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Dosage Adjustment before and after Warfarin - Rifampin Combination Therapy (와파린-리팜핀 병용 시 용량 조절)

  • Kim, Dong-Hyun;Kim, Kyung-Hwan;Choi, Kyung-Hee;Lee, Kwang-Ja;Lee, Hye-Suk;Son, In-Ja;Kim, Ki-Bong;Lee, Jae-Woong;Ahn, Hyuk
    • Journal of Chest Surgery
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    • v.41 no.3
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    • pp.354-359
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    • 2008
  • Background: Warfarin is used as an anticoagulant and it is mainly excreted by the liver metabolism (the R-form is mainly metabolized by cytochrome p450 3A4, and the S form by cytochrome p450 2C9). Rifampin is usually used for tuberculosis or endocarditis, and it is a representative drug that induces the CYP families, including 3A4 and 2C9. The anticoagulation effect of warfarin decreases through the increased metabolism that's due to the induction of enzymes, and this iscaused by rifampin when patients take these two medicines together. No one has suggested appropriate guidelines regarding this drug interaction even though an appropriate adjustment of warfarin's dosage is needed. We examined the drug interaction in patients who received warfarin-rifampin combination therapy according to the time interval, and the factors affecting drug interaction were analyzed. Based on the data, we tried to determine the clinically available warfarin dosage guidelines before and after taking this drug combination. Material and Method: We reviewed the OO University Hospital anticoagulation service team's follow up sheets that were filled out from Jan '1998 to Sep 2006 for the patient who took warfarin - rifampin combination therapy (n=15). Result: The average INR of all the patient before rifampin administration was $2.25{\pm}0.52$ $(mean{\pm}SD)$, and that value for the first 100 days after rifampin administration was $1.98{\pm}0.28$. The p value for these two sets of data showed no correlation (paired t-test, p>0.05). The average INR of all the patient before rifampin cessation was $2.19{\pm}0.34$, and the value after rifampin cessation was $2.49{\pm}0.43$. The p value of these two showed correlation (paired t-test, p<0.05) but the average INR falls between the therapeutic INR range. Conclusion: The warfarin dose adjustment equation of before and after warfarin-rifampin combination therapy was derived based on this study's results because the warfarin dosage adjustment of the anticoagulation service team was considered appropriate.

A Study on the Autonomic Nerve Function of Oligomenorrheic Patients by Using HRV(Heart Rate Variability) (HRV(Heart Rate Variability) 측정을 통한 희발월경 환자의 자율신경기능에 관한 연구)

  • Heo, Ja-Kyung;Lee, Jin-Moo;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub
    • The Journal of Korean Obstetrics and Gynecology
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    • v.20 no.4
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    • pp.101-110
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    • 2007
  • Purpose: Oligomenorrhea is clinically important because it can be progressed to amenorrhea. The purpose of this study is to analyse Autonomic Nerve Function of some oligomenorrheic patients by using HRV(Heart Rate Variability). Methods: We studied 35 patients visiting OO Oriental Hospital from 1st November 2006 to 31th May 2007. One woman who takes antidepressant is excluded. 17 oligomenorrheic group and 17 normal menstrual cycle group were compared with HRV. The SPSS 12.0 for windows was used to analyze the data and Mann Whitney U-test were used to verify the results. Results: Mean PR, LF norm, LF/HF ratio of oligimenorrheic group are higher than normal menstrual cycle group. But there is no statistically significance. SDNN, RMS-SD, ln TP, ln VLF, ln LF, ln HF, HF norm of oligimenorrheic group are lower than normal menstrual cycle group. But there is no statistically significance. Conclusion: It can be suggested that oligomenorrhea can be related to increased activities of sympathetic nerve and decreased activities of general autonomic nerve function. But, we need study with more subjects for settling this.

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A Study on the D.I.T.I Patterns of Climacteric Patients. (갱년기 증상을 호소하는 여성들의 적외선 체열 영상 유형에 대한 연구)

  • Heo, Ja-Kyung;Hwang, Deok-Sang;Lee, Chang-Hoon;Kim, Yong-Suk;Lee, Kyung-Sub
    • Journal of Oriental Medical Thermology
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    • v.7 no.1
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    • pp.14-21
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    • 2009
  • Purpose : Among many symptoms that the climacteric patients complain of, the major symptom is heat and cold sensation of body in various pattern. So, we are intended to study patterns of climacteric patients by using D.I.T.I. Methods : We studied 55 patients visiting OO Oriental Hospital from 1st January 2008 to 31th December 2008. The patients were distributed one of patterns by inspecting D.I.T.I. And we investigated the temperature of the region of body in 5 groups. Results : There are five groups in D.I.T.I. Those are heat sensation of face pattern, heat sensation of chest pattern, cold sensation of hand & foot pattern, heat sensation of hand pattern and cold sensation of lower abdomen pattern. 22 subjects are in heat sensation of face group. 12 subjects are in heat sensation of chest group. 12 subjects are in heat sensation of hand group. 6 subjects are in cold sensation of lower abdomen group. 3 subjects are in cold sensation of hand & foot group. Conclusion : 5 patterns of D.I.T.I is showed in climacteric patients. To help oriental medical diagnosis, further studies are needed.

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A Study on Characters of DITI, HRV and Body Composition Analysis in Amenorrhea (무월경 환자의 DITI와 HRV, 체성분 분석을 통한 특성 연구)

  • Jeong, Jae-Hyuk;Lee, Jin-Moo;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub
    • Journal of Oriental Medical Thermology
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    • v.7 no.1
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    • pp.30-36
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    • 2009
  • Purpose : The purpose of this study is investigate the characters of DITI, HRV and Body composition analysis in Amenorrhea. Methods : We studied 47 patients visiting OO hospital from 1st October 2007 to 19st September 2009. The subjects were categorized in two groups, amenorrhea group(26) and normal group(21). We studied the difference of DITI, HRV and Body composition analysis between two groups by Mann-whitney test using SPSS for windows(version 12.0). Results : there is not statistically significant difference of DITI, HRV and BMI between amenorrhea group and normal group. But there is statistically significant difference of percent body fat and waist-hip ratio between amenorrhea group and normal group. Conclusion : Percent body fat and Waist-Hip ratio of amenorrhea groups is lower than normal groups. Percent body fat and Waist-Hip ratio can be diagnosis index.

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A Study of DITI in Women with Premenstrual Syndrome (월경전증후군 환자의 적외선 체열영상 소견에 관한 후향적 연구)

  • Hwang, Deok-Sang;Cho, Jung-Hoon;Lee, Chang-Hoon;Lee, Jin-Moo;Jang, Jun-Bock;Lee, Kyung-Sub
    • Journal of Oriental Medical Thermology
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    • v.6 no.1
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    • pp.8-15
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    • 2008
  • Purpose: Although premsnstrual syndromes(PMS) have long been recognized, there has been difficulty to evaluate the symtoms. Usually the questionnaire has been used to dignose the PMS. Objective is to investigate the relationship of body temperature between women with PMS and without PMS. Methods: We studied 23 patients visiting OO hospital from 26th December 2005 to 26th April 2006. The Questionnaire for PMS was used to evaluate physical, emotional, and behavioral symptoms accompanying the menstrual cycle of the subjects. The subjects were categorized in two groups, non-PMS(11) and PMS group(12). Body temperature was assessed by Dorex spectrum 9000MB (DOREX Inc., USA). We measured CV4, CV3, CV12 and CV17 to evaluate the distribution of body temperature, compared the difference of temperature(${\Delta}T$) between CV17-CV4, CV17-CV3, CV17-CV12 and CV12-CV3. We investigated the of temperature and ${\Delta}T$ between two groups by Mann-Whitney U-test. Results: The temperature of CV3 and CV4 of PMS located in low abdomen were lower than those of non-PMS located in chest. But there was no statistical significance of temperature between two groups. There was lower temperature of low abdomen in PMS group than non-PMS group without statistical significance. Conclusion: The results suggest that DITI could be useful to assess the PMS objectively. But more research should be needed.

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A Study on Stress and Blood Stasis Pattern for 55 Uterine Myoma, Adenomyosis, Endometriosis Patients (자궁근종, 자궁선근증, 자궁내막증 환자 55명의 스트레스 정도와 어혈증(瘀血證) 연구)

  • Cho, Jun-Young;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub;Lee, Jin-Moo
    • The Journal of Korean Obstetrics and Gynecology
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    • v.23 no.4
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    • pp.130-145
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    • 2010
  • Purpose: The purpose of this study is to know stress and blood stasis pattern for the patients who had hysterectomy related with uterine myoma, adenomyosis, endometriosis. Methods: We got questionnaires from 55 patients among 243 patients who had hysterectomy related with uterine myoma, adenomyosis, endometriosis in the department of obstetrics and gynecology, OO medical center from April 11th 2010 to October 14th 2010, and analyzed them. We conducted correlation analysis between age, pain(VAS), duration of pain and blood stasis score, and between duration of pain, blood stasis score and the sum of Stress Response Index. We compared the sum of Stress Response Index, blood stasis score, VAS according to the result of pathology. For statistics, we used Pearson's correlation coefficient, Mann-Whitney test, oneway analysis of variances(ANOVA) and SPSS version 17.0 for windows. Results: The correlation between duration of pain and blood stasis score showed statistical significance. The correlation between sum of the Stress Response Index and blood stasis score showed statistical significance. There is no statistically correlation between age, VAS, duration of the pain and blood stasis score. There is no statistically significant difference in sum of Stress Response Index, blood stasis score, VAS according to the result of pathology. Conclusion: The result showed that Stress is related with static blood, and the longer patients suffer from pain, the easier patients' blood to be static. Further study will be needed.

Effects of Functional Electrical Stimulation of Rectus Abdominis on Respiratory Capabilities in Children with Spastic Cerebral Palsy (복직근의 기능적 전기자극이 경직형 뇌성마비 아동의 호흡 능력에 미치는 효과)

  • Cho, Mi-Suk;Park, Rae-Joon
    • The Journal of Korean Physical Therapy
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    • v.17 no.4
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    • pp.601-612
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    • 2005
  • 본 연구는 복직근의 기능적 전기자극이 경직형 뇌성마비 아동의 1회 호흡용적과 폐활량 등의 호흡능력과 복직근의 근육활동에 미치는 영향을 알아보기 위해서 대구 시내 OO특수학교에 재학 중인 14세 이상 16세 미만의 경직형 사지 뇌성마비 아동 6명(남자 3, 여자 3)을 대상으로 하여 복직근에 1회 20분. 주 3회씩 총 6주간 기능적 전기자극을 적용하였다. 기능적 전기자극의 적용 6주 전과, 직전에 두 번의 사전 검사와 적용 후 사후 검사를 실시하였다. MP30(Biopack, USA)을 이용하여 폐활량과 예측치 폐활량 백분율, 1회 호흡용적을 검사하였으며 Table면전극 근전도(Noraxon, USA)를 이용하여 복직근의 근육 활동량을 측정하였다. 분석결과는 다음과 같다. 1. 복직근의 기능적 전기자극 적용 6주 전과 직전의 폐활량은 유의한 차이가 없었으나, 적용 후의 폐활량은 적용 전에 비해 유의한 증가를 나타내었다(p<0.05). 2. 복직근의 기능적 전기자극 적용 6주 전과 직전의 예측치 폐활량 백분율은 유의한 차이가 없었으나, 적용 후의 예측치 폐활량 백분율은 적용 전에 비해 유의한 증가를 나타내었다(p<0.05). 3. 복직근의 기능적 전기자극 적용 6주 전과 직전의 1회 호흡용적은 유의한 차이가 없었으나, 적용 후의 1회 호흡용적은 적용 전에 비해 유의한 증가를 나타내었다(p<0.05). 4. 복직근의 기능적 전기자극 적용 6주 전과 직전의 복직근의 활동 값은 유의한 차이가 없었으나 적용 후의 복직근의 활동 값은 적용 전에 비해 유의한 증가를 나타내었다(p<0.05). 이상의 결과를 종합해 볼 때 6주간의 복직근의 기능적 전기자극이 경직형 뇌성마비 아동에 있어서 복직근의 근력을 강화시킴으로써 폐활량과 1회 호흡 용적 등의 호흡능력을 향상시킴을 확인할 수 있었다.

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Effect of Execution Time-oriented the Elementary EPL Education on Computational Thinking Ability of Elementary School Students (수행시간 중심의 초등 EPL 교육이 초등학생 컴퓨팅 사고력에 미치는 효과)

  • Moon, Woojong;Boo, YongHo;Kim, Jonghoon
    • Journal of The Korean Association of Information Education
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    • v.24 no.3
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    • pp.233-241
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    • 2020
  • This study has developed and applied an elementary EPL education program centered on execution time as an educational method for improving Computational thinking of elementary school students, and then its effect has been verified. The education program was developed based on the results of preliminary demand analysis conducted on 48 elementary school students. In order to verify the effectiveness of the education program, 25 students were asked to participate in the class of elementary school students on a seven hours for six days. Using the "Korea Bebras Challenge 2018", educational effects were analyzed through the results of pre- and post-mortem examinations, and the analysis showed that elementary EPL education centered on performance time was effective in improving computational thinking of elementary school students

A Study on the Reliability Analysis of Anti-ship missile using Field Data (야전 운용자료를 이용한 대함유도탄의 신뢰도 분석 연구)

  • Kim, Seok-Kon;Wang, Young-Jin;Kim, Yong-Jin;Kim, Sung-Ouk;Lee, In-Hyun;Lee, Key-Seo
    • The Journal of the Korea institute of electronic communication sciences
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    • v.6 no.6
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    • pp.881-887
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    • 2011
  • In this paper, age exploration of ${\bigcirc}{\bigcirc}$ anti-ship missiles which were deployed on RoKN ships were analysed using parametric estimation method. Additionally, Life distribution and failure pattern of ${\bigcirc}{\bigcirc}$ anti-ship missile were analysed by using field data such as collected inspection, fail, maintenance record for 6 years. Storage failure and MTBF of missile and components were analysed by using reliability analysis s/w Weibull++ v7. The results were compared with maintenance policy including periodic inspection and MTBF which were analysed during development phase. Finally, the suggested methodology using field data analysis of oo anti-ship missile will be applied on re-estabilishment of maintenance policy of ${\bigcirc}{\bigcirc}$ anti-ship missile for TLCSM(Total Life Cost System Management) effectively.

A Comparative Study on the Literature of Korean and Chinese Shroud (한국수의와 중국수의와의 문화적 비교연구)

  • 유관순
    • Journal of the Korean Society of Costume
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    • v.34
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    • pp.79-89
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    • 1997
  • Comparison of Korean shroud with Chinese shroud are as follows. 1. Taetae Simeui P'oo Hansam Ko, Mal, Nukpaek, Kwatu, Ch'ungi Po-kkon Myokmok Ri Aksu Mo and Om were used the most inchina. However Mangkon Tapho Tanko Sotae Ri and Kop'o were used more widely in Korea. 2. The cloths of Chinese shroud were p'o, Paek and Kyun but those of the orean were paek Chu Chung and P'o The colors of the chinese and Koean shroud was Hyun Hun and white. 3. The size of the Cinese shroud is as follows. The size of the Ch ungi ws si-milar tothe size of jujube kernel the len-gth of Myokmok was one Ch'ok two Ch'on or one Ch'ok five Ch'on the length of Aksu was one Ch'ok two Ch'on and its width was five Ch'on. The chil of Mo reached the hands and the length of Sw-ae was three Ch'ok and the length of Om ws five Ch'on. the size of the Korean shroud was the same as Chinese shroud except that the size fo Myokmok and the lenth of Chil and Swae was seven Ch'ok respectively,. 4. In Korean and Chinese shroud Aksu was tied by the strings at two corners Myokmok was teid by the strings of four corners. The tip of the Om was divided and Mo wrapped the shole body. 5. The clothes of Soryom was nineteen Ch'ing in Korean and chinese shroud. The clothes of Taeryom in Kun were one hundred Ch'ing in the chinese and ninety Ch'ing in the Korean shroud. The imple-ment of Soryom were Kum Kyo Sangeui Saneui Ch'im Yok and Kyon in the Chinese shroud and were Kum Kyo Sangeui Saneui Ch'im Yok Kyonand Sinmyon in the Korean shroud. In the case of the implement of Taeryom the Chinese shroud had Kum Kyo Sangeui Saneui Ch'im and Yok the same as Korean shroud.

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