• Laboraroty Animal Research
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• 제34권4호
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• pp.248-256
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• 2018

O-2-$^{18}F$-fluoroethyl-l-tyrosine ($[^{18}F]FET$) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to examine the value of $[^{18}F]FET$ for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic mouse model of GBM. Human U87MG cells were implanted into nude mice and then bevacizumab, a representative anti-angiogenic drug, was administered. We monitored the effect of anti-angiogenic agents using multiple imaging modalities, including bioluminescence imaging (BLI), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET/CT). Among these imaging methods analyzed, only $[^{18}F]FET$ uptake showed a statistically significant decrease in the treatment group compared to the control group (P=0.02 and P=0.03 at 5 and 20 mg/kg, respectively). This indicates that $[^{18}F]FET$ PET is a sensitive method to monitor the response of GBM bearing mice to anti-angiogenic drug. Moreover, $[^{18}F]FET$ uptake was confirmed to be a significant parameter for predicting the prognosis of anti-angiogenic drug (P=0.041 and P=0.007, on Days 7 and 12, respectively, on Pearson's correlation; P=0.048 and P=0.030, on Days 7 and 12, respectively, on Cox regression analysis). However, results of BLI or MRI were not significantly associated with survival time. In conclusion, this study suggests that $[^{18}F]FET$ PET imaging is a pertinent imaging modality for sensitive monitoring and accurate prediction of treatment response to anti-angiogenic agents in an orthotopic model of GBM.

• 항공우주시스템공학회지
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• 제13권3호
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• pp.23-31
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• 2019

현대의 위성들의 설계요구조건은 운용되는 목적에 따라 다양해진다. 기존 중/대형 위성과는 달리 저궤도에서 운용되는 소형위성의 경우 군사적인 목적을 나타내기도 한다. 그렇기 때문에 고해상도의 사진 및 영상 수요가 증가하며 다표적 관측이 중요하게 된다. 이에 다표적 관측을 하기 위해서 위성의 기동성은 중요한 설계변수이다. 기동성이 증가하기 위해서 소형화가 되면 전체 질량관성모멘트가 감소하기 때문에 위성의 강성을 높여야한다. 본체에 비해서 강성이 낮은 태양전지판의 경우 진동이 발생하기 때문에 영상획득에 큰 영향을 미친다. 이러한 진동특성을 확인하기 위하여 본 연구에서는 위성을 축소모델로 제작하여 자세기동을 모사하기 위한 실험 치구를 도입하였고, 위성의 강성을 모사하기 위한 모사장치를 제시하였다. 또한 실험방식은 스텝모터를 이용하여 와이어의 감는 길이에 따라 위성의 기동각을 모사하였으며, 기동실험 시 발생되는 위성의 본체 및 태양전지판에 대하여 진동특성을 실험적으로 검증하고자 한다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8호
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• pp.1145-1152
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• 2019

Objective: Mulberry (Morus alba L.) is a cultivated shrub grown widely in the sub-tropical and tropical areas. It has been shown that mulberry leaf contains high levels of protein while having polyphenols as phytonutrients. Therefore, it is important to conduct an experiment to assess potential toxic level from mulberry on behavior, blood hematological and coagulation parameter using Sprague-Dawley (SD) rats. Methods: Both male and female SD rats were given an intragastric administration of respective treatments of mulberry leaf intakes (control, low and high levels). Parameters of feed intake, hematological and coagulation of blood parameters, as well as liveweight changes were taken during the 7 d of adaptation, 28 d of treatment exposure, and 14 d of recovery periods, respectively. All treatment data were statistically analyzed using analysis of variance of SPSS17.0 for Windows Statistical Software following the Randomized complete block design with sex as a block. Results: Most of the parameters of the physical symptoms of the SD rats, were not significantly different (p>0.05) when compared with that of the control group. Those which remain unchanged in each dose group were, body weight (BW) gain, feed intake, the hematology and coagulation indexes. Although, there were a few individual indicators that were abnormal, but the overall physiological appearance of the rats were normal. Conclusion: Results under this experiment revealed that most hematological and coagulation parameters of the SD rats in both male and female were normal, although the weight gain of female rats in high-dose group was significantly reduced than those of the male rats. Under this study, the use of mulberry leaf up to 2 g/kg BW did not result in abnormal phenomenon in the SD rats. These findings would offer useful information for further in vivo feeding trials in animals to extensively use of mulberry leaf to improve animal production, particularly in P.R. China.

• 대한후두음성언어의학회지
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• 제31권2호
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• pp.71-77
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• 2020

Background and Objectives OperaVOXTM (Oxford Wave Research Ltd.) is a portable voice analysis software package designed for use with iOS devices. As a relatively cheap, portable and easily accessible form of acoustic analysis, OperaVOXTM may be more clinically useful than laboratory-based software in many situations. The aim of this study was to evaluate the agreement between OperaVOXTM and Multi-Dimensional Voice Program (MDVP; Computerized Speech Lab) to assess voice quality before and after laryngeal microsurgery in patient with vocal polyp. Materials and Method Twenty patients who had undergone laryngeal microsurgery for vocal polyp were enrolled in this study. Preoperative and postoperative voices were assessed by acoustic analysis using MDVP and OperaVOXTM. A five-seconds recording of vowel /a/ was used to measure fundamental frequency (F0), jitter, shimmer and noise-to-harmonic ratio (NHR). Results Several acoustic parameters of MDVP and OperaVOXTM related to short-term variability showed significant improvement. While pre-operative value of F0, jitter, shimmer, NHR was 155.75 Hz (male: 125.37 Hz, female: 183.37 Hz), 2.20%, 6.28%, 0.16, post-operative values of these parameter was 164.34 Hz (male: 129.42 Hz, female: 199.26 Hz), 2.15%, 5.18%, 0.14 Hz in MDVP. While pre-operative value of F0, jitter, shimmer, NHR was 168.26 Hz (male: 135.16 Hz, female: 201.37 Hz), 2.27%, 6.95%, 0.26, post-operative values of these parameters was 162.72 Hz (male: 128.267 Hz, female: 197.18 Hz), 1.71%, 5.36%, 0.20 in OperaVOXTM. There was high intersoftware agreement for F0, jitter, shimmer with intraclass correlation coefficient. Conclusion Our results showed that the short-term variability of acoustic parameters in both MDVP and OperaVOXTM were useful for the objective assessment of voice quality in patients who received laryngeal microsurgery. OperaVOXTM is comparable to MDVP and has high intersoftware reliability with MDVP in measuring the F0, jitter, and shimmer

• Animal Bioscience
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• 제34권3_spc호
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• pp.434-442
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• 2021

Objective: This study aims to evaluate the influence of dietary flavonoids on the growth performance, blood and intestinal profiles, and carcass characteristics of broilers by employing a meta-analysis method. Methods: A database was built from published studies which have reported on the addition of various levels of flavonoids from herbs into broiler diets and then monitored growth performance, blood constituents, carcass proportion and small intestinal morphology. A total of 42 articles were integrated into the database. Several forms of flavonoids in herbs were applied in the form of unextracted and crude extracts. The database compiled was statistically analyzed using mixed model methodology. Different studies were considered as random effects, and the doses of flavonoids were treated as fixed effects. The model statistics used were the p-values and the Akaike information criterion. The significance of an effect was stated when its p-value was <0.05. Results: Dietary flavonoids increased (quadratic pattern; p<0.05) the average daily gain of broilers in the finisher phase. There was a reduction (p<0.01) in the feed conversion ratio of the broilers both in the starter (linear pattern) and finisher phases (quadratic pattern). The mortality rate tended to decrease linearly (p<0.1) with the addition of flavonoids, while the carcass parameter was generally not influenced. A reduction (p<0.001) in cholesterol and malondialdehyde concentrations (both linearly) was observed, while super oxide dismutase activity increased linearly (p<0.001). Increasing the dose of flavonoids increased (p<0.01) the villus height (VH) and villus height and crypt depth (VH:CD) ratio (p<0.05) in the duodenum. Similarly, the VH:CD ratio was elevated (p<0.001) in the jejunum following flavonoid supplementation. Conclusion: Increasing levels of flavonoids in broilers diet leads to an improvement in growth performance, blood constituents, carcass composition and small intestinal morphology.

• Animal Bioscience
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• 제35권12호
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• pp.1967-1976
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• 2022

Objective: The aim of this study was to characterize the fecal microbiota of broiler chickens reared in the presence of different shades of light-emitting diode (LED) lights, correlating this information with biochemical and molecular evidence that allowed drawing conclusions on the state of health of the animals. Methods: Overall, the metagenomic approach on fecal samples was associated with evaluations on enzymes involved in the cellular response to oxidative stress: glutathione peroxidase (GPX), superoxide dismutase and catalase; while the inflammatory aspect was studied through the dosage of a proinflammatory cytokine, the interleukin 6 (IL-6), and the evaluation of the matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9). Specifically, analysis was performed on distinct groups of chickens respectively raised in the presence of neutral (K = 3,300 to 3,700), cool (K = 5,500 to 6,000), and warm (K = 3,000 to 2,500) LED lightings, and a direct comparison was performed with animals reared with traditional neon lights. Results: The metagenomic analysis highlighted the presence of two most abundant bacterial phyla, the Firmicutes and the Bacteroidetes, with the latter characterized by a greater relative abundance (p<0.05) in the group of animals reared with Neutral LED light. The analysis on the enzymes involved in the antioxidant response showed an effect of the LED light, regardless of the applied shade, of reducing the expression of GPX (p<0.01), although this parameter is not correlated to an effective reduction in the tissue amount of the enzyme. Regarding the inflammatory state, no differences associated with IL-6 and MMP-9 were found; however, is noteworthy the significant reduction of MMP-2 activity in tissue samples obtained from animals subjected to illumination with neutral LED light. Conclusion: This evidence, combined with the metagenomic findings, supports a potential positive effect of neutral LED lighting on animal welfare, although these considerations must be reflected in more targeted biochemical evaluations.

• Composites Research
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• 제20권4호
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• pp.31-41
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• 2007

시스템 요구 조건에 따른 다양한 돔 형상 설계를 위하여 외부 하중이 고려된 돔 형상 설계 식이 제시되었고, 동일 원통부와 보스 오프닝을 가지면서 다른 돔 형상을 갖는 압력 용기의 성능(파열압력*내부용적/복합재무게) 변화를 유한요소해석을 통하여 평가하였다. 해석 결과는 돔 형상이 낮아질수록 파열 압력이 저하되어 압력 용기 성능이 저하됨을 나타내었다. 특히 원통부 반경과 보스 오프닝간의 비를 나타내는 보스 오프닝 크기 비율(${\rho}\;o$)이 큰 경우는 돔 형상이 낮아짐에 따라 복합재 무게 증가율이 크게 나타남으로서 압력 용기 성능 저하의 원인이 되었고, 파열 압력 상승을 위하여 돔 부위에 추가적인 보강설계가 요구되었다. 예를 들어 ${\rho}\;o=0.35$ 이하의 돔인 경우, 돔 형상 변화가 크지 않음으로서 돔 형상 변화에 따른 압력 용기 성능 변화도 크지 않은 것으로 나타난 반면, ${\rho}\;o=0.54$ 이상의 압력 용기인 경우 낮은 돔으로 변화됨에 따라 파열 압력 감소와 복합재 무게 증가로 압력 용기 성능 저하가 비교적 크게 나타나서 압력 용기 내부 용적 증가나 스커트와 돔간의 공간 확보가 우선인 설계 조건을 제외하고는 낮은 돔 형상 설계가 바람직하지 않은 것으로 나타났다.

• 한국컴퓨터정보학회논문지
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• 제14권6호
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• pp.41-49
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• 2009

본 논문에서는 광학식 모션캡처 장비를 위한 다중 카메라 보정 방법을 제안한다. 이 방법은 DLT(Direct linear transformation) 알고리즘을 이용하여 7개의 마커가 있는 3축 보정틀의 영상을 획득하여 1차 카메라 보정을 한다. 그리고 2개의 마커가 있는 보정봉을 측정하고자 하는 영역에서 움직여서 2차 카메라 보정을 실시한다. 1차 카메라 보정에서는 카메라 보정뿐만 아니라 렌즈 왜곡 계수를 계산하여 2차 카메라 보정에서의 최적화를 위한 초기해로 사용한다. 2차 카메라 보정에서는 보정봉에 있는 마커사이의 거리가 일정하기 때문에 계산된 마커 거리와 실제 마커 거리의 차가 최소화 되도록 최적화를 수행한다. 제안한 방법에 의한 다중 카메라 보정 방법을 검증하기 위하여 재투영에러를 계산하였고 3축 보정틀에 있는 마커사이의 거리와 보정봉에 있는 마커사이의 거리를 계산하여 다른 상용장비의 값과 비교하였다. 3축 보정틀에 있는 마커를 복원하여 에러를 비교한 결과 평균오차가 상용장비의 1.7042mm에 비해 0.8765mm로 51.4% 수준으로 나타났고, 보정봉에 있는 마커를 복원하여 에러를 비교한 결과 상용장비의 평균에러 1.8897mm에 비해 2.0183mm로 0.1286mm 크게 나타났다.

• 대한토목학회논문집
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• 제30권2C호
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• pp.85-93
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• 2010

전단 강성은 지반 거동을 이해하기 위한 필수적인 요소로 인식되고 있으며, 특히 탄성계수 및 간극비는 구조물의 기본적인 설계 정수로서 그 중요성이 점차 증가하고 있다. 본 연구의 목적은 전단파와 압축파 같은 탄성파 및 전기비저항 측정이 가능한 현장 탄성파 및 전기비저항 측정 장비(FVRP)를 개발하고, 이를 이용하여 대상지반의 탄성계수 및 간극비를 산정하는 것이다. 압축파 및 전단파는 각각 피에조 디스크 엘리먼트와 벤더 엘리먼트를 이용하여 측정하였다. 그리고 전기비저항은 소형 전기비저항 측정 프로브를 제작하여FVRP 선단에 설치하여 측정하였다. 개발된 장비는 실내의 대형토조와 현장에 적용되었다. 대형 토조실험의 경우, 모래와 점토를 슬러리 상태에서 혼합하여 지반을 조성한 후 상재하중을 가하여 조성된 지반을 압밀 시킨 후 진행되었으며, 탄성파 및 전기비저항의 측정은 매 심도 1cm 간격으로 수행되었다. 현장 실험은 남해안 지역에서 수행되었으며, 탄성파 및 전기비저항 측정은 관입심도 6m부터 20m까지 10cm 간격으로 수행하였다. 토조 및 현장 실험을 통해 측정된 탄성파와 전기비저항은 이론적인 관계식을 이용하여 탄성계수 및 간극비로 환산되었다. 탄성파와 전기비저항을 이용한 간극비는 부피를 이용하여 산정한 간극비와 유사한 값을 나타내었다. 본 연구에서 개발된 탄성파와 전기비저항을 동시에 측정할 수 있는 FVRP는 연약지반의 탄성계수 및 간극비 산정에 유용한 장비가 될 수 있음을 보여준다.

• Korean Journal of Radiology
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• 제21권6호
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• pp.707-716
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• 2020

Objective: To evaluate pharmacokinetic variables from contrast-enhancing lesions (CELs) and non-enhancing T2 high signal intensity lesions (NE-T2HSILs) on dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging for predicting progression-free survival (PFS) in glioblastoma (GBM) patients. Materials and Methods: Sixty-four GBM patients who had undergone preoperative DCE MR imaging and received standard treatment were retrospectively included. We analyzed the pharmacokinetic variables of the volume transfer constant (Ktrans) and volume fraction of extravascular extracellular space within the CEL and NE-T2HSIL of the entire tumor. Univariate and multivariate Cox regression analyses were performed using preoperative clinical characteristics, pharmacokinetic variables of DCE MR imaging, and postoperative molecular biomarkers to predict PFS. Results: The increased mean Ktrans of the CEL, increased 95th percentile Ktrans of the CELs, and absence of methylated O⁶-methylguanine-DNA methyltransferase promoter were relevant adverse variables for PFS in the univariate analysis (p = 0.041, p = 0.032, and p = 0.083, respectively). The Kaplan-Meier survival curves demonstrated that PFS was significantly shorter in patients with a mean Ktrans of the CEL > 0.068 and 95th percentile Ktrans of the CEL > 0.223 (log-rank p = 0.038 and p = 0.041, respectively). However, only mean Ktrans of the CEL was significantly associated with PFS (p = 0.024; hazard ratio, 553.08; 95% confidence interval, 2.27-134756.74) in the multivariate Cox proportional hazard analysis. None of the pharmacokinetic variables from NE-T2HSILs were significantly related to PFS. Conclusion: Among the pharmacokinetic variables extracted from CELs and NE-T2HSILs on preoperative DCE MR imaging, the mean Ktrans of CELs exhibits potential as a useful imaging predictor of PFS in GBM patients.