• 대한예방의학회:학술대회논문집
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• 2001.10a
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• pp.428-428
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• 2001

• Proceedings of the KSCN Conference
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• 2000.11a
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• pp.71-71
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• 2000

• Journal of the Korean Society of School Health
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• v.21 no.1
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• pp.53-58
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• 2008

• Genomics & Informatics
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• v.15 no.1
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• pp.28-37
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• 2017

Obesity is a highly prevalent, chronic disorder that has been increasing in incidence in young patients. Both epigenetic and genetic aberrations may play a role in the pathogenesis of obesity. Therefore, in-depth epigenomic and genomic analyses will advance our understanding of the detailed molecular mechanisms underlying obesity and aid in the selection of potential biomarkers for obesity in youth. Here, we performed microarray-based DNA methylation and gene expression profiling of peripheral white blood cells obtained from six young, obese individuals and six healthy controls. We observed that the hierarchical clustering of DNA methylation, but not gene expression, clearly segregates the obese individuals from the controls, suggesting that the metabolic disturbance that occurs as a result of obesity at a young age may affect the DNA methylation of peripheral blood cells without accompanying transcriptional changes. To examine the genome-wide differences in the DNA methylation profiles of young obese and control individuals, we identified differentially methylated CpG sites and investigated their genomic and epigenomic contexts. The aberrant DNA methylation patterns in obese individuals can be summarized as relative gains and losses of DNA methylation in gene promoters and gene bodies, respectively. We also observed that the CpG islands of obese individuals are more susceptible to DNA methylation compared to controls. Our pilot study suggests that the genome-wide aberrant DNA methylation patterns of obese individuals may advance not only our understanding of the epigenomic pathogenesis but also early screening of obesity in youth.

• The Korean Journal of Food And Nutrition
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• v.22 no.2
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• pp.286-292
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• 2009

This study was conducted to examine the effects of an 8-week weight loss program, on body composition, body shape satisfaction, body shape esteem in 15 obese children. This program included nutritional education and regular physical fitness. After completion of this program, height and body weight increased slightly but body compositions changed. BMI, degree of obesity, and body fat levels dropped slightly, however these differences were not significant. After the 8-week program body weight increased from $63.61{\pm}8.80\;kg$ to $64.07{\pm}9.11\;kg$, degree of obesity and BMI decreased from $151.73{\pm}13.62%$, and $29.08{\pm}2.35$ to $146.60{\pm}12.92%$, and $28.57{\pm}2.26$, respectively, and the percentage of body fat decreased slightly from $42.70{\pm}4.87%$ to $41.46{\pm}4.88%$. There were slight changes in weight of body muscle and lean body mass from $19.62{\pm}3.48\;kg$ and $36.17{\pm}5.78\;kg$ to $20.30{\pm}3.64\;kg$ and $37.16{\pm}6.18\;kg$, respectively. LBM and amount of muscle were higher after this weight loss program. The body shape esteem score increased from $7.60{\pm}4.01$ to $9.00{\pm}6.20$. There was no significant difference in body shape satisfaction before and after the program, and the participants also wanted to be leaner. Finally, body weight, BMI, and body fat showed negative correlations to body shape esteem.

• Journal of the Korean Society of School Health
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• v.20 no.2
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• pp.1-12
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• 2007

Purpose: This study was to examine the effects of a obesity management program for obese children at a urban elementary school. Methods: The study subjects were fifty five 4^th-6^th graders (experimental = 29, control = 26) whose obesity indices were 120% or over fiunr two schools in a urban area. Obesity management program was conducted weekly 12 sessions with 60-day morning group exercises. Study instruments were Imbody 310 (BIOSPACE, 2005) and summated scales. Data were collected from April 6 to June 22, 2006 and analysed by descriptive statistics, X²-test and ANCOVA using SPSS/PC+ 14.0 program. Results: 1. Obesity management program was effective to reduce body weight (t = -2.54, p = .014), fat mass percent (t = -2.37, p = .021) and to increase muscle mass (t = 2.36, p = .022). And all these were also significant statistically in ANCOVA 2. Obesity management program were also effective to decrease level of obesity (t = -3.28, p = .002), and that of stress (t = -2.19, p = .033) and to improve food habit (t = 2.52, p = .016). And all these were also significant statistically in ANCOVA. Conclusion: School-based obesity management program for obese children was effective to reduce weight, fat mass percent, obesity, and stress; increase muscle mass; and improve food habit. School-based obesity management program, therefore, can be recommended as a health promotion measure in elementary school as curricular basis.

• Journal of Korean Public Health Nursing
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• v.27 no.3
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• pp.513-526
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• 2013

Purpose: The purpose of this study was to determine the effects of the Traditional Play-centered Obesity Control Cooperative Learning Program based on the cooperative learning theory on obesity rate, physical fitness, self-esteem, and body image specifically in obese elementary school children. Methods: The research design for this study was based on a non- equivalent control group pretest-posttest design. The study was conducted from September, 5 to November 30, 2012. The subjects included 74 obese children ($Exp.=25^{(a)}$, $Com.=24^{(b)}$, $Cont.=25^{(c)}$) with an obesity rate above 20% at an elementary school in G City. Data analysis was performed using SPSS/WIN 18.0, using Chi-square test, one-way ANOVA, and Scheffe test. Results: The obesity rate (F=4.033, p<.022) in the experimental group was significantly lower than that in the group (Com, Cont), in which the Traditional Play-Centered Obesity Control Cooperative Learning Program was not implemented. Self-esteem (F=4.310, p<.017) also caused significant differences. However, physical fitness (Muscular endurance F=1.545, p=.220; Flexibility F=.671, p=.514; Agility F=1.594, p=.210; Speed F=5.386, p<.007, scheffe (a,b

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.11
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• pp.4266-4272
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• 2010

The purpose of this study was to find the effects of physical activity program on obese young children's body composition and basic motor skills. The physical activity program was conducted with 16 participants whose Kaup Index were higher than 20 were divided into 2 groups(experimental group and control group) for 12 weeks three times a week. Results of the study are as following. First, the physical activity program was found to improve sub-factors of body composition(weight, body fat mass, % body fat, lean body mass and total body water) in the experimental group compared to the control group. There was statistically significant difference between two groups. Second, the physical activity program was found to improve locomotor and manipulation skills of basic motor skills in the experimental group compared to the control group. There was a statistically significant difference between two groups. Based on these results, the physical activity program have positive effects on the changes in obese young children's body composition and basic motor skills.

• The Journal of Pediatrics of Korean Medicine
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• v.37 no.3
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• pp.101-110
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• 2023

Objectives This study was written to report Korean medicine treatment for obese children. Methods This study included obese children who visited the Department of Korean Pediatrics at the Daejeon Korean Medicine Hospital of Daejeon University from September 18, 2020 to March 30, 2023. Height and weight at the first visit and on the day of the last herbal medicine termination were measured, and changes before and after treatment were observed. Liver function tests were performed before and after the treatment. Results Of the nine obese children who received Korean medicine treatment, five were male (55.6%) and four, female (44.4%). In term of age, there were five 8-year-olds (55.6%), two 6-year-olds, and two 10-year-olds (22.2%); the patients' mean age was 8.00 ± 1.414 years. The treatment period was more than three months, and the average treatment period was 177.11 ± 106.013 days. After treatment with Korean medicine, the patients' heights increased, and the body mass index (BMI) percentile and obesity decreased. Liver levels were maintained within the normal range without abnormal liver function after herbal medicine treatment, and no adverse reactions were observed during Korean medicine treatment. As a result of the pattern identification analysis, gastrointestinal damp-heat type and yin deficiency with internal heat were reported at a high frequency. Conclusions Korean medical treatment can reduce the degree of obesity without hindering the growth of childhood obesity.

• Clinical and Experimental Pediatrics
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• v.49 no.6
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• pp.617-622
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• 2006

Purpose : High-Sensitivity C-reactive protein(hs-CRP) has been recognized as a very useful and sensitive predictor of the future risk of myocardial infarction. But the clinical significance of hs-CRP in children remains uncertain. To confirm the existence of obesity-induced vascular inflammation and the association between metabolic syndromes and elevation of CRP in children, we investigated the relationship among CRP, obesity, blood pressure(BP), and serum lipids in schoolboys. Methods : Twenty-eight obese(BMI $29.61{\pm}3.29kg/m^2$) and 93 non-obese(BMI $18.99{\pm}2.21kg/m^2$) boys aged 14 years were examined. Serum CRP levels was measured by the high sensitive latex turbidimetric immunoassay and subjects with CRP levels below 0.3 mg/dL were adopted to avoid the influence of acute infection. Results : Obese children had significantly higher hs-CRP levels than their non-obese group($0.104{\pm}0.075$ vs. $0.054{\pm}0.005mg/dL$). In the obese group, BMI, systolic blood pressure, diastolic blood pressure, apolipoprotein B, atherogenic index, and triglyceride were significantly higher than in nonobese. The BMI, diastolic blood pressure, apolipoprotein E, atherognic index, and triglyceride showed positive correlation with log CRP by simple regression. Multiple regression analysis indicated that BMI and apolipoprotein E were strongly related to CRP. Conclusion : This study revealed that obese children tended to have higher levels of serum hsCRP, BP elevation and dyslipidemia than the control group and that BMI and apolipoprotein E were strongly related to CRP. These results indicate that obesity related metabolic syndrome can be developed in children.