• Journal of Yeungnam Medical Science
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• 제16권2호
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• pp.193-199
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• 1999

저자들은 다양한 진료 환경과 연구 수행에 폭 넓게 이용할 수 있는 새로운 온도측정 시스템을 개발하기 위하여 임상에서 필요한 기능과 연구에 요구되는 기능을 가진 간편하고 편리한 온도측정 시스템을 개발하였다. 이 측정 시스템은 일정한 지점의 온도를 정확하고 신속하게 측정하여 기록할 수 있는 장치로서 실용 가능성을 다양하게 검증해 본 결과 기존의 평면적인 열 분포도보다 진보된 등온곡선을 도출할 수 있었으며, 기존의 체온 측정장치보다 더욱 편리하게 진료의 각 분야에 효과적으로 이용할 수 있음을 확인하였다. 본 연구결과에 의한 기대효과 및 향후 활용방안으로는 1) 환자의 체온 변화를 신속하게 진단할 수 있어서 치료효과의 극대화와 부작용의 최소화에 기여할 수 있다. 2) 체온의 변화를 일으키는 다양한 질환의 진단 및 치료성과 판정에 이용할 수 있다. 3) phantom을 이용한 다양한 실험적 연구를 수행할 수 있다. 4) 장기 입원중인 환자들을 대상으로 중앙통제 방식으로 환자들의 상태를 지속적으로 감시할 수 있어서 간호인력의 노동력 절약에 많은 도움을 줄 수 있다. 5) 현재의 기능을 더욱 발전시키면 다양한 질환의 환자들에게 두루 적용할 수 있으며, 환자 감시체제를 위한 필수장비로 이용할 수도 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7171-7178
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• 2015

Background: This descriptive study was performed in order to assess health perspectives of women, who applied to Yildirim Beyazit University Ataturk Education and Research Hospital, Outpatient Clinic of Obstetrics and Gynecology for cervical cancer scans and were in the reproductive years. Factors influencing their perspectives were also assessed. Materials and Methods: In this study, a simple random sampling formula was adopted to calculate the volume (300) of the targeted sample. Results of the research were obtained through individual diagnosis form and cervical cancer and the Pap smear test health belief model scale (HBMS). Results: It was found that 75.0% of the women heard of the Pap smear test before, and 48.7% had undertaken one. Some 51.4% of the women who had Pap smear test expressed that they had the test at irregular periods. Most of the women stated that they heard about the smear test from the health staff (51.7%). Lack of any health complaints (28.3%) and not having adequate information about the test (21.0%) were among the reasons for not undergoing a Pap smear test. It was found that lower dimension average scores of the women obtained from the cervical cancer and Pap smear test HBMS varied from $7.7{\pm}2.3$ to $33.5{\pm}9.3$. When the lower dimension average scores of women from the HBMS were examined, the perception of usefulness was high but the susceptibility and health motivations were low. Conclusions: In this study, it was determined that the awareness of women about cervical cancer and the Pap smear test was insufficient, and susceptibility and motivation perception towards having a Pap smear test were low.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.317-321
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• 2016

Detection of micrometastasis in sentinel lymph nodes (SLNs) is a very useful tool for appropriate assessment of the clinical stage of disease in breast cancer patients. Early identification of clinically relevant disease could lead to early treatment or staging approaches for breast cancer patient. Micrometastases in SLNs of women with invasive breast cancer are of great significance in this context. In this study we examined SLN biopsies considered to have small numbers of cancerous cells by real time RT-PCR. All of the samples underwent immunohistochemical staining for cytokeratin for confirmation of the presence or absence of micrometastases. BUB1b expression assay of selected patients with and without metastasis showed overexpression in the former, but not in normal breast and lymph node tissue. Our results may be taken into account in the discussion about the merits of routine use of molecular assessment in pathogenetic studies of SLNs.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1493-1498
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• 2016

Background: Breast cancer is the most common cancer in women worldwide with a rising incidence rate in most countries. Considering the increase in life expectancy and change in lifestyle of Iranian women, this study investigated the age-adjusted trend of breast cancer incidence during 2000-2009 and predicted its incidence to 2020. Materials and Methods: The 1997 and 2006 census results were used for the projection of female population by age through the cohort-component method over the studied years. Data from the Iranian cancer registration system were used to calculate the annual incidence rate of breast cancer. The age-adjusted incidence rate was then calculated using the WHO standard population distribution. The five-year-age-specific incidence rates were also obtained for each year and future incidence was determined using the trend analysis method. Annual percentage change (APC) was calculated through the joinpoint regression method. Results: The bias adjusted incidence rate of breast cancer increased from 16.7 per 100,000 women in 2000 to 33.6 per 100,000 women in 2009. The incidence of breast cancer had a growing trend in almost all age groups above 30 years over the studied years. In this period, the age groups of 45-65 years had the highest incidence. Investigation into the joinpoint curve showed that the curve had a steep slope with an APC of 23.4% before the first joinpoint, but became milder after this. From 2005 to 2009, the APC was calculated as 2.7%, through which the incidence of breast cancer in 2020 was predicted as 63.0 per 100,000 women. Conclusions: The age-adjusted incidence rate of breast cancer continues to increas in Iranian women. It is predicted that this trend will continue until 2020. Therefore, it seems necessary to prioritize the prevention, control and care for breast cancer in Iran.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.179-183
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• 2016

Breast cancer is the most prevalent type of cancer among women around the world, and mortality is primarily caused by micro-metastatic disease. The complex mechanisms of breast cancer invasion and metastasis are intrinsically related to the malignant cell type so that early detection of micro-metastases can help prolongation of survival for patient. The aim of the present research work was evaluation of the expression status of mammoglobin protein as a candidate molecular marker in the negative sentinel lymph node (SLN). Fifty tumor specimens, and 50 normal adjacent breast tissue samples from the same patients were selected on the basis of having more than 10% tumor content for RNA extraction from SLNs. Tumor samples and normal adjacent breast tissue were archived in the form of frozen fresh tissue in liquid nitrogen. Real-time PCR was performed on a Bioner life express gradient thermal cycler system. Mammoglobin gene overexpression in breast cancer metastasis was investigated. Single marker results were mammaglobin 66.7% and CK19 50.0%, with 58.3% for the two in combination. Due to improved outcome with at least 3 genes (83.3%), it seems, triple marker evaluation will be most likely useful for detecting micro-metastases instead of studying separate genes.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.46-52
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• 2019

Objective : The aim of this nationwide study was to analyze the current state of patients with newly diagnosed metastatic spine tumors according to surgical methods. Methods : Data was extracted from the Korean Health Insurance Review and Assessment Service database. Surgery was categorized into three methods : fusion, decompression, and vertebroplasty. Data included patient age, sex, health insurance type, and co-morbidities. Survival rates of metastatic spine tumor patients according to each surgical method were evaluated. Results : Among 1677 patients who had an operation, 823 patients were treated by fusion, 141 patients underwent decompression, and 713 patients were treated by vertebroplasty. The three most prevalent primary tumor sites were the lung, breast, and liver & biliary. On the other hand, the three most prevalent primary tumor sites of patients who underwent surgery were the lung, liver & biliary, and the prostate. The median survival periods for each surgical method in the metastatic spine tumor patients were 228 days for those who underwent surgery, 249 days for decompression, and 154 days for vertebroplasty. Age, sex, and comorbidities significantly affected survival rate. Conclusion : For every primary tumor site, decompression was the least common surgical method during the study period. Although the three surgical methods did not significantly affect the survival period, patients with a poor prognosis tended to undergo vertebroplasty.

• 한국산학기술학회논문지
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• 제19권1호
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• pp.506-516
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• 2018

본 연구의 목적은 진행암 환자의 통증강도와 통증강도에 영향을 미치는 요인을 확인하는 것이다. 자료 수집은 설문지를 사용하여 2016년 6월 1일부터 9월 30일까지 수집하였다. 표본 크기는 종합병원 이상 상급병원 종양내과에 입원하거나 외래를 방문하는 진행암 환자 221명이었다. 자료 분석은 기술통계, Pearson 상관분석 및 단계적 다중 회귀분석으로 하였다. 진행암 환자의 일평균 통증강도는 4.23(${\pm}1.68$)점이었다. 통증강도에 영향을 미치는 요인은 질병지각(${\beta}=.27$, p<.001), 마약성 진통제에 대한 신념(${\beta}=.24$, p<.001), 교육수준(중학교, ${\beta}=.24$, p=.001), 월 가계경제 상태($${\geq_-}400$$, ${\beta}=.20$, p=.001), 성별(여성, ${\beta}=.14$, p=.017), 통증관리교육(${\beta}=-.14$ p=.020), 암 종류(췌장암, ${\beta}=.14$, p=.020)로 이들 변인에 의한 설명력은 28%이었다. 본 연구결과 진행암 환자가 느끼는 통증강도에 가장 중요한 영향을 미치는 요소는 질병지각과 마약성 진통제에 대한 신념이었다. 따라서 진행암 환자의 통증을 조절하기 위해 통증관리 지식과 진통제에 대한 신념뿐만 아니라 암에 대한 질병지각 개선이 포함된 통증관리 프로그램 개발이 필요한 것으로 생각된다.