• The Journal of Internal Korean Medicine
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• v.45 no.2
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• pp.287-302
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• 2024

Background: Bronchiectasis is a chronic respiratory condition leading to recurrent respiratory infections. Despite the use of antibiotics and other standard treatments, managing bronchiectasis remains challenging due to the frequent recurrence of airway infections and concerns about antimicrobial resistance. Given these challenges, traditional Korean medicine (TKM) has gained attention due to its potential to reduce the frequency of respiratory infections, possibly minimizing the need for antibiotics. Case report: A 59-year-old female with bronchiectasis experienced recurrent pneumonia and was treated with antibiotics for over 2 weeks without any significant improvement in clinical symptoms. She received comprehensive Korean medicine treatment, including herbal medicine (Sikyungbanha-tang combined with Bigwabojungikki-tang-gami), acupuncture, and Chuna manual therapy, for pulmonary rehabilitation. Post-treatment, clinically meaningful improvements were observed in symptoms, serum C-reactive protein (CRP) levels, and bronchopneumonic lesions on chest X-rays. Conclusion: This case suggests that complex traditional Korean medicine treatments for recurrent chronic airway inflammation due to bronchiectasis can lead to clinically significant improvements in symptoms and help to prevent recurrence.

• The Journal of Korean Medicine
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• v.35 no.4
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• pp.10-23
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• 2014

Objectives: This study evaluated the effects of Guibi-tang (GBT) on neuronal apoptosis and cognitive impairment induced by beta amyloid ($A{\beta}$), (1-42) injection in the hippocampus of ICR mice. Methods: $A{\beta}$ (1-42) was injected unilaterally into the lateral ventricle using a Hamilton syringe and micropump ($2{\mu}g/3{\mu}{\ell}$, $0.6{\mu}{\ell}/min$). Water extract of GBT was administered orally once a day (500 mg/kg) for 3 weeks after the $A{\beta}$ (1-42) injection. Acquisition of learning and retention of memory were tested using the Morris water maze. Neuronal damage and $A{\beta}$ accumulation in the hippocampus was observed using cresyl violet and Congo red staining. The anti-apoptotic effect of GBT was evaluated using TUNEL labeling in the hippocampus. Results: GBT significantly shortened the escape latencies during acquisition training trials. GBT significantly increased the number of target headings to the platform site, the swimming time spent in the target quadrant, and significantly shortened the time for the 1st target heading during the retention test trial. GBT significantly attenuated the reduction in thickness and number of CA1 neurons, and $A{\beta}$ accumulation in the hippocampus produced by $A{\beta}$ (1-42) injection. GBT significantly reduced the number of TUNEL-labeled neurons in the hippocampus. Conclusion: These results suggest that GBT improved cognitive impairment by reducing neuronal apoptosis and $A{\beta}$ accumulation in the hippocampus. GBT may be a beneficial herbal formulation in treating cognitive impairment including Alzheimer's disease.

• The Journal of Internal Korean Medicine
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• v.25 no.4
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• pp.426-432
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• 2004

Pressure sore(decubitus ulcer) is the an ulceration and necrosis of the skin and underlying tissue usually occuring on a bony prominence of the body after prolonged or repeated pressure. This study was designed to evaluate the effects of an oriental medicine(Sipjeondaebo-tang) on pressure sores complicated by cerebrovascular diseases. Methods: As For treatment, we used Sipjeondaebo-tang. Results: Both patients were treated with Sipjeondaebo-tang. After treatment, the pressure sores of two patients were improved. Conclusions: This study suggests that Sipjeondaebo-tang is effective in treatment of pressure sores(decubitus ulcer) complicated by cerebrovascular diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.142-147
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• 2008

This study was purpose to investigate that Gucheokbogol-tang(GBT), mainly used in osteoporosis, has possible regulatory effect on bone regeneration by operating in proliferation and calcification of osteoblast. So that, their cytotoxicity and proliferation was investigated with MTT by ELISA, and morphological change was observed by optical microscope and electron microscope. And activation of alkaline phosphates(ALP) which is secreted in early stage of bone formation was measured, and accumulation of $Ca^{2+}$ in the process of calcification was investigated by alizaline red S assay(ARS). The results were as follows: The MG-63 cell, originated from human cell was activated in $10^{-5}$ treated group, and the level of ALP was also increased in the treated group, highest on the third day. And from the outcome of ARS assay of calcification process in the Gucheokbogol-tang(GBT) treated group for 21days. These results suggested that Gucheokbogol-tang(GBT) is effective in proliferation and calcification of osteoblast.

• The Journal of Internal Korean Medicine
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• v.26 no.1
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• pp.281-289
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• 2005

Objective : Pheochromocytoma may arise within the adrenal medulla, or in other locations, where symptheic ganglia or chromaffin tissues are known to exist. Approximately 0.1 % of hypertensive patients have Pheochromocytoma, This study is to report the clinical effects of ShiHo-GuiZhiTang on pateints who have suffered from such symptoms of Pheochromocytoma as sweating, hypertention, Indigestion, anxiety neurosis, nausea, headache, and epigastric discomfort. Method : ShiHo-GuiZhiTang was used for a patient who had suffered from symptoms of Pheochromocytoma which was diagnosed as Banpeubanri-jueng of soyang disease in Sanghan-Ron. Result : In treating the patient with symptoms of Pheochromocytoma with ShiHo-GuiZhiTang, results were good. Conclusion : The results of this study suggest that ShiHo-GuiZhiTang is effective for such symptoms of Pheochromocytoma as sweating, hypertention, Indigestion, anxiety neurosis, nausea, headache, and epigastric discomfort.

• The Journal of Internal Korean Medicine
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• v.43 no.3
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• pp.413-422
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• 2022

Objectives: To investigate the weight loss effect of Gambi-tang in obese and overweight adults. Methods: From September 1, 2016 to December 31, 2021, a retrospective chart analysis was conducted on adult men and women who were prescribed Gambi-tang to address obesity and overweight in the National Medical Center (NMC). Partial analysis by age, obesity (Body Mass Index, BMI), duration of dose, and cumulative dose was also conducted. Results: The weight and BMI of the study subjects showed a significant decrease of more than 5% on average before and after treatment. In an analysis of age, significant differences by age could not be confirmed. In the analysis by obesity level, the effect of reducing weight, body fat, and abdominal fat rates in the obese and highly obese groups was greater than in the normal and overweight groups. There was no significant difference by group in the analysis by dosage period. In the analysis by cumulative dose, the greater the cumulative dose up to 1,800 g, the greater the decrease in weight and body fat. The side effect that patients appealed to the most was misjudgment, but not to a serious extent. Conclusions: Gambi-tang has been shown to be effective in weight and body fat loss for both obese and overweight adult men and women.

• CELLMED
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• v.5 no.1
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• pp.2.1-2.2
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• 2015

According to the traditional Korean medicine, Dampness-heat (DH)is an abnormal state of the body that results in a pathological accumulation of dampness and heat. DH is caused by overeating fatty, sweet foods or overdrinking alcohol. Exposure to hot and humid atmospheres is another cause of DH. Although many experimental animal model on various diseases related with DH syndrome were established, DH syndrome dermatitis model is not established. Thus, we introduce the experimental animal model of the dermatitis with DH syndrome.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.171-176
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• 2010

Jaeumgeonbi-tang Gamibang is noted as effective method to treat a dizziness in Korean Medicine. The main purpose of this research is analysis of the effects of Jaeumgeonbi-tang Gamibang on dizziness patients. In following research, 70 cases of dizziness patients who treated in Daejeon oriental medicine hospital from Oct, 2004 to Feb, 2009 were researched. The research is focused on clinical efficacy of Jaeumgeonbi-tang Gamibang. This research measured DHI and VAS before Jaeumgeonbi-tang Gamibang were prescribed. And Jaeumgeonbi-tang Gamibang were treated to all 70 patients. Finally DHI and VAS were measured again. Before this research, We had characterized and searched such as age, prevalence period, prescribed dosage, sex, vertigo type, pathological history in 70 patients. And DHI and VAS score were compared each other. The compared characteristic data shows that every cases were effective, in the DHI and VAS comparison, between pre-treatment and post-treatment group, vertigo and dizziness group, man and woman group. but In the age case, some age group were not effective. Conclusion: Most cases, we gained effective results. These result suggest that Jaeumgeonbi-tang might be effective in treatment of dizziness patients although man or woman, vertigo or dizziness.

• The Journal of Internal Korean Medicine
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• v.30 no.4
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• pp.657-673
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• 2009

This experiment was performed to determine the antihypertensive effect of Yangganhwadam-tang(YHT) on hypertension in spontaneously hypertensive rat. The results obtained were as follows : 1. YHT showed scavenging activity on DPPH free radical and SOD-like activity. 2. YHT significantly decreased heart weight. 3. YHT significantly decreased blood pressure and pulse. 4. YHT significantly decreased the level of plasma aldosterone. 5. YHT significantly decreased the level of norepinephrine. 6. YHT significantly decreased the levels of potassium and calcium. 7. YHT significantly decreased the level of BUN. 8. YHT decreased eosinophilic changes in the heart cells, and dilated renal arterioles stenosis. These results suggest that YHT might be effective in treatment and prevention of hypertension.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.563-566
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• 2002

To evaluate the effect of Jingansikpung-tang(JST) water extract on cultured mouse spinal sensory neuron which was inhibited by glucose oxidase(GO)-induced cytotoxicity, MTT and LDH activity assay were carried out after the cultured mouse spinal sensory neuron were pre-incubated with various concentrations of JST extract for 3 hours prior to exposure of GO. The results obtained were as follows: GO, a oxygen radical, decreased the survival rate of the cultured mouse spinal sensory neuron cells on MTT assay. JST water extract have efficacy of decreasing LDH activity increasing by GO in cultured mouse spinal sensory neuron. From above the results, it is concluded that JST water extract has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process.