• Journal of architectural history
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• v.31 no.1
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• pp.19-28
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• 2022

The construction period of the ondol (Korean floor heating system) at Hoeamsa Temple Site is known as Joseon. The main reason is that a large number of remains in the Joseon era were excavated from the ondol floor with an all-around ondol method. This article partially accepts the theory of the creation of Ondol at Hoeamsa Temple Site during the Joseon Dynasty and suggests a new argument that some Ondol remains were built during the Goryeo Dynasty. The grounds for them are as follows. First, through the building sites consistent with the arrangement of the Cheonbosan Hoeamsa Sujogi (天寶山檜巖寺修造記, Record of Repair and Construction of Hoeamsa at Cheonbosan Mountain), it is highly likely that the ondol remains as a basic floor was maintained during the reconstruction period in Goryeo. Second, the all-around ondol method of the Monastery Site has already been widely used since the Goryeo Dynasty. Third, some ondol remains consist of "Mingaejari" and "Dunbeonggaejari," which were the methods of the gaejari (which dug deeper and stayed in the smoke) in the pre-Joseon Dynasty. Based on the above evidence, this study argues that the building sites such as Dongbangjangji, Seobangjangji, Ipsilyoji, Sijaeyoji, Susewaryoji, Seogiyoji, Seoseungdangji, Jijangryoji, and Hyanghwaryoji were constructed during the late Goryeo Dynasty.

• Animal cells and systems
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• v.9 no.2
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• pp.79-85
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• 2005

Oxidized abasic residues arise as a major class of DNA damage by a variety of agents involving free radical attack and oxidation of deoxyribose sugar components. 2-deoxyribonolactone (dL) is a C1'-oxidized abasic lesion implicated in DNA strand scission, mutagenesis, and covalent DNA-protein cross-link (DPC). We show here that mammalian cell-free extract give rise to stable DPC formation that is specifically mediated by dL residue. When a duplex DNA containing dL at the site-specific position was incubated with cell-free extracts of Po ${\beta}-proficient$ and -deficient mouse embryonic fibroblast cells, the formation of major dL-mediated DPC was dependent on the presence of DNA polymerase (Pol) ${\beta}$. Formation of dL-specific DPC was also observed with histones and FEN1 nuclease, although the reactivity in forming dL-mediated DPC was significantly higher with Pol ${\beta}$ than with histones or FEN1. DNA repair assay with a defined DPC revealed that the dL lesion once cross-linked with Pol ${\beta}$ was resistant to nucleotide excision repair activity of cell-free extract. Analysis of nucleotide excision repair utilizing a model DNA substrate containing a (6-4) photoproduct suggested that excision process for DPC was inhibited because of DNA single-strand incision at 5' of the lesion. Consequently DPC mediated by dL lesion may not be readily repaired by DNA excision repair pathway but instead function as unusual DNA damage causing a prolonged DNA strand break and trapping of the major base excision repair enzyme.

• Journal of Korean Neurosurgical Society
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• v.58 no.6
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• pp.504-507
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• 2015

Objective : Our aim was to evaluate the histopathological effects of tissue adhesives on peripheral nerve regeneration after experimental sciatic nerve transection in rats and to search whether these tissue adhesives may possess a therapeutic potential in peripheral nerve injuries. Methods : This experimental study was performed using 42 female Wistar-Albino rats distributed in 6 groups subsequent to transection of right sciatic nerves. Group I underwent external circumferential neurolysis; Group II received suture repair; Group III had local polymeric hydrogel based tissue adhesive administration; Group IV received suture repair and polymeric hydrogel based tissue adhesive application together; Group V had gelatin based tissue adhesive application and Group VI had suture repair and gelatin based tissue adhesive together. After a 6-week follow-up period, biopsies were obtained from site of neural injury and groups were compared with respect to histopathological scoring based on inflammatory, degenerative, necrotic and fibrotic changes. Results : There were remarkable differences between control group and study groups with respect to inflammation (p=0.001), degeneration (p=0.002), necrosis (p=0.007), fibrosis (p<0.001) and vascularity (p=0.001). Histopathological scores were similar between study groups and the only noteworthy difference was that Group V displayed a lower score for necrosis and higher score in terms of vascularization. Conclusion : Our results imply that tissue adhesives can be useful in repair of peripheral nerve injuries by decreasing the surgical trauma and shortening the duration of intervention. Results with gelatin based tissue adhesive are especially promising since more intense vascularity was observed in tissue after application. However, trials on larger series with longer durations of follow-up are essential for reaching more reliable conclusions.

• Journal of Plant Biotechnology
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• v.42 no.3
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• pp.154-160
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• 2015

The plant breeding technology was developed with genetic engineering. Many researchers and breeders have turned from traditional breeding to molecular breeding. Genetically modified organisms (GMO) were developed via molecular breeding technology. Currently, molecular breeding technologies facilitate efficient plant breeding without introducing foreign genes, in virtue by of gene editing technology. Gene targeting (GT) via homologous recombination (HR) is one of the best gene editing methods available to modify specific DNA sequences in genomes. GT utilizes DNA repair pathways. Thus, DNA repair systems are controlled to enhance HR processing. Engineered sequence specific endonucleases were applied to improve GT efficiency. Engineered sequence specific endonucleases like the zinc finger nuclease (ZFN), TAL effector nuclease (TALEN), and CRISPR-Cas9 create DNA double-strand breaks (DSB) that can stimulate HR at a target site. RecQl4, Exo1 and Rad51 are effectors that enhance DSB repair via the HR pathway. This review focuses on recent developments in engineered sequence specific endonucleases and ways to improve the efficiency of GT via HR effectors in plants.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2015.11a
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• pp.66-67
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• 2015

This study compared and analyzed the job importance that site managers perceived by dividing the study scope into customized and expansion remodeling projects and deriving the job descriptions from previous studies. As a result, a total of 7 construction stages and 53 job descriptions were derived. As job importance in customized remodeling projects, removal and demolition works were the most important, followed by preliminary survey, and repair and reinforcement works. In addition, as job importance in expansion remodeling projects, preliminary survey is the most important, followed by civil engineering work, and repair and reinforcement works. It is considered that the job importance of the remodeling projects derived in this study will contribute to improving their job efficiency in the future.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.797-800
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• 2008

The pre-mixed concrete shotcrete, which can pre-bag the shotcrete materials and thus can save considerable labor activity, will be developed through extensive experiments. The proposed pre-mixed High performance Shooting concrete system included hydro-demolition will be verified though field tests in actual repair and rehabilitation construction sites. This research was on developing of the High performance Shooting concrete by evaluation of site application by field test using new automatic Hydro-demolition and Shotcrete equipment.

• Clinics in Shoulder and Elbow
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• v.8 no.1
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• pp.9-13
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• 2005

An isolated tear of the subscapularis is uncommon, and there are a few literatures regarding the treatment of this problem. But, the incidence has increased with development of the arthroscopic techniques. An all-arthroscopic rotator cuff repair is a challenging procedure that can be effectively performed for treatment of subscapularis tendon tears. Often, tears of the subscapularis tendon do not involve entire tendon, and retraction of the torn edge is within to 2 cm of its attachment site. Occasionally, the entire tendon is torn and retracted medially to the glenoid. This article outlines the examination, preoperative planning and details the steps necessary to perform this procedure on upper third of subscapularis tears.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.11a
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• pp.189-192
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• 2006

Following the evaluation of the irrigation & drainage structure, a suitable repair and reinforcing procedure can be selected based on this report. Successful procedures take into account the causes of the crack. This provides a survey of crack repair methods, including a summary of the characteristics of the cracks that may be repaired with each procedure, the type of irrigation & drainage structure that have been repaired and a summary of the procedures that are used. Readers are also directly contacted to the website(http:/rri.karico.co.kr/rricon). This report is intended to support the purposes, philosophy, and needs, using easily understood graphics and photos from the construction fields. The results of this study will be distributed to the public official in technical post, the operator in construction site and the member of Korea Agricultural & Rural Infrastructure Corporation and etc.

• Korean Journal of Construction Engineering and Management
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• v.14 no.1
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• pp.32-42
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• 2013

The Korean Government introduced a cultural heritage supervision system in January 2010 to control quality and to prevent poor construction. However, cultural heritage related constructions that require supervision, a scope of supervision, supervision cost and placement of supervisors have not been standardized yet. For this reason, standards of supervision for repair works of cultural heritage that reflect the characteristics of small-scale repair works and restoration of cultural heritage are required. Accordingly, this study has suggested standards of supervision works and cost by analyzing the average construction period that is suitable for the characteristics of cultural heritage repair works. In other words, this study has suggested standards of full-time supervision costs by applying the fixed amount-added method (adding direct labor cost, direct expenses, overhead expenses, engineering fee, charges for additional works and VAT) which is the same as the method of calculating supervision costs for public construction projects because a supervisor has to work full time at a construction site to perform supervision if the project is a mid/large-scale cultural heritage repair work. Also, this study has suggested standards of part-time supervision costs for a small-scale cultural heritage repair work and the ways of supervising the construction projects by visiting the project site on important occasions. According to the result of the analysis by applying the forgoing standards of supervision costs for cultural heritage, a full-time supervision cost for cultural heritage repair works is approximately 98% compared to the construction supervision of a public construction project, and a part-time supervision is approximately 158% compared to architectural construction supervision. It is expected that the valuable cultural heritage of Korea will be preserved by controlling quality of cultural heritage repair works through the application of this study result - the standards of supervision costs for cultural heritage repair works - to an actual project.

• Journal of the Korean Institute of Educational Facilities
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• v.12 no.6
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• pp.56-67
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• 2005

The purpose of this study is to give the detailed evaluation index which is considered by reconstruction and repair for the school facilities on the ground of the efficiency evaluation result in each plan through analyzing the school facilities to every case classified into the evaluation index such as the school site plan, the site plan, the floor plan. On this study through the detailed evaluation index each case to the school facilities is to get the result of the efficiency evaluation. Through analysing the result, to make an alternative plan of the school facilities which are fit in both the new educational process and the educational state is to give it as a guide.