• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제25권1호
• /
• pp.52-60
• /
• 2022

Purpose: Colonoscopy is considered the most reliable method for the diagnosis of juvenile polyps. However, colonoscopic screening is an invasive and expensive procedure. Fecal calprotectin (FCP), a marker of intestinal inflammation, has been shown to be elevated in patients with polyps. Therefore, this study aimed to evaluate FCP as a screening biomarker for the diagnosis of juvenile polyps. Methods: This cross-sectional, observational study was conducted at the Pediatric Gastroenterology and Nutrition Department, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. For children with polyps, colonoscopic polypectomy and histopathology were performed. FCP levels were analyzed before and 4 weeks after polypectomy in all patients. Information was recorded in a datasheet and analyzed using the computer-based program SPSS. Results: The age of the children was between 2.5 and 12 years. Approximately 93% of the polyps were found in the rectosigmoid region. Children with juvenile polyps had elevated levels of FCP before polypectomy that subsequently normalized after polypectomy. The mean FCP levels before and after polypectomy were 277±247 ㎍/g (range, 80-1,000 ㎍/g) and 48.57±38.23 ㎍/g (range, 29-140 ㎍/g) (p<0.001), respectively. The FCP levels were significantly higher in patients with multiple polyps than in those with single polyps. Moreover, mean FCP levels in patients with single and multiple polyps were 207.6±172.4 ㎍/g and 515.4±320.5 ㎍/g (p<0.001), respectively. Conclusion: Colonic juvenile polyps were found to be associated with elevated levels of FCP that normalized after polypectomy. Therefore, FCP may be recommended as a noninvasive screening biomarker for diagnosis of colonic juvenile polyps.

• 한국지구과학회지
• /
• 제45권1호
• /
• pp.48-71
• /
• 2024

태풍은 지구 시스템 내 상호작용을 일으키는 대표적인 해양-대기 현상으로 최근 들어 기후변화로 인해 점점 더 강력해지는 추세이다. 2022 개정 과학과 교육과정은 미래 사회 시민으로서의 디지털 소양 함양을 위하여 첨단 과학기술을 활용한 교수-학습 활동의 중요성에 대해 강조하고 있다. 따라서 교과서 삽화의 시공간적 한계점을 해결하고 지구과학 분야에서 다루는 전지구적 규모의 빅데이터를 활용한 효과적인 수업자료의 개발이 필요하다. 본 연구에서는 PDIE (준비, 개발, 실행, 평가) 모형의 절차에 따라 천리안 위성 2A호 영상 자료를 활용하여 태풍의 경로를 시각화하는 탐구활동 자료를 개발하였다. 준비 단계에서는 2015 및 2022 개정 교육과정과 현행 교과서의 탐구활동 내용을 분석하였다. 개발 단계에서는 관측 데이터를 수집, 처리, 시각화, 분석할 수 있는 일련의 과정들로 탐구활동을 구성하였으며, 간단한 조작만으로도 결과를 도출할 수 있는 GUI (Graphic User Interface) 기반 시각화 프로그램을 제작하였다. 실행 및 평가 단계에서는 학생들을 대상으로 수업을 진행하였으며 코드를 활용한 수업과 GUI 프로그램 활용 수업을 각각 실시하여 각 활동의 특징을 비교하고 학교 현장에서의 적용 가능성을 확인하였다. 본 연구에서 제시한 수업자료는 전문적인 프로그래밍 지식이 없어도 GUI 기반으로 실제 관측 데이터를 활용한 탐구활동에 활용될 수 있으며, 이를 통해 학생들의 지구과학 분야의 이해도와 디지털 소양 함양에 기여할 수 있을 것으로 기대된다.

• Child Health Nursing Research
• /
• 제4권2호
• /
• pp.159-176
• /
• 1998

In effort to conduct comparative study on the caregiving environment of Neonatal Intensive Care Unit(NICU) in both U. S and Korea, this study was been conducted first in the U.S. Purpose : The purpose of this study is to identify the physical environment and direct caregiving practices to lowbirth weight infants in NICU in the US. It also aims to examine the NICU outcome status and behavioral reponses of lowbirth weight infants. Methods : A study design using descriptive and inferential statistics was been conducted through an observational, field method. A sample of 15 preform infants admitted to NICU were recruited for the study. The subjects were those with birth weight between 1,000 gm to 1,500 gm, born at the gestation period of 27 to 33 weeks, and without any chromosomal or other genetic anomalies, major congenital infections, or maternal illness. Thirty minutes observation(three times of ten minutes of continuous observation)of the infant's behavior and physiological status, and an four-hour observation of the physical environment and direct care giving procedures were been conducted on the 3rd and 10th day after birth, and on the day of discharge from the NICU or at 34weeks postconception. The data to be collected were in four areas : the demograghic characteristics of the infants, the physical environment and care giving procedures, the frequency of the infant's designated behavior and physiological response, and NICU outcome variables. A descriptive analysis and Kruskal-Wallis, Pearson r were been applied according to variable characteristics. Results : 1. Mother's mean age was 29.47. The sample consisted of 6 males and 9 females. Mean gestational ages were 29.17 weeks. Mean birth weight was 1236.33g. Mean Apgar scores at one minute were 6.6, and 7.8 at five minutes. 2. The location for the incubator was in the distance from the light, X-ray screens and nursing station, in proximity to side-lamp, telephone and faucet on the third day after birth. The location for the incubator was in the distance from the light and radio on the tenth day and in proximity to nursing station on the day of dischage from the NICU or at 34weeks postconception. 3. Nesting was the most applying aids to the infants. And foot roll, shielding and plastic frame were frequently using by nurses for facilitating well modulated restful posture. 4. There were statistically significant changes in the patterns of physical environment included locating the infant's incubator and bedding, specific aids to self regulation on the 3rd and 10th day after birth, and on the day of discharge from the NICU or at 34weeks postconception. 5. Statistically significant changes were not appeared in the patterns of direct caregiving procedure to the infants included stress inducing or reducing manipulations on the 3rd and 10th day after birth, and on the day of discharge from the NICU or at 34weeks postconception. 6. The stress response of the infants in NICU were significantly reduced as the infants grow older. 7. There were not statistically significant correlation between the physical envronment and the stress responses of the infants in NICU. 8. There were statistically significant correlation between the direct caregiving procedure to the infants and the stress response of the infants in NICU in the second and third observation on the day three. 9. Average weight gain per day from birth to discharge was 38.73g, number of days in the hospital was 42.60, number of days before bottle feeding was 3.6. Postconception age starting bottle feed ing was 31/sup +5/ weeks. Number of days on mechanical ventilator was average 7.64, 11.42 was an average number of days of oxygen need. Conclusion : It, thus, appears that to minimize the sensorymotor stimulation for the low birthweight preterm infant in NICU, manipulation of care giving practices to the babies whatever the stress inducing or reducing procedures, have to be limited in the immediate early stage after birth. And it needed to be reexamine to identify the appropriate and specific physical environment and the patterns of direct caregiving to the low birthweight preform infant as the infants grow older in NICU.