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Effect of a 20 kHz Sawtooth Magnetic Field Exposure on the Estrous Cycle in Mice

  • Jung, Kyung-Ah;Ahn, Hae-Sun;Lee, Yun-Sil;Gye, Myung-Chan
    • Journal of Microbiology and Biotechnology
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    • v.17 no.3
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    • pp.398-402
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    • 2007
  • Abstract Female mice post weaning were exposed to 20 kHz sawtooth electric and magnetic fields (EMF) with $6.25{\mu}T$ peak intensity for 6 weeks. Estrous cycles were checked using vaginal smears over the last 10 days of the experimental period. The vaginal smears from EMF-exposed mice revealed an increase in the frequency of one or two phases persisting. The number of estrous cycles less than 1 was more in the EMF-exposed group than in the sham control group. Furthermore, in the EMF-exposed group, the duration of proestrous and metestrous stages of the estrous cycle was significantly increased compared with the control group. In conclusion, our results suggest that exposure to 20 kHz sawtooth EMF may affect normal cycling of the estrous cycle by disrupting the female reproductive endocrine physiology. We should not disregard the possible adverse reproductive effect of the 20 kHz sawtooth EMF generated under the occupational exposure situation in females.

Genetic relationship between the SPT3 gene and ARS/cAMP pathway in yeast cell cycle control (Genetic Relationship between the SPT3 Gene and RAS/cAMP Pathway in Yeast Cell Cycle Control)

  • Shin, Deug-Yong;Yun, Jean-Ho
    • Journal of Microbiology
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    • v.34 no.2
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    • pp.158-165
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    • 1996
  • The signal transduction pathways through the RAS gene product and adenyl cyclease play a critical role in regulation of the cell cycle in yeast, Saccharomyces cerevisiae. We examined the genetic relationship between the spt3 gene and ras/cAMP pathway. A mutation in the SPT3 gene suppressed cell cycle arrest at the G1 phase caused by either an inactivation of the RAS or CYR1 gene which encodes a yeast homologue of human ras proto-oncogene or adenyl cyclase, respectively. The phenotypes such as sporulation and heat shock resistancy, that resulted from a partial inactivation of the RAS or CYR1 genes, were also suppressed by the spt3 mutation. Expression of the SSA1 gene encoding one of th heat shock proteins (Hsp70) can be induced by heat shock or nitrogen starvation. Expression of this gene is derepressed in cry1-2 and spt3 mutants. The bcy 1 mutation repressed by the bcy1 mutation, but not in spt3 mutants. These results suggest that the SPT gene is involved in expression of genes that are affected by the RAS/cAMP pathway.

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METHOD FOR THE ANALYSIS OF TEMPORAL CHANGE OF PHYSICAL STRUCTURE IN THE INSTRUMENTATION AND CONTROL LIFE-CYCLE

  • Goring, Markus;Fay, Alexander
    • Nuclear Engineering and Technology
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    • v.45 no.5
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    • pp.653-664
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    • 2013
  • The design of computer-based instrumentation and control (I&C) systems is determined by the allocation of I&C functions to I&C systems and components. Due to the characteristics of computer-based technology, component failures can negatively affect several I&C functions, so that the reliability proof of the I&C systems requires the accomplishment of I&C system design analyses throughout the I&C life-cycle. On one hand, this paper proposes the restructuring of the sequential IEC 61513 I&C life-cycle according to the V-model, so as to adequately integrate the concept of verification and validation. On the other hand, based on a metamodel for the modeling of I&C systems, this paper introduces a method for the modeling and analysis of the effects with respect to the superposition of failure combinations and event sequences on the I&C system design, i.e. the temporal change of physical structure is analyzed. In the first step, the method is concerned with the modeling of the I&C systems. In the second step, the method considers the analysis of temporal change of physical structure, which integrates the concepts of the diversity and defense-in-depth analysis, fault tree analysis, event tree analysis, and failure mode and effects analysis.

Effects of Copper, Zinc and Cadmium on the Recovery Pattern of Aryl Sulfotransferase IV Activity in Rats fed 2-Acetylaminofluorene Diet

  • Chung Keun Hee;Ringel David P.;Shin Kyung Ok
    • Nutritional Sciences
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    • v.9 no.1
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    • pp.29-34
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    • 2006
  • Purified rat liver aryl sulfotransferase IV (AST IV) was found to be inhibited in vitro by zinc, copper, cadmium and terbium. Among these four elements, zinc, copper and cadmium were all strongly inhibitory to the AST IV activity at very low concentrations (2.5 $\mu$M to 0.025 $\mu$M). In rat liver cytosol, zinc, copper and cadmium at 25 $\mu$M to 0.025 $\mu$M also decreased the AST IV activity to $50\%$ of the controls. In order to assess the possible effects of these metals on the AST IV activity recovery pattern in vivo, studies on the relationship between these minerals and dietary 2-acetylaminofluorene were conducted. Total of forty rats were fed one of five diets for 6 weeks: diet 1, Control diet plus 2-acetlyaminofluorene ($0.05\%$); diet 2, zinc-deficient diet plus 2-acetlyaminofluorene; diet 3, zinc-supplement diet plus 2-acetylaminofluorene; diet 4, copper-supplement diet plus 2-acetylaminofluorene; diet 5, cadmium-supplement diet plus 2-acetylaminofluorene. Half of the rats from each diet were changed to individual diet after 3 weeks of 2-acetylaminofluorene feeding. Placement of rats on the control diet following one cycle of 2-acetylaminofluorene feeding of 3 weeks without 2-acetylaminofluorene resulted in nearly full recovery of AST IV activity within 3 or 4 weeks. However, the rats fed diets that supplemented with zinc, copper or cadmium without 2-acetylaminofluorene showed a new pattern of lowered AST IV activity as early as the first cycle. Also, lowering in cytosolic AST IV contents was appeared in the livers from the rats, following one cycle of 2-acetylaminofluorene feeding of 3 weeks, fed one of the diets that supplemented with copper, cadmium or zinc without 2-acetylaminofluorene for ensuing 3 weeks.

An Efficient Mobile Transaction Processing Scheme over Multiple Wireless Broadcast Channels (다중 무선 방송채널에서의 효과적인 모바일 트랜잭션 처리 기법)

  • Jeong, Ho-Ryun;Jung, Sung-Won;Park, Sung-Wook
    • Journal of KIISE:Databases
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    • v.35 no.3
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    • pp.257-271
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    • 2008
  • Wireless broadcast environments has character that a number of mobile client can receive data streaming from central server no matter how they are so many. Because it is asymmetric bandwidth in that uplink and downlink bandwidth are different. This advantage helps wireless broadcast environments is used in many applications. These applications work almost read operation and need control concurrency using transaction unit. Previous concurrency control scheme in single channel is not adapted in multi channel environments because consistency of data are broken when a mobile client tunes in a broadcast cycle in a channel and then move into another channel and listen to different broadcast cycle with already accessed broadcast cycle. In this paper, we propose concurrency control for read-only mobile transactions in multiple wireless broadcast channel. First of all, we adapt index and data dedicated channel and propose LBCPC(Longest Broadcast Cycle Per Channel) as new unit of consistency. In index dedicated channel, it is repeatedly broadcasted data in same BCPC(Broadcast Cycle Per Channel) until LBCPC. And mobile transaction executes validation using control information every LBCPC. As a result, consistency of data is kept and average response time is shorter than one in single channel because waiting time for restart reduces. And as control information is broadcasted more frequently than in single channel, it is guaranteed currency about data accessed by transaction. Finally, according to the simulation result, we verify performance of our scheme in multi channel as comparing average response time with single channel.

The Effects of the Learning Cycle Model by Learner's Characteristics in Junior High School (중학교 과학수업에서 학습자 특성에 따른 순환학습 모형의 효과)

  • Jeong, Jin-Su;Chung, Wan-Ho
    • Journal of The Korean Association For Science Education
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    • v.15 no.3
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    • pp.284-290
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    • 1995
  • This study examined the effects of the learning cycle model by learner's characteristics such as I.Q., cognitive levels, inquiry skins, cognitive style, activity, reflectiveness. To see the effects of the learning cycle model, nonequivalent control group pretest-posttest multiple treatment designs was used in the study. 99 middle school second-graders(female) were divided into two groups. One group was selected as the experimental group (n=50), the other served at the comparison group(n=49). During the eight-month period, the students in the experimental group were instructed according to the learning cycle model, while the students in the comparison group were instructed according to the traditional instruction methods. Achievement data from science achievement test were analyzed by an ANOVA technique. The results of the study are as follows : 1. Science knowledge achievement. For the lower level students of activity, the learning cycle model is superior to the traditional approaches in science knowledge achievement. 2. Science inquiry skills. For the upper level students of I.Q., cognitive levels, inquiry skills, cognitive style and reflectiveness, the learning cycle model is superior to the traditional approaches in science inquiry skills. 3. Attitudes toward science. For the lower level students of I.Q., cognitive levels, inquiry skills, cognitive style, activity and reflectiveness, the learning cycle model is superior to the traditional approaches in attitudes toward science.

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A Study on the Decision Determination of Replenishment using Dynamic Approach in (1,m)Type Inventory System (DP법을 이용한 (1,m)형 재고시스템의 보충 의사결정에 관하여)

  • 이재원;이철영;조덕필
    • Journal of Korean Port Research
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    • v.14 no.1
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    • pp.37-45
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    • 2000
  • Centralized safety stock in a periodic replenishment system which consists of one central warehouse and m regional warehouse can reduce backorders allocating the centralized safety stocks to regional warehouse in a certain instant of each replenishment cycle. If the central warehouse can not monitoring inventories in the regional warehouse, then we have to predetermine the instant of allocation according to demand distribution and this instant must be same for all different replenishment cycle. However, transition of inventory level in each cycle need not to be same, and therefore different instant of the allocation may results reduced shortage compare to the predetermined instant of allocation. In this research, we construct a dynamic model based on the assumption of monitoring inventories in the regional warehouse everyday, and develop an algorithm minimize shortage in each replenishment cycle using dynamic programming approach.

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Minimize Shortages in Two-Phase Periodic Replensihment System Using Dynamic Approach ((1, m)형 재고시스템에 의한 안전재고의 집중과 최적분배계획에 관한 연구)

  • 이재원;이철영;조덕필
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 1999.10a
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    • pp.83-90
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    • 1999
  • Centralized safety stock in a periodic replenishment system which consists of one central warehouse and m regional warehouse can reduce backorders allocation the centralized safety stocks to regional warehouse in a certain instant of each replenishment cycle. If the central warehouse can not monitoring inventories in the regional warehouse, then we have to predetermine the instant of allocation according to demand distribution and this instant must be same for all different replenishment cycle. However, transition of inventory level in each cycle need not to be same, and therefore different instant of the allocation may results reduced shortage compare to the predetermined instant of allocation. In this research, we construct a dynamic model based on the assumption of monitoring inventories inventories in the regional warehouse everyday, and develop an algorithm minimize shortage in each replenishment cycle using dynamic programming approach.

Design of prevention spillback agorithm using fuzzy rule

  • Hong, Yousik;Cho, Hyungki;Park, Chongkug
    • 제어로봇시스템학회:학술대회논문집
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    • 1996.10a
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    • pp.32-35
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    • 1996
  • Traffic signal cycle optimization is one of the most efficient ways for reducing fuel consumption and improving vehicle waiting time of highsaturated traffic conditions. But most research focused on lowsaturated traffic conditions. Only a few studies have researched traffic control for highsaturated traffic conditions. In this paper reviews the problem of conventional traffic signal system and creates optimal traffic cycle of at the bottom traffic intersection using 27 fuzzy rules. Moreover, to prevent spillback, it can adapt control even though upper traffic intersection has a different saturation rate, road length, road slope and road width.

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A High-Speed Dual-Modulus Prescaler Using Selective Latch Technique (Selective Latch Technique을 이용한 고속의 Dual-Modulus Prescaler)

  • 김세엽;이순섭김수원
    • Proceedings of the IEEK Conference
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    • 1998.10a
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    • pp.779-782
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    • 1998
  • This paper describes a high-speed Dual-modulus Prescaler (DMP) for RF mobile communication systems with pulse remover using selective latch technique. This circuit achieves high speed and low power consumption by reducing full speed flip-flops and using a selective latch. The proposed DMP consists of only one full speed flip-flop, a selective latch, conventional flip-flops, and a control gate. In order to ensure the timing of control signal, duty cycle problem and propagation delay must be considered. The failling edgetriggered flip-flops alleviate the duty cycle problem andthis paper shows that the propagation delay of control signal doesn't matter. The maximum operating frequency of the proposed DMP with 0.6um CMOS technology is up to 2.2㎓ at 3.3V power supply and the circuit consumes 5.24mA.

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