• Korean Journal of Exercise Nutrition
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• v.23 no.1
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• pp.28-35
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• 2019

[Purpose] The purpose of this study was to investigate the effects of treadmill exercise on oxidative stress in the hippocampal tissue and mitochondrial dynamic-related proteins in rats fed a long-term high-fat diet (HFD). [Methods] Obesity was induced in experimental animals using high fat feed, and the experimental groups were divided into a normal diet-control (ND-CON; n=12), a high fat diet-control (HFD-CON; n=12) and a high fat diet-treadmill exercise (HFD-TE; n=12) group. The rats were subsequently subjected to treadmill exercise (progressively increasing load intensity) for 8 weeks (5 min at 8 m/min, then 5 min at 11 m/min, and finally 20 min at 14 m/min). We assessed weight, triglyceride (TG) concentration, total cholesterol (TC), area under the curve, homeostatic model assessment of insulin resistance, and AVF/body weight. Western blotting was used to examine expression of proteins related to oxidative stress and mitochondrial dynamics, and immunohistochemistry was performed to examine the immunoreactivity of gp91phox. [Results] Treadmill exercise effectively improved the oxidative stress in the hippocampal tissue, expression of mitochondrial dynamic-related proteins, and activation of NADPH oxidase (gp91phox) and induced weight, blood profile, and abdominal fat loss. [Conclusion] Twenty weeks of high fat diet induced obesity, which was shown to inhibit normal mitochondria fusion and fission functions in hippocampal tissues. However, treadmill exercise was shown to have positive effects on these pathophysiological phenomena. Therefore, treadmill exercise should be considered during prevention and treatment of obesity-induced metabolic diseases.

• Journal of the Korean Society of Clothing and Textiles
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• v.39 no.6
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• pp.812-825
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• 2015

This study explored various issues related to the quality-of-life for obese Korean men. In-depth interviews were conducted with thirty men over BMI 25 whose age ranged from 20's to 50's. Projective techniques along with semi-structured interviews were used. The results of interviews were analyzed based on grounded theory. "Stress" was the main phenomenon resulting from the causal conditions of obesity and stigma. Stress consisted of social, psychological, physical and environmental factors. Contextual conditions mediating the relationship between causal conditions and main phenomenon were obesity level, pressure, and public appearance. Avoidance, change of personal traits, and insensitivity were the action/reactions to the main phenomenon. Various factors due to obesity disappeared and quality-of-life increased when they succeed in weight reduction; however, factors related to obesity and lowered condition of quality-of-life continued if they experienced a weight gain/loss yo-yo.

• Journal of Yeungnam Medical Science
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• v.38 no.2
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• pp.83-94
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• 2021

The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

• Journal of Sasang Constitutional Medicine
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• v.16 no.1
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• pp.100-111
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• 2004

Objectives To study on the relation between Sasang constitution and obesity and that of obese patient's clinical symptom. Methods The subjects were 129 female patients to visit to diet. The subjects were 129 female patients to diet who answered questionnaire QSCC II and were diagnosed by the Sasang constitution from May to December in 2001 at Nara oriental medical clinic. Results 1. Of obese patients 79.1% were Taeumin, 11.6% Soeumin, and 9.3% Soyangin. 2. A relation of a grade of obesity and Sasang constitution. 2-1) 45.8% of the obese patients were high level obesity who had over 35% of body fat. Out of these people, 91.5% were Taeumin. 2-2) 40.3% of the obese patients weight hip ratio was between 0.84 to 0.89 and 84.6% of these people were proved to be Taeumin. 2-3) 39.2% of the people who had a minimum weight hip ratio of 0.90 were significantly Taeumin, 6.7% Soeumin and 16.6% Soyangin. 2-4) 65.7% of Taeumin were obese patients. 3. Obesity treatment with constitution. 3-1) 59.8% of Taeumin were Pyo-zng patients. 3-2) As treatment periods tended to increase, Taeumin and Soeumin patients showed a large decling of body fat, whereas Soeumin patients showed the opposite reaction. 3-3) The weight hip ratio was led by Taeumin with 0.03 and then came Soeumin and Soyangin with a 0.02 ratio. As treatment was taken into process longer Taeumin patients showed a great progress in decreasing their weight hip ratios. 4. Costitutional related symptom with Obesity. 4-1) Taeumin was followed by Soyangin and then Soeumin in family history. 4-2) Soeumin was followed by Taeumin, then Soyangin when complain of physical fatigue was taken into consideration. 4-3) The ordinary exercise was led by Soyangin, Taeumin then Soeumin. 4-4) People who receive stress turned out to be 72.9% much higher than the people who don't. 4-5) Overeating due to stress was found in 83.3% of Soyangin.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.459-468
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• 2017

This study investigated the factors influencing how obesity stress and health belief impact weight control behavior among nursing students. Data were collected from nursing students in U city between September 1 and October 10, 2016 and analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and hierarchical multiple regression. Among the general characteristics of the subjects, gender (t=2.30, p=0.044) and health status (F=8.03, p<0.001) significantly influenced weight control behavior. There were negative correlations between diet therapy of weight control behavior (r=-0.26, p<0.001), exercise therapy (r=-0.25, p<0.001), behavior modification therapy (r=-0.29, p<0.001), and perceived barriers in health belief. In addition, acquiring special knowledge for weight control behavior showed positive correlations in obesity stress (r=0.42, p<0.001), perceived susceptibility (r=0.25, p<0.001) and perceived benefits (r=0.19, p<0.001). Furthermore, the significant factors influencing weight control behavior were perceived barriers (${\beta}=-0.30$, p<0.001) and obesity stress (${\beta}=0.20$, p<0.05) in health belief, and these factors explained 17.2% of the variance. Based on the study results, it is necessary to develop and apply effective educational programs that can influence weight control behavior through gender, health status, obesity stress and health beliefs, which determine weight control behavior of nursing students.

• Journal of Nutrition and Health
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• v.42 no.4
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• pp.358-365
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• 2009

The study was performed for investigation with 257 female adults to find out the factors affecting health control behavior and obesity stress by personality type. First of all, BMIs of the respondents showed 30 low weight (11.7%), 170 normal weight (66.1%), 33 overweight (12.8%) and 24 obese respondents (9.4%). Comparing with low weight or normal weight, overweight or obesity could be seen as strong with diet control behaviors, from which obesity stress showed the tendency to be high accordingly. Second, the result of the investigation showed that for the open personality, which was featured as strongly desired to accomplish, very sincere and sensitive, they were more eager to control through health or diet. Third, the result of the investigation showed that for the more nervous, which is featured as emotionally unstable, bad at self control of impetus and clumsy to handle stress, the obesity stress was escalating.

• Journal of Korean Biological Nursing Science
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• v.18 no.4
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• pp.305-317
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• 2016

Purpose: Recent studies demonstrated disruption of the circadian clock gene is associated with the development of obesity and metabolic syndrome. Obesity is often caused by the high calorie intake, In addition, the chronic stress tends to contribute to the increased risk for obesity. To evaluate the molecular mechanisms, we examined the expression of circadian clock genes in high fat diet-induced mice models with the chronic stress. Methods: C57BL/6J mice were fed with a 45% or 60% high fat diet for 8 weeks. Daily immobilization stress was applied to mice fed with a 45% high fat for 16 weeks. We compared body weight, food consumption, hormone levels and metabolic variables in blood. mRNA expression levels of metabolic and circadian clock genes in both fat and liver were determined by quantitative RT-PCR. Results: The higher fat content induced more severe hyperglycemia, hyperlipidemia and hyperinsulinemia, and these results correlated with their relevant gene expressions in fat and liver tissues. Chronic stress had only minimal effects on metabolic variables, but it altered the expression patterns of metabolic and circadian clock genes. Conclusion: These results suggest that the fat metabolism regulates the function of the circadian clock genes in peripheral tissues, and stress hormones may contribute to its regulation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.346-351
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• 2017

This research examines 240 patients who visited a center a specific city, between July-September 2017. Subjects underwent body composition analysis and brainwave measurements, and were subsequently divided into groups according to BMI and body fat percentage. These patients were measured by timeseries linear analysis for their brain function and observed via brainwave activities. Results of the research are as follows: there is a difference in stress-resistance between obese and those in the healthy weight range. This implies there is a causal relationship between stress and obesity. In addition, the methodology used in this study, which is a scientific and objective physiological indicator of a scientific and objective physiological index, suggests that the results of the study are reliable. Results support that managing stress moderates obesity-related problems.

• Journal of Korean Public Health Nursing
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• v.21 no.1
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• pp.75-84
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• 2007

Purpose: The purpose of this study was to investigate the state and factors associated with level of physical activity and exercise in adolescents. Method: The subjects in this study included 528 adolescents registered at two junior high schools and two senior high schools in J City. The data were collected between October 20 and 30, 2006. Result: The study results showed that 23.8% of the adolescents engaged in vigorous activities for at least 20 minutes, three times a week, while 3.8% of the adolescents participated in moderate activities for at least 30 minutes, five times a week. The subjective level of health was determined to be $3.51\pm.91$ points on a 5-point scale. The level of stress was $2.58\pm.83$ points on a 4-point scale. The obesity index was $4.26\pm20.84$ points. Significant correlations were found between the subjective level of health and level of stress (r=-.201, p=.000), the subjective level of health and the obesity index (r=-.135, p=.004), and between the level of stress and the obesity index (r=.107, p=.024). Conclusion: These results showed that developing a health promotion program that includes an exercise program specific to gender and level of education, individualized strategies of stress control and optimal weight control is required.

• Korean Journal of Clinical Laboratory Science
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• v.46 no.1
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• pp.31-37
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• 2014

Metabolic syndrome such as, hypertension, diabetes, obesity, dyslipidemia etc are well known lifestyle diseases which threaten a health state. The purpose of this study is to evaluate antioxidant status and reactive oxygen species (ROS) in various stressful conditions. A group of persons (n=28) were enrolled in this study and stress status was evaluated using questionnaire of psychological well-being index (PWI-SF) and hematologic analysis of free oxygen radical defense (FORD), free oxygen radical test (FORT), lipid profiles and serum cortisol level. Analysis was done according to stress index, BMI status and overtime working. Blood samples from diabetics were used for control. Results are as in followings: Higher PWI-SF group showed higher FORT. Obese persons with BMI > $25kg/m^2$ showed statistically lower FORD (p<0.05) and higher FORT level (p<0.01). When compare with diabetics, an overweight group had similar levels in FORD and FORT while a normal body weight group showed quite different with diabetics in FORD (p<0.001). Higher ROS group has higher triglyceride, CRP and insulin levels but lower in FORD and HDL-cholesterol levels. Overtime working at night showed no meaningful result against our expectations. These results suggested that obesity showed most unfavorable correlations in an antioxidant status in various situations.