• 정보보호학회논문지
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• 제33권2호
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• pp.235-242
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• 2023

ORAM(Oblivious RAM)은 사용자가 믿을 수 없는 서버, 혹은 하드웨어를 이용할 때 해당 기기에서 발생할 수 있는 부채널 공격을 방어할 수 있는 알고리즘이다. ORAM은 데이터 접근 패턴을 감추어 해당 접근패턴을 통해 정보가 유실되는 것을 방어하게 된다. 그러나, ORAM은 하드웨어의 보안을 강화하나 그로 얻는 이점에 비해 훨씬 큰 처리 속도 감소를 유발하는 단점이 존재하여 현재까지 실용화 되지 못하였다. 본 논문에서는 새롭게 개발되고 있는 하드웨어인 PIM(Process In Memory)를 활용하여 ORAM을 가속화하여 실용적으로 활용할 수 있는 방안을 모색해 보고자 한다.

• Journal of Genetic Medicine
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• 제9권2호
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• pp.98-100
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• 2012

Holt-Oram syndrome (HOS) is the most common heart-hand syndrome, which is inherited in an autosomal dominant manner, but most cases are sporadic. This condition is characterized by upper-extremity malformations involving radial-ray, thenar, and carpal bones, and congenital heart malformations including atrial septal defect and ventricular septal defect. It is caused by mutations in the TBX5 gene. In this report, a Korean case with HOS is described, which is inherited from her father. A novel nonsense mutation, $p.Glu294^*$, was identified. This is the first Korean case with HOS confirmed by genetic testing.

• Journal of Genetic Medicine
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• 제12권1호
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• pp.44-48
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• 2015

Townes-Brocks syndrome (TBS) is a rare genetic disorder characterized by the classic triad of congenital anomalies of the anus, thumbs, and ears, with variable expressivity. Additionally, renal malformations, cardiac anomalies, and endocrine and eye abnormalities can accompany TBS, although less frequently. TBS is inherited in an autosomal dominant fashion; however, about 50% of patients have a family history of TBS and the remaining 50% have de novo mutations. SALL1, located on chromosome 16q12.1, is the only causative gene of TBS. SALL1 acts as a transcription factor and may play an important role in inducing the anomalies during embryogenesis. Clinical features of TBS overlap with those of other multiple anomaly syndromes, such as VACTERL syndrome, Baller-Gerold syndrome, Goldenhar syndrome, cat eye syndrome, and Holt-Oram syndrome. Consequently, there are some difficulties in differential diagnosis based on clinical manifestations. Herein, we report a Korean family with two generations of TBS that was diagnosed based on physical examination findings and medical history. Although the same mutation in SALL1 was identified in both the mother and the son, they displayed different clinical manifestations, suggesting a phenotypic diversity of TBS.