• Food Science and Biotechnology
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• v.17 no.4
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• pp.700-704
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• 2008

Anti-obesity effects of $\beta$-cyclodextrin in obese C57BL/6J mice induced by a high fat diet (HD) were observed. The administration of $\beta$-cyclodextrin reduced the gain of body weight, abdominal fat, liver weight, the lipid deposits of hepatocytes and the size of adipocytes in the HD group. In serum analysis, the total and low-density lipoprotein-cholesterols were significantly decreased in the $\beta$-cyclodextrin-supplemented HD group than in the HD group. However, high-density lipoprotein-cholesterol was not changed in these groups. In hypothalamic homogenates, the decrease of neuropeptide Y and increase of $\alpha$-melanocyte stimulating hormone were detected in the $\beta$-cyclodextrin-supplemented HD group compared to that in the HD group. These effects of $\beta$-cyclodextrin were similar to those of Garcinia cambogia, which is widely used as a natural anti-obesity product. These results suggest that $\beta$-cyclodextrin has anti-obesity effects through the lowering of the abdominal fat pad and inhibits the central effects of hunger.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.328-337
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• 2023

We investigated the effects of single and combined administrations of Lactobacillus species (L. plantarum, LP; L. gasseri, LG; L. casei, LC) on blood lipid metabolism and obesity in mice fed a high-fat diet (HFD). The mice were continuously supplemented with LP, LP/LG, or LP/LG/LC, along with HFD, for 12 weeks. The consumption of HFD led to significant increases in body weight, total cholesterol, and triglyceride levels compared to the normal control group. However, administration of LP, LP/LG, or LP/LG/LC to HFD-fed mice reduced body weight gain and showed a tendency to suppress the levels of total cholesterol, triglycerides, and LDL-cholesterol, while increasing HDL-cholesterol levels. The HFD group exhibited increased abdominal fat weight and larger adipocytes in the epididymal adipose tissue compared to the NC group. However, the administered probiotics led to a significant reduction in adipocyte size with decreasing tendency in abdominal fat weight compared with the HFD group. Additionally, the deposition of giant vesicular fat cells in the liver of the HFD group considerably decreased in the probiotic-administered group. Microbiome analysis revealed an imbalance in intestinal microbes in the HFD group, characterized by lower Bacteroidetes and higher Proteobacteria ratios. However, probiotic administration tended to restore the microbial distribution by controlling the abundance of Bacteroidetes and Proteobacteria, resulting in decreased Firmicutes/Bacteroidetes and Proteobacteria/Bacteroidetes ratios. These results suggest that single and combined administration of LP and other probiotics holds enormous potential in reducing obesity in HFD-fed mice as they regulate lipid metabolism, reduce adipocyte size, and restore the balance of intestinal microbes.

• Journal of Nutrition and Health
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• v.26 no.3
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• pp.299-312
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• 1993

Anthropometry, computed tomography(CT) at the umbilical level, nutrient intake, blood pressure, serum levels of lipids and lipoproteins and response of glucose, c-peptide, insulin, and free fatty acid(FFA) during oral glucose tolerance test(OGTT) were estimated on 11 normal-weight controls and 35 overweight and obese middle-agd men. The areas of total abdominal, subcutaneous and visceral were determined by CT scanning technique. Total abdominal fat area correlated the most significantly with the levels of serum lipids, lipoproteins and insulin among several obese indices. Compared with normal-weight controls, overweight and obese men with abdominal fat lower than 29000$\textrm{mm}^2$ showed an increase in waist-hip ratio, areas of total abdominal(35%), visceral and subcutaneous fat and C-peptide response area during OGTT, though age, percent ideal body weight, body mass index, % body fat, and all biochemical indices except C-peptide response area were not different between two groups. Overweight and obese men with abdominal fat greater than 29000$\textrm{mm}^2$ showed a higher values in total abdominal fat(85%), serum levels of triglyceride, total-and LDL-cholesterol, the ratio of LDL-to HDL-cholesterol, and response areas of FFA, insulin and C-peptide during OGTT than normal-weight controls. Overweight and obese men with great abdominal fat showed an increase in alcohol ingestion and percent calorie intake per total energy expenditure, compared with normal-weight controls. Our results indicate that obesity and a certain level of total abdominal fat accumulation is required to observe abnormal levels of serum lipids, lipoproteins and insulin in Korean middle-aged men. In addition, increased alcohol and calorie intake and decreased physical activity could partly explain total abdominal fat accumulation in men.

• Journal of Sasang Constitutional Medicine
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• v.29 no.1
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• pp.40-49
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• 2017

Objectives Sleep duration and sleep quality are closely related to obesity, however there are few studies considering the Sasang constitution. This study is to investigate the relationship between sleep status and obesity according to Sasang constitution. Methods This cross-sectional research studied 2,672 participants (1,293 men and 1,379 women) using the Korean Medicine Data Center (KDC) of the KIOM. Sasang constitution was diagnosed by KS-15 questionnaire. Obesity was divided into two categories: general obesity was defined as Body Mass Index(BMI) ${\geq}25kg/m^2$, and abdominal obesity was defined as waist circumference ${\geq}90cm$ in men and ${\geq}85cm$ in women. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. Results The distribution of the subjects was 56.9% for Taeumin and 43.1% for non-Taeeumin., Poor sleep quality increased both BMI and waist circumference in Taeeumin. In men Taeeumin, sleep duration was correlated with BMI, and sleep quality was correlated with waist circumference. The prevalence of obesity was significant difference according to sleeping duration in men Taeeumin, it was the highest at 6 hours of sleeping time. Conclusions Sleep duration and sleep quality was associated with obesity in Taeeumin. Especially, in men Taeeumin, adequate sleep duration was an important factor for prevention and treatment of obesity.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.6
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• pp.555-563
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• 2021

Purpose: The aim of this study was to evaluate the pancreatic fat fraction (PFF) using magnetic resonance imaging (MRI) in children with and without obesity and to correlate PFF with body mass index (BMI) z-score, hepatic fat fraction (HFF), and ultrasonography-derived pancreato-perihepatic fat index (PPHFI). Methods: This prospective study included 45 children with obesity and 19 without obesity (control group). PFF and HFF were quantitatively assessed using the abdominal multi-echo Dixon method for MRI. The PPHFI was assessed using transabdominal ultrasonography. Anthropometric, MRI, and ultrasonographic characteristics were compared between the two groups. Correlations between PFF, HFF, PPHFI, and BMI z-scores in each group were also analyzed. Results: The PFF, HFF, PPHFI, and BMI z-score were higher in the group with obesity than in the control group (PFF: 6.65±3.42 vs. 1.78±0.55, HFF: 19.5±13.0 vs. 2.31±1, PPHFI: 3.65 ±1.63 vs. 0.94±0.31, BMI z-score: 2.27±0.56 vs. 0.42±0.54, p<0.01, respectively). PFF was correlated with BMI z-scores, PPHFI, and HFF in the obesity group, and multivariate analysis showed that PFF was strongly correlated with BMI z-score and PPHFI (p<0.05). The BMI z-score was strongly correlated with PFF in the control group (p<0.01). Conclusion: These results suggest that MRI-derived PFF measures are associated with childhood obesity. PFF and PPHFI were also highly correlated in the obesity group. Therefore, PFF may be an objective index of pancreatic fat content and has the potential for clinical utility as a non-invasive biomarker for the assessment of childhood obesity.

• Journal of Life Science
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• v.20 no.12
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• pp.1867-1871
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• 2010

The purpose of this study was to investigate the effects of 12 weeks of abdominal breathing exercises, through AB spur, on weight and BMI, % body fat, and waist-hip ratio in healthy college students. The subjects consisted of 20 obese young college students, and all of whom had no other health complications. The subjects were shown in detail the proper way to utilize the equipment and practice abdominal breathing in a laboratory setting. They were told to wear the AB spur for at least six hours a day in order to induce abdominal breathing exercise. Because the subjects were students, most of the abdominal breathing exercises took place while they were sitting in lectures at school, and they wore the equipment for 12 weeks. At 4, 8, and 12 weeks after the subjects started using the AB spur, there were significant decreases in weight, % body fat, BMI, and waist-hip ratio (p<0.05). In conclusion, the results of the stud suggest that abdominal breathing exercise may be a good weight loss method, as well as a beneficial way to decrease obesity factors, in obese college students.

• Journal of Acupuncture Research
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• v.29 no.1
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• pp.61-66
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• 2012

Objectives : The purpose of this study was to examine the duplicate effect of thread-embedding therapy against obesity. Methods : 5 women from 20 to 30 with obesity were treated with thread-embedding therapy and compared the results with physical measurement, body composition tests and fat thickness measured by ultrasound. Results : The thread-embedding therapy locally reduced body size and fat thickness and had a cumulative effect, but showed the greatest effect in the abdominal region. It didn't affect to the overall change of body composition. Conclusions : The duplicate procedure of thread-embedding therapy for obesity had a cumulative effect, but it depended on the treatment region.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.231-244
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• 2008

Purpose: The purpose of this study is to analyze body composition, obesity according to working pattern of working women. The subjects were workers in the automobile manufacturing industry. Methods: The subjects consisted of 514 industrial women workers who had received Korean oriental medicine health examination and submitted questionires about working pattern, during 8 months from April 2005 to November 2005. The body composition was measured by X-scan(Jawon medical, Seoul, Korea). We analyzed the relationship between body composition analysis, obesity and shift pattern with $X^2-test$ using the SPSS Ver. 12.0 Results: Regarding the realationship between body composition and working pattern, shift worker group had a significantly higher level of body weight, ratio of body fat, visceral fat and abdominal fat than normal worker. Conclusion: From this study, we can know that shift work can influence on working women's body composition and obesity.

• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.336-344
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• 1996

Clinical studies were done on 72 peoples (1 male, 71 females) who were treated with the electric acupuncture therapy to decrease body weight and abdominal length in the Yong oriental medicine clinic from march 1, 1994 to June 30, 1995. The result were obtained as follows : 1. Total judgement of efficacy: good(18.0%) moderate(31.0%) unchanged(32.0%) 2. Degree of average body weight loss during 1 week: 0-0.9Kg(22.2%) 1-1.9Kg(20.8%) 2-2.9Kg(16.6%). 3. Degree of average abdominal length decreased during electric acupuncture treatment : 1-1.9cm (40.2%) 2-2.9cm(22.2%) 3-3.9cm(9.7%)

• KOREAN ASSOCIATION OF OCCUPATIONAL HEALTH NURSES
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• v.21 no.1
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• pp.45-45
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• 2014