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Cancer subtype's classifier based on Hybrid Samples Balanced Genetic Algorithm and Extreme Learning Machine (하이브리드 균형 표본 유전 알고리즘과 극한 기계학습에 기반한 암 아류형 분류기)

  • Sachnev, Vasily;Suresh, Sundaram;Choi, Yong Soo
    • Journal of Digital Contents Society
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    • v.17 no.6
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    • pp.565-579
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    • 2016
  • In this paper a novel cancer subtype's classifier based on Hybrid Samples Balanced Genetic Algorithm with Extreme Learning Machine (hSBGA-ELM) is presented. Proposed cancer subtype's classifier uses genes' expression data of 16063 genes from open Global Cancer Map (GCM) data base for accurate cancer subtype's classification. Proposed method efficiently classifies 14 subtypes of cancer (breast, prostate, lung, colorectal, lymphoma, bladder, melanoma, uterus, leukemia, renal, pancreas, ovary, mesothelioma and CNS). Proposed hSBGA-ELM unifies genes' selection procedure and cancer subtype's classification into one framework. Proposed Hybrid Samples Balanced Genetic Algorithm searches a reduced robust set of genes responsible for cancer subtype's classification from 16063 genes available in GCM data base. Selected reduced set of genes is used to build cancer subtype's classifier using Extreme Learning Machine (ELM). As a result, reduced set of robust genes guarantees stable generalization performance of the proposed cancer subtype's classifier. Proposed hSBGA-ELM discovers 95 genes probably responsible for cancer. Comparison with existing cancer subtype's classifiers clear indicates efficiency of the proposed method.

Solution processed inverted organic solar cells with hybrid inorganic/organic cathode interlayers

  • Lee, Jung Suk;Cha, Myoung Joo;Park, Yu Jung;Kim, Jin Young;Seo, Jung Hwa;Walker, Bright
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.154.2-154.2
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    • 2016
  • In this work, we introduce a solution-processed CdS interlayer for use in inverted bulk heterojunction (BHJ) solar cells, and compare this material to a series of standard organic and inorganic cathode interlayers. Different combinations of solution-processed CdS, ZnO and conjugated polyelectrolyte (CPE) layers were compared as cathode interlayers on ITO substrates to construct inverted solar cells based on $PTB7:PC_{71}BM$ and a $P3HT:PC_{61}BM$ as photoactive layers. Introduction of a CdS interlayer significantly improved the power conversion efficiency (PCE) of inverted $PTB7:PC_{71}BM$ devices from 2.0% to 4.9%, however, this efficiency was still fairly low compared to benchmark ZnO or CPE interlayers due to a low open circuit voltage ($V_{OC}$), stemming from the deep conduction band energy of CdS. The $V_{OC}$ was greatly improved by introducing an interfacial dipole (CPE) layer on top of the CdS layer, yielding outstanding diode characteristics and a PCE of 6.8%. The best performing interlayer, however, was a single CPE layer alone, which yielded a $V_{OC}$ of 0.727 V, a FF of 63.2%, and a PCE of 7.89%. Using $P3HT:PC_{61}BM$ as an active layer, similar trends were observed. Solar cells without the cathode interlayer yielded a PCE of 0.46% with a poor $V_{OC}$ of 0.197 V and FF of 34.3%. In contrast, the use of hybrid ZnO/CPE layer as the cathode interlayer considerably improved the $V_{OC}$ of 0.599 V and FF of 53.3%, resulting the PCE of 2.99%. Our results indicate that the CdS layer yields excellent diode characteristics, however, performs slightly worse than benchmark ZnO and CPE layers in solar cell devices due to parasitic absorption below 550 nm. These results suggest that the hybrid inorganic/organic interlayer materials are promising candidates as cathode interlayers for high efficiency inverted solar cells through the modification of interface contacts.

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Characteristics of Velocity Fields around 3-Dimensional Permeable Submerged Breakwaters under the Conditions of Salient Formation (설상사주 형성조건 하에 있는 3차원투과성잠제 주변에서 내부유속변동의 특성)

  • Lee, Kwang-Ho;Bae, Ju-Hyun;An, Sung-Wook;Kim, Do-Sam
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.29 no.6
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    • pp.399-409
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    • 2017
  • This study numerically investigates the characteristics of the velocity field including the average flow velocity, longshore current and turbulent kinetic energy acting as the main external forces of the salient formed behind the permeable submerged breakwaters. Shoreline response is also predicted by the longshore-induced flux. In this paper, a three-dimensional numerical wave tank based on the OLAFOAM, CFD open source code, is utilized to simulate the velocity field around permeable submerged breakwaters under the formation condition of salient. The characteristics of the velocity field around permeable submerged breakwaters with respect to the gap width between breakwaters and the installing position away from the shoreline under a range of regular waves for different wave height are evaluated. The numerical results revealed that as the gap width between breakwaters increases, the longshore currents become stronger. Furthermore, as the gap width becomes narrower, the point where flow converges moves from the center of the breakwater to the head part. As a result, it is possible to understand the formation of the salient formed behind the submerged breakwaters. In addition, it was found that the longshore currents caused by the gap width between breakwaters and the installation position away from the shoreline are closely related to the turbulent kinetic energy.

Characteristics of Water Surface Variations around 3-Dimensional Permeable Submerged Breakwaters under the Conditions of Salient Formation (설상사주 형성조건하에 있는 3차원투과성잠제 주변에서 수면변동의 특성)

  • Lee, Kwang-Ho;Bae, Ju-Hyun;An, Sung-Wook;Kim, Do-Sam
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.29 no.6
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    • pp.335-349
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    • 2017
  • Submerged breakwaters installed under the water surface are a representative coastal structure to prevent coastal erosion, and various types of submerged breakwaters have been proposed and discussed so far. Generally, submerged breakwaters make the complex wave fields due to abrupt change in water depth at the crown of the breakwater. In this study, wave heights and mean water level formed around a breakwater are examined numerically for three-dimensional permeable submerged breakwaters. OLAFOAM, CFD open source code, is applied in the numerical analysis, and the comparisons are made with available experimental results on the permeable upright wall and the impermeable submerged breakwater to verify its applicability to the three-dimensional numerical analysis. Based on the applicability of OLAFOAM numerical code, the wave height and mean water level distribution formed around the permeable submerged breakwaters are investigated under the formation condition of salient. The numerical results show that as the gap width between breakwaters decreases, the wave height in the center of the gap increases, while it decreases behind the gap, and the installing position of the breakwater from the shoreline has little influence on the change of the wave height. Furthermore, it is found that the decrease of the mean water level near the gap between breakwaters increases with decreasing of the gap width.

A Study on the Spatial Distribution of Medical Waste Generation and Treatment in Korea (한국의 의료폐기물 발생 및 처리의 공간적 분포에 관한 연구)

  • Oh, Se-Eun;Lee, Jinheon;Ahn, Hoki;Kim, Ki-Youn;Park, Seokhwan;Ha, Kwonchul;Ji, Kyunghee;Hwang, Sungho;Yoon, Oh-Sub;Hong, Young-Seoub;Lee, Eunil;Kim, Pangyi;Lee, Kyoung-Mu
    • Journal of Environmental Health Sciences
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    • v.41 no.6
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    • pp.449-457
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    • 2015
  • Objectives: In Korea, the system of management of medical waste largely relies on the incineration method. Our study aimed to identify any regional imbalances between the generation and treatment of medical waste, and provide reference data for future policy in Korea. Methods: We analyzed data on the amount of medical waste from 2,000 hospitals in 2012, 2013, and 2014 obtained from the Korea Environment Corporation. In the Arc GIS program (version 10.2.3), the addresses of hospitals and incinerators were transformed into map coordinates. The amount of waste generated by each hospital and the amount incinerated were represented by density and size of a triangle symbol, respectively. Results: As of 2014, the total amount of medical waste from the top 2,000 hospitals was 136,073 tons, out of which about half (49%) was generated in the capital area. Eleven incineration companies (three in the capital area, two in the Chungcheong Provinces area, one in the Jeolla Provinces area, and five in the Gyeongsang Provinces area) treated this waste. For the years 2012, 2013, and 2014, about 60% of the medical waste generated from the hospitals in the capital area was treated within the capital area and about 40% was transported to other areas, especially the Gyeongsang Provinces area, for treatment. On the other hand, about 90% of the medical waste incinerated in the capital area originated from the capital area. Conclusion: Our results suggest a spatial imbalance between the generation and treatment of medical waste in Korea and warrants multilateral policies, including the expansion of on-site treatment, strengthening regulation of the containment of medical wastes, promoting reductions in medical waste and more.

A Clinicostatistical Study of 677 Mandibular Fractures (하악골 골절 667 증례의 임상통계학적 분석)

  • Lee, Sang-Han;Lee, Seoung-Ho
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.11 no.1
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    • pp.50-62
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    • 1989
  • This is clinicostatistical study of mandibular fractures. This study was based on a series of 677 patients with mandibular fracture during the period of 1982 to 1987. This results obtained were as follows : 1. In respect of incidence, there were high frequency in May and September, and in large city(63%). 2. The age frequency was the highest in the 20s-year old group (38.7%), and the ratio of male to female was 4.64 : 1. 3. The most common etiologic factor was blow(31.5%), but in children that was traffic accident followed by fall down. 4. The most common site of bone fractures was symphysis, followed by angle, condyle. In comparison of right and left sides, left side was more frequently involved(364 cases) than right side(257 cases). 5. The patients arrived in hospital immediately within 24 hours after accident were 62.9% of all, and 42.4% was arrived via private medical and dental clinic. 6. In respect of treatment, open reduction was 55.5% of all, closed reduction was 37.2%. In children, closed reduction was done in 50.6%.

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A Study on the Effect of STAD Group Study using Gradual Self-Leading Learning Materials on the Accomplishments of Math Curriculum (자기주도적 수준별 학습지를 이용한 STAD 협동학습이 수학교과 학습 성취도에 미치는 효과)

  • 송영무;나덕수
    • Journal of the Korean School Mathematics Society
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    • v.6 no.1
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    • pp.65-85
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    • 2003
  • The purpose of this research is to increase mathematical problem solving abilities VIa STAD evaluation after completing classes. to which ST AD group study is applied, and promoting the learning accomplishments of students by developing gradual self-leading learning materials about the research project on ' How to use an hour math class efficiently\ulcorner ' For this purpose, the items below were studied. Firstly, gradual self-leading learning materials were developed and applied which were composed of textbook abstracts, basic problems, developing problems and intensive problems rather than existing textbooks. Secondly, the ST AD group study model was selected and applied which invokes competitions among small groups of which learning goals were clear. individual responsibility was important. and successive opportunities were equal. The evaluation using STAD at each end of a chapter was announced instantly using the EXCEL scoring system. Though the results of experimental classes were limited in their size. experimental time, and class selection, there were meaningful changes in the aspect of being able to heighten the accomplishment desire of students by inducing voluntary competitions among small groups without any student omitted. As the result of applying this research to my class, the ST AD group study using gradual self-leading learning materials invoked the interests of students and increased learning accomplishments via increasing problem solving abilities in mathematics. The ST AD group study was easy to use by beginning teachers, and its process was simple. It increased interactions among students and learning motives because its compensation system was open to all students. Among various studying methods for small groups. STAD group study is expected to be widely used for mathematics classes.

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Energy Balance and Methane Production of Hanwoo Cows Fed Various Kind of Roughage (다양한 조사료 급여조건에서 한우 암소 경산우의 에너지분배 및 메탄배출량)

  • Oh, Young Kyoon;Kim, Do Hyung;Moon, Sang Ho;Park, Jae Hyun;Nam, In Sik;Arokiyaraj, Selvaraj;Kim, Kyoung Hoon
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.34 no.4
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    • pp.283-287
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    • 2014
  • This experiment was conducted to determine methane production and emission factors for a range of roughage diets fed to Hanwoo cows at a level of maintenance energy requirement. Seven cows were fed mixed hay only, 12 cows were fed mixed hay containing 30~50% rice straw and 6 cows were fed a mixed hay diet supplemented with 1.0 kg of wheat bran. Each cow was placed in a metabolic crate for 10 consecutive days, including last 7 days for sampling of feces and urine. At the end of the sampling period, the cows were transferred to an open-circuit respiration chamber for 24 consecutive hours. Methane conversion rate (5.5~6.2%, mean value = 5.8%) and emission factor (33.6~38.6 kg/head/year, mean value = 35.2) were not significantly affected by the diets although the mixed hay only diet resulted in 11 and 15% higher respective rates than the other two. However, in light of the many assumptions that forage with good quality might reduce methane production, additional experiments should be required for participation in the greenhouse gas emission trading system.

Health Promotion Behavior and Related Factors of College Students (전문대학생들의 건강증진행위에 영향을 미치는 요인)

  • Shim, Gyu-Beom
    • The Journal of Korean Society for School & Community Health Education
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    • v.8 no.2
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    • pp.35-48
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    • 2007
  • Background & Objective: The purpose of this study was to identify the level of health behavior and taking courses related with those subjects by college students and analyse the factors that have effect on these issues so that provide a basic material in developing policy and education program that can increase the level of health behavior for them. Methods: A questionnaire was applied 1,500 college students for two months from October 10 to 30, 2007. Results: 1) When viewing the objects of this study as general traits and social economic ratio, 'female' was 59.4%, BMI index of '20-14' was 52.7%, department of natural science was 47/7%, and 'their own house' was 51.0%. 2) When viewing the experience of taking courses related with health by the trait of demography and sociology, 'no' was most high by showing 42.2%, and those of female. under 19 in BMI index, and the department of natural science showed no experience. 3) When viewing satisfaction with college life they showed $3.00{\pm}0.71$, stress level in college life $2.84{\pm}0.41$, the level of health behavior $2.06{\pm}0.65$. 4) When viewing taking courses related with health, stress in college life. and health behavior according to satisfaction with college life they showed $2.06{\pm}0.59$. 5) When viewing the level of health behavior according to demographic and sociological traits, the habit of eating was $2.48{\pm}0.52$ and health care was $2.96{\pm}0.47$. 6) When viewing the effect of factors on health behavior, there were gender, age, residence area, grade, and satisfaction with college life. Conclusion: As we can see from the results above, it is the fact that the students in college are neglecting the subjects related with health owing to short period of education and major based education by the education aim of fostering professional career manpower. Therefore it needs open many culture courses for the subject related with health in college for the students to increase their health level as well as their major, and also there needs combined improvement of college and government system.

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Effect of Community Intervention on Knowledge, Attitude and Behavior of Low-salt Diet among College Students (대학생의 저염식이 지식, 태도, 행위에 대한 지역사회 중재효과)

  • Chung, Younghae;Woo, Sang Jun;Cho, Yoo Hyang;Park, Young Hee
    • The Journal of Korean Society for School & Community Health Education
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    • v.18 no.1
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    • pp.57-68
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    • 2017
  • Objectives: The purpose of the study was to evaluate the effect of community intervention on reducing salt intake among college students on their knowledge, attitude and practice of low-salt diet. Methods: A community intervention planned to increase college students' knowledge, attitude and practice of low-salt diet. The intervention comprised of 1 lecture on salt and health, 4 campaigns on low-salt diet, and 2 taste testing was carried out from March 24 to May 19, 2015. All the intervention was open to entire university while data was collected from a panel of convenient sample. We used the baseline data of 251 students, 226 students completed post-test. Post-test data on knowledge, attitude, and practice, blood pressure measurement, and urine salt test were collected on May 25 and 26 by trained nursing students and graduates. Baseline data were collected on March 17 and 18. Data were analyzed using IBM-SPSS 21.0 for t-test and ANCOVA. Results: Regarding a general characteristic and health behavior, there was statistically significant difference in living arrangement(p<0.001), amount of monthly allowance(p=0.005) and frequency of eating-out(p<0.001) between the two regions in this study. However, there was no statistically significant difference in gender, major, smoking, drinking and frequency of breakfast. Regarding a characteristic related to low-salt diet, there was statistically significant difference in diastolic blood pressure level(p=0.002), urine test(p=0.001). But there was no statistically significant difference in knowledge, attitude, practice of low-salt diet and systolic blood pressure. There was no statistically significant difference in their knowledge of low-salt diet(F=1.588, p=0.209), attitude(F=2.182, p=0.141), practice(F=3.507, p=0.062) and systolic blood pressure(F=1.723, p=0.191), diastolic blood pressure(F=1.552, p=0.214), urine test after a community intervention. Conclusions: Community intervention that does not have concrete target group doesn't seem to be effective on increasing knowledge, attitude and practice of the entire community, not even in university-a somewhat closed community. It is suggested to apply a target specific intervention in order to have efficient and effective outcome from a intervention.

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