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Central nervous system depressant activity of Leucas aspera root

  • Rahman Shafiur;Sarder Mokaddez;Ali Yusuf;Rashid Abdur
    • Advances in Traditional Medicine
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    • 제6권3호
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    • pp.174-178
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    • 2006
  • The ethanolic extract of Leucas aspera root was studied for its effect on the central nervous system (CNS) using pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to control. In open field test the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed significant from the third observation period (60 min) and persisted up to the seventh observation period (240 min) except at fourth observation (90 min) for 250 mg dose group and depressing effect was significant from second observation (30 min) up to seventh observation period (240 min) for 500 mg dose group. These results support the finding that Leucas aspera root may contain biologically active constituent(s) having CNS activity.

Central nervous system depressant activity of Diospyros peregrina bark

  • Shilpi, Jamil Ahmad;Uddin, Shaikh Jamal;Rouf, Razina;Billah, Md. Morsaline
    • Advances in Traditional Medicine
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    • 제4권4호
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    • pp.249-252
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    • 2004
  • The methanol extract of Diospyros peregrina bark was studied for its effect on the central nervous system (CNS) using the pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract, at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to the control. In open field test, the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed from the second observation period (30 min) and persisted up to fifth observation period (120 min) for 250 mg dose group and up to sixth observation period (180 min) for 500 mg dose group. These results support the finding that D. peregrina bark extract at the above doses has CNS depressing effects and indicate that D. peregrina bark may contain biologically active constituent(s) having CNS depressant activity.

A Study on the Domain Discrimination Model of CSV Format Public Open Data

  • Ha-Na Jeong;Jae-Woong Kim;Young-Suk Chung
    • 한국컴퓨터정보학회논문지
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    • 제28권12호
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    • pp.129-136
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    • 2023
  • 정부는 공공데이터 품질관리 수준평가를 진행하여 공공 개방데이터의 품질관리를 진행하고 있다. 공공 개방데이터는 XML, JSON, CSV 등 여러 오픈포맷 형태로 제공되며 CSV 형식이 대다수를 차지한다. 이러한 CSV 형식의 공공 개방데이터 품질진단 시 품질진단 담당자가 공공 개방데이터 파일의 필드명과 필드 내 데이터에 의존하여 필드 별 도메인을 판단하여 진단한다. 그러나 대량의 개방 데이터 파일을 대상으로 품질진단을 수행하기 때문에 많은 시간이 소요된다. 또한 의미 파악이 어려운 필드의 경우 품질진단의 정확성이 품질진단 담당자의 데이터 이해도 역량의 영향을 받는다. 본 논문은 필드명과 데이터 분포 통계를 이용한 CSV 형식 공공 개방데이터의 도메인 판별 모델을 제안하여 품질진단 결과가 품질진단 담당자의 역량에 좌지우지 되지 않도록 일관성과 정확성을 보장하고 진단 소요 시간 단축을 지원한다. 본 논문의 모델 적용 결과 행정안전부에서 제공하는 파일형식 개방데이터 진단도구보다 2.8% 높은 약 77%의 정답률을 보였다. 이를 통해 공공데이터 품질관리 수준진단·평가에 제안 모델 적용 시 정확성을 향상시킬 수 있을 것으로 기대한다.

공동 주위에서의 압력 변화에 대한 연구 (Study on Pressure Variation around an Open Cavity)

  • 허대녕;이덕주
    • 한국소음진동공학회:학술대회논문집
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    • 한국소음진동공학회 2004년도 춘계학술대회논문집
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    • pp.843-846
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    • 2004
  • Cavity tone is generated due to the feedback between flow and acoustic wave. It is recognized that the period is determined by the time required for the flow convection in one direction, the time required for the acoustic propagation in the other direction and the time for phase shift depending on the flows and mode. Most of the phenomena have been investigated by experiments and a simple but fundamental theory. But the cause of the phase shift and the correctness of the theory have not been clearly explained so far. In this paper, the phenomena are calculated numerically to obtain detail information of flow and acoustic wave to explain the mechanism including the phase. High order high resolution scheme of optimized high order compact is used to resolve the small acoustic quantities and large flow quantities at the same time. The data are reduced using cross correlation function in space and time and cross spectral density function which has phase information. Abrupt change in pressure near corner in cavity is observed and is relate to phase variation. The time required for the feedback between the flow and acoustic wave is calculated after the numerical simulation f3r various modes. The periods based on the time calculated using the above method and direct observation from the acoustic waves generated and propagated in the numerical simulation are compared. It is found that no phase shift is required if we examine the time required carefully. Rossiter's formula for the cavity tone used for quick estimation needs to be modified far some modes.

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OpenRISC 코어의 성능향상을 위한 캐쉬 구조 설계 (Cache Architecture Design for the Performance Improvement of OpenRISC Core)

  • 정홍균;류광기
    • 대한전자공학회논문지SD
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    • 제46권1호
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    • pp.68-75
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    • 2009
  • 최근 마이크로프로세서의 성능이 빠르게 향상됨에 따라 주 메모리의 접근 시간이 증가하고 있어 캐쉬의 필요성이 증대되고 있다. 직접사상 캐쉬는 주 메모리의 각각의 블록이 하나의 캐쉬 라인에 사상되는 구조로서 사상되는 규칙이 간단하지만 서로 다른 블록이 하나의 캐쉬 라인에 사상될 경우 블록의 충돌에 의한 접근 실패율이 집합연관 캐쉬에 비해 높아진다. 본 논문에서는 OpenRISC 코어의 직접사상의 단점을 개선하기 위해 사원 집합연관 캐쉬 구조를 제시한다. 제시한 캐쉬는 주 메모리의 네 개의 블록이 하나의 캐쉬 라인에 사상되는 구조로서 직접사상 캐쉬에 비해 접근 실패율이 감소한다. 또한 라인 교체 방식으로 Pseudo-LRU 방식을 채택하여 LRU 정보를 저장하는 비트 수를 감소시켰다. FPGA 에뮬레이션을 이용하여 사원 집합연관 캐쉬를 포함한 OpenRISC 코어를 검증하였고, 테스트 프로그램을 이용하여 성능을 측정한 결과, 사원 집합연관 캐쉬를 포함한 OpenRISC 코어의 성능이 기존의 OpenRISC 코어의 성능에 비해 약 50% 향상되었고, 미스율은 15%이상 감소하였다.

The Clinical Comparison between Open Surgery and Percutaneous Endoscopic Lumbar Discectomy in Extraforaminal Lumbar Disc Herniation

  • Jeong, Jin-Seok;Lee, Sang-Ho;Lee, Sang-Jin;Hwang, Byeong-Wook
    • Journal of Korean Neurosurgical Society
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    • 제39권6호
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    • pp.413-418
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    • 2006
  • Objective : The objective of this study is to evaluate and compare the clinical results between classical open surgery and percutaneous endoscopic lumbar discectomy[PELD] in cases of extraforaminal lumbar disc herniation. Methods : We obtained the clinical data from 47 patients with extraforaminal lumbar disc herniations who underwent the open paramedian muscle-splitting approach or percutaneous endoscopic lumbar discectomy[PELD] between January 2001 and February 2004. This study consisted of patients with soft disc extraforaminal herniations. The patients were assessed with the visual analogue scale[VAS] and MacNab's criteria before surgery, just before discharge, and postoperative 1 year. Results : There were 25 cases in the open surgery group and 22 cases in the PELD group. The average operating time was $78{\pm}36.71\;min$ in the PELD group and $110{\pm}29.68\;min$ in the open surgery group. The mean hospital stay was $2.73{\pm}2.62$ days in the PELD group and $7.68{\pm}2.59$ days in the open surgery group. VAS decreased from $8.34{\pm}0.66$ to $1.29{\pm}2.27$ in the PELD group and from $8.40{\pm}1.40$ to $1.70{\pm}1.72$ in the open surgery group at the one-year follow-up. The success rate of PELD was 86.4%, compared with 80.0% for open surgery. However, there were no statistically significant difference between two groups for success rate and VAS. Conclusion : Although the success rates were similar in both groups, PELD is less invasive, faster, and safe procedure than open surgery for extraforaminal disc herniation in selected patients.

오픈 콘텐츠를 활용한 디지털 리터러시 학습 요소 구성과 활용 (A Study on Composition and Utilization of Digital Literacy Education elements Using Open Contents)

  • 홍명희;이순영
    • 정보교육학회논문지
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    • 제22권6호
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    • pp.711-721
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    • 2018
  • 인공 지능 기술의 발달과 소프트웨어 중심 사회로의 변화로 누구나 접근 가능할 수 있으며 안정적이고 지속 가능한 다양한 오픈 콘텐츠 속에서 어떻게 접근, 이해, 활용하고, 또한 새로운 오픈 콘텐츠를 어떻게 만들고 공유하는지에 대한 디지털 리터러시 교육의 필요성이 제기되고 있다. 이러한 시점에서 본 논문은 디지털 리터러시를 데이터, 도구, 장치 요소에 대한 각각 하위의 리터러시 개념인 컴퓨터 리터러시, ICT 리터러시, 정보 리터러시로 계층화하고 인지적 능력과 비인지적 능력을 포함하는 개념으로 정의하였다. 또한 오픈 콘텐츠는 OER(Open Educational Resource)과 Open Access 운동과 같이 누구나 자유롭게 사용하고 공유할 수 있는 교수-학습 자료로 정의하고, 두 정의를 기반으로 한 디지털 리터러시 요소 활용 방안으로 디지털 리터러시 교육을 위한 3단계 전략을 마련하여 디지털 환경에서 오픈 콘텐츠를 선정하고, 다음으로 디지털 리터러시 교육 방안을 제시하며, 마지막으로 디지털 리터러시 역량을 함양하기 위한 교육 활동을 실시하는 교육 프레임을 제시하였다.

개합추(開闔樞)에 대한 문헌학적 고찰 (A Philological Study of Previous Research on Open-Close-Pivot(開闔樞))

  • 최동현;백유상;정창현;장우창
    • 대한한의학원전학회지
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    • 제32권2호
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    • pp.33-47
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    • 2019
  • Objectives : To review the meaning of Open-Close-Pivot and its transition over time. Methods : Annotations and explanations in chapters where the theory of Open-Close-Pivot originated from in the "Suwen(素問)" and "Lingshu(靈樞)" were examined, followed by philological examination of key physicians. Results & Conclusions : Yang Shang Shan(楊上善) compared the 'Open-Close-Pivot' to a door. Wang Bing(王冰) explained it's movement and stillness to be the principle behind the Three-Yin-Three-Yang's threefold division. Wang Ji(汪機), in "XuSuwenChao(續素問鈔)" explained its physiological function as the entering and exiting of Ying Wei(營衛), and its scope to be exterior, interior, and center. Ma Shi(馬蒔) stratified it similar to "Shanghanlun(傷寒論)"'s six stages, while Wu Kun(吳崑) categorized Shaoyang(少陽) as being in-between exterior and interior. Zhang Jing Yue(張景岳) suggested a standard for the entering-exiting and exterior-interior-center concepts of the Open-Close-Pivot. Zhang Zhi Cong(張志聰) argued a theory of Open-Close-Pivot that emphasized the meaning of Three-Yin-Three-Yang, while Gao Shi Zong(高士宗) explained the relationship between Open, Close, Pivot and the functioning process. Shi Shou Tang(石壽棠) explained the physiology and pathology in the actions among Open-Close-Pivot with a focus on Pivot. Ke Qin(柯琴) applied Open-Close-Pivot to "Shanghanlun(傷寒論)" and used it as the basic principle to the Six Channel Ground Theory(六經地面說), also clinically applying it in the identification and treatment of the Six Channel patterns. Conclusions : Counting based word embedding methods seems to be more effective than.

학교담장허물기에 관한 의식조사 연구 -원주지역 5개 학교담장에 관한 의식조사를 중심으로- (A Survey Study on the Consciousness of the School Fence Removal -focused on the consciousness of the five schools on fence removal, in Wonju city-)

  • 이은희;서덕석;최재석
    • 교육녹색환경연구
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    • 제9권1호
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    • pp.11-22
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    • 2010
  • Recently, the necessity of open spaces is increased greatly in the city. But in many reasons, open spaces are diminishing gradually in the existing cities. It is more difficult to keep that space because of expensive land price, and the interests between the neighbors. To solve this problem, the local governments tries to change the street system more convenient to the pedestrian by adapting no vechile street system during some specific time. In this point of view, the street which include fence of school, house, and apartment can be the open space. Especially, removal of the school fence can be a useful solution providing open spaces to small cities suffering from lack of open spaces. In this researching background, several schools in Wonju were selected in this research, some has already been opened, and others yet. Opinions of students, presidents of these schools, and citizens are surveyed about removal of fence. In the basis of this result, we deduce problems followed by removing the fence, and reflect it in the plan of opening the fence to present the guidance to cross over the functional limitation of the fence and use it as a open space.

Evaluation of hyoid bone movements in subjects with open bite: a study with real-time balanced turbo field echo cine-magnetic resonance imaging

  • Karacay, Seniz;Gokce, Sila;Yildirim, Ersin
    • 대한치과교정학회지
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    • 제42권6호
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    • pp.318-328
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    • 2012
  • Objective: To assess the position and movements of the hyoid bone during deglutition in patients with open bite. Methods: Thirty-six subjects were divided into 2 groups according to the presence of anterior open bite. The open bite group (OBG) and control group each comprised 18 patients with a mean overbite of $-4.9{\pm}1.9$ mm and $1.9{\pm}0.7$ mm. The position of the hyoid bone during the 4 stages of deglutition was evaluated by measuring vertical and horizontal movement of the bone. Results: Interactions of group and stage showed no significant effect on the measurements (p > 0.05). However, when group and stage were evaluated individually, they showed significant effects on the measurements (p < 0.001). In OBG, the hyoid bone was more inferiorly and posteriorly positioned, and this position continued during the deglutition stages. Conclusions: The hyoid bone reaches the maximum anterior position at the oral stage and maximum superior position at the pharyngeal stage during deglutition. Open bite does not change the displacement pattern of the bone during deglutition. The hyoid bone is positioned more inferiorly and posteriorly in patients with open bite because of released tension on the suprahyoid muscles.