• World Technopolis Review
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• v.7 no.2
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• pp.82-96
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• 2018

This paper discussed the application process of the Dot Idea program. The Dot Idea program is an incubation and open innovation program co-created by Unitec, an incubator at Tecnosinos Tech Park, and an SAP innovation team. The main objective of this study was to cover an existing gap in the literature regarding the practical application of an open innovation methodology. Many companies seek interaction with external parties to enable advancement toward identified innovation opportunities. Technology clusters, parks, and incubators have played an important role in promoting connections and interaction. Consequently, the Dot Idea program emerged as a result of a joint effort to create a program using a design science research methodology aiming to foster new businesses and strengthen Brazil and Latin America as a hub to develop new solutions for traditional organizations. In regards to lessons learned, the Dot.health trial had some success but also experienced difficulties; these related to the relationships between startups and a hospital's internal teams, and startups' needs to be funded from the beginning in order to be fully dedicated to a project.

• Applied Chemistry for Engineering
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• v.33 no.3
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• pp.242-257
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• 2022

Microalgae is becoming a vital component for a circular economy and ultimately for sustainable development. Herein, recent developments in different outcomes of microalgae for wastewater treatment and biorefinery were reviewed. From its primary function as a third-generation resource of biofuel, the usage of microalgae has been diversified as an integral element for the CO₂ sequestration and production of economically valuable products (e.g., pharmaceuticals, animal feeds, biofertilizer, biochar, etc.). Principles and recent challenges for each microalgae application were presented to suggest a motivation for future research and the direction of development. The integration of microalgae within the concept of the circular economy was also discussed with various routes of microalgae-based biorefinery.

• Molecules and Cells
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• v.46 no.1
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• pp.10-20
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• 2023

Antisense oligonucleotide (ASO) technology has become an attractive therapeutic modality for various diseases, including Mendelian disorders. ASOs can modulate the expression of a target gene by promoting mRNA degradation or changing pre-mRNA splicing, nonsense-mediated mRNA decay, or translation. Advances in medicinal chemistry and a deeper understanding of post-transcriptional mechanisms have led to the approval of several ASO drugs for diseases that had long lacked therapeutic options. For instance, an ASO drug called nusinersen became the first approved drug for spinal muscular atrophy, improving survival and the overall disease course. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Although Trikafta and other CFTR-modulation therapies benefit most CF patients, there is a significant unmet therapeutic need for a subset of CF patients. In this review, we introduce ASO therapies and their mechanisms of action, describe the opportunities and challenges for ASO therapeutics for CF, and discuss the current state and prospects of ASO therapies for CF.

• International Journal of Computer Science & Network Security
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• v.24 no.4
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• pp.1-10
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• 2024

In the era of big data, the growth of e-commerce transactions brings forth both opportunities and risks, including the threat of data theft and fraud. To address these challenges, an automated real-time fraud detection system leveraging machine learning was developed. Four algorithms (Decision Tree, Naïve Bayes, XGBoost, and Neural Network) underwent comparison using a dataset from a clothing website that encompassed both legitimate and fraudulent transactions. The dataset exhibited an imbalance, with 9.3% representing fraud and 90.07% legitimate transactions. Performance evaluation metrics, including Recall, Precision, F1 Score, and AUC ROC, were employed to assess the effectiveness of each algorithm. XGBoost emerged as the top-performing model, achieving an impressive accuracy score of 95.85%. The proposed system proves to be a robust defense mechanism against fraudulent activities in e-commerce, thereby enhancing security and instilling trust in online transactions.

• International Journal of Fluid Machinery and Systems
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• v.2 no.1
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• pp.61-71
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• 2009

Machine fault diagnostic and prognostic techniques have been the considerable subjects of condition-based maintenance system in the recent time due to the potential advantages that could be gained from reducing downtime, decreasing maintenance costs, and increasing machine availability. For the past few years, research on machine fault diagnosis and prognosis has been developing rapidly. These publications covered in the wide range of statistical approaches to model-based approaches. With the aim of synthesizing and providing the information of these researches for researcher's community, this paper attempts to summarize and classify the recent published techniques in diagnosis and prognosis of rotating machinery. Furthermore, it also discusses the opportunities as well as the challenges for conducting advance research in the field of machine prognosis.

• Journal of Technology Innovation
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• v.9 no.2
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• pp.120-139
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• 2001

The purpose of this paper is to evaluate the Indian Software Industry and t government's industrial policy by analysing the characteristics of the software industry, authority, development process, social infrastructure, and public sector. The Information age is creating profound changes in the way we live and work. It is transforming all aspects of society, stimulating new opportunities. Over the past decade, India has deliberately prepared itself to meet the new challenges of the information age. India became an important player in shaping world software industry. Through the industrial policy, Indian government is focusing on 1) the development of software industry, 2) dramatic increase in IT scientists engineers, and the promotion of education institutes, 3) the establishment of the software technology Parks (STP), 4) the inducement of foreign direct investment, 5) extensive standardization, 6) the coordination of the law and system. India has liberalized finance and telecommunications system in an effort to bring in more business, and has revamped education curriculums to encourage more creativity among students. Government has played crucial role in bringing India one of advanced software nation by presenting the grand vision and sophisticated plan, liberalizing telecommunication market, and enhancing the efficiency of bureaucratic system.

• CELLMED
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• v.7 no.1
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• pp.2.1-2.3
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• 2017

World health organization has recently published a strategic plan for the development and promotion of traditional system of medicine. Herbal pathies especially Unani and Ayurvedic systems of medicines have great scope in this aspect. But, there are several problems with these pathies in the current era, as the way of research and identification is still on classical system. The correct identification of medicinal plant is one of the major problems in both the system. This should be corrected with the modern tools and techniques. The various types of data including recent discoveries, economical growth, ethnobotanical literature and extremely rapid increase in herbal journals and books have emerged great scope for these pathies. At the same time several challenges and threats are present including herb-drug interaction, false reports, toxicity studies etc. In this review paper, opportunities, threats, and researches to be focused will be discussed.

• Journal of Community Nutrition
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• v.8 no.2
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• pp.90-95
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• 2006

Asian Americans is a minority population contributing approximately 4% to the total population of the United States, however it is one of the fastest growing populations. Although Asian Americans as a group have socioeconomic profiles that are similar to white Americans, significant variations exists within and across Asian ethnic groups. The top ten leading causes of death for Asian Americans includes cancer, heart diseases, stroke, unintentional injuries, diabetes, influenza and pneumonia, chronic lower respiratory disease, suicide, nephritis, and septicemia. The prevalence of obesity is lower among Asian Americans, however this should be taken with considerations specific to Asians. High salt and low calcium consumption seem to be dietary risk factors for Asian Americans, although dietary patterns are changing with acculturation. Factors affecting dietary patterns are discussed in this paper. A proactive nutrition education approach for Asian Americans should be promoting maintaining 'healthy' aspects of ethnic diets and adopting 'healthy' American diets. Collaboration with nutrition educators in Asian countries would be helpful to overcome limited resources available for researching and developing nutrition education messages and materials for Asian Americans. (J Community Nutrition 8(2): 90-95, 2006)

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.2
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• pp.462-483
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• 2016

The research on optimization of cellular network's energy efficiency (EE) towards environmental and economic sustainability has attracted increasing attention recently. In this survey, we discuss the opportunities, trends and challenges of this challenging topic. Two major contributions are presented namely 1) survey of proposed energy efficiency metrics; 2) survey of proposed energy efficient solutions. We provide a broad overview of the state of-the-art energy efficient methods covering base station (BS) hardware design, network planning and deployment, and network management and operation stages. In order to further understand how EE is assessed and improved through the heterogeneous network (HetNet), BS's energy-awareness and several typical HetNet deployment scenarios such as macrocell-microcell and macrocell-picocell are presented. The analysis of different HetNet deployment scenarios gives insights towards a successful deployment of energy efficient cellular networks.

• Journal of Hydrogen and New Energy
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• v.27 no.6
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• pp.702-711
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• 2016

The authors reviewed information about biorefining of biomass by using academic information databases. Feedstocks were classified into triglycerides biomass, sugar biomass, starchy biomass, lignocellulosic biomass, and organic waste biomass. Biorefinery is an integrated system converting biomass into biofuels and biochemicals by various physical, chemical, biological, and thermochemical technologies. This paper presented a comprehensive summaries of opportunities, recent trends and challenges of biorefinery. A brief overview of promising building blocks, their sources from biomass, and their derivatives were also provided. In conclusion, this paper demonstrated the feasibility of biorefinery producing biofuels and biochemicals from biomass.