospective study included data for 287 head and neck cancer patients treated with concurrent chemoradiation from 2012 to 2014. Results: The mean age of the patients was 48.8 years. The most common site of involvement was oral cavity. Most of the study patients presented with advanced stage disease. The mean overall treatment time was 56.9 days. Some 67.2% had overall complete response to treatment as documented till 90 days from the start of treatment. According to the Radiation Therapy Oncology Group (RTOG) acute radiation morbidity scoring criteria, mucositis was seen in 95.1% of the patients. Dermatitis and emesis were observed in 81.9% and 98.6%, respectively. Regarding haematological toxicity, 48.8% and 29.6% suffered from anaemia and leukopenia, respectively, during treatment. Acute kidney injury was assessed using the Common Terminology Criteria for Adverse Events (CTCAE), and was found in 18.8% of the patients. Conclusions: Concurrent chemoradiotherapy with weekly cisplatin is an effective treatment regime for head and neck cancers with reasonable toxicity which can be used in developing countries, where cost of treatment is so important.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8661-8666
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• 2014

Background: Docetaxel and cisplatin in combination with fluorouracil (DCF) regimen is accepted to be one of the standard regimens in the treatment of advanced gastric cancer. However, substantial toxicity has limited its use in daily clinical practice. Therefore, modification of DCF regimens, including introduction of capecitabine has been investigated to improve the safety profiles. In the present study, the efficacy and toxicity of a regimen with a modified dose of docetaxel and cisplatin in combination with oral capecitabine (DCX) was evaluated in untreated patients with HER2-negative advanced gastric cancer. Materials and Methods: Fifty-four patients with HER2-negative locally advanced or metastatic gastric cancer were included in this cohort. Patients received docetaxel $60mg/m^2$ plus cisplatin $60mg/m^2$ (day 1) combined with capecitabine $1650mg/m^2$ (days 1-14) every 3 weeks. Treatment response, survival, and toxicity were retrospectively analyzed. Results: The median age was 54 years (range: 24-76). The majority of patients (70%) had metastatic disease, while 11 patients (21%) had recurrent disease and underwent curative gastrectomy, and 5 patients (9%) had locally advanced disease (LAD). The median number of DCX cycles was 4. There were 28 partial responses and 11 complete responses, with an overall response rate of 72%. Curative surgery could be performed in four patients among five with LAD. At the median follow-up of 10 months, the median progression-free survival (PFS) and overall survival (OS) of the entire cohort of patients were 7.4 and 12.1 months, respectively. Dose modification was done in 12 patients due to toxicity in 8 and noncompliance in 4 patients. The most common hematological toxicity was neutropenia, which occurred at grade 3-4 intensity in 10 of 54 patients (27.7%). Febrile neutropenia was diagnosed only in two cases. Conclusions: DCX regimen offers prominent anti-tumor activity and considered to be effective first-line treatment with manageable toxicity for patients with HER2-negative advanced gastric cancer.

• Journal of Korean society of Dental Hygiene
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• v.8 no.2
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• pp.93-106
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• 2008

This study is to enforce to ready basic data of effective school dental health education for dental caries prevention， relation knowledge of class, feeding practice and snack intake preference actual conditions, food and caries executed investigation by own recording way using questionnaire consisted of dental health education awareness to some business world man high school locating in Kyonggi Province. Analyzes result that total 487 people respond in SPSS WIN 13.0 programs and got following sequence The obtain result were as follows 1. Results about habit of breakfast was the most by 36.1% a student who have breakfast every day, and a student who hardly eat dominated 32.9%. Second-year student hardly had breakfast (p<.01). 2. A student who answer that snack kind that often eat was cookies and snack kind was the most by 37.2%, and a student who answer that symbol drink was a carbonated drink was the most by 50.9%. 3. Relation knowledge degree appeared grand mean among 18 points perfect score by 12.36 with food and caries. Third-year student knowledge degree was the highest, and second-year student was the lowest knowledge degree by class (p<.01). 4. Existence and nonexistence of experience of dental health education appeared a student who experience that take dental health education does not exist by 57.1%. There was experience that take dental health education as class is low by class, and as class is high, experience did not exists (p<.05). 5. Time that take dental health education for the first time was the most by 56.7% a student who respond 'Babyhood', grade in school is low by class 'Babyhood', and is high by class responded 'Middle school'(p<.05). 6. Awareness of dental health education necessity 'may educate dental health and does not' a student 56.3%, half was looked attitude which students who exceed are insincere about dental health education necessity. 7. When educate dental health, contents was the most by 44.6% 'brushing and mouth article directions' to be educated importantly, and was expose by caries 31.2%, gum disease 10.1%, scaling 9.0%, prosthetic dentistry and implant 5.1% period of ten days, third-year student 50.8% said that 'brushing and mouth article directions' is important (p<.05). Dental health education is practiced during life, and is a teaching that should be remembered. Need to develop epoch-making and interesting education program that is correct in subject to do as quickly as possible, and should be achieved major road of dental hygienist. Dental hygienist will have to settle as quickly as possible as expert of prevention that is natural business and education and help in dental health education development under effort between country and dental association effective.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.813-818
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• 2014

Aims: To describe our institutional experience with high dose rate (HDR) interstitial brachytherapy (IBT) compared with previously reported results on the low dose rate (LDR) practice for head and neck cancer. Materials and Methods: Eighty-four patients with oral cavity (n=70) or oropharyngeal cancer (n=14) were treated with 192Ir HDR-IBT. Seventy-eight patients had stage I or II tumour. The patients treated with IBT alone (n=42) received 39-42 Gy/10-14 fractions (median=40 Gy/10 fractions). With respect to the combination therapy group (n=42), prescription dose comprised of 12-18 Gy/3-6 fractions (median=15 Gy/5 fractions) for IBT and 40-50 Gy/20-25 fractions (median=50 Gy/25 fractions) for external radiotherapy. Brachytherapy was given as 2 fractions per day 6 hours apart with 4 Gy per fraction for monotherapy and 3 Gy per fraction for combination therapy. Results: Four patients were not evaluable in the analysis of outcome. The primary site relapse rates were 23.8% (10/42) and 68.4% (26/38) in patients treated with IBT alone and combination therapy, respectively (p<0.001). Salvage surgery was performed in 19 patients. The 5-year local control rate was estimated at 62% and the disease-free survival (DFS) rate at 52% for all patients. Local control with respect to T1 and T2 tumours was 84% and 42%, respectively. Conclusions: Our present series on HDR-IBT and the previous report on LDR-IBT for head and neck cancer demonstrated similar DFS rates at 5 years (52%). The rate of regional failure in node-negative patients was <20% in both of our series. HDR-IBT offers similar results to LDR-IBT for head and neck cancer.