• YAKHAK HOEJI
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• v.43 no.5
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• pp.652-658
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• 1999

To reveal the inhibitory mechanism of NO-dependent vasorelaxation by quinone derivatives (OQ1 and OQ21), we have compared the generation of free radicals by oxidative stress and the formation of cellular adducts by arylation. First, we measured oxygen consumption by quinone derivatives as a marker of oxidative stress in order to investigate whether these quinone compounds could generate reactive oxygen species. Both OQ1 and OQ21 generated free radicals and OQ21 was more potent. These results suggested that free radicals be involved in the inhibition of vasorelaxation by quinones. Next, we measured the binding capacity of quinone derivatives with intracellular GSH and protein thiols (-SH) in order to investigate whether these quinones have arylation capacity. Compared to positive control groups (menadione), both OQ1 and OQ21 depleted intracellular GSH and protein thiols very slightly. These compounds have low toxicities in mammalian tissues. From these results, we concluded that the inhibition of vasorelaxation by quinone derivatives (OQ1, OQ21) may be cuased by generation of free radicals.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.05a
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• pp.131-131
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• 2001

Two 6-(fluorinated-phenylamino)-5, 8-quinolinedione derivatives, OQ21 and OQ1, were newly synthesized as potent inhibitors of endothelial-dependent vasorelaxation. The purpose of the present study was to investigate the effect of OQ21 and OQ1 on different types of vasorelaxation and to pursue their action mechanisms. (omitted)

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.1
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• pp.7-16
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• 2015

The transmitter of quadrature multiplexed GMSK (QM-GMSK) is composed of two quadrature multiplexed GMSK modulators. QM-GMSK has a slightly increased spectrum main lobe compared with $Q^2PSK$ or QMSK, but it has highly suppressed side lobes. As a result, practical spectrum efficiency of QM-GMSK is achieved. By replacing the baseband elementary pulses of QM-GMSK with their approximate, the squared sinusoid of half-period, offset-$Q^2PSK$($OQ^2PSK$) is obtained. The $OQ^2PSK$ signal has similar spectral properties to QM-GMSK. The transmitter of $OQ^2PSK$ can be simply implemented without the Gaussian lowpass filter, which is required in QM-GMSK transmitter. In this paper, we propose an overlapped pulse shaping in $OQ^2PSK$ with RC(raised-cosine) or SRC(squared raised-cosine) pulses of length longer than the symbol period. Power spectrum of the proposed modulation scheme exhibits further suppressed side lobes, hence enhanced spectrum efficiency is obtained. Simulation results indicate that BER performance of the proposed scheme is comparable to that of $OQ^2PSK$.

• YAKHAK HOEJI
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• v.49 no.4
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• pp.347-354
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• 2005

Lipopolysaccharide (LPS) induces synthesis of several inflammatory cytokines and nitric oxide (NO). NO in brain is involved not only in the regulation of important metabolic pathways via intracellular cyclic GMP-dependent path­ways, but also in neurotoxic damage by reacting with superoxide ion leading to form peroxynitrite radical. Oxidative stress has suggested to be related to the inhibition of NO synthase/cyclic GMP pathway. OQ21 is a new fluorinated quinone compound that is recently known to have inhibitory effects on both NO synthase (NOS) and guanylyl cyclase (GC). In this study, we examined effects of OQ21, other known NOS or GC inhibitors, or an antioxidant, melatonin, on the oxidative stress produced by LPS in rat brain. Oxidative stress was observed by using the 2',7'-dichlorofluorescin diacetate to measure intra-cellular reactive oxygen species (ROS) production and by measuring the formation of thiobarbituric acid reactive substances to measure lipid peroxidation. LPS induced significant increase in both ROS produdction and lipid peroxidation in all brain regions tested (striatum, hippocampus and cortex), which were dissected 6hr after intraperitoneal administration of LPS to rats. Direct striatal injection of two NOS inhibitors, N-nitro-L-arginine methyl ester and diphenyleneiodonium, or a GC inhibitor, IH-[1,2,4]oxadiazolo[4,3-a]quinoxaline-l-one, produced no significant ROS increase. However, OQ21 enhanced ROS formation in striatal tissues from LPS-treated rats. Melatonin decreased LPS-induced ROS formation and decreased ROS formation increased by OQ21 in striatum of LPS-treated rats.

• Phonetics and Speech Sciences
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• v.2 no.3
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• pp.47-63
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• 2010

This study provides a description of the glottal characteristics of the word-initial low vowels /a, $\ae$/ in terms of a set of acoustic parameters and discusses glottal configuration as their acoustic correlates. Furthermore, it examines the effect of prosodic boundary on the glottal properties of the vowels, seeking an account of the possible role of prosodic structure based on prosodic theory. Acoustic parameters reported to indicate glottal characteristics were obtained from the measurements made directly from the speech spectrum on recordings of Korean and English collected from 45 speakers. They consist of two separate groups of native Korean and native English speakers, each including both male and female speakers. Based on the three acoustic parameters of open quotient (OQ), first-formant bandwidth (B1), and spectral tilt (ST), comparisons were made between the speech of males and females, between the speech of native Korean and native English speakers, and between Korean and English produced by native Korean speakers. Acoustic analysis of the experimental data indicates that some or all glottal parameters play a crucial role in differentiating the speech groups, despite substantial interspeaker variations. Statistical analysis of the Korean data indicates prosodic strengthening with respect to the acoustic parameters B1 and OQ, suggesting acoustic enhancement in terms of the degree of glottal abduction and the glottal closure during a vibratory cycle.

• Speech Sciences
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• v.8 no.1
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• pp.143-157
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• 2001

This paper focused on glottal parameters contributing to the perception of loud voices because energy of a voice is not the only effective factor. We used a formant synthesizer to synthesize loud voices. We divided F0 tilt (the tilt of F0 contour), SQ (Speed Quotient), OQ (Open Quotient) and TL (spectral Tilt Level) into three levels to get different combinations with default values for the other synthesizer parameters. Analysis of listening tests indicated that F0 tilt, SQ, OQ and TL in descending order had significant influence on the perception of loud voices. F0 tilt had a far more significant effect than the others. The influence of SQ increased greatly with the exclusion of F0 tilt as a factor. The interaction between parameters was not significant.

• Journal of Korean Society for Quality Management
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• v.30 no.1
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• pp.74-96
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• 2002

The objectives of this study is to suggest the rectifying sampling inspection plan considering quality cost. Limiting quality level(LQL) plans(also called LTPD plans) and outgoing quality(OQ) plans are considered. The Hald's linear cost model is discussed with and without a beta prior for the distribution of the fraction of nonconforming items in a lot. It is assumed that the sampling inspection is error free. We consider the design of reliability acceptance sampling plan (RASP) for failure rate level qualification at selected confidence level. The lifetime distribution of products is assumed to be exponential. MIL-STD-690C and K C 6032 standards provide this procedures. But these procedures have some questions to apply in the field. The cost of test and confidence level(1-$\beta$ risk) are the problem between supplier and user. So, we suggest that the optimal life test sampling inspection plans using simple linear cost model considering product cost, capability of environment chamber, environmental test cost, and etc. Especially, we consider a reliability of lots that contain some nonconforming items. In this case we assumed that a nonconforming item fail after environmental life test. Finally, we develope the algorithm of the optimal sampling inspection plan based on minimum costs for rectifying inspection and RASP. And computer application programs are developed So, it is shown how the desired sampling plan can be easily found.

• The Journal of Korean society of community based occupational therapy
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• v.4 no.1
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• pp.1-10
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• 2014

Objective : The purpose of this study was to comparatively analyze time use and quality of life in stroke patients who use Local community or convalescent Hospital environment. Methods : The study subjects were 74 stroke patients who were admitted to convalescent Hospital or who were being rehabilitated as outpatients. The Occupational Questionnaire(OQ)was used for measuring time use and the Stroke Specific Quality of Life(SS-QOL) utilized to measure Quality of life. Excluding 8 patients who did not fit selection criteria, 66 patients were selected and analyzed. Results : After comparatively analyzing time use in Local community and convalescent Hospital environment, significant differences were found in daily living(p<.05), resting(p<.05). In addition, in quality of life, significant differences were found in family(p<.05), self-management(p<.05), and social roles(p<.05). Conclusion : Local community patients used their time in daily living, resting more efficiently than convalescent Hospital patients, and also had a higher quality of life.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.5 no.1
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• pp.5-10
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• 1994

In vivo canine model was made in two mongrel dogs under the general Ⅰ-Ⅴ anesthesia. A vertical skin incision was made on the neck, the larynx and the trachea were dissected. Two tracheal openings were made : lower one for the insertion of the anesthesia tube and upper one for the delivery of air to the larynx to induce phonation. External branch of the superior laryngeal nerves and recurrent laryngeal nerves bilaterally were identified and stimulated electrically constantly. Subglottic pressure. fundamental frequency, intensity, and open quotient were measured when the air flow rate was varying low, medium and high. Glottic resistence was calculated. As the air flow rate was increased, the subglottic pressure and the sound intensity were increased. However, glottic resistance was decreased as the air flow was increased. In falsetto register, fundamenatal frequency was increased with the increment of air flow, but in modal register fundamental frequency was not increased statistically significant Open quotient by the electroglottography was increased according to the increment of airflow.

• Journal of the Korean Applied Science and Technology
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• v.40 no.4
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• pp.881-889
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• 2023

The genus Hymenobacter, type genus of the family Hymenobacteraceae and a member of the phylum Bacteroidota includes gram-negative and red-pigmented rods. Those bacteria have been isolated from various environments of the earth. I isolated a red-pigmented, gram-negative rod from a pond in the campus of the Changwon University, Changwon, Kyeongnam and designated this bacterium as strain B2. Strain B2 was further analyzed phylogenetically and biochemically, and concluded as a member of genus Hymenobacter. BLAST search of the 16S rRNA gene sequence of strain B2 showed its homology lower than 98.7% with those sequences of the other bacteria whose 16S rRNA gene sequences have been reported. Fatty acid composition of the strain B2 was analyzed and its major fatty acids are summed feature 3(C_16:1 ω7c and/or C_16:1 ω6c, 22.8%), iso-C_15:0 (16.2%), anteiso-C_15:0(12.9%), C_16:1ω5c(12.4%) and summed feature 4 (iso-C_17:1 I/anteiso-C_17:1)(9.5%) showing significant differences in fatty acid compositions between strain B2 and the other known Hymenobacter species. DNA sequence of 16S rRNA gene of strain B2 was deposited in genbank under accession number OQ318247.