• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2005년도 하계학술대회
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• pp.329-332
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• 2005

In this paper, we describe implementation of personal media gateway (PMG) for applications over BcN networks. PMG is a TV based set-top terminal, which enables transmission of Full D1 high quality video and audio at the speed of maximum 2Mbps. It supports SIP protocol and QoS for the BcN networks. The hardware of the PMG consists of host module, audio/video codec processing module, DTMF module, and remote control I/O module. H.263 and MPEG4 software are implemented in DSP as codec for hi-directional communication and streaming, respectively. G.711 and Ogg-Vorbis are implemented as audio codec. We examined the quality of video using the Video Quality Test Equpment, which was developed by KT Convergence Lab. The experimental results show the video quality of MOS 4.1 and audio quality of MOS 4.3. We expect that PMG will be prospective business models, and create new customer value.

• 동의생리병리학회지
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• 제19권6호
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• pp.1585-1593
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• 2005

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-tang on the stress were studied with cDNA microarray analyses, RT-PCR on hypothalamus using an immobilization-stress mice as an animal model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hrs once a day, and this challenge was repeated for seven· consecutive days. In the change of body weight it showed that the Boshimgeonbi-tang is effected recovery on weight loss caused by the immobilization-stress. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with $CyDye^{TM}$ fluorescence dyes and then hybridized to CDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix4000 series scanner and GenePix $Pro^{TM}$ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis-, stress protein, transcriptional factor, and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosysthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 5.5 fold. The 11 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Ogg1 (DNA repair), Aatk (apoptosis), Dffa (apoptosis), Fkbp5 (protein folding) were restored to the normal one by the treatment of Boshimgeonbi-tang.

• Journal of Oral Medicine and Pain
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• 제30권3호
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• pp.287-300
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• 2005

두경부에서 발생하는 편평세포암종은 같은 조직학적 분류, 조직학적 단계 및 임상 단계에 있다하더라도 항암제 투여에 따른 감수성은 환자마다 다양하게 나타난다. 따라서, 본 연구의 목적은 기존에 가장 많이 사용하는 항암제인 5-FU 와 Cisplatin의 감수성을 예측할 수 있는 생물학적 표지자를 찾아 환자에게 맞는 항암제를 선택하기 위해서이다. 5종의 구강 편평암세포암주를 이용하였으며, 5-FU 와 Cisplatin의 항암제 감수성을 측정하기 위해 MTT assay를 시행하였다. 각 세포 주의 전 RNA를 추출하였으며 이어서 cDNA를 합성하였다. 다양한 유전자를 1) 돌연변이 2) 염증(COX pathway) 3) 세포주기 4) 노화 5) 세포외기질 과 관련되게 분류하였고 RT-PCR을 시행하여 유전자의 발현량을 살펴보았다. 결과물은 Scion image 프로그램을 통해 분석하였고, Sigma plot을 이용해 표시하였다. 5-FU의 감수성과 비례하는 유전자들은 XPA, XPC, OGG, APEX, COX-2, PPAR, Cyclin E, Cyclin B1, CDC2, hTERT, hTR, TIMP-3, TIMP-4 및 HSP47이었으며, Cisplatin의 감수성과 비례하는 유전자들은 COX-1, iNOS, eNOS, PCNA, Col-1 및 MMP-9 으로 알 수 있었다. 위 결과는 암환자에게 알맞은 항암제를 선택 시 항암제의 감수성과 관련한 유전자들의 발현 정도를 파악한다면 올바른 항암제를 선택하는데 도움이 되리라 사료된다.

• The Korean Journal of Physiology
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• 제3권1호
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• pp.19-28
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• 1969

Skin temperatures on 10 sites and rectal temperature at every 10 minutes, oxygen consumption at every 20 minutes were measured on 18 male subjects (ages between 14 and 47 years) after exposure to cold air at $15^{\circ}C$ for two hours in a climatic room. Total body fat measured by means of a skinfold method and ratio of body surface area (S) to body volume (V), S/V, were utilized as basis of observations. Surface area was calculated after DuBois equation and body volume was calculated by our original formula. In influencing on the heat loss from the body core to the cold environment, % fat showed inverse relations, whereas, S/V ratio showed direct relations. Thus these two factors acted antagonistically on the body heat loss. Local skin temperatures showed negative correlations with skinfold thickness on the same site, nemaly, on chest, r=-.567; on back, r=-.507; and on upper arm, r=-.353. The other 7 skin sites showed low correlations with % fat. Minimum mean weighted skin temperature (MWST) showed a negative correlation (r=-.443) with % fat, and showed no correlation with S/V ratio. Oxygen consumption in the cold air at $15^{\circ}C$ increased from the first measurement at 20 minutes after exposure and maintained the same increasing trend up to 120 minutes. ${\Delta}T_R$ was greater in tile lean subjects who showed a greater % change in oxygen consumption. The antagonistic actions of % fat and S/V ratio on the heat loss were manifested by observations as follows: minimum rectal temperature was higher In fat subjects (r=.600) and lower in subjects with a greater S/V ratio (=-.582), ${\Delta}T_R$ was smaller in fat subjects (r=-.738) and greater in subjects with a greater S/V ratio (r=.618). Temperature difference between body core and skin surface (minimum rectal temperature minus minimum MWST) showed a positive correlation with % fat (r=.600) and a negative correlation with S/V ratio (r=-.881). Decrease in the mean body temperature and heat debt, respectively, showed negative correlations with % fat and positive correlations with S/V ratio.