• Toxicological Research
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• v.17 no.3
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• pp.187-194
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• 2001

The oxidative stress causes the cell damage and death and thereby, stimulates membrane lipid peroxidation. In this study, the correlation between the lipid peroxidation product and the parameter of liver fibrosis (cirrhosis) was investigated in cholestasis induced rats. The Sprague-Dawley rats were divided into 3 groups (sham: sham operation, BDL/S-I and BDL/S-II : bile duct ligation/scission) and were observed for 2 or 4 weeks. After observation period, the organs were weighed and the ratio of organ weight/body weight was calculated. Sera and liver tissue were used for the measurement of malondealdehyde (MDA), parameter of clinical biochemistry, total collagen content and the staining. The ratio of organ weight/body weight in BDL/S-I and BDL/S-II was significantly increased compared to sham operated group. Serological parameters (Alanine transaminase, Aspartate transaminase, Alkaline phosphatase and Total bilirubin) in BDL/S-I and BDL/S-II group were significantly higher than those in sham operated group. Concentration of MDA in BDL/S-I (261%) and BDL/S-II(790%) was significantly increased compared to MDA in sham operated group. And the content of hydroxyproline (hyp) in BDL/S-I and BDL/S-II group was significantly increased 2~4 times than in sham operated group. The good correlations between hyp in liver tissue and MDA in sera of sham operated group and all operated group were found (r=0.825). The significantly higher value of MDA, hyp and serological parameters in BDL/S-I and BDL/S-II group suggests the stimulation of lipid peroxidation and chronic liver damage. Especially the activation of lipid peroxidation and the stimulation of liver fibrosis was stronger in BDL/S-II group than in BDL/S-I group. The stronger fibrosis, portal-portal septum formation, the more massive bile duct proliferation in portal triads and stroma, and hepatocytes swelling were observed in liver tissue of and BDL/S-II group compared to BDL/S-I group. Conclusively, a good correlation between MDA as a lipid peroxidation marker and hyp as a liver fibrotic parameter could be connected with the process of liver fibrosis. Moreover, cholestasis condition may cause jaundice, activation of lipid peroxidation, and collagen accumulation in liver. Additionally, optimal observation period of bile duct obstruction for the screening of antioxidant and antifibrotic effect in rats would be four weeks.

• Journal of Korea Spatial Information System Society
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• v.8 no.1 s.16
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• pp.93-106
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• 2006

A Grid Database is a database management system to process effectively and use the distributed data in a grid computing environment. Spatial data is more important than other general data according to the local characteristics and requires a large storage. The grid database can be used as the optimal system for the management of the spatial data. However, contrary to the conventional distributed database systems, the Grid Database which guarantees the local autonomy has a possibility not to provide an effective system, or it is impossible to use a centralized management environment. In order to allow flexible responses to a dynamically changing environment, it is required to use effectively reorganized method. In this paper, hierarchical reorganization method is presented for dynamic reorganization in a grid database. When the reorganization is conducted, an organizer is created to collect the information of databases. In addition, the organizer which is constructed by the hierarchical structure supports information communication and reorganization, and then it allows the support of regional reorganization operation and effective balance control. The performance assessment of the proposed method shows that the processing capacity is increased after the reorganization.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.7 no.3
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• pp.175-182
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• 2009

The spent cationic exchange resins and anionic exchange resins were separated from mixed spent exchange resins by a fluidized bed gravimetric separator. The separated resins were identified by an elemental analysis and thermogravimetric analysis. The each test sample was prepared by diluting the slurry made by wet ball milling the cationic exchange resins and the anionic exchange resins separated as a spherical granular form for 24 hours. The resulting test samples showed a slurry form of less than $75{\mu}m$ of particle size and 25,000ppm of $COD_{cr}$. The decomposition conditions of each test samples from a thermal power plant were obtained with a lab-scale(reactor volume : 220mL) supercritical water oxidation(SCWO) facility. Then pilot plant(reactor volume : 24 L) tests were performed with the test samples from a thermal power plant and a nuclear power plant successively. Based on the optimal decomposition conditions and the operation experiences by lab-scale facility and the pilot plant, a commercial plant(capacity : 150kg/h) can be installed in a nuclear power plant was designed.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.5
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• pp.277-283
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• 2016

Tetrapod is one of the most widely used concrete armor units for rubble mound breakwaters. The calculation of the stability number of Tetrapods is necessary to determine the optimal weight of Tetrapods. Many empirical formulas have been developed to calculate the stability number of Tetrapods, from the Hudson formula in 1950s to the recent one developed by Suh and Kang. They were developed by using the regression analysis to determine the coefficients of an assumed formula using the experimental data. Recently, software engineering (or machine learning) methods are introduced as a large amount of experimental data becomes available, e.g. artificial neural network (ANN) models for rock armors. However, these methods are seldom used probably because they did not significantly improve the accuracy compared with the empirical formula and/or the engineers are not familiar with them. In this study, we propose an explicit method to calculate the stability number of Tetrapods using the weights and biases of an ANN model. This method can be used by an engineer who has basic knowledge of matrix operation without requiring knowledge of ANN, and it is more accurate than previous empirical formulas.

• Journal of Energy Engineering
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• v.26 no.3
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• pp.105-112
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• 2017

A lot of piping systems have been used from nuclear power systems to water supply systems. The maintenance of the piping systems is needed to ensure proper operation of the piping systems. Failure of the large pipe systems especially such as KDHC(Korea District Heating Corporation) can be a matter directly related to the enterprise productivity and profitability. It can also lead to very important issues in promoting public safety and convenience. Therefore a method of quick and safety repairs have been emerged as the most important problem. In this study, freezing seal isolation method using liquid nitrogen cryogenic refrigerant was developed for the maintenance of a pre insulated heat transport pipe of KDHC with a diameter of 300 mm. In this study, by employing computational analysis techniques we performed the flow and heat transfer analysis for the targeted pre insulated heat transfer pipe and freezing seal jacket(ice-Plug) and have selected for optimal system. The detailed design model based on the results of the computational analysis finally was produced. A laboratory-scale test apparatus were designed and the freezing seal isolation self-test carried out. Also the performance assessment tests in the test bed of KDHC were carried out for on-site application.

• Journal of Environmental Impact Assessment
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• v.23 no.4
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• pp.296-314
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• 2014

In recent years, Ministry of Environment (MOE) has been implementing a phased strengthening of the effluent standards for sewage treatment plants. In this regard, a comprehensive system should be developed to help check the appropriateness of such standards by specifying the grounds for standard-setting and investigating the current operation of sewage treatment plants clearly. It is necessary to establish a new standard-setting system for the effluent that is in a closer connection with the environmental criteria and rating systems. In the United States, the federal government provides guidelines on the least provisions and requirements for the Publicly Owned Treatment Works (POTWs). Local governments set the same or stricter guidelines that reflect the characteristics of each state. In Japan, the sewage treatment plants are subject to both the effluent standards and the discharge acceptable limits to pubic waters under the sewerage law. Specific requirements and limits are set in accordance with local government regulations. The European Union imposes sewage treatment plants with different provisions for effluent standards, depending on the sensitivity of public waters to eutrophication. The effluent standards for sewage treatment plants are classified by pollutant loads discharged to receiving waters. MOE also needs to introduce systems for setting new parameter standards on a POTW effluent by applying statistical means and treatment efficiencies or optimal treatment techniques, as seen in the cases of the US National Pollutant Discharge Elimination System (NPDES) or the EU Integrated Pollution Prevention and Control (IPPC).

• Applied Chemistry for Engineering
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• v.9 no.4
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• pp.486-490
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• 1998

Pt/C powder which was used as electrocatalyst in a Phosphoric Acid Fuel Cell(PAFC) was fabricated by colloid method. It was reported that the sulfur from reductant, $Na_2S_2O_4$, worked as a poison against catalyst during long term operation. To remove these sulfurs, we try to treat Pt/C powder by three different methods. First, we tried to remove the sulfur according to temperature and time in $H_2$ atmosphere. As the heat treatment temperature is raised up, the effect of the removal is increased but the electrode performance is decreased because of the growth of Pt particle size. The optimal heat treatment temperature is $400^{\circ}C$, the size of Pt particle is approximately $35{\sim}40{\AA}$ and the electrode performance is $360mA/cm^2$ at 0.7 V. At $400^{\circ}C$, even though the time of heat treatment is extended, size of Pt, amounts of remaining sulfur and electrode performance is almost constant. Secondly, when we removed in a crucible at $900^{\circ}C$ the removal of the sulfur was not better, but the size of Pt particle, approximately $80{\AA}$, was smaller than that of heat treatment in $H_2$ atmosphere at $900^{\circ}C$. Lastly we treated with solvents such as acetone, benzene, and carbon disulfide. It was observed that sulfur components were removed partly by extraction with solvents, the electrode performances were similar each other.

• KSBB Journal
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• v.20 no.2 s.91
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• pp.112-115
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• 2005

E. coli in combination with bacteriophage $\lambda$ was used to overcome the intrinsic plasmid instability that is frequently found in recombinant fermentation especially in long-term operation. In order to enhance the stability and productivity, the bacteriophage ${\lambda}NM1070$ was used in this study. It is a $\lambda$ mutant, which is deficient in the synthesis of protein related to DNA packaging and cell lysis. The ${\lambda}NM1070$ is also a temperature-sensitive mutant. To optimize the production of recombinant protein in this temperature-sensitive system, the temperature effects on growth and cloned gene expression were investigated for stable and efficient recombinant gene expression. The induction to the lytic state was not complete at $36^{\circ}C$ while the temperature above $40^{\circ}C$ induced the lytic state completely. However, the productivity was decreased at $42^{\circ}C$ by temperature inhibition. The L-free cell concentration increased with the increase of temperature until $40^{\circ}C$. In conclusion, ${\lambda}NM1070$ has the optimal temperature at $38^{\circ}C$ for stability and at $40^{\circ}C$ for expression.

• Journal of the Korea Society of Computer and Information
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• v.5 no.2
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• pp.30-36
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• 2000

The hidden node plays a role of the functional units that classifies the features of input pattern in the given question. Therefore, a neural network that consists of the number of a suitable optimum hidden node has be on the rise as a factor that has an important effect upon a result. However there is a problem that decides the number of hidden nodes based on back-propagation learning algorithm. If the number of hidden nodes is designated very small perfect learning is not done because the input pattern given cannot be classified enough. On the other hand, if designated a lot, overfitting occurs due to the unnecessary execution of operation and extravagance of memory point. So, the recognition rate is been law and the generality is fallen. Therefore, this paper suggests a method that decides the number of neural network node with feature information consisted of the parameter of learning algorithm. It excludes a node in the Pruning target, that has a maximum value among the feature value obtained and compares the average of the rest of hidden node feature value with the feature value of each hidden node, and then would like to improve the learning speed of neural network deciding the optimum structure of the multi-layer neural network as pruning the hidden node that has the feature value smaller than the average.

• Korean Journal of Microbiology
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• v.36 no.4
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• pp.279-284
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• 2000

Simultaneous reduction of Cr(VI) and degradation of phenol was observed in batch and bench-scale continuous stirred tank reactors using Rhodococcus sp. CP01 isolated from leachate. The strain CP01, which was capable of utilizing phenol as a sole source of carbon and energy, completely reduced added hexavalent chromium (0.25 mM) to its trivalent form during 60 hr batch assay under optimal conditions (pH 7.0 and 1,000 mg/L of phenol concentration). The rates of Cr(VI) reduction and phenol degradation were estimated as 4.17 $\mu$M Cr(VI) and 38.4 mg phenol.$L^{-1}{\cdot}hr^{-1}$, respectively. The continuous culture experiment was conducted for 46 days using synthetic feed containing different levels of chromate (0.0625 to 0.25 mM) and phenol(1,000 to 4,000 mg/L). With a hydraulic retention time of 100 hr, Cr(VI) reduction efficiency was mostly 100% for influent Cr(VI) and phenol concentrations of 0.125 mM and 3,000 mg/L, respectively. During quasi-steady-state operation, specific rate of Cr(VI) reduction was calculated as 0.34 mg Cr(VI).g $protein^{-1}{\cdot}hr^{-1}$ which was comparable to reported values obtained by using glucose as growth substrate. The results suggest the potential application of biological treatment for detoxification of wastewater contaminated simultaneously with Cr(VI) and pheonol.