• Title/Summary/Keyword: Oasis

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Alternative Sample Preparation Techniques in Gas Chromatographic-Mass Spectrometric Analysis of Urinary Androgenic Steroids

  • Cho, Young-Dae;Choi, Man-Ho
    • Bulletin of the Korean Chemical Society
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    • v.27 no.9
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    • pp.1315-1322
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    • 2006
  • The following study describes the gas chromatography-mass spectrometry (GC-MS) based screening and confirmation analysis of urinary androgenic steroids. Four commercially available solid-phase extraction (SPE) cartridges, Serdolit PAD-1, Sep-pak $C_{18}$, amino-propyl, and Oasis HLB, and three different extractive organic solvents, diethyl ether, methyl tert-butyl ether (MTBE), and n-pentane, were tested for sample preparation. Overall, Oasis HLB combined with MTBE extraction provided the highest recoveries in 39 of 46 total androgenic steroids examined and it showed a good extraction yield (>82.1%) for polar steroids, such as metabolites of fluoxymesterone, oxandrolone, and stanozolol, which gave a poor recovery in both n-pentane (9.2-64.3%) and diethyl ether (22.2-73.6%) extractions. All SPE sorbents tested showed potential, because they were efficient in extraction for most or selective steroids. When applied to positive urine samples based on the results obtained, the present method allowed selective and sensitive analysis for detection of urinary androgenic steroids. The experiments showed that the high-resolution MS method is clearly more efficient than the low-resolution MS technique for the detection of many urinary steroids. However, comprehensive sample clean-up procedures also might be needed especially in confirmation analysis to increase detectability.

Determination of phenol using solid-phase extraction and HPLC/MSD/FLD in water (고체상추출법과 HPLC/MSD/FLD를 이용한 수질중의 페놀 분석)

  • Lee, Taejoon;Park, Keun-Young;Pyo, Dongjin
    • Analytical Science and Technology
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    • v.28 no.6
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    • pp.370-376
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    • 2015
  • An analytical method for determining phenol considered priority pollutants of the US EPA and precursor of toxic phenolic compounds by solid-phase extraction (SPE) and high performance liquid chromatographic systems (HPLC) equipped with fluorescence and mass selective detectors have been developed. The SPE process for sample preconcentration was performed on a commercially available Oasis HLB cartridge packed with polymeric sorbents. The effect of pH, elution solvent, and elution volume on the recoveries of the analytes were investigated with HPLC/FLD. Average recovery of >87.0% was achieved with 60 mg sorbents using 5 mL of methanol as an elution solvent at pH=3.

The Coordinates Computation of the GPS Base Station by Precise Point Positioning (정밀절대측위(PPP)기법에 의한 GPS 기준점 좌표의 산정)

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    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.17 no.2
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    • pp.145-152
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    • 1999
  • JPL(Jet Propulsion Laboratory) has been routinely produced the precise GPS ephemeris and clock's correction parameter using data collected from globally distributed permanent GPS tracking stations, and has been offering the automated GPS data analysis(Precise Point Positioning: PPP) service by using them. In this study, after investigating the potential capacity of JPL's PPP service, the coordinates computation of the GPS base station by this service were investigated. For this, the dual frequency P codes data of 24 hours were observed from continuously operating four reference stations in USA. sent to the JPL's main computer through E-mail and/or ftp, and then were processed by Gipsy/Oasis-II (GOA-II) software with the precise GPS transmitter parameters. Centimeter-level positioning results were available to obtain in X, Y, Z geocentric rectangular coordinate system.

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Analysis of the Statistical Techniques and Errors in the Field of Sasang Constitution Researches: from 2011 to 2015 (최근 5년간(2011~2015) 사상체질분야 논문의 통계기법 분석 및 오류에 관한 연구)

  • Kim, Sujung;Kim, Sanghyuk;Lee, Siwoo
    • Journal of Sasang Constitutional Medicine
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    • v.28 no.1
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    • pp.51-56
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    • 2016
  • Objectives This study was to identify the types of errors in the statistical analysis and trends of previous reported papers that used various statistical techniques.Methods We have selected 118 original articles for statistical review from the OASIS(http://oasis.kiom.re.kr) and the Pubmed(http://www.pubmed.gov) in the field of Sasang constitutional medicine. Published year was restricted from 2011 to 2015.Results 1. The ANOVA(25.72%) was the statistic of choice overall, followed by the chi-square test(21.74%), regression analysis(14.13%), t-test(11.59%), and etc. 2. By examining the errors of the statistical methods, there were 42(59.2%) thesis with errors among 71 thesis using ANOVA, 19(31.7%) thesis among 60 thesis using chi-square test, and 35(89.7%) over 39 thesis using regression analysis.Conclusions To improve the quality of Sasang Constitution, the participation of statisticians in research design will reduce the significant errors in statistical interpretation of the results.

Adopting DITA Standard for Developing Technical Documentation Efficiently (효율적인 기술문서 개발을 위한 DITA 표준 적용)

  • Koo, Heung-Seo
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.65 no.1
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    • pp.171-178
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    • 2016
  • In engineering industry, technical documentation refers to any type of documentation that describes handling, functionality and architecture of a technical product. The intended audiences for product technical documentation is the end user, the administrator, service or maintenance technician. Competition and rapid technological evolutions have created pressure to release new and improved products on an increasingly frequent basis. As the technical capabilities of products advance, the technical documentation for those products is becoming longer and complex. The Darwin Information Typing Architecture (DITA) is and XML-based, end-to-end architecture for authoring, producing, and delivering technical documents. DITA is an OASIS standard that allows documentation groups to single-source document for multiple products and users, to automatically publish that documentation in several media formats including PDF and HTML, and to efficiently maintain and update that documentation. This paper study on the various implementation projects for technical documentation using OASIS DITA standard and examines the potential for using DITA as a solution for reconstructing existing technical documentation. Also We offer an incremental adoption approach to effectively implement DITA standard of technical documentation project for domestic firms, while reducing failures.

The Implementation of Korean Medicine Prescription Information System (한약처방 정보 검색 시스템 구축)

  • Yea, Sang-Jun;Shin, Hyeun-Kyoo;Kim, Chul
    • Herbal Formula Science
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    • v.20 no.2
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    • pp.47-54
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    • 2012
  • Objectives : This study aimed to build up information system for the 25 cases of Korean Medicine (KM) prescriptions which are used mostly often in clinic and aimed to offer information about its effect and safety to public and researcher. Methods : We used KM prescription data-bank which came from 'The Bio-informatics for herbal formula' and 'The evidence based medicine for herbal formula' projects of Korean Institute of Oriental Medicine (KIOM) Results : First, we analyzed prescription data and categorized 7 classes, then we built up prescription database based on it. Second, we designed and developed user functions of prescription information system, then we link it to OASIS. Third, we developed adminstration system to manage the prescription data. Conclusions : From this study we hope that KM prescription information system will be used for fusion research based on KM. Because the implemented system is linked to OASIS, we expect it will be widely used.

Tunicamycin negatively regulates BMP2-induced osteoblast differentiation through CREBH expression in MC3T3E1 cells

  • Jang, Won-Gu;Kim, Eun-Jung;Koh, Jeong-Tae
    • BMB Reports
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    • v.44 no.11
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    • pp.735-740
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    • 2011
  • Tunicamycin, an endoplasmic reticulum (ER) stress inducer, specifically inhibits N-glycosylation. The cyclic AMP (cAMP) response element-binding protein H (CREBH) was previously shown to be regulated by UPR-dependent proteolytic cleavage in the liver. On the other hand, the role of CREBH in other tissues is unknown. In the present study, tunicamycin increased the level of CREBH activation (cleavage) as well as mRNA expression in osteoblast cells. Adenoviral (Ad) overexpression of CREBH suppressed BMP2-induced expression of alkaline phosphatase (ALP) and osteocalcin (OC). Interestingly, the BMP2-induced OASIS (structurally similar to CREBH, a positive regulator of osteoblast differentiation) expression was also inhibited by CREBH overexpression. In addition, inhibition of CREBH expression using siRNA reversed the tunicamycin-suppressed ALP and OC expression. These results suggest that CREBH inhibited osteoblast differentiation via suppressing BMP2-induced ALP, OC and OASIS expression in mouse calvarial derived osteoblasts.

Development of Deposit Process and Function Design for Web Archiving of Digital Resources (디지털 자원의 웹 아카이빙을 위한 납본 프로세스 개발 및 기능 설계)

  • Oh, Sang-Hoon;Choi, Young-Sun
    • Journal of the Korean Society for information Management
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    • v.25 no.4
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    • pp.5-23
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    • 2008
  • The National Library of Korea is administering a legal deposit system for the printedpublications. Whereas, OASIS(Online Archiving & Searching Internet Sources) has to design a system to collect, manage and preserve web sites and web resources for Web Archiving. The purpose of this study is to develop a digital deposit process for digital resources. As a result, this study defines the subjects and objects for digital deposits, and describes the definitions and the functions according to digital deposit steps. Also, this study designs the data flow diagram and proposes the function definitions on unit works and the structure for the flow of information.

Assessment of the Forecasting Studies on 12 Traditional Korean Medicine Policy Realization (12개 미래 예측 한의약 정책 과제의 실현 평가 연구)

  • Park, Ju-Young;Shin, Hyeun-Kyoo
    • Journal of Society of Preventive Korean Medicine
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    • v.17 no.1
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    • pp.65-76
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    • 2013
  • Objectives : Aim of this study is to contribute to establishment of the Traditional Korean Medicine (TKM) policies in the future. Final assessment for 12 of the forecasting projects was carried out on the TKM policies that deduced by professionals in 1996 whether or not to realize in 2013. Methods : We investigated governmental and private research projects, reports and papers, and laws and systems on the forecasting projects. We reviewed them through the Traditional Korean Medicine Information Portal OASIS (http://oasis.kiom.re.kr), Korean studies Information Service System (KISS) (http://kiss.kstudy.com/) and DBpia (http://www.dbpia.co.kr/), Akomnews(http://www.akomnews.com/), THE MINJOK MEDICINE NEWS(http://www.mjmedi.com/), Ministry of Government Legislation(http://www.law.go.kr/). Results : Of the 12 forecasting projects, five were judged as 'realization', four were as 'partial realization' and three were as 'un-realization', The realization rate was 75.0%. Three un-realized projects included the TKM insurance coverage for various herbal medicines, leadership secure on medical technicians and commercialization of the TKM managing system on senior medicare policy. Realization of the future forecasting TKM policy projects was decided depending on conditions such as the importance, domestic capability levels, principal agents, methods and restrains. Conclusions : Continuous studies and new developed forecasting projects for the TKM policies will be required to realize the projects in the future.