• Nutritional Sciences
• /
• 제5권3호
• /
• pp.129-133
• /
• 2002

Obesity is a major public health problem in western countries. Genetic and environmental factors, separately or in combination are major determinants of fat mass. Both central effectors (primarily hypothalamus) and peripheral tissues (such as adipose tissue) are implicated in the pathogenesis of obesity. A significant number of studies have documented potential contribution of adipose tissue -via its newly discovered secretory function- to the pathogenesis of obesity and co-morbid conditions including cardiovascular disease, diabetes and hypertension. Applications of analytical techniques such as genomics and proteomics have enabled better understanding of biological sciences in general and have only being applied recently to nutritional sciences including obesity research. Here, we review the recent progress in adipose tissue functional genomics and proteomics, and the importance of these studies in energy metabolism and obesity research.

• 한방비만학회지
• /
• 제23권2호
• /
• pp.98-111
• /
• 2023

Objectives: The purpose of this study was to review predictive factors associated with weight loss in moderate to severe obesity treatment. The direction of the treatment for moderate to severe obesity will be suggested in consideration of various factors. Methods: Authors searched the articles published from 2018 to 2023 in three international databases (PubMed, Embase and the Cochrane Central Register of Controlled Trials) and two domestic databases (Research Information Sharing Service, Korean studies Information Service System). Studies including treatment with moderate to severe obese patients were selected. Results: A total of 43 studies were included. The main factors of weight loss were unchangeable predictors such as low initial degree of obesity, younger age, non-diabetes and high resting energy expenditure with changeable predictors such as increase in protein, physical activity, self-efficacy, initial weight loss and attendance of the treatment. Conclusions: Our review results suggest that based on the characteristics of moderate to severe obese patients, predictors of weight loss can be used to determine treatment and prognosis in various aspects.

• 대한임상검사과학회지
• /
• 제53권4호
• /
• pp.342-352
• /
• 2021

제7기 국민건강영양조사 자료(2016~2018)를 이용해서 고감도 C반응성 단백(hsCRP)과 요산의 비만에 대한 위험도와 상호 작용이 있는지 알아보고자 하였다. 비만은 체질량지수(BMI)가 25 kg/m² 이상으로, 중증 비만은 BMI가 30 kg/m² 이상으로, 병적 비만은 BMI가 35 kg/m² 이상으로 정의하였다. 복합표본 다중 로지스틱 회귀분석에서 주요한 위험인자를 추가하여 보정하였음에도 불구하고 고농도의 hsCRP와 고농도의 요산이 동시에 존재하는 그룹은 기준 그룹보다 비만의 오즈비(odds ratio, OR)가 모든 단계에서 높았다(비만, OR 1.89, P<0.001 vs. 심한 비만, OR 5.04, P<0.001 vs. 병적인 비만, OR 8.20, P<0.001). 비만의 단계가 높아질수록 비만에 대한 hsCRP와 요산의 오즈비가 1.89에서 8.20으로 높아졌다, 이는 BMI가 증가된 참가자일수록 hsCRP와 요산의 관련성이 크다는 것을 암시한다. 더욱이, 복합표본 일반선형분석에서 주요한 교란 요인을 보정한 후 비만에 대한 hsCRP와 요산 사이의 상호 작용이 분석되었다(P for interaction=0.009).

• 보건행정학회지
• /
• 제30권3호
• /
• pp.345-354
• /
• 2020

Background: This study purposed to examine the difference in the prevalence of obesity at each stage among people with and without disabilities considering the severity and type of disability. Methods: The study targeted a total of 1,315,967 people, including 68,418 disabled and 1,247,549 non-disabled, who completed the national health screenings. Logistic analysis and average marginal effect analysis were conducted in three stages (pre-obesity, obesity, severe obesity). Those analyses were conducted considering the severity and type of disabilities. Results: People with disabilities were more likely to be at all stages of obesity than non-disabled people. In severely disabled people, the probability of obesity was higher than non-disabled people at all stages of obesity, but mildly disabled people had a higher only in the severe obesity stage, no difference in obesity stage, and a low in the pre-obesity stage. In physical and mental disabilities, the probability of obesity was higher than non-disabled people at all stages of obesity, but external physical function and internal organs disabled had a lower in the obesity and pre-obesity stage, and no difference in severe obesity stage. Conclusion: This study found that people with disabilities had a higher relationship with obesity than people without disabilities. In addition, severity and types of disabilities have different effects on the stage of obesity. Therefore, it is necessary to care about the health inequality and health of disabled people considering their severity and types of disabilities.

• 한방비만학회지
• /
• 제23권2호
• /
• pp.86-97
• /
• 2023

Objectives: The purpose of this study is to review clinical studies related to the effect of Traditional Chinese Medicine (TCM) on moderate to severe obese patients with hypertension. Methods: Clinical studies from the China National Knowledge Infrastructure (CNKI) were searched by specific keywords and criteria. Total of 7 randomized controlled trials were selected and analyzed. Results: Various evaluation methods were used to see the effect of TCM compared to conventional western medicine. Most of the studies used herbal medicine combined with conventional anti-hypertensive western medicine. The effective rate of anti-hypertension was higher when TCM was added to conventional anti-hypertensive medicine. Traditional medicine treatment showed significant effect on lowering blood pressure and body mass index. Conclusions: Based on the results of the clinical studies from China, TCM can be a valuable option for moderate to severe obese patients with hypertension. Applying Traditional medicine has a significant effect on lowering blood pressure and weight loss. Combining herbal medicine can be worthy of clinical promotion and application for moderate and severe obese patients with hypertension.

• The Korean Journal of Pain
• /
• 제33권3호
• /
• pp.245-257
• /
• 2020

Background: Musculoskeletal pain is associated with obesity; however, information on factors associated with pain in adults with obesity and severe obesity is limited. The purpose of this study was to assess the prevalence of musculoskeletal pain by site and intensity of pain and associated factors in individuals with severe obesity (body mass index ≥ 35.0 kg/㎡). Methods: Baseline data from the DieTBra Trial study evaluating pain symptoms in nine body regions over the last seven days using the Nordic Questionnaire on Musculoskeletal Symptoms and Numerical Pain Scale. The variables analyzed using multiple Poisson regression with hierarchical analysis were: sociodemographic, lifestyle, food consumption, clinical, and anthropometric, and the outcome was moderate and intense pain. Results: In 150 participants, there was a high prevalence of ankle and foot pain (68.7%), lower back pain (62.7%), pain in the knees (53.3%) and upper back pain (52.0%), with a predominance of intense pain. Factors associated with pain according to specific sites were: type 2 diabetes with hand/wrist pain; sedentary time with hip pain; insomnia with pain in the hip and knee; edema in the lower limbs with pain in the lower back and ankles/feet; degree of obesity with ankle/foot pain; and percentage of total fat with ankle/foot pain. Conclusions: There was a high prevalence of pain and intense pain in individuals with severe obesity and an association with clinical variables, the degree of obesity, and sedentary lifestyle.

• The Korean Journal of Pain
• /
• 제35권3호
• /
• pp.345-352
• /
• 2022

Background: Optimal needle depth in transforaminal epidural injection (TFEI) is determined by body measurements and is influenced by the needle entry angle. Physician can choose the appropriate needle length and perform the procedure more effectively if depth is predicted in advance. Methods: This retrospective study included patients with lumbosacral pain from a single university hospital. The skin depth from the target point was measured using magnetic resonance imaging transverse images. The depth was measured bilaterally for L4 and L5 TFEIs at 15°, 20°, and 25° oblique angles from the spinous process. Results: A total of 4,632 measurements of 386 patients were included. The lengths of the left and right TFEI at the same level and oblique angle were assessed, and no statistical differences were identified. Therefore, linear regression analysis was performed for bilateral L4 and L5 TFEIs. The R-squared values of height and weight combined were higher than the height, weight, and body mass index (BMI). The following equation was established: Depth (mm) = a - b (height, cm) + c (weight, kg). Based on the equation, maximal BMI capable with a 23G, 3.5-inch, Quincke-type point spinal needle was presented for three different angles (15°, 20°, and 25°) at lumbar levels L4 and L5. Conclusions: The maximal BMI that derived from the formulated equation is listed on the table, which can help in preparations for morbid obesity. If a patient has bigger BMI than the one in the table, the clinician should prepare longer needle than the usual spinal needle.

• Molecular & Cellular Toxicology
• /
• 제4권1호
• /
• pp.5-10
• /
• 2008

The effect of obesity on the drug-metabolizing enzymes remains an important issue for clinician since obesity is a world wide epidemic problem. However, little is known about the effects of obesity on flavincontaining monooxygenase (FMO) production and activity. We show here for the first time that in vivo FMO activity determined by urinary ranitidine (RA) metabolites ratio in human, was higher in subjects with a high body mass index (BMI, kg/$m^2$, 21.97-30.32) than in those with an intermediate BMI (range 19.38-21.83). Moreover, there was a significant correlation between FMO activity and BMI in 209 subjects. In high fat diet-induced obese mice, we also observed that the hepatic expression of FMO (225% of lean mice) and the activity measured by the RA Noxidation rate ($513{\pm}58.1$ vs. $349{\pm}66.0$ pmol/hr per mg protein) were significantly higher than in lean mice fed a control diet. Unknown factors rather than leptin or insulin appeared to regulate the hepatic FMO production. Thus, FMO activity may be increased in obese or overweight individuals. Moreover, the regulation of FMO activity in subjects with morbid obesity, with or without complications and its clinical implications, should be investigated further.

• 한방비만학회지
• /
• 제5권1호
• /
• pp.9-20
• /
• 2005

Objectives : This study was performed to investigate the effect of Aromatherapy using Foeniculum vulgare Mill(Fennel) for decrease in the appetite of female obese patients. Methods : We analyzed 32 obese patients who had been hospitalized in Kirin Oriental Hospital from October 1, 2004 to January 30, 2005. The patient were classified in two groups, aroma inhalation group(IH group), and non-inhalation group(NIH group). Test was applied 2 times a week(Inhalation and Non-inhalation test) for 4 weeks. The effect of both groups was analyzed by using VAS scores about appetite. The scores were checked before inhalation, and 0, 15, 30, 45, 60 minutes after inhalation. Results : The VAS appetite scores decreased more significantly in inhalation group than non-inhalation group on every checked time(15, 30, 45, 60 minutes after inhalation)(p<0.05). And VAS scores of aroma inhalation group decreased more significantly on every checked time(0, 15, 30, 45, 60 minutes after inhalation) than pre-inhalation(p<0.05), and morbid obesity group is more sensitive than obesity group shortly after the inhalation(0 minute after inhalation)(p<0.05). Conclusions : In this study, we can conclude that aromatherapy using Foeniculum vulgare Mill(Fennel) has an effect on decreasing appetite of female obese patients.

• 대한치과마취과학회지
• /
• 제13권2호
• /
• pp.51-54
• /
• 2013

A 30-year-old man with morbid obesity (height: 176 cm, body weight: 100 kg, body mass index: 32.28) was scheduled for reconstruction of the mandibular fracture. During induction of general anesthesia and nasotracheal intubation, we experienced massive epistaxis, hypoxemia and difficult airway management. Fortunately, we performed oro-tracheal intubation with direct laryngoscopy and it barely succeeded. He recovered without any residual complications and rescheduled seven days later and we successfully performed awake fiberoptic nasotracheal intubation. The patient discharged on the fourth postoperative day.