• Clinics in Shoulder and Elbow
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• 제21권4호
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• pp.200-206
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• 2018

Background: The purpose of this study was to assess the relevance of preoperative magnetic resonance imaging (MRI) evaluation by occupation ratio (OR) at maximum diameter of supraspinatus muscle. Methods: Patients from the Inje University Sanggye Paik Hospital who received rotator cuff repair and underwent pre- and postoperative MRI were selected as subjects of this study. On T1-weighted MRIs, OR of fat and muscle at Y-shaped view, OR at a location on supraspinatus muscle where its diameter was maximum on coronal view, and pre- and postoperative Goutallier Classification and changes in the tangent sign were measured. Statistical significance of postoperative OR was assessed regarding time from symptom onset to surgery, size of rotator cuff tear, preoperative OR, and the difference between ORs measured at maximum diameter of supraspinatus muscle and Y-shaped view. Results: Preoperative OR at Y-shaped view was $52.28{\pm}8.57$ (32.5-65.3). Preoperative OR difference between maximum diameter and Y-shaped view was $13.76{\pm}10.51$ (2.38-42.04), and Pearson correlation coefficient was 0.604 (p=0.001). Postoperative OR at Y-shaped view was $63.77{\pm}9.35$ (37.3-76.1). Pearson correlation coefficient of pre- and postoperative Goutallier Classification was -0.579 (p=0.002) and Pearson correlation coefficient of the postoperative difference between ORs measured at maximum diameter of supraspinatus muscle and Y-shaped view was -0.386 (p=0.047). Conclusions: Fatty degeneration of supraspinatus muscle in rotator cuff tear patients should be evaluated not only in the conventional Y-shaped view, but also at location of maximum diameter of supraspinatus muscle to establish patients' therapeutic plan.

• 한국수정란이식학회지
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• 제17권1호
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• pp.61-65
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• 2002

한우 미성숙 난자의 vitrification 동결시 발생단계별 생존성과 체외발생율을 알아보고자 난자를 0, 10, 14 및 20시간 성숙배양시킨 후 vitrification 동결 융해 후의 체외발생율을 조사하였다 본 연구에서 나타난 결과를 요약하면 다음과 같다. 1. 0, 10, 14 및 20시간 성숙배양시킨 난자를 vitrification 동결보존 후 MR 단계로의 발생율은 각각 33.3%, 55.0%, 68.3% 73.3%였으며, diploid로의 발생율은 26.7%, 21.7%, 6.7%, 1.7%로서 대조군의 M II 단계의 78.2%에 비해 낮게 나타났으나 diploid단계의 3.6%에 비해서는 높게 나타났다. 2. 미성숙 난자를 0, 10, 14 및 20시간 성숙배양 시킨 후 vitrification 동결 응해 후의 생존율은 각각 38.0%, 30.0%, 20.0% 및 12.0%로서 비동결 대조군의 48.0%에 비해 낮은 생존율을 나타냈다. 3. 미성숙 난자를 0, 10, 14 및 20시간 성숙배양 시킨 다음 vitrification동결 응해 후 수정하였 때 체외수정율은 64.6%, 61.6%, 54.8%, 32.3% 였으며, 배 반포로의 체 외 발생 율은 각각 32.3%, 21.7%, 14.5%, 4.6%로서 대조춘의 80.0%와 55.0%에 비해 낮은 체외수정율과 체외발생율을 나타냈다.

• 대한약리학회지
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• 제9권1호
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• pp.23-37
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• 1973

This paper presents the effect of chronic administration of psychotropic drugs on rats. The experimental animals were litter mates (average initial body weight $47{\pm}1.1g$) whose mother were bred at our laboratory. Each litter mate was treated as one group. Control animals were treated with tap water and each experimental group was treated with caffeine citrate 0.1%, nialamide 0.1%, ethyl alcohol 2.5%, phenobarbital sod. 0.1%, diphenylhydantoin 0.1%, chlorpromazine 0.1%, reserpine 0.005%, diazepam 0.01%, chlorpheniramine 0.01% solutions respectively in drinking water over a period of ten weeks. All rats were allowed food and drinking water ad libitum. The mortality rate and the per cent increase of body weight were recorded weekly throughout the course of the experiment. The effects of above agents on the pentobarbital sleeping time, gastric secretion, and brain and liver weights were studied at the end of ten weeks treatment. The obtained results are summarized as follows: 1. Mortality rate was highest in the groups treated with phenobarbital and chlorpromazine respectively. Through the experimental period (ten weeks), the mortality rate was higher in earlier stage than in the later period. 2. During the period of prolonged administration of psychotropic drugs, only diazepam treated group showed remarkable difference in per cent increase of body weight from the control group of rats. 3. Acute treatment with psychotropic drugs delayed the onset of pentobarbital sleeping time. In contrast, the sleeping time was significantly shortened (p<0.001) when the rats were treated chronically with those agents. 4. The effects of chronic treatment with phenobarbital or diphenylhydantoin on the gastric secretion are as follows: the total acidity was remarkably decreased while the pH was increased. 5. The brain weight was significantly decreased in the ethyl alchol and in the chlorpheniramine treated groups, in the mean time, there was no change in liver weight treated with any psychotropic drugs.

• The Korean Journal of Physiology and Pharmacology
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• 제17권3호
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• pp.229-235
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• 2013

Among several animal models of retinitis pigmentosa (RP), the more recently developed rd10 mouse with later onset and slower rate of retinal degeneration than rd1 mouse is a more suitable model for testing therapeutic modalities. We therefore investigated the time course of retinal degeneration in rd10 mice before adopting this model in our interventional studies. Electroretinogram (ERG) recordings were carried out in postnatal weeks (PW) 3~5 rd10 (n=23) and wild-type (wt) mice (n=26). We compared the amplitude and implicit time of the b-wave of ERG records from wt and rd10 mice. Our results showed that b-wave amplitudes in rd10 mice were significantly lower and the implicit time of b-waves in rd10 mice were also significantly slower than that in wt mice ($20{\sim}160{\mu}V$ vs. $350{\sim}480{\mu}V$; 55~75 ms vs. 100~150 ms: p<0.001) through PW3 to PW5. The most drastic changes in ERG amplitudes and latencies were observed during PW3 to PW4. In multichannel recording of rd10 retina in PW2 to PW4.5, we found no significant difference in mean spike frequency, but the frequency of power spectral peak of local field potential at PW3 and PW3.5 is significantly different among other age groups (p<0.05). Histologic examination of rd10 retinae showed significant decrease in thickness of the outer nuclear layer at PW3. TUNEL positive cells were most frequently observed at PW3. From these data, we confirm that in the rd10 mouse, the most precipitous retinal degeneration occurs between PW3~PW4 and that photoreceptor degeneration is complete by PW5.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권6호
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• pp.464-469
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• 2011

Introduction: As dental implant surgery is becoming increasingly popular, it has become one of the causes for the hypesthesia of the inferior alveolar nerve, along with other surgical procedures, such as a third molar extraction. In addition, it tends to cause legal problems between the operator and patient. Therefore, there must be a proper method that is reliable, objective and economical to assess the nerve impairment. For this reason, an attempt was made to use an Electric Pulp Tester to assess inferior alveolar nerve block anesthesia. Materials and Methods: Thirty patients were tested. Electric pulp testing of the lower jaw skin was performed at the three different times, before anesthesia, at the onset of sensory changes and after 15 minutes waiting from the onset, and on the 10 points of the chin, which produced 10 sections on the skin area. Results: Twenty seven patients (90%) could feel the electric stimulus on the chin at all 10 points before local anesthesia and the scores represent the statistical differences between the right and left points except R4 and L4. After anesthesia, the difference between the right and left points (L3-R3, L4-R4, L5-R5) increased significantly with time but two points (L2, R2) showed no significant difference. The scores on the left chin (L3, L4, L5) increased, whereas the other points (R1-R5, L1, L2) showed no significant differences. Conclusion: This study highlights the potential clinical use of an electric pulp tester for an assessment of inferior alveolar nerve impairment.

• Environmental Analysis Health and Toxicology
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• 제15권3호
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• pp.61-67
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• 2000

Toxic lesions of styrene in the Japanese Medaka (Oryzias latipes) were compared with those of styrene oxide, the active metabolite of styrene, using embryo-larval assays. The developmental stages of Japanese Medaka (Oryzias latipes) treated with both chemicals were not altered and progressed normally. However, styrene oxide was more toxic than styrene in terms of causing death and lesions . High concentrations of styrene (higher than 4.9 ppm) and styrene oxide (higher than 2.4 ppm), resulting in more than 50% mortality, caused similar lesions of cardiovascular system, craniofacial bone formation and spinal deformities, although a number of lesions were not observed by both chemicals . In the group treated with styrene, eyeball sizes and intereye distances were reduced, while, in the group treated with styrene oxide , the eyes and eye cups were not developed and two eyes were sometimes fused. In addition, styrene oxide caused the lesion which involved the posterior brain and brain stem were herniated through the spinal cord . The noticeable difference of toxic symptoms between these two chemicals was the time of onset. Toxicities of cardiovascular system and craniofacial bone formation appeared on day 3 of development in styrene oxide treated group, but, styrene treated group staned to show hemorrhages on day 3 and the craniofacial malformation were appeared on day 5, These differences between two chemicals may be due to the metabolism of styrene to styrene oxide, the reactive intermediate.

• 말소리와 음성과학
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• 제7권1호
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• pp.39-45
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• 2015

Changes in speech production in normal elderly might be subtle and gradual. Therefore, an acoustic analysis is appropriate to identify the effect of aging on speech. For this purpose, this study examined four speech parameters; voice onset time (VOT), VOT range, $f_0$ of following vowel($f_0FV$), and $f_0FV$ difference in two age groups, old (mean age 74.57 yrs.) and young (m: 27.43 yrs.). The results show that compared to the older group the younger demonstrated significantly shorter VOTs in lenis and longer in aspirated stop. VOT ranges were relatively broad and consequently overlapped between the phonation types (e.g., lenis, fortis, aspirated). The $f_0FV$ values in the older group which are an integral parameter with VOT were lower compared with the young group. The $f_0FV$ differences in the old female group were significantly narrower than the young female group, therefore, clear distinction became difficult. In conclusion, contrast in temporal information was obscured, and the domain of glottal information was diminished on stop consonants in Korean elderly. The findings suggest that central/peripheral changes by aging could lead to a deficit in coordination between phonation and articulation.

• 말소리와 음성과학
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• 제5권3호
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• pp.11-20
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• 2013

The purpose of this study is to compare the acoustic parameters of English stop consonants at the initial and after-initial-/s/ positions in a message produced by 47 Korean and American speakers in order to provide better pronunciation skills of English stops for Korean learners. A Praat script was developed to obtain voice onset time (VOT), maximum consonant intensity (maxCi), and rate of rise (ROR) from six target words with stops at the positions in the message. Results show that VOT and maxCi were significantly different between the two language groups while ROR wasn't. The Korean speakers generally produced the stop consonants with longer VOTs and higher consonant intensity. From the comparison of consonant groups at the two different positions, the Korean participants did not distinguish them as clearly as the American participants did at the after-initial-/s/ position. Finally a comparison of each language and sex group revealed that the major difference was attributed to stop consonants in the after-/s/ position. The author concluded that Korean speakers should be careful not to produce all the stops with longer VOTs and higher intensity. Further studies would be desirable to examine how Americans evaluate Korean speakers' English proficiency with modified acoustic values of English stops.

• The Korean Journal of Pain
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• 제1권1호
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• pp.91-97
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• 1988

Herein is a review of eigthy six surgical cases from March to August, 1986 which recieved tetracaine hydrochloride spinal anesthesia. In an attempt to relieve postoperative pain, 0.5 mg morphine sulfate was administrated into the lumbar subarachnoid space. Pruritus, a side effect of intraspinal morphine, was explored in detail. The results were as follows : 1) The incidence of pruritus was 67.4%, 65.5% in man and 71.0% in woman. 2) The time of onset of pruritus was between 30 and 120 minutes with an average of 79.1 minutes. 3) Pruritus primary occurred on the face(87.9%), especially on the nasal, perinasal and periocular areas. Other sites included the scalp, neck, chest, abdomen, shoulder, hip, thigh, flank, and whole body. 4) The severity of pruritus was classified as mild and moderate, but 4 cases(6.9%) were regarded as severe and were treated with naloxone. 5) The duration of pruritus was from 15 minutes to 19 hours with an average of 4.7 hours. 6) There was no significant difference in the prevention of pruritus between the group recieving diphenhydramine and the one which received normal saline.

• 대한통합의학회지
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• 제6권4호
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• pp.191-206
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• 2018

Purpose : This study investigated the correlation between speech intelligibility and acoustic measurements of speech sounds produced by the children with speech sound disorders and children without any diagnosed speech sound disorder. Methods : A total of 60 children with and without speech sound disorders were the subjects of this study. Speech samples were obtained by having the subjects? speak meaningful words. Acoustic measurements were analyzed on a spectrogram using the Multi-speech 3700 program. Speech intelligibility was determined according to a listener's perceptual judgment. Results : Children with speech sound disorders had significantly lower speech intelligibility than those without speech sound disorders. The intensity of the vowel /u/, the duration of the vowel /${\omega}$/, and the second formant of the vowel /${\omega}$/ were significantly different between both groups. There was no difference in voice onset time between the groups. There was a correlation between acoustic measurements and speech intelligibility. Conclusion : The results of this study showed that the speech intelligibility of children with speech sound disorders was affected by intensity, word duration, and formant frequency. It is necessary to complement clinical setting results using acoustic measurements in addition to evaluation of speech intelligibility.