• 한국윤활학회:학술대회논문집
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• 한국윤활학회 1998년도 제27회 춘계학술대회
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• pp.286-291
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• 1998

The aim of this paper is to measure the tappet rotation in OHC valve train system. Tappet is eccentric from the cam center to rotate for preventing the partial wear. The experimental system is developed to measure the tappet rotation by using the laser beam and optical fiber. The characteristics of tappet rotation is presented for various operating conctitions. Specially, it is observed that tappet is rotated at the base circle.

• 오토저널
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• 제14권4호
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• pp.79-89
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• 1992

The behavior of belt tension in OHC drive timing belt system was investigated analytically and experimentally for (1)fixed and (2)automatic tensioner. From the numerical results it was found that the automatic tensioner makes the belt tension larger than those of the fixed tensioner. When the initial belt tension decreased due to the belt elongation, the belt tension of the fixed tensioner could decrease to near zero while the belt tension for the automatic tensioner maintained above zero by the tensioner spring. The mean valve and the difference between the maximum and the minimum belt tension for the automatic tensioner increased compared with those of the fixed tensioner. Also, the numerical results for a hydraulic tensioner showed that the hydraulic tensioner has the good parts of both tensioners; i.e., thesmaller amplitude in belt tension and the higher mean tension. Experimental results for the automatic and fixed tensioner of the OHC timing belt system were in agreement with the theoretical results.

• 한국환경성돌연변이발암원학회지
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• 제25권3호
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• pp.104-109
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• 2005

[ $7{\beta}$ ]-Hydroxycholesterol (cholest-5-ene-3, 7-diol, $7{\beta}$-OHC) showed the cytotoxicity on human cervical carcinoma cells (HeLa), $10{\mu}M$ of 50% inhibitory concentration. We evaluated $7{\beta}$-OHC as the possibility of radiation sensitizer. The combination effect of $7{\beta}-OHC\;and\;{\gamma}$-irradiation was measured using colony forming assay and flow cytometer with propidium iodide and $DiOC_6$ stained cells, respectively. The combined treatment of $7{\beta}-OHC\;and\;{\gamma}$-irradiation did not show significant enhancing effects on HeLa cells.

• 한국멀티미디어학회논문지
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• 제6권5호
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• pp.824-830
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• 2003

메모리 기반 추론에서 기억공간의 효율적인 사용과 분류성능의 향상을 위하여 제안되었던 RPA(Recursive Partition Averaging)알고리즘은 대상 패턴 공간을 분할 한 후 대표 패턴을 추출하여 분류 기준 패턴으로 사용한다. 이 기법은 구성된 초월 평면상에서 단순히 대표패턴을 추출하여 분류 성능 저하의 원인이 되는 단점을 가지고 있었다. 여기에서는 기존 RPA의 단점을 보완하기 위해 FPD (Feature-based Population Densimeter)를 이용한 OHC (Optimized Hyperrectangle Calving) 알고리즘을 제안한다. 제안된 알고리즘은 RPA분할 종료 후 OHC를 이용하여 초월 평면을 최적화한 후 패턴 평균 기법을 적용하여 학습 결과를 산출한다. 제안된 알고리즘은 k-NN분류기에서 필요로 하는 메모리 공간의 40%정도를 사용하며 분류에 있어서도 RPA보다 우수한 인식 성능을 보이고 있다. 또한 저장된 패턴의 감소로 인하여, 실제 분류에 소요되는 시간비교에 있어서도 k-NN보다 월등히 우수한 성능을 보이고 있다.

• Tribology and Lubricants
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• 제14권1호
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• pp.23-27
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• 1998

The characteristics of friction in direct acting OHC vane train system have been investigated by the comparison of experimental and theoretical results. A modified friction model was presented to calculate the friction force at cam/tappet contact. A simple experimental system was evaluated to measure the friction force and the camshaft driving torque. The friction force was measured by using the dynamic loadcell. Good agreement was found between theoretical and experimental results in friction force, but there was a little difference in driving torque.

• 한국자동차공학회논문집
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• 제4권6호
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• pp.97-108
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• 1996

A modeling technique is proposed for dynamic simulations of OHC valve trains with HLA(hydraulic lash adiuster). HLA is expressed by an air-oil mixture model considering HLA leak-down and aeraton effects. A compact nonlinear equation is derived which describe the short term dynamic behavior of the HLA. Valve spring is analyzed by a distributed parameter model including nonlinear characteristics in the spring surge phenomena. Global behavior of the remaining valve train is expressed by a lumped mass model. The experiental results prove that the simulation model developed here is accurate and useful for the dynamic simulations of OHC valve trains with HLA.

• 생명과학회지
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• 제32권3호
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• pp.256-262
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• 2022

옥시스테롤은 담즙산 합성 동안 일련의 효소 반응에 의해 생성된 콜레스테롤의 산화물로써, 콜레스테롤과 유사하게 세포내 영역으로 빠르게 이동하여 면역 세포 반응, 지질 대사 및 콜레스테롤 항상성과 같은 다양한 세포 과정을 조절한다. 글루코코르티코이드 수용체(GR), 에스트로겐 수용체(ER) 및 간 X 수용체(LXR)와 같은 종류의 핵 수용체는 여러 조직에서 옥시스테롤에 의해 조절될 수 있다. 가장 풍부한 옥시스테롤인 27-하이드록시콜레스테롤(27-OHC)은 조직 특이적 방식에 의해 에스트로겐 수용체 활성을 활성화하거나 억제하기 때문에 선택적 에스트로겐 수용체 조절자로 규명되었다. 특히 27-하이드록시콜레스테롤이 동맥 경화증 플라크에서 많이 발견되고 대식세포가 거품 세포로 변형되는 것을 가속화하기 때문에 동맥 경화증 발병에 기여하는 것이 분명해 보이나, 다른 연구들에서는 27-하이드록시콜레스테롤이 간 및 지방 조직을 포함한 다양한 대사 기관에 미치는 영향에 대해 반대 의견이 존재한다. 따라서 본 총설을 통해 대사 조직에서의 27-하이드록시콜레스테롤 역할에 대한 논의와 함께, 죽상 동맥 경화증 및 대사 증후군에 영향을 주는 27-하이드록시콜레스테롤의 세부 기전에 대해 논의하고자 한다.

• 한국환경성돌연변이발암원학회지
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• 제25권2호
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• pp.76-81
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• 2005

25-Hydroxycholesterol (cholest-5-ene-3, 25-diol, 25-OHC) showed the cytotoxicity on HeLa human cervix and NCI-H460 human lung cancer cells, $0.5{\mu}M\;of\;50\%$ inhibitory concentration. We studied 25-OHC as the possibility of radiation sensitizer. The combination effect of 25-OHC and y-irradiation measured using flow cytometer with propidium iodide stained cells. The combined treatment of 25-OHC and $\gamma-irradiation$ did not show significant enhancing effects on Hela and NCI-H460 cells.

• Biomolecules & Therapeutics
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• 제13권4호
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• pp.220-226
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• 2005

The present study was performed to evaluate combination effect of 7$\beta$-hydroxycholesterol (7$\beta$-OHC) and $\gamma$-radiation in NCI-H460 human lung cancer cells. 7$\beta$-OHC in combination with $\gamma$-irradiation has an enhanced effect in decreasing clonogenic survival and increasing cellular DNA damage. Pretreatment of cells with 7$\beta$-OHC enhanced radiation-induced apoptosis. Apoptosis of the cells by combined treatment of 7$\beta$-OHC and $\gamma$-irradiation was associated with reactive oxygen species generation and loss of mitochondrial membrane potential, resulting in the activation of caspase 9 and caspase 3. The combined treatment also resulted in an increased G1 cell cycle distribution. These results indicate that 7$\beta$-OHC shows the additive effect of radiation sensitivity in human lung carcinoma cells in vitro.

• 한국자동차공학회논문집
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• 제6권3호
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• pp.78-87
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• 1998

A dynamic model of direct-acting OHC valve train system has been used to determine the load conditions in the system. The modified equations for calculating the friction forces between cam and HLA, and at a camshaft bearing have been defined considering the lubrication conditions. Then, to understand the frictional characteristics in the system, a parameter study has been performed. As the results of the analysis, valve spring stiffness and preload have great effects on the friction in the system, but the effects of other parameters are negligible. So, how to design the valve train system with respect to the reduction of friction is to minimize the valve spring stiffness and preload in the limit of satisfying the dynamic constraints.