• East Asian mathematical journal
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• v.39 no.1
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• pp.65-73
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• 2023

In this paper, we present an optimal control strategy to prevent the EMT process by downregulating the level of overexpressed β-catenin in the cytoplasm. To do this, we propose a mathematical model that expresses relationship between the Wnt signaling pathway and TGF-β in cancer cells. We also define an optimal control problem considering the side effects that occur simultaneously with the method for controlling the concentration of β-catenin. Finally numerical simulations show that treatment effect is quantitatively changes depending on the concentration of core proteins of the Wnt signaling pathway.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.7
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• pp.809-815
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• 2018

Distributed generations (DGs) using renewable energy resources in power systems have been widely integrated, and many of these DGs have intermittency. DGs can significantly affect the overall voltage profile of the system through the reactive power control for a voltage support. Therefore, in the planning stage of the optimal operation and dispatch of voltage regulation devices, DGs' hosting capacity with the reactive power control scheme should be considered. In this paper, we model the IEEE 34-bus test feeder, including all essential equipment. An optimization method is utilized to determine the optimal siting and operation of the voltage regulation devices in the presence of DGs with reactive power control scheme. Finally, we compare the optimal results of the each case to analyze the relationship among the hosting capacity of the DGs and voltage regulation devices operation.

• Journal of Biomedical Engineering Research
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• v.28 no.4
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• pp.569-576
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• 2007

Ventricular Assist Device(VAD) has switched its goal from a short-tenn use for bridge-to-transplantation to a long-tenn use for destination therapy, With this goal, the importance of long-tenn reliability gets more interests and importances, H-VAD is an portable extracorporeal biventricular assist device, and adopts an electro-pneumatic driving mechanism. The pneumatic pressure to pump out blood is generated with compression of bellows, and is transmitted in a closed pneumatic circuit through a pneumatic line. The existing pneumatic VAD adopts a air compressor which can generate stable pressures but has defects such as a noise and a size problem. Thus, it is not suitable for being used as a portable device, These problems are covered with adopting a closed pneumatic circuit mechanism with a bellows which has a small size and small noise generation, but it has defects that improper pneumatic setting causes a failure of adequate flow generation. In this study, the pneumatic pressure regulation system is developed to cover these defects of a bellows-type pneumatic VAD. The optimal pneumatic pressure conditions according to various afterload conditions for an optimal flow rate were investigated and the afterload estimation algorithm was developed, The final pneumatic regulation system estimates a current afterload and regulate the pneumatic pressure to the optimal point at a given afterload condition. The afterload estimation algorithm showed a sufficient performance that the standard deviation of error is 8.8 mmHg, The pneumatic pressure regulation system showed a sufficient performance that the flow rate was stably governed to various afterload conditions. In a further study, if a additional sensor such as ultrasonic sensor is developed to monitor the direct movement of diaphragm in a blood pump part, the reliability would be greatly increased. Moreover, if the afterload estimation algorithm gets more accuracy, it would be also helpful to monitor the hemodynamic condition of patients.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1993.10a
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• pp.194-211
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• 1993

This paper proposes an optimal incentive scheme for environmental pollution and output control in oligopoly markets under asymmetric information situation where the regulator has no information about each firm's technology on output productions and pollution abatements. We compare two interesting optimal incentive schemes (one is static model previously proposed and the other is dynamic model suggested in this paper), analyze features of these schemes, and carefully discuss its relevances to other schemes.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2000.05a
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• pp.483-492
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• 2000

In this paper, we explore the economic principle behind the revenue-sharing rule for interconnection charges. First, we assert that firms can collude by splitting tile revenues equally i.e., choosing the revenue-sharing ratio equal to l/2. Also, we characterize the optimal revenue-sharing ratio in a model of horizontal interconnection and discuss the relation between the optimal ratio and the optimal access price.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.11B
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• pp.700-708
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• 2007

This paper considers an incentive regulation in the telecommunications industry with respect to the sale of retail and access services. This regulation scheme induces the monopoly carrier who owns bottleneck facilities to adopt socially optimal outcomes when providing access and retail services. It is well known that upstream carriers can realize an integrated level of profit, without integration, by means of a two-part tariff. First, this paper introduces a framework for regulating an access and retail price combined with budget balancing. Second, this paper introduces two-part tariff (price discrimination) scheme for both access (upstream) and retail (downstream) services and discusses the resulting implications for incentive regulation when the regulator has incomplete information about cost functions. By imposing a self-selection mechanism, the regulator can induce firms to adopt socially optimal prices in both access and retail markets.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.1
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• pp.168-178
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• 2002

The purpose of this study is to develop an optimal performance design ova concrete median barrier using the design of experiment and crash simulation which is done by Pam-Crash, one of the commercial crash simulation software. A formula of characteristic value was suggested to obtain an optimal performance design considering all of von Mises stress, volume and acceleration at center of gravity of a heavy truck. An optimal design of a concrete median barrier was obtained by the analysis of variance based on design of experiment and crash simulation. A crash simulation with the optimal design was accomplished in order to verify the suitability of the suggested formula and the proper application of the design of experiment. The obtained optimal design was satisfied for a domestic design regulation of a concrete median barrier.

• ETRI Journal
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• v.37 no.2
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• pp.273-282
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• 2015

Vehicle-to-grid presents a mechanism to meet the key requirements of an electric power system, using electric vehicles (EVs) when they are parked. The most economic ancillary service is that of frequency regulation, which imposes some constraints regarding the period and duration of time the vehicles have to be connected to the grid. The majority of research explores the profitability of the aggregator, while the perspective of the EV fleet owner, in terms of their need for usage of their fleet, remains neglected. In this paper, the optimal allocation of available vehicles on a day-ahead basis using queuing theory and fuzzy multi-criteria methodology has been determined. The proposed methodology is illustrated on the daily scheduling of EVs in an electricity distribution company.

• Journal of Electrical Engineering and Technology
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• v.13 no.6
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• pp.2236-2244
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• 2018

We make optimal consecutive offer curves for an energy storage system (ESS) integrated wind power producer (WPP) in the co-optimized day-ahead energy and regulation markets. We build the offer curves by solving multi-stage stochastic optimization (MSSO) problems based on the scenarios of pairs consisting of real-time price and wind power forecasts through the progressive hedging method (PHM). We also use the rolling horizon method (RHM) to build the consecutive offer curves for several hours in chronological order. We test the profitability of the offer curves by using the data sampled from the Iberian Peninsula. We show that the offer curves obtained by solving MSSO problems with the PHM and RHM have a higher profitability than offer curves obtained by solving deterministic problems.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.12B
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• pp.1112-1121
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• 2006

This Paper deals with the model of fixed-mobile interconnection. Specifically, how interconnection charge and originating price are determined when there is customer ignorance about terminating network or the price. This paper shows that the terminating charge with customer ignorance is higher than without that, and therefore the retail price becomes higher. This paper discusses the several methods to prevent the increase of the retail price and suggests the scheme to regulate the retail price and interconnection charge, simultaneously.