• 한방비만학회지
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• 제4권1호
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• pp.45-54
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• 2004

Objective: To evaluate the effect of Ephedra Sinica and Evodia Rutaecarpa on resting metabolic rate(RMR), weight and body composition in obese women during low-calorie diet. Methods: We recruited 90 healthy premenopausal women$(body\;mass\;index{\geq}25kg/m^2)$ and randomly assigned to three groups(ephedra group, evodia group and placebo group). Subjects were administered Ephedra Sinica(6g twice a day) or Evodia Rutaecarpa(6g twice a day) or placebo in a double-blind fashion and participated in low-calorie diet for 8 weeks. Resting metabolic rate and body composition were measured at baseline, 4 and 8 weeks. Results: RMR change for 4 weeks was significantly higher in the ephedra group compared with the placebo group(p<.05). But the change for 8 weeks was not significant and the Evodia group showed no significant RMR change. Weight and percent body fat changes for 4 weeks and 8 weeks were significantly higher than the placebo group in the ephedra group(p<.05), but the Evodia group didn't show significant level. Conclusions: This study supports and emphasizes the benefits of herbal medicine in maintaining or increasing RMR during low-calorie diet. Especially Ephedra treatment was effective on significant maintainment of RMR, loss of weight and percent body fat(P<.05).

• 생명과학회지
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• 제32권7호
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• pp.523-531
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• 2022

본 연구에서는 한방복합추출물(마황, 창출, 석고, 카카오닙스)을 제조하여, 추출물에 대한 항산화 활성 및 지방세포형성억제 활성을 확인하고자 하였다. 한방복합물의 항산화 활성을 확인하기 위하여 DPPH, ABTS⁺ radical 소거능 및 xanthine oxidase 저해 활성을 측정한 결과 추출물 1,000 ㎍/ml 농도에서 각각 75.0, 100.8 및 79.5%로 높은 소거능을 나타내었다. 3T3-L1 지방전구세포에서 한방복합물에 의한 지방형성 및 지방세포 분화 억제를 조사한 결과 0~50 ㎍/ml 농도에서 3T3-L1 세포 생존율에 영향을 미치지 않았다. 3T3-L1 지방전구세포에서 25, 50 및 75 ㎍/ml의 한방복합물 처리는 농도 의존적으로 지질 축적을 억제하였다. Western blot 실험 결과 한방복합물은 MDI 유도 분화 3T3-L1 세포에서 분화 전사인자인 PPARγ, C/EBPα 을 75 ㎍/ml 농도에서 각 44.2, 76.6% 억제함을 나타내었다. 또한, 지방산 합성 조절 인자인 FAS의 발현도 억제하였다. 이와 같은 결과를 바탕으로 본 연구는 항비만 기능성 소재로서 한방복합추출물의 활용 가능성을 제시해 줄 수 있을 것으로 사료 된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제10권2호
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• pp.179-184
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• 2007

목 적: 비만 인구 증가와 함께 비알코올성 지방간염의 유병율이 증가하고 있어 이에 대한 관심이 높아지고 있지만, 비만아 중 비알코올성 지방간염 발생의 위험요인에 대한 연구는 별로 없는 실정이어서, 비만아 중 비알코올성 지방간염을 예측할 수 있는 위험 요인을 알아보고자 하였다. 방 법: 영남대학교 병원 소아 비만 클리닉을 방문한 비만아 84명을 대상으로 하였으며, ALT 40 IU/L 이하 (Group 1), 41 IU/L 이상(Group 2)로 나누었으며, 간염이 있는 경우에는 다른 원인에 의한 간염은 배제 시켰으며 나이와 총콜레스테롤, 고밀도와 저밀도 지단백 콜레스테롤, 중성지방, 비만도, 체지방률을 비교하고 빈도를 분석하였다. 결 과: 연령, 총콜레스테롤, 고밀도와 저밀도 지단백 콜레스테롤, 중성지방, 비만도, 체지방율의 평균을 비교하였을 때 1군에서는 연령이 $10.5{\pm}1.6$세, 2군은 $10.7{\pm}2.0$세였으며, 총콜레스테롤은 1군에서 $183.0{\pm}29.1$ mg/dL, 2군에서 $183.7{\pm}31.3$ mg/dL였고, 고밀도 지단백 콜레스테롤은 1군, 2군 각각 $53.0{\pm}10.2$ mg/dL, $55.7{\pm}13.0$ mg/dL, 저밀도 지단백 콜레스테롤은 1군에서 $113.4{\pm}30.2$ mg/dL, 2군에서 $113.0{\pm}30.0$ mg/dL, 중성지방은 1군에서 $99.4{\pm}62.9$ mg/dL, 2군에서 $114.2{\pm}47.3$ mg/dL, 비만도는 1군에서 $44.7{\pm}12.2%$, 2군에서 $47.9{\pm}15.1%$, 체지방률은 각각 $32.7{\pm}5.0%$, $34.0{\pm}4.8%$로 두 군 간에 통계적으로 유의한 차이가 없었으나, 이상지혈증의 분포는 총콜레스테롤, 고밀도와 저밀도 지단백 콜레스테롤은 두 군에서 통계적으로 유의한 차이가 없었으나, 중성지방은 110 mg/dL 이상인 경우가 1군에서 13명(28.9%), 2군에서 21명(53.8%)으로 2군에서 통계적으로 유의하게 많았다(p-value=0.023). 결 론: 비만아에서 비알코올성 지방간염을 예측할 수 있는 위험요인으로 중성지방이 유용할 것으로 생각된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제9권1호
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• pp.48-57
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• 2006

목 적: 연구자는 adipocytokine의 일종인 leptin, adiponectin과 leptin/adiponectin 비를 이용하여 비만아에서 신체 계측치와 인슐린, 지질 농도와의 상관관계를 알아보고자 한다. 방 법: 2005년 1월부터 2005년 6월까지 조선대학교병원 소아과에 방문한 BMI 95백분위수 이상인 7~15세 사이의 비만군 25명(남: 20명, 여: 5명)과 정상 체중 아동인 대조군 25명(남: 20명, 여: 5명)을 대상으로 하였다. 신체 계측(신장, 체중, 팔둘레, 피부주름두께, 체지방률)을 시행하고 공복상태에서 채혈하여 adiponectin, leptin과 혈당, 인슐린, 지질 농도를 측정하였다. 통계는 Student t-test와 Pearson's correlation coefficient 분석법을 이용하였다. 결 과: 비만군에서 대조군에 비해 체질량 지수, 체지방률, 팔둘레, 삼두박근 피부주름두께 및 견갑골하 피부주름두께가 대조군에 비해 유의하게 높았고, 인슐린 농도($17.9{\pm}15.6{\mu}U/mL$ vs $6.5{\pm}2.7{\mu}U/mL$, p<0.05)는 유의하게 높았으며 고밀도 지질 단백 콜레스테롤($50.0{\pm}12.4mg/dL$ vs $68.9{\pm}15.9mg/dL$, p<0.005)은 유의하게 낮았다. Leptin은 비만군에서 $10.6{\pm}5.1ng/mL$로 대조군에 비해 유의하게 높았고(p<0.001), adiponectin은 비만군에서 $2.85{\pm}0.7{\mu}g/mL$로 유의하게 낮았다.(p<0.05). 비만군에서 leptin은 체질량지수, 체지방률과 유의한 양의 상관관계를 보였고 adiponectin은 체질량지수, 체지방률과 유의한 음의 상관관계가 있었다. 대조군에서 leptin은 유의한 상관관계를 보인 인자가 없었으나, adiponectin은 인슐린과 유의한 양의 상관관계가 있었다. Leptin/adiponectin 비는 비만군에서 대조군에 비해 유의하게 높았고($4.03{\pm}2.8$ vs $1.53{\pm}0.74$, p<0.01), 비만군에서는 체지방률, leptin과 유의한 양의 상관관계가 있었으나 대조군에서는 체질량지수 및 체지방률과 유의한 양의 상관관계가 있었다. 결 론: 소아비만에서 leptin과 adiponectin은 비만지표들과 유의한 연관성이 있었음에도 불구하고, 대사장애를 나타내는 인자들과는 연관성이 없었다. Leptin/adiponectin 비는 비만군에서 대조군에 비해 유의하게 높았고, 비만군뿐만 아니라 대조군에서도 비만지표들과 유의한 상관관계가 있었다.

• 대한영양사협회학술지
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• 제2권2호
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• pp.105-111
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• 1996

The trial was conducted to assess the impact of consulting through telephone on body weight reduction among 18 obese adult women. The degree of obesity, food intake pattern, and life style were examined through phone calls. Subjects visited our clinic and their body fat percentages were measured using impedance fat meter (model SIF-891), and were recommended and recorded to have a low calory diet with changes in the food habit and behavior. The study results are as follows: 1. There is a positive relationship between food habit, lifestyle, obese degree, and fat percentage. 2. 8-10kg and 5kg reductions in the body weight were observed among 14 subjects and 2 subjects, respectively. However, 2 subjects maintained their body weights. 3. The body reduction curve looked like a stairway (type) with low slope and was related with food intake amount. 4. It was possible to have the adequate protein intake only through the vegetable diet. 5. 15 out of 18 subjects were on the prescribed low calory diets for 3 days. Therefore, there is a time limitation to follow the diet treatment. 6. A body weight reduction altered dietary intake of foods which were rich in sweet taste, and the favorite foods were chocolate and candy.

• 대한예방한의학회지
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• 제18권2호
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• pp.101-113
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• 2014

Objective : Ephedra Herba has been widely used for patients with common cold, asthma in eastern countries, especially china japan and korea. Recently it has been also used for obesity in clinic with high frequency. This study was designed to investigate the effects of Ephedra Herba ethyl-acetate fraction (EEAF) on hyperlipidemic mice. Method : Effects on total cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured in this experiment, and in addition, histopathological and gene expression changes in liver tissue was also observed. Results : In our study, EEAF did not affect weight gain in hyperlipidemic mice. Oral administration of EEAF lowered levels of total cholesterol which were elevated by induction of hyperlipidemia. And administration of EEAF lowered fasting blood glucose significantly. By carrying out ontological analysis, large numbers of genes were identified in up or down regulated genes. The expression of the genes that were altered in response to high-fat diet was restored to normal levels in EEAF treated mice, with a recovery rate of 49%. And it was considered that fatty acid metabolism was one of important key pathway of the recovery. Conclusion : Results in our study suggest that EEAF can prevent obese and through regulation of dyslipidemia and hyperglycaemia.

• Journal of Nutrition and Health
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• 제31권5호
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• pp.927-938
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• 1998

Epidemiological studies have indicated that a relationship between overweight and cardiovascular disease exists. To assess the relationship of unfavorable changes in serum lipid concentrations, apolipoprotein B, lipoprotein(a), blood sugar and blood pressure to anthropometric variables, nutrient intakes and dietary behavior,64 obese children were chosen as subjects and 24-hour dietary intake, dietary behavior as well as blood pressure, apolipoprotein B, lipoprotein(a), three kinds of cholesterol concentrations were measured in November 1976. More than half(57.8%) of the children had serum cholesterol concentrations over 175mg/d1, and 26.6% of them had over 200mg/d1 and this group could be classified as a high risk group. Abdominal obesity as measured with waist circumference and waist hip ratio was negatively co..elated to high density lipop개tein(HDL) cholesterol. Dietary behavior rather than nutrient intakes appeared to have associations with unfavorable lipid profiles. Total dietary behavior scores and fish and bean product consumption had strong correlations with potentially atherogenic lipoprotein concentrations. This study suggests that fir the early prevention of cardiovascular disease, waist hip ratio together with obese rate should be included in selective programs to identify risk group of children in Korea. furthermore, interventions in cardiovascular disease risk groups in obese children should emphasize maintenance of ideal body weight through reducing body fat and adopting desirable dietary behaviors such as increasing intake of fish or bean products. (Korean J Nutrition 31(5) : 927~938, 1998)

• 대한한방소아과학회지
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• 제24권1호
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• pp.36-45
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• 2010

Objectives The purpose of this study is to evaluate the effect of herbal medicine in children's growth and to report the children's expectation. Methods 171 children visited the department of Pediatrics, Kyung-Hee Oriental Medical Hospital from June 2009 to December 2009 were studied. They were treated more than 6 months and they visited our clinic more than 3 times. Every time when patients visited our hospital, their height, body weight and obesity degree was examined using DS-102(dszenix, Seoul). Also, height percentile of first and the last visit was measured, and those were compared by the Growth Statistics Curve made by the Korean Association of Pediatrics, 2007. Results and Conclusions The mean growth of total children increased by 4.42 percent; the increased percent for boys was 4.17 and that of girls was 5.00. Herbal medical treatment helped growth in children who took medicine for growth retardation problem. Plus, majority of parents who visited the department of Pediatrics, Oriental Medical Hospital satisfied with the service and their children's height. Although thinking genetic factor is important for their height, but they think that herbal medical treatment help the growth with changing eating habit.

• Journal of Community Nutrition
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• 제4권1호
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• pp.51-58
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• 2002

Eating behavior change as a result of nutrition education interventions as secondary prevention strategies can contribute to an increase in life expectancy and better health for older adults in the United States (U.S.). Many of the chronic conditions prevalent in older adults are modifiable by dietary changes, including heart disease, diabetes mellitus, hypertension, obesity and osteoporosis. Important demographic observations in the U.S. including the projected large increase in number of older adults by 2030 have implications for nutrition education focus and services. A comprehensive review of nutrition education interventions for older adults in the U.S. published in 1995 identified elements from adult education theories that contribute to the effectiveness of nutrition education. These elements have been the focus of more recent studies with older adults providing additional evidence for relationships between concepts from commonly used behavior change theories and dietary patterns or change. In the U.S, an important program contributing to nutritional adequacy of the diet for older adults is the Elderly Nutrition Program which provides resources for congregate dining and includes a mandatory nutrition education component. Nutrition education is also provided through clinic based programs, and print and broadcast media. Application of the Transtheoretical Model has shown that the level of interest or motivation to comply with dietary guidance may be greater for some older adults due to an increasing burden of chronic disease and poorer quality of life, while others may not feel a need to change lifestyle habits.

• Toxicological Research
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• 제21권3호
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• pp.255-261
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• 2005

Gami-Samhwang-San, a herbal prescription for obesity treatment, is composed of seven crude herbs such as Rehmanniae Radix Preparata, Ephedrae Herba, Scutellariae Radix, Acori Gramineri Rhizoma, Polygalae Radix, Typhae Pollen, Armeniacae Semen, Menthae Herba. In this study, marker substances in n-butanol fraction (SH-21-B) from Gami-Samhwang-San were analyzed by high performance liquid chromatography (HPLC) and acute toxicity of standardized SH-21-B was evaluated by good laboratory practices (GLP) guideline of Korea Food and Drug Administration. Therefore we confirmed that there were baicalin of 15.92%, amygdalin of 6.57% and ephedrine of 2.49% in SH-21-B. SH-21-B was administered in rats at dose of 0 mg/kg, 2,000 mg/kg, and 5,000mg/kg. Clinical signs of both sexes of rats were observed daily for 14 days after single oral administration. Two female rats one administered at 2,000 mg/kg and the other administered at 5,000 mg/kg, died, but no dead animal was observed among male rats. Therefore $LD_{50}$ in the female rat is observed to be 8,710 mg/kg, and MLD (Minimun Lethal Dose) of the male rat is observed to be more than 5,000 mg/kg.