• Title/Summary/Keyword: Opportunities and Challenges

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Sarcoma Immunotherapy: Confronting Present Hurdles and Unveiling Upcoming Opportunities

  • Sehan Jeong;Sharmin Afroz;Donghyun Kang;Jeonghwan Noh;Jooyeon Suh;June Hyuk Kim;Hye Jin You;Hyun Guy Kang;Yi-Jun Kim;Jin-Hong Kim
    • Molecules and Cells
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    • v.46 no.10
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    • pp.579-588
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    • 2023

  • Sarcomas are rare and heterogeneous mesenchymal neoplasms originating from the bone or soft tissues, which pose significant treatment challenges. The current standard treatment for sarcomas consists of surgical resection, often combined with chemo- and radiotherapy; however, local recurrence and metastasis remain significant concerns. Although immunotherapy has demonstrated promise in improving long-term survival rates for certain cancers, sarcomas are generally considered to be relatively less immunogenic than other tumors, presenting substantial challenges for effective immunotherapy. In this review, we examine the possible opportunities for sarcoma immunotherapy, noting cancer testis antigens expressed in sarcomas. We then cover the current status of immunotherapies in sarcomas, including progress in cancer vaccines, immune checkpoint inhibitors, and adoptive cellular therapy and their potential in combating these tumors. Furthermore, we discuss the limitations of immunotherapies in sarcomas, including a low tumor mutation burden and immunosuppressive tumor microenvironment, and explore potential strategies to tackle the immunosuppressive barriers in therapeutic interventions, shedding light on the development of effective and personalized treatments for sarcomas. Overall, this review provides a comprehensive overview of the current status and potential of immunotherapies in sarcoma treatment, highlighting the challenges and opportunities for developing effective therapies to improve the outcomes of patients with these rare malignancies.

  • https://doi.org/10.14348/molcells.2023.0079 인용 PDF

Prediction of ocean surface current: Research status, challenges, and opportunities. A review

  • Ittaka Aldini;Adhistya E. Permanasari;Risanuri Hidayat;Andri Ramdhan
    • Ocean Systems Engineering
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    • v.14 no.1
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    • pp.85-99
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    • 2024

  • Ocean surface currents have an essential role in the Earth's climate system and significantly impact the marine ecosystem, weather patterns, and human activities. However, predicting ocean surface currents remains challenging due to the complexity and variability of the oceanic processes involved. This review article provides an overview of the current research status, challenges, and opportunities in the prediction of ocean surface currents. We discuss the various observational and modelling approaches used to study ocean surface currents, including satellite remote sensing, in situ measurements, and numerical models. We also highlight the major challenges facing the prediction of ocean surface currents, such as data assimilation, model-observation integration, and the representation of sub-grid scale processes. In this article, we suggest that future research should focus on developing advanced modeling techniques, such as machine learning, and the integration of multiple observational platforms to improve the accuracy and skill of ocean surface current predictions. We also emphasize the need to address the limitations of observing instruments, such as delays in receiving data, versioning errors, missing data, and undocumented data processing techniques. Improving data availability and quality will be essential for enhancing the accuracy of predictions. The future research should focus on developing methods for effective bias correction, a series of data preprocessing procedures, and utilizing combined models and xAI models to incorporate data from various sources. Advancements in predicting ocean surface currents will benefit various applications such as maritime operations, climate studies, and ecosystem management.

  • https://doi.org/10.12989/ose.2024.14.1.085 인용