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Data Mining for High Dimensional Data in Drug Discovery and Development

  • Lee, Kwan R.;Park, Daniel C.;Lin, Xiwu;Eslava, Sergio
    • Genomics & Informatics
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    • v.1 no.2
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    • pp.65-74
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    • 2003
  • Data mining differs primarily from traditional data analysis on an important dimension, namely the scale of the data. That is the reason why not only statistical but also computer science principles are needed to extract information from large data sets. In this paper we briefly review data mining, its characteristics, typical data mining algorithms, and potential and ongoing applications of data mining at biopharmaceutical industries. The distinguishing characteristics of data mining lie in its understandability, scalability, its problem driven nature, and its analysis of retrospective or observational data in contrast to experimentally designed data. At a high level one can identify three types of problems for which data mining is useful: description, prediction and search. Brief review of data mining algorithms include decision trees and rules, nonlinear classification methods, memory-based methods, model-based clustering, and graphical dependency models. Application areas covered are discovery compound libraries, clinical trial and disease management data, genomics and proteomics, structural databases for candidate drug compounds, and other applications of pharmaceutical relevance.

Evaluation Model Platform based on Mature to improve IS audit quality (IS 감리 품질 향상을 위한 성숙도 기반의 평가 모델 플랫폼)

  • Jong-Seok Lee;Young-Gon Kim
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.23 no.6
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    • pp.9-14
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    • 2023
  • The purpose of information system audit is to proactively identify and efficiently manage all risk factors that may arise during the process of constructing an information system, in order to assist in achieving the objectives of information system development. However, there is currently significant dissatisfaction with the quality and effectiveness of the auditing process, leading to ongoing research aimed at finding effective solutions. In this paper, we propose a multi-level evaluation model to enhance mutual understanding between auditors and evaluators and present a model that undergoes a maturity process, improving its levels and stages. We introduce a maturity-based evaluation model platform, enabling efficient communication between auditors and evaluators, allowing for real-time feedback, and supplementing it through continuous search. By presenting this multi-level model aimed at maturing the entire system, we aim to efficiently manage the system development process.

A Research on the Implementation and Estimation of an Integrated System for Information Management in the Field of Nuclear Science and Engineering (원자력분야 학술정보 통합정보관리시스템 구현에 관한 연구)

  • Chun, Young-Choon
    • Journal of Information Management
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    • v.34 no.4
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    • pp.63-84
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    • 2003
  • This research is a case study that describes the NUCLIS21(Nuclear Information System 21), an integrated web-based information management system of KAERI(Korea Atomic Energy Research Institute), implemented to carry out the role of a national nuclear information center with government support as an information infra implementation programme. Through its user-centered single interface, the system aims at building an infrastructure for the national nuclear information center, as well as improving the information management system of the TID(Technical Information Department) within the institute. The system consists of two major parts which are an integrated module of the MIS and six different kinds of system. These include the Integral search system with OPAC, My Library, the Acquisition system, the Catalogue system, the Information Supply system, and the Serial Publication system. The DB is composed of Bibliographical DB, Original text DB and Abstract DB. A special feature of this system was designed as a unified network system through connection to MIS(Management Integration System) of the institute, so users can get research information for projects. Therefore, they have access to available information easily and access to the ongoing service of this system. Furthermore, users can share information by using our system. The survey has it that 75.7%(200 persons), 62.1%(164 persons) and 78.4%(207 persons) of the respondents are satisfied with the fidelity, speediness, and convenience of the system respectively, and the overall satisfaction of the respondents is comparably high.

The Neuroanatomy and Psychophysiology of Attention (집중의 신경해부와 정신생리)

  • Lee, Sung-Hoon;Park, Yun-Jo
    • Sleep Medicine and Psychophysiology
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    • v.5 no.2
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    • pp.119-133
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    • 1998
  • Attentional processes facilitate cognitive and behavioral performance in several ways. Attention serves to reduce the amount of information to receive. Attention enables humans to direct themselves to appropriate aspects of external environmental events and internal operations. Attention facilitates the selection of salient information and the allocation of cognitive processing appropriate to that information. Attention is not a unitary process that can be localized to a single neuroanatomical region. Before the cortical registration of sensory information, activation of important subcortical structures occurs, which is called as an orienting response. Once sensory information reaches the sensory cortex, a large number of perceptual processes occur, which provide various levels of perceptual resolution of the critical features of the stimuli. After this preattentional processing, information is integrated within higher cortical(heteromodal) systems in inferior parietal and temporal lobes. At this stage, the processing characteristics can be modified, and the biases of the system have a direct impact on attentional selection. Information flow has been traced through sensory analysis to a processing stage that enables the new information to be focused and modified in relation to preexisting biases. The limbic and paralimbic system play significant roles in modulating attentional response. It is labeled with affective salience and is integrated according to ongoing pressures from the motivational drive system of the hypothalamus. The salience of information greatly influences the allocation of attention. The frontal lobe operate response selection system with a reciprocal interaction with both the attention system of the parietal lobe and the limbic system. In this attentional process, the search with the spatial field is organized and a sequence of attentional responses is generated. Affective, motivational and appectitive impulses from limbic system and hypothalamus trigger response intention, preparation, planning, initiation and control of frontal lobe on this process. The reticular system, which produces ascending activation, catalyzes the overall system and increases attentional capacity. Also additional energetic pressures are created by the hypothalamus. As psychophysiological measurement, skin conductance, pupil diameter, muscle tension, heart rate, alpha wave of EEG can be used. Event related potentials also provide physiological evidence of attention during information process. NI component appears to be an electrophysiological index of selective attention. P3 response is developed during the attention related to stimulus discrimination, evaluation and response.

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Phenolic Constituents from the Flowers of Hamamelis japonica Sieb. et Zucc.

  • Yim, Soon-Ho;Lee, Young Ju;Park, Ki Deok;Lee, Ik-Soo;Shin, Boo Ahn;Jung, Da-Woon;Williams, Darren R.;Kim, Hyun Jung
    • Natural Product Sciences
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    • v.21 no.3
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    • pp.162-169
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    • 2015
  • Hamamelis japonica (Hamamelidaceae), widely known as Japanese witch hazel, is a deciduous flowering shrub that produces compact clumps of yellow or orange-red flowers with long and thin petals. As a part of our ongoing search for phenolic constituents from this plant, eleven phenolic constituents including six flavonol glycosides, a chalcone glycoside, two coumaroyl flavonol glycosides and two galloylated compounds were isolated from the flowers. Their structures were elucidated as methyl gallate (1), myricitrin (2), hyperoside (3), isoquercitrin (4), quercitrin (5), spiraeoside (6), kaempferol 4'-O-β-glucopyranoside (7), chalcononaringenin 2'-O-β-glucopyranoside (8), trans-tiliroside (9), cis-tiliroside (10), and pentagalloyl-O-β-D-glucose (11), respectively. These structures of the compounds were identified on the basis of spectroscopic studies including the on-line LCNMR-MS and conventional NMR techniques. Particularly, directly coupled LC-NMR-MS afforded sufficient structural information rapidly to identify three flavonol glycosides (2 - 4) with the same molecular weight in an extract of Hamamelis japonica flowers without laborious fractionation and purification step. Cytotoxic effects of all the isolated phenolic compounds were evaluated on HCT116 human colon cancer cells, and pentagalloyl-O-β-D-glucose (11) was found to be significantly potent in inhibiting cancer cell growth.

Quality Evaluation Factors and Continuance Intention for Web-based Legal Information Services (웹기반 법률정보서비스 품질 평가요인 및 지속의도에 관한 연구)

  • Park, Ji-Hong
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.28 no.4
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    • pp.57-76
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    • 2017
  • The purpose of this study is to investigate the determinants of the quality of Web-based legal information services and their significant influences on the user continuance intentions. Based on the main dimensions of the SERVQUAL, this study conceptualizes five dimensions of reliability, assurance, design, empathy, and responsiveness. It measures the level of expectation and satisfaction on the basis of these five dimensions. Regression analysis was conducted to extract and analyze the determinants of the service quality and the factors affecting continuous intention. The level of legal information service quality is superior in empathy, responsiveness, and design category, but it is relatively insufficient in reliability and assurance category. In the reliability category, the relevance of the search results was an issue. The problems related to the authority and information sources were recognized as important. Reliability implies that there is a relatively close relationship between empathy and responsiveness, and that it is necessary to improve the quality of contents such as empathy and responsiveness in order to increase reliability. In order to increase the ongoing use of legal information services in the future, it is more effective to make sure that assurance is top priority.

Analyzing the Main Paths and Intellectual Structure of the Data Literacy Research Domain (데이터 리터러시 연구 분야의 주경로와 지적구조 분석)

  • Jae Yun Lee
    • Journal of the Korean Society for information Management
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    • v.40 no.4
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    • pp.403-428
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    • 2023
  • This study investigates the development path and intellectual structure of data literacy research, aiming to identify emerging topics in the field. A comprehensive search for data literacy-related articles on the Web of Science reveals that the field is primarily concentrated in Education & Educational Research and Information Science & Library Science, accounting for nearly 60% of the total. Citation network analysis, employing the PageRank algorithm, identifies key papers with high citation impact across various topics. To accurately trace the development path of data literacy research, an enhanced PageRank main path algorithm is developed, which overcomes the limitations of existing methods confined to the Education & Educational Research field. Keyword bibliographic coupling analysis is employed to unravel the intellectual structure of data literacy research. Utilizing the PNNC algorithm, the detailed structure and clusters of the derived keyword bibliographic coupling network are revealed, including two large clusters, one with two smaller clusters and the other with five smaller clusters. The growth index and mean publishing year of each keyword and cluster are measured to pinpoint emerging topics. The analysis highlights the emergence of critical data literacy for social justice in higher education amidst the ongoing pandemic and the rise of AI chatbots. The enhanced PageRank main path algorithm, developed in this study, demonstrates its effectiveness in identifying parallel research streams developing across different fields.

Leision Detection in Chest X-ray Images based on Coreset of Patch Feature (패치 특징 코어세트 기반의 흉부 X-Ray 영상에서의 병변 유무 감지)

  • Kim, Hyun-bin;Chun, Jun-Chul
    • Journal of Internet Computing and Services
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    • v.23 no.3
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    • pp.35-45
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    • 2022
  • Even in recent years, treatment of first-aid patients is still often delayed due to a shortage of medical resources in marginalized areas. Research on automating the analysis of medical data to solve the problems of inaccessibility for medical services and shortage of medical personnel is ongoing. Computer vision-based medical inspection automation requires a lot of cost in data collection and labeling for training purposes. These problems stand out in the works of classifying lesion that are rare, or pathological features and pathogenesis that are difficult to clearly define visually. Anomaly detection is attracting as a method that can significantly reduce the cost of data collection by adopting an unsupervised learning strategy. In this paper, we propose methods for detecting abnormal images on chest X-RAY images as follows based on existing anomaly detection techniques. (1) Normalize the brightness range of medical images resampled as optimal resolution. (2) Some feature vectors with high representative power are selected in set of patch features extracted as intermediate-level from lesion-free images. (3) Measure the difference from the feature vectors of lesion-free data selected based on the nearest neighbor search algorithm. The proposed system can simultaneously perform anomaly classification and localization for each image. In this paper, the anomaly detection performance of the proposed system for chest X-RAY images of PA projection is measured and presented by detailed conditions. We demonstrate effect of anomaly detection for medical images by showing 0.705 classification AUROC for random subset extracted from the PadChest dataset. The proposed system can be usefully used to improve the clinical diagnosis workflow of medical institutions, and can effectively support early diagnosis in medically poor area.

Self-optimizing feature selection algorithm for enhancing campaign effectiveness (캠페인 효과 제고를 위한 자기 최적화 변수 선택 알고리즘)

  • Seo, Jeoung-soo;Ahn, Hyunchul
    • Journal of Intelligence and Information Systems
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    • v.26 no.4
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    • pp.173-198
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    • 2020
  • For a long time, many studies have been conducted on predicting the success of campaigns for customers in academia, and prediction models applying various techniques are still being studied. Recently, as campaign channels have been expanded in various ways due to the rapid revitalization of online, various types of campaigns are being carried out by companies at a level that cannot be compared to the past. However, customers tend to perceive it as spam as the fatigue of campaigns due to duplicate exposure increases. Also, from a corporate standpoint, there is a problem that the effectiveness of the campaign itself is decreasing, such as increasing the cost of investing in the campaign, which leads to the low actual campaign success rate. Accordingly, various studies are ongoing to improve the effectiveness of the campaign in practice. This campaign system has the ultimate purpose to increase the success rate of various campaigns by collecting and analyzing various data related to customers and using them for campaigns. In particular, recent attempts to make various predictions related to the response of campaigns using machine learning have been made. It is very important to select appropriate features due to the various features of campaign data. If all of the input data are used in the process of classifying a large amount of data, it takes a lot of learning time as the classification class expands, so the minimum input data set must be extracted and used from the entire data. In addition, when a trained model is generated by using too many features, prediction accuracy may be degraded due to overfitting or correlation between features. Therefore, in order to improve accuracy, a feature selection technique that removes features close to noise should be applied, and feature selection is a necessary process in order to analyze a high-dimensional data set. Among the greedy algorithms, SFS (Sequential Forward Selection), SBS (Sequential Backward Selection), SFFS (Sequential Floating Forward Selection), etc. are widely used as traditional feature selection techniques. It is also true that if there are many risks and many features, there is a limitation in that the performance for classification prediction is poor and it takes a lot of learning time. Therefore, in this study, we propose an improved feature selection algorithm to enhance the effectiveness of the existing campaign. The purpose of this study is to improve the existing SFFS sequential method in the process of searching for feature subsets that are the basis for improving machine learning model performance using statistical characteristics of the data to be processed in the campaign system. Through this, features that have a lot of influence on performance are first derived, features that have a negative effect are removed, and then the sequential method is applied to increase the efficiency for search performance and to apply an improved algorithm to enable generalized prediction. Through this, it was confirmed that the proposed model showed better search and prediction performance than the traditional greed algorithm. Compared with the original data set, greed algorithm, genetic algorithm (GA), and recursive feature elimination (RFE), the campaign success prediction was higher. In addition, when performing campaign success prediction, the improved feature selection algorithm was found to be helpful in analyzing and interpreting the prediction results by providing the importance of the derived features. This is important features such as age, customer rating, and sales, which were previously known statistically. Unlike the previous campaign planners, features such as the combined product name, average 3-month data consumption rate, and the last 3-month wireless data usage were unexpectedly selected as important features for the campaign response, which they rarely used to select campaign targets. It was confirmed that base attributes can also be very important features depending on the type of campaign. Through this, it is possible to analyze and understand the important characteristics of each campaign type.

Access Restriction by Packet Capturing during the Internet based Class (인터넷을 이용한 수업에서 패킷캡쳐를 통한 사이트 접속 제한)

  • Yi, Jungcheol;Lee, Yong-Jin
    • 대한공업교육학회지
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    • v.32 no.1
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    • pp.134-152
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    • 2007
  • This study deals with the development of computer program which can restrict students to access to the unallowable web sites during the Internet based class. Our suggested program can find the student's access list to the unallowable sites, display it on the teacher's computer screen. Through the limitation of the student's access, teacher can enhance the efficiency of class and fulfill his educational purpose for the class. The use of our results leads to the effective and safe utilization of the Internet as the teaching tools in the class. Meanwhile, the typical method is to turn off the LAN (Local Area Network) power in order to limit the student's access to the unallowable web sites. Our program has been developed on the Linux operating systems in the small network environment. The program includes following five functions: the translation function to change the domain name into the IP(Internet Protocol) address, the search function to find the active students' computers, the packet snoop to capture the ongoing packets and investigate their contents, the comparison function to compare the captured packet contents with the predefined access restriction IP address list, and the restriction function to limit the network access when the destination IP address is equal to the IP address in the access restriction list. Our program can capture all passing packets through the computer laboratory in real time and exactly. In addition, it provides teacher's computer screen with the all relation information of students' access to the unallowable sites. Thus, teacher can limit the student's unallowable access immediately. The proposed program can be applied to the small network of the elementary, junior and senior high school. Our research results make a contribution toward the effective class management and the efficient computer laboratory management. The related researches provides teacher with the packet observation and the access limitation for only one host, but our suggested program provides teacher with those for all active hosts.