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Synthesis of Xanthone Derivatives (키산톤 유도체의 합성)

  • Ko, Ok-Hyun
    • YAKHAK HOEJI
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    • v.41 no.3
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    • pp.294-297
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    • 1997
  • The efficient synthesis of xanthone derivatives, which are important intermediates in the synthesis of psorospermin as a anticancer agent, from 3-(benzyloxy)-2-hydroxybenzoic ac id and 6-allyl-3,5-dihydroxyl-1-tosyloxybenzene as a starting material will be reported herein.

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Reexamination of Tris(hydroxymethyl)aminomethane-Catalyzed Hydrolysis of p-Nitrotrifluoroacetanilide

  • Suh, Jung-Hun;Han, Ok-Soo
    • Bulletin of the Korean Chemical Society
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    • v.5 no.5
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    • pp.207-208
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    • 1984
  • The tris(hydroxymethyl)aminomethane (Tris)-catalyzed hydrolysis of p-nitrotrifluoroacetanilide was kinetically studied. On the contrary to the previously reported results (R. M. Pollack and T. C.Dumsha, J. Am. Chem. Soc., 1973, 95, 4463), the dependence of the rate on [Tris] consists of an initial curve portion and a subsequent linear increase. This indicates that erroneous conclusions were made in the reported work due to the insufficient amount of data. The initial portions of the rate[Tris] profiles are attributed to the catalyzed breakdown of the tetrahedral intermediate, and the linear portions to the general base-catalyzed water attack at the substrate.

The Effects of Three Stimulus Modes on receptive Language Performance and expressive Language Performance in Aphasics. (세 가지 자극 양식이 실어증자의 언어이해력과 언어표현력에 미치는 영향)

  • Lee, Moo-Kyoung;Yoo, Jae-Youn;Lee, Ok-bun;Jeong, Ok-Ran
    • Speech Sciences
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    • v.7 no.3
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    • pp.263-272
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    • 2000
  • The purpose of this study was to compare receptive language performance and expressive language performance in 13 patients with aphasia by using three stimulus presentation modes: Stimulus mode I (picture), Stimulus mode II (written word), Stimulus m (question using verbal explanation). The stimulus consisted of 10 words. They included 5 functional words and 5 non-functional words. The 13 subjects with aphasia were divided into 2 aphasic types: 5 Broca's aphasics and 8 anomie aphasics. The results were as follows: Firstly, the three stimulus modes didn't affect receptive language performance of aphasia subjects. Secondly; the three stimulus modes were effective on expressive language performance of aphasia subjects. Particularly, stimulus mode II (written words) was effective in naming the aphasia subjects. Thirdly, the functional words with high frequency were better than non-functional words with low frequency on expressive language performance, but not on receptive language performance of aphasia subjects. Finally, the interaction between three stimulus modes and the functional (nonfunctional) words affected expressive language performance only, but not receptive language performance. Particularly, presenting stimulus in written words which are functional words produced the best expressive language performance.

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Marine Pollution of the East China Sea by Floating Marine Debris(I) - Temporal quantity distribution of each zone - (부유성 해양 폐기물에 의한 동지나해의 해양오염(I) - 해역별 수량 분포를 중심으로 -)

  • Kim, Jong-Hwa;Kim, Yong-Bok
    • Journal of Fisheries and Marine Sciences Education
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    • v.23 no.4
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    • pp.642-647
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    • 2011
  • In order to analyze the influence of floating marine debris (FMD) in the East China Sea (ECS), a sighting survey was conducted from July 1st to July 14th, 2009 navigating about 966 km using a training vessel "Kaya (1,737 ton)" of Pukyong National University. The sampled zones are divided into 5 transect by observation day during the survey days and again specified with 45 segments per unit hour on the survey routes. The results of distribution of FMD are as follows: 1. The quantities of FMD at the central China Sea(CE) and northern part of Taiwan(NT) were found as total mean of 90.8 ea/hr, 56.7 ea/hr, respectively, and also 36.8 ea/hr, western part of Kyushu district(WJ), 10.7 ea/hr, 8.0 ea/hr, western(OK1) and northern part(OK2) of Okinawa, respectively. 2. Temporal variation of FMD is represented by depicting the sinusoidal curve as shape as tide in CE and OK1. 3. The higher sea surface temperature (SST) is as likely as if Kuroshio current exists strongly, the less quantities are decreased. On the other hand, the coastal zone of ECS and near of Yellow Sea are increased by lower SST.

Studies on enterotoxigenic Escherchia coli isolated from piglets with diarrhea (설사 자돈에서 분리된 병원성 대장균에 관한 연구)

  • 김광재;윤교복;최봉출;신은경;김종술;박양주;이유섭
    • Korean Journal of Veterinary Service
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    • v.20 no.4
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    • pp.359-370
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    • 1997
  • This study was carried out to Investigate the biochemical characteristics, antibiotic susceptibility, serogroups and pili producibility test of enterotoxigenic Escherichia coli(ETEC) isolated from piglets with diarrhea in Kangwon province from March to October 1996. 1. Sixty eight E coli strains were isolated from 72 piglets with diarrhea and the biochemical and cultural reaction were compared with the classification criteria of Edwards and Ewing. 2. The serogroups of 26 isolates were classified as 08 : K87 6(8.8%), O20 : K1O1 4(5.9%), O141 : K85 4(5.9%), 09 : K103 : P987 3(4.4%), O45 : K 2(2.9%) 0139 : K82 2(2.9%), O64 : $K^{-}$2(2.9%), O149 : K91 1(1.5%), O157 : K88ac 1(1.5%) and O115 : $K^{-}$1(1.5%), respectively. 3. In antibiotic susceptibility test, the isolates showed high susceptible to Ak, Eno, Na, Gm, Am and Km, whereas resistance to Tc, Sm and Cf. 4. Sixty one strains(89.7%) of 68 I coli Isolates were resistant to one or more drugs. The isolates resistant to 2 and 3 or more drugs were 60.3% and 19.1%, respectively. Amog the 16 multiple resistant patterns, Sm Tc(11.5% ), Cf Sm Tc(11.5% ), Cf Cp Sm Su Tc(9.8% ) and Cf Cp Sm Su Tc(8.2%) patterns were frequently observed. 5. MRHA of guinea pig erythrocytes was detected in 9 out of 26 OK serotype and 9 out of 42 unidentified serotypes. MRHA titers of serotypes showed from 16 to 32 in O141 : K85 and no titers in O139 : K82. 6. By the GM1 ganglioside ELISA, $\beta$-, $\alpha$-, and $\gamma$-hemolysin producing strains was detected as 36, 6, and 5 from heat labile enterotoxin(LT) of 47 ETEC, respectively. The distribution of LT toxin from 112 isolates was showed $\beta$- hemolysin, 2 isolates $\alpha$-hemolysin and 3 isolates $\gamma$-hemol-ysin from 26 OK serotypes.

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A Regioselectio Synthesis of ${\beta}-Lactones$; Bromolactonization of 2-Substituted-1-Cyclohexenyl-1-acetic acid

  • Jew, Snag-Sup;Lee, Hee-Soon;Koo, Bon-Am
    • Archives of Pharmacal Research
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    • v.17 no.5
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    • pp.327-330
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    • 1994
  • Bromolactonization of 2-substituted-1-cyclohexenyl-1-acetic acids with 1, 3-dibromo-5, 5-dime-thylhydantoin 9DBH) and potsssium tertiary butoxide (t-BuOK0 in anhydrous DMF was found to proceed in a highly regioselective manner. The reaction predominantly resulted in the formation of ${\betha}-lactones$ (greater than 96%).

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Thymol Derivatives form Carpesium divaricatum

  • Zee, Ok-Pyo;Kim, Dae-Keun;Lee, Kang-Ro
    • Archives of Pharmacal Research
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    • v.21 no.5
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    • pp.618-620
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    • 1998
  • Four thymol derivatives, 2,5-dimethoxythymol (1), 2-methoxythymol isobutyrate (2), 10-isobutyloxy-8,9-epoxythymolisobutyrate (3) and 10-(2-methylbutyloxy)-8,9-eposythymolisobutyrate (4) were isolated from the aerial parts of Carpesium divaricatum. the structures were elucidated by high field 1D and 2D NMR techniques.

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A Study on the natural environment of Hoe-ok cave in Wonju (원주(原州) 회옥굴(窟)의 자연환경(自然環境)에 관(關)한 연구(硏究))

  • Kim, Byoung-Woo;Park, Jong-Beom
    • Journal of the Speleological Society of Korea
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    • no.84
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    • pp.10-21
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    • 2008
  • In order to accumulate the basic informations to assess the scientific and natural values of the Hoe-ok Cave located in Mountain Chi-ak, Seong-nam 2 ri, sin-rim myeon, the natural environments in the cave were investigated from November 2004 to June 2005. The results are as follows; The average temperature in the cave was 2.5$^{\circ}C$ in the winter, 5.5$^{\circ}C$ in the spring, 6.8$^{\circ}C$ in the summer. The average humidity in the cave was 82.5% in the winter, 86.0% in the spring, 86.0 in the summer. this results show that the temperature was 10$^{\circ}C$ lower, and the humidity was 4$\sim$10% lower than those in the Go-su Cave. Inside of the Heo-og Cave, the damages from the garbages and smoke stains by the reckless civilians are expanding. It is necessary to execute the research on the geological facts of the cave and the reassessment on its values in the natural history.

Job Satisfaction Influenced Personal Traits among Officers and Noncommissioned Officers Working in Army Hospital (군병원 간부들의 개인적 성향에 따른 직무 만족도)

  • OH Jung Yi;Jung Moon Sook
    • Journal of Korean Public Health Nursing
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    • v.9 no.1
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    • pp.1-16
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    • 1995
  • The purpose of this study was to find out and analyze the satisfaction degree related to job by general characteristics, satisfaction factors. This survey was based on the questionnaire method. The sample consisted of 51 noncommissioned officers, 72 administrative officers and 160 nurse officers from army hospitals. The data were collected from March 14 to April 18, 1994 and statistically analysed by percentage, mean and $x^2$ test. Factors of job satisfaction consist of 6 categories; job pristige, interaction, autonomy, task requirements, pay, and organizational requirements. The overall job satisfaction degree was $62.8\%$ in NCOs, $54.2\%$ in administrative officers and $33.3\%$ in nurse officers. The job satisfaction of NCCs increased in factors of job prestige (p<0.01), autonomy (p<0.05), task requirement (p<0.05), and was higher as age. There were statistically significant in the factors of pay in school background, Job prestige in rank (p<0.05). 'I'm OK and You're OK' type was $76.5\%$ which was the highest rate and A major personal traits also showed the highest job satisfaction $(63.7\%)$. There were significant difference between major personal traits and interaction (p<0.01), autonomy (p<0.05), organizational requirement (p<0.01), pay (p<0.05) and task requirement. The job satisfaction of administrative Officers was represented significant differences in factors of pay (p<0.05), task requirements (p<0.05) by school background. Long term Workers showed the highest job satisfaction and significant difference in factors of job prestige and organizational requirement (p<0.01). Job satisfaction in 'I'm OK but you're not OK' type was slightly high, and CP major personal traits also showed the highest job satisfaction. The job satisfaction of nurse officers was represented significant difference in factors of autonomy (p<0.01), job prestige (p<0.05), organizational requirement (p<0.05), and pay by age. In CP major personal traits. job satisfaction showed the highest rate (75.0)

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