• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.431-437
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• 2016

In this investigation, global DNA methylation patterns and the specific methylation status of 5 genes were studied in DNA from peripheral blood (PB) and impact on progression free survival (PFS) and overall-survival (OS) in patients with de novo or relapsed acute myeloid leukemia (AML) treated with decitabine-based regimens waas assessed. DNA was isolated from PB samples at the time of -1, 1, and 7 days of chemotherapy. Global methylation was determined by ELISA, and the CpG island DNA methylation profile of 5 genes using a DNA methylation PCR system. Our data demonstrated that patients with a high level of 5-mC had a poor prognosis after demethylation therapy and those who have low levels of 5-mC in PB achieved higher CR and better SO, but there was no significant correlation found between the 5-mC levels and other clinical features before treatment except the disease status. Higher methylation status of Sox2 and Oct4 genes was associated with differential response to demethylation therapy. A relatively low methylation percentage in one or both of these two genes was also associated with longer OS after decitabine based chemotherapy. We also suggest that global DNA and Oct-4/Sox2 methylation might impact on the pathogenesis of leukemia and play an important role in the initiation and progression. Moreover, dynamic analysis of 5-mC and Oct-4/Sox2 in peripheral blood nucleated cells of leukemia patients may provide clues to important molecular diagnostic and prognostic targets.

• 한국응용곤충학회지
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• 제25권4호
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• pp.209-213
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• 1986

사과, 복숭아, 배나무등을 가해(加害)하는 진딧물의 종류(種類)와 우점종(優占種) 및 발생소장(發生消長)을 $'82{\sim}'84$년(年)까지 농기연(農技硏)과 원예시험장(園藝試驗場)의 살충제(殺蟲劑) 무살포(無撤布) 과수원(果樹園)에서 조사(調査)한 결과(結果)는 다음과 같다. 1. 사과나무를 가해(加害)하는 진딧물은 사과혹진딧물과 조팝나무진딧물로 우점종(優占種)은 $4{\sim}7$월(月)에 사과혹진딧물, $8{\sim}10$월(月)에 조팝나무진딧물로 시기(時期)에 따라서 변화(變化)하였고, 사과혹진딧물은 6월상순(月上旬), 8월상순(月上旬), 10월상순(月上旬)에, 조팝나무진딧물은 6월상순(月上旬), 8월중순(月中旬), 9월하순(月下旬)에 최대밀도(最大密度)를 형성(形成)하였다. 그 이후(以後)에는 복숭아가루진딧물진딧물이었으며, 복숭아혹진딧물은 5월하순(月下旬)$\sim$6월상순(月上旬), 복숭아가루진딧물은 6월중순(月中旬)과 10월중순(月中旬)에 최대밀도(最大密度)를 형성(形成)하였다. 3. 배나무를 가해(加害)하는 진딧물은 배나무동글밑진딧물, 자주동글진딧물, 조팝나무진딧물등으로 우점종은 4월(月)$\sim$6월(月)과 10월(月)에는 배나무동글밑진 2. 복숭아나무를 가해(加害)하는 진딧물은 복숭아혹진딧물, 복숭아가루진딧물, 복숭아잎혹진딧물등으로 우점종(優占種)은 초봄에는 복숭아혹진딧물이었고 딧물, $7{\sim}9$월(月)에는 조팝나무진딧물이였으며, 배나무동글밑진딧물은 5월하순(月下旬)과 10월하순(月下旬)에 조팝나무진딧물은 6월상순(月上旬)과 9월상순(月上旬)에 최대밀도(最大密度)를 형성(形成)하였다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2002년도 춘계학술발표대회 발표논문초록집
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• pp.62-62
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• 2002

The relationship of Oct-4 to pluripotent cells is suggested by its tightly restricted expression pattern during embryonic development. Just prior to implantation it is limited to pluripotent cells of the inner cell mass (ICM) that will form the embryo proper but is not expressed in the trophectoderm, the structure that will form the extraembryonic tissues. (omitted)

• 천문학회보
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• 제35권2호
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• pp.34.2-34.2
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• 2010

The 3C84 (NGC 1275), one of Seyfert 2 galaxy, is an interesting object with its peculiar sub-mas structure. We found that the inner jet (r < 2.5mas) of 3C84 seemed to even changed its position angle and flux over one and a half years based on the result of global 86GHz VLBI survey (Lee et al. 2008). In order to confirm the 'precession' of jet, we observed the object in 4 epochs May07, Oct.07, May08 and Oct.08 with the GMVA (Global mm-VLBI Array) at 3mm (86.25GHz) and the each observation time is about 14 hours. Here we present observation and preliminary result of Oct.07 and May08 epochs.

• 한국임상수의학회지
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• 제30권4호
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• pp.324-328
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• 2013

A 5-year-old intact male Yorkshire terrier dog was referred with a 1-week history of blindness. In both eyes, menace responses and pupillary light reflexes were absent. The indirect ophthalmoloscopy revealed multiple small gray-white and discoloration lesion in mid-nontapetum area in both eyes. Electroretinograms showed diminished amplitude of a- and b-waves. Multifocal serous retinal detachments were detected with optical coherence tomography (OCT) over the small gray-white and discoloration lesion in the fundus. After one week of treatments, the indirect ophthalmoloscopy showed that irregular patches and hyperpigmentation in the center of hyperreflectivity area. Reattachment and retinal thinning were observed by the OCT. The results indicate that OCT scanning is considered to be a useful method for retinal evaluation in dogs with chorioretinitis.

• Journal of Veterinary Science
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• 제24권2호
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• pp.30.1-30.6
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• 2023

A 4-year-old Chihuahua dog was referred for bilateral corneal ulcers. Slightly raised white fluorescein-positive plaque-like corneal lesions in both eyes appeared as intense hyperreflective areas with posterior shadowing on optical coherence tomography (OCT). Based on corneal cytology and culture, Candida albicans-induced fungal keratitis was diagnosed. Despite treatment, on OCT, endothelial plaques, increased stromal infiltration thickness, vertical shapes of the ulcer edge, and necrotic stromal space were judged to be aggravation of the disease, and surgery was performed. Conjunctival grafting surgery with topical 1% voriconazole effectively resolved fungal keratitis. OCT can provide detailed and objective information related to the disease prognosis.

• 한국광학회:학술대회논문집
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• 한국광학회 2009년도 동계학술발표회 논문집
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• pp.169-170
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• 2009

We present a quantification protocol to get the alignment factors of a custom-made spectrometer and the nonlinear fitting function between the measured CCD pixel domain and the wavelength domain to apply the spectral-domain optical coherence tomography using fiber Bragg gratings. We have used 4 different center wavelength gratings with a narrow spectral bandwidth (<0.05 nm) and the same reflectivity (>92 %) to calibrate and align the custom-made spectrometer.

• 한국미생물·생명공학회지
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• 제19권1호
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• pp.82-87
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• 1991

원유 분해세균에 의한 원유 분해능을 조사한 결과, Xanthomonas camperstris M12, Xanthomonas sp. M28, Acintobacter lwoffi G1, Klebsiella pneumoniae L25, 그리고 Pseudomonas maltophilia N246 등의 순서로 나타났다. Xanthomonas maltophilia M12, Xanthomonas sp. M28, 그리고 Pseudomonas maltophilia N246 균주 모두 pctane 분해시의 온도는 $30^{\circ}C$에서 최적이었으며, 최적 pH는 X.camperstris M12와 Xanthomonas sp. M28이 7.0-7.5 이었고, P.maltophilia N246이 7.5-9.0이었다. N246 균주의 최적 NaCl농도는 3.0-3.5 이었다. P.maltophilia N246와 X.campestris M12는 모두 플라스미드를 갖고 있음을 확인하였고, N246 균주로 부터 플라스미드를 제거하였을 경우 octane 분해능이 소실되었으므로 이 플라스미드 위에 octane 분해 유전자가 있음이 확인되었다. 이 균주이 OTC 플라스미드의 크기는 118kb이었다. 또한, N246 균주는 ampicillin 항생제에 내성을 나타내었다.

• 한국안전학회지
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• 제31권1호
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• pp.13-18
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• 2016

KTX wheelset bearings have thus far been maintained in accordance with the maintenance system of French national railway company, SNCF. The overhaul cycle time (OCT) of KTX wheelset bearings is now 1.4 million km in mileage. This value, however, has not been validated in Korea that has much different railway environments with France. In fact, it is impossible to validate OCT of wheelset bearings directly because they are disassembled and cleaned only when some faults are detected. In this paper, the accuracy of the current OCT value was evaluated indirectly by investigating the effect of grease lubricants on the bearing life. Five grease samples (one new and four aged greases) were used in this study. Four aged greases of different conditions were obtained from four wheelset bearings whose mileages were about 0.3, 1.2, 1.3, and 1.8 million km, respectively. Each grease sample was then injected into the RCF (Rolling Contact Fatigue) tester and fatigue lifetime was experimentally estimated. In addition, the wt% of Fe in each grease sample was analysed. The experiment results reveal that the bearing lifetime is inversely proportional to the mileage of grease sample while the wt% of Fe increases with the mileage of grease sample. Based on the experimental results, it can be concluded that the current OCT value is appropriate for the first overhaul of wheelset bearings. However, further validation is required to determine the second and third OCT values.

• Journal of Periodontal and Implant Science
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• 제47권1호
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• pp.13-19
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• 2017

Purpose: The purpose of this study was to examine whether periodontal pocket could be satisfactorily visualized by optical coherence tomography (OCT) and to suggest quantitative methods for measuring periodontal pocket depth. Methods: We acquired OCT images of periodontal pockets in a porcine model and determined the actual axial resolution for measuring the exact periodontal pocket depth using a calibration method. Quantitative measurements of periodontal pockets were performed by real axial resolution and compared with the results from manual periodontal probing. Results: The average periodontal pocket depth measured by OCT was $3.10{\pm}0.15mm$, $4.11{\pm}0.17mm$, $5.09{\pm}0.17mm$, and $6.05{\pm}0.21mm$ for each periodontal pocket model, respectively. These values were similar to those obtained by manual periodontal probing. Conclusions: OCT was able to visualize periodontal pockets and show attachment loss. By calculating the calibration factor to determine the accurate axial resolution, quantitative standards for measuring periodontal pocket depth can be established regardless of the position of periodontal pocket in the OCT image.