• 대한두경부종양학회지
• /
• 제12권1호
• /
• pp.65-68
• /
• 1996

The incidence of plunging ranula has been reported as about 10% of all ranula cases. Treatment consists of wide surgical excision or marsupialization. However, it seldom provides a satisfactory result and various modalities of treatment have been proposed in addition to surgical extirpation. We reported our experience using intralesional OK-432 sclerotherapy for a case of plunging ranula in 20 year-old male patient. The OK-432 solution was prepared by dissolving 0.1 KE in 2ml of physiologic saline and was instilled in the same amount of the aspirated cystic fluid. Following two instillations, the lesion completely disappeared. The side effects were mild fever for 3 days and a mild local induration for several days. At present, 9 months after instillation, no recurrence was observed. OK-432 sclerotherapy appears to be simple, safe and effective method for the treatment of plunging ranula.

• 대한기관식도과학회지
• /
• 제14권2호
• /
• pp.31-37
• /
• 2008

Background and Objectives: In most cases of benign neck cysts, surgical excision has been considered as treatment of choice. However, sometimes complete excision is very difficult, and recurrences has been occured due to insufficient surgery frequently. In this point of view, non-surgical treatment has been attempted with sclerosing agents such as picibanil(OK-432). In this study, we evaluated the efficacy of picibanil sclerotherapy for benign neck cysts. Materials and methods: We retrospectively reviewed 53 patients(27 males, 26 females) who had undergone sclerotherapy with picibanil for benign neck cysts such as ranula, lymphangioma, thyroglossal duct cyst and branchial cyst. Information was gathered with respected to age, sex, number of injections, side effect and outcome of treatment. All patients were treated with intralesional aspiration of cystic contents and injection of picibanil, and followed on neck ultrasonography or neck CT. Results: 53 patients received sonoguided sclerotherapy using picibanil(OK-432). 31 patients(41.3%) showed total shrinkage, near total shrinkage(more than 90% of volume) in 7 patients(9.3%), marked shrinkage(more than 70%) in 5 patients(6.6%) and partial shrinkage(less than 70%) in 17 patients. 15 patients(20%) reaveled no response and 8 patients showed recurrences with repeated sclerotherapy. The side effects of therapy were observed by symptoms such as fever, localized pain and odynophagia. However, these complications disappeared after several days in all cases. Conclusions: We recognized that picibanil(OK-432) sclerotherapy for benign neck cyst is a safe and effective procedures as a primary treatment before considering surgery.

• 대한기관식도과학회지
• /
• 제13권1호
• /
• pp.33-38
• /
• 2007

Background and Objectives: A plunging ranula represents a mucus escape reaction occuring because of the disruption of the sublingual salivary gland. It is commonly a condition of young adults, although the reported age range is 6-43 years. There is said to be a slightly female preponderance of about 1.9:1(F:M). Surgical incision has been considered the definite treatment, but sometimes complete excision is very difficult. Non-surgical treatment of these lesions has been attempted, but the results have not been satisfactory. In this study, we present our experiences with picibanil (OK-432) sclerotherapy for a plunging ranula. Materials and Methods: We retrospectively reviewed 41 patients who have undergone sclerotherapy with picibanil for plunging ranula. Information was collected on age, sex, a number of injection, post-sclerotherapy side effect and outcome of treatment. Results: 17 patients (41.5%) showed a complete response, and 20 patients (48.7%) showed inter-mediate response. No response was seen in 4 patients (9.8%). As a side effect of intracystic OK-432 injection therapy, fever (26.8%) and pain(39.0%) were observed. However, fever and pain disappeared after several days in all cases. Conclusion: The results are showing that OK-432 injection is an effective and safe treatment for plunging ranula.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제32권3호
• /
• pp.267-271
• /
• 2006

Lymphangiomas are benign tumors of the lymphatic system characterized by congenital lymphatic malformation such as anastomosis or obstruction of the lymphatic channels. They are most frequently diagnosed in children younger than 2 years, and the lymphangiomas in head and neck represent about 50-75% of all lymphangiomas. Spontaneous regression is rare, and rapid enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequence such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosing agents. Problems associated with surgical excision include the risk of scarring, damage to surrounding vital structure and the high risk of incomplete excision. The sclerosing agents previously used have numerous local and systemic side effects as their problems. We present a case of lymphangioma occured in tongue that was treated by surgical excision and sclerotherapy with OK-432.

• 대한기관식도과학회지
• /
• 제16권1호
• /
• pp.59-63
• /
• 2010

Cystic hygroma is a rarc congenital malformation of the lymphatic system and seen rarely in adults. It represents an error in communication between the large draining lymphatic channels and the venous system, Conventional surgical excision remains the most popular method of treatment in many developing countries despite the dangers associated with treatment modality. We present a case of huge cervical cystic hygroma in a 26-year old female who was treated with OK-432 sclerotherapy.

• Tuberculosis and Respiratory Diseases
• /
• 제52권6호
• /
• pp.590-596
• /
• 2002

목 적 : 폐암은 악성 흉막 삼출액의 가장 흔한 원인으로 흉관 삽입후 흉막유착술을 시행하는 것이 치료에 널리 이용 되어왔다. 흉막경화제는 여러 종류가 알려져 있으나 그 효과나 부작용은 약제마다 차이가 있다. 이에 저자들은 대표적 흉막경화제인 doxycycline과 새로운 약제인 OK-432의 효과, 부작용 및 무병기간의 차이를 알아보기 위해 본 연구를 시행하였다. 방 법 : 1994년 1월부터 2001년 8월까지 흉막천자 세포진검사 혹은 흉막조직검사상 악성 흉막염이 확인된 폐암환자 중 OK-432나 doxycycline으로 흉막유착술을 시행한 79명의 환자에게서 흉막 유착술 후 30일째의 성공률을 조사하였으며, 약제의 부작용과 무병 생존기간을 후향적으로 조사하였다. 결 과 : OK-432와 doxycycline을 이용한 흉막유착술 후 30일째의 성공률은 각각 83%와 87%으로 유의한 차이가 없었으며 (p=0.677), 부작용으로 발열은 OK-432군 (59%, p=0.001)에서 유의하게 많았고, 통증은 doxycycline군 (73%, p=0.008)에서 유의하게 많았다 무병기간은 두 군 사이에 유의한 차이가 없었다(OK-432 : 13.6개월, doxycycline : 11.6개월)(p=0.532). 결 론 : 폐암으로 인한 악성 흉막액을 치료하는 OK-432는 doxycycline과 비슷한 흉막유착술치료 효과가 있을 것으로 생각된다.

• Advances in pediatric surgery
• /
• 제8권2호
• /
• pp.95-100
• /
• 2002

Lymphangiomas or cystic hygromas are quite commonly seen in children. During a 22-year period, from January 1980 to December 2001, 117 patients with lymphangioma were treated and followed in the Department of Pediatric Surgery at Hanyang University Hospital. The male-to-female ratio was 1.9:1(77:40) with a male preponderance. As for the age incidence at time of diagnosis, 10(8.5 %) patients were noted under 1 month of age, 37(31.6%) were between 1 month and 1 year of age, 12(10.3%) between 1 and 2 years of age, so 59(50.4%) were under 2 years of age. Sixty one (52.1%) lymphangioma-cases were located in the neck, including one case at the nape. Axilla was the second in frequency and the rest were scattered at various sites. The intrascrotal lymphangioma is very rare but we have experienced one case of primary intrascrotal lymphangioma. Eighteen (15.4%) cases were located in the intraabdominal area, 10 in the mesentery, 2 in the greater omentum and 6 in the retroperitoneum. The chief complaints of intraabdominal lymphangioma were abdominal pain, intestinal obstruction, inguinal hernia, palpable mass, and/or abdominal distension. Among 77 histologically proven cases, 14 cases were cavernous lymphangiomas and the rest were cystic lymphangiomas. Bleeding in the lymphangioma was noted in 20(17.1%) cases of all. As for the treatment, a complete excision was performed in 77(65.8%) patients and $AgNO_3$ sclerotherapy after incomplete excision was performed in 23(19.7%). Picibanil (OK-432) sclerotherapy was performed in 17(14.5%) patients. Recurrence rate was 7.7 % and mortality occurred in one case who had a large neck lymphangioma extending into the mediastinum.