• Journal of Korean Neurosurgical Society
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• 제58권2호
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• pp.101-106
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• 2015

Objective : The aim of this study was to explore the immunity in rats transplanted with adipose-derived mesenchymal stem cells (ADSCs) and acellular nerve (ACN) for repairing sciatic nerve defects. Methods : ADSCs were isolated from the adipose tissues of Wistar rats. Sprague-Dawley rats were used to establish a sciatic nerve defect model and then divided into four groups, according to the following methods : Group A, allogenic nerve graft; Group B, allograft with ACN; Group C, allograft ADSCs+ACN, and Group D, nerve autograft. Results : At the day before transplantation and 3, 7, 14, and 28 days after transplantation, orbital venous blood of the Sprague-Dawley rats in each group was collected to detect the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets using flow cytometry and to determine the serum concentration of interleukin-2 (IL-2), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and $interferon-{\gamma}$ ($IFN-{\gamma}$) using enzyme-linked immunosorbent assay (ELISA). At each postoperative time point, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ in group C were all near to those in group B and group D, in which no statistically significant difference was observed. As compared with group A, the proportion of $CD3^+$, $CD4^+$, and $CD8^+$ subsets and the serum concentration of IL-2, $TNF-{\alpha}$, and $IFN-{\gamma}$ were significantly reduced in group C (p<0.05). Conclusion : The artificial nerve established with ADSCs and ACN has no obvious allograft rejection for repairing rat nerve defects.

• Journal of Korean Neurosurgical Society
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• 제61권5호
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• pp.618-624
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• 2018

Objective : We evaluated the clinical manifestation and surgical results following operative treatment of cubital tunnel syndrome (CuTS) caused by anconeus epitrochlearis (AE) muscle. Methods : Among 142 patients who underwent surgery for CuTS from November 2007 to October 2015, 12 were assigned to the AE group based on discovery of AE muscle; 130 patients were assigned to the other group. We analyzed retrospectively; age, sex, dominant hand, symptom duration, and weakness in hand. Severity of the disease was evaluated using the Dellon classification and postoperative symptom were evaluated using disability of arm shoulder and hand (DASH) and visual analogue scale (VAS) scores. Surgery consisted of subfascial anterior transposition following excision of AE muscle. Results : AE muscle was present in 8.5% of all patients, and was more common in patients who were younger and with involvement of their dominant hand; the duration of symptom was shorter in patients with AE muscle. All patients showed postoperative improvement in symptoms according to DASH and VAS scores. Conclusion : The possibility of CuTS caused by AE muscle should be considered when younger patients have rapidly aggravated and activity-related cubital tunnel symptoms with a palpable mass in the cubital tunnel area. Excision of AE muscle and anterior ulnar nerve transposition may be considered effective surgical treatment.

• 대한인간공학회지
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• 제33권2호
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• pp.109-124
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• 2014

Objective: This study was conducted for one-hand users including hemiplegic clients currently using general folding manual wheelchairs, so as to analyze their specific problems and recommend solutions regarding usage. Background: Traditional manual wheelchairs require considerable use and control of both hands for operation, thus adaptations become necessary for individuals with asymmetrical use of hands. Method: Thirty hemiplegic clients who were admitted to rehabilitation and convalescent hospitals participated as subjects. The research tools were general folding manual wheelchairs commonly used by people with impaired gait, and the Wheelchair Skills Tests (WST) WST-M/WCU 4.1 version was adopted as the assessment tool. All participants were asked to fill out questionnaires on demographics and wheelchair usage characteristics. Assessment procedures were performed with currently used manual wheelchairs and with/without the use of foot to control the wheelchair. Results: When the participants drove folding manual wheelchairs without the use of foot, even the lowest failure rate among the WST items tested recorded 96.7%. On the contrary, with the use of foot in maneuvering the wheelchairs, failure rates dropped noticeably and success rate among the WST items tested was as high as 86.7%. Conclusion: These findings imply that the use of one-arm (hand) propellable (drivable) wheelchair can be an active and effective solution in resolving problems for hemiplegic clients using existing manual wheelchairs. As such, the government should provide institutional support to further develop and distribute this device or technology, and promote relative research in tandem. For now, the supply of commercially available device to hemiplegic clients is deemed urgent and also a mechanism to provide the devices and relevant services. Application: This study offers viable solutions for hemiplegic clients who rely on existing manual wheelchairs to increase their mobility and occupational performance.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1781-1786
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• 2013

Objective: The study was designed to assess the skin and subcutaneous toxicity in patients with advanced colorectal carcinoma treated with four different schedules of FOLFOX. Methods: The patients with histologically confirmed advanced colorectal carcinoma (CRC) were included in the study as per specified inclusion criteria. Toxicity was graded according to CTC v2.0. The frequency of grade 3 and 4 adverse effects were comparatively assessed in each treatment arm. Results: Very severe toxicity was attributed to the FOLFOX7 schedule. The difference between the incidence rate of grade 4 toxicity with all other grades for all parameters of skin and subcutaneous toxicity was highly significant (p=0.00<0.001). Grade 4 hand and foot syndrome was reported only in the FOLFOX7 treatment arm. The most frequent adverse symptom of skin and subcutaneous toxicity reported in the patients treated with modified schedule of FOLFOX was pruritus (grade 1). Frequency and onset of skin and subcutaneous toxic symptoms like alopecia (p=0.000), nail discoloration (p=0.021) and pruritis (p=0.000) was significantly different in each FOLFOX treatment arm. A few cases of oncholysis were also reported in the FOLFOX7 treatment arm. Hand and foot syndrome was fast progressing in patients with grade 1 toxicity. Conclusion: Higher frequency and severity of hand and foot syndrome and pruritus wasa found in the FOLFOX7 treatment arm. Skin and subcutaneous toxicity was comparatively low in the FOLFOX6 treatment arm.

• Journal of Acupuncture Research
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• 제18권6호
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• pp.151-160
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• 2001

Objective : Assuming that the characteristic of meridian system has been similar to this of electric potentials in human body and that measurements of electric potential at well(井穴) and sea(合穴) points in branches of the twelve meridians will be representative of measurements of the twelve meridians, to measure the electric potentials in twenty aged and fifty aged healthy volunteers groups at sleeping(SG) and awakening(AG), and then to find out the characteristic of meridian system among 2 groups. Methods : We selected who thirty healthy volunteers were diagnosed by a blood test, urine examination and differentiation of syndromes by five viscera(五臟辨證) among volunteers. Their electric potential of well and sea points in the meridians were simultaneously measured by physiograph. Results : Measurements were analyzed by statistical factor analysis, we obtained that the both left and right side electric potential of well and sea points in branches of the twelves meridians were unclearly divided into four factors according to age and whether sleeping or not, which were the three Yin meridians of the hand, the three Yang channels of the hand, the three Yin meridians of the foot, and the three Yin meridians of the foot. Conclusion : In conclusion, using the sequently measuring method, we obtained that electrical potentials of well and sea points in branches of the twelves meridians were divided into two factors, but the simultaneously measuring method, those were divided into four factors. The latter result means that the electrical potentials of twelve meridians were reflected by the function of the viscera and bowels.

• 한국건설관리학회논문집
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• 제7권4호
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• pp.61-68
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• 2006

안전은 건설산업에서 가장 중요한 관리요소 중의 하나이다. 작업관련성 질병은 계속적으로 증가하고 있는 추세이며 특히 상지와 관련된 근골격계질환은 전체질환의 40%를 차지하고 있다. 본 연구는 건축공사현장에서 사용되는 수공구와 작업관련성 질병의 상관관계를 파악하기 위한 목적으로 작업분석, 설문 및 면담조사를 수행한 결과 기능인력 중 일부 직종의 근골격계부담작업 및 통증부위, 수공구와 통증부위와의 상관관계는 매우 강한 것으로 나타났다. 본 연구의 결과는 건설현장의 작업환경의 개선 및 수공구의 인간공학적 개발을 위한 기초자료로 사용될 수 있을 것이다.

• 한국산학기술학회논문지
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• 제18권2호
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• pp.254-260
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• 2017

사회기반시설물은 적절한 수명관리를 통해 경제적이고 안전한 구조성능을 유지한다. 일반적으로 최적화 기법을 적용하여, 유지보수의 시점과 방법을 결정하게 되는데, 이 적용에 있어서 단일 목적함수만을 고려하기 보다는 다수의 목적함수를 동시에 고려하는 것이 보다 합리적인 의사결정을 유도한다. 최근까지 수명관리에 관련한 연구는 생애주기 비용 최소화 또는 구조성능 최대화와 관련한 목적함수를 적용하여 왔으며, 새로운 확률론적 구조성능 및 안전성 평가 기법을 이용하여 다양한 형태의 목적함수를 개발/적용하고 있다. 이러한 다수의 목적함수를 동시에 고려하는 다목적 최적화 기반 사회기반시설물 수명관리가 최근 국내외에서 많이 적용되고 있다. 하지만, 수명관리 최적화를 위한 목적함수의 개수가 증가함에 따라 신뢰성있는 결과를 얻기 위해서는 많은 계산시간이 소요되며, 특히 확률론적 계산을 위한 시뮬레이션 기법이 적용되는 목적함수의 경우 계산시간은 더욱 증가하게 된다. 또한, 목적함수의 개수 증가에 따라 계산결과의 차수가 증가하기 때문에 이를 시각화하고 나아가 의사결정에 어려움이 발생한다. 따라서, 본 논문에서는 다목적 최적화 문제의 계산된 결과를 바탕으로 한 의사결정의 효율성 향상을 위해 최소 필수 목적함수를 구별하는 목적감소 기법을 적용하여 콘크리트 교량 상판의 수명관리에 대한 연구를 수행하였으며, 최초 4개의 목적함수가 2개까지 감소되는 결과를 보여준다.

• Archives of Plastic Surgery
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• 제44권3호
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• pp.223-227
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• 2017

Background Carpal tunnel release is one of the most common surgical procedures performed by hand surgeons. The authors created a surgical simulation of open carpal tunnel release utilizing a mobile and rehearsal platform app. This study was performed in order to validate the simulator as an effective training platform for carpal tunnel release. Methods The simulator was evaluated using a number of metrics: construct validity (the ability to identify variability in skill levels), face validity (the perceived ability of the simulator to teach the intended material), content validity (that the simulator was an accurate representation of the intended operation), and acceptability validity (willingness of the desired user group to adopt this method of training). Novices and experts were recruited. Each group was tested, and all participants were assigned an objective score, which served as construct validation. A Likert-scale questionnaire was administered to gauge face, content, and acceptability validity. Results Twenty novices and 10 experts were recruited for this study. The objective performance scores from the expert group were significantly higher than those of the novice group, with surgeons scoring a median of 74% and medical students scoring a median of 45%. The questionnaire responses indicated face, content, and acceptability validation. Conclusions This mobile-based surgical simulation platform provides step-by-step instruction for a variety of surgical procedures. The findings of this study help to demonstrate its utility as a learning tool, as we confirmed construct, face, content, and acceptability validity for carpal tunnel release. This easy-to-use educational tool may help bring surgical education to a new- and highly mobile-level.

• 한국환경보건학회지
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• 제38권5호
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• pp.438-447
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• 2012

Objective: The objective of this study was to suggest a method through which load duration curve was used to assess the achievement of water quality targets in accordance with the criteria for pollutant load depending on flow rate variation. Methods: The stage-discharge curve and flow duration curve of Jungnang Stream were deduced. Using water quality targets and measurement of the stream, the flow duration curve was also drawn. Based on these, the feasibility of achievement of water quality targets in respect to flow rate was assessed. Results: In terms of the load duration curve of the stream, it was observed that excess of criteria for concentrations of $BOD_5$, $COD_{Mn}$ and SS frequently occurred. On the other hand, when the flow rate was low, the concentrations of T-N and T-P exceeded the criteria. Conclusions: Through the load duration curve, the overall water quality of Jungnang Stream was understood. When the flow rate is high, management of point source of $BOD_5$, $COD_{Mn}$ and SS is needed to achieve water quality targets for Jungnang Stream. On the other hand, when the flow rate is low, the management of non-point source T-N and T-P is necessary to attain the water quality goal.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권6호
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• pp.2480-2496
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• 2020

Considering that high-dose X-ray radiation during CT scans may bring potential risks to patients, in the medical imaging industry there has been increasing emphasis on low-dose CT. Due to complex statistical characteristics of noise found in low-dose CT images, many traditional methods are difficult to preserve structural details effectively while suppressing noise and artifacts. Inspired by the deep learning techniques, we propose a densely connected residual network (DCRN) for low-dose CT image noise cancelation, which combines the ideas of dense connection with residual learning. On one hand, dense connection maximizes information flow between layers in the network, which is beneficial to maintain structural details when denoising images. On the other hand, residual learning paired with batch normalization would allow for decreased training speed and better noise reduction performance in images. The experiments are performed on the 100 CT images selected from a public medical dataset-TCIA(The Cancer Imaging Archive). Compared with the other three competitive denoising algorithms, both subjective visual effect and objective evaluation indexes which include PSNR, RMSE, MAE and SSIM show that the proposed network can improve LDCT images quality more effectively while maintaining a low computational cost. In the objective evaluation indexes, the highest PSNR 33.67, RMSE 5.659, MAE 1.965 and SSIM 0.9434 are achieved by the proposed method. Especially for RMSE, compare with the best performing algorithm in the comparison algorithms, the proposed network increases it by 7 percentage points.