• Nutrition Research and Practice
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• 제18권4호
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• pp.451-463
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• 2024

BACKGROUND/OBJECTIVES: The umami taste receptor (TAS1R1/TAS1R3) is endogenously expressed in skeletal muscle and is involved in myogenesis; however, there is a lack of evidence about whether the expression of the umami taste receptor is involved in muscular diseases. This study aimed to elucidate the effects of the umami taste receptor and its mechanism on muscle wasting in cancer cachexia using in vivo and in vitro models. MATERIALS/METHODS: The Lewis lung carcinoma-induced cancer cachexia model was used in vivo and in vitro, and the expressions of umami taste receptor and muscle atrophy-related markers, muscle atrophy F-box protein, and muscle RING-finger protein-1 were analyzed. RESULTS: Results showed that TAS1R1 was significantly downregulated in vivo and in vitro under the muscle wasting condition. Moreover, overexpression of TAS1R1 in vitro in the human primary cell model protected the cells from muscle atrophy, and knockdown of TAS1R1 using siRNA exacerbated muscle atrophy. CONCLUSION: Taken together, the umami taste receptor exerts protective effects on muscle-wasting conditions by restoring dysregulated muscle atrophy in cancer cachexia. In conclusion, this result provided evidence that the umami taste receptor exerts a therapeutic anti-cancer cachexia effect by restoring muscle atrophy.

• 대한지역사회영양학회지
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• 제5권3호
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• pp.444-451
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• 2000

This study was conducted to investigate how body size and weight control experience affect the nutrient intakes and the health status of adolescent females. The survey was carried out by self-questionnaires with 463 female high school and college students in Daegu. Analysis of data was done by using a t-test, and ANOVA with the SAS computer program. The average height, weight and BMI of the subjects were 161.2 cm, 53.4 kg, and 20.51 kg/$m^2$ respectively. However, 25.1% of the subjects belonged to the underweight group when we divided the subjects into 3 groups- underweight, normal-weight, overweight-according to their present body size. The average Fe intake of the subjects was less than 50% of the Korean recommended dietary allowances. The dietary intakes of energy and Vit. A were significantly higher in the underweight group than in other groups. However, no significant differences among body size groups were observed in the dietary habit score and the nutritional knowledge score. It also appeared that the dietary habit score and the nutritional knowledge score of the weight control attemptees were worse than those of the non-attemptees. The physical health status of the subjects significantly differed according to weight control experience, and the psychological health status of the subjects differed with present body size. The physical health condition of the weight control attemptees was worse than the non-attemptees. and the psychological health condition of the overweight group was worse than other groups. The results indicated that unnecessary weight control in adolescent females induces unhealthy food behavior which is linked to undesirable health status.

• Animal Bioscience
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• 제34권4호
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• pp.539-545
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• 2021

Objective: Endometritis is a major disease, that causes infertility in cattle, and is usually categorized as clinical or subclinical endometritis (SCE). The nutritional condition during the dry period is important for recovery after the last stage of the lactation period, and for postpartum production and reproduction. This study aimed to clarify the relationship between nutritional and metabolic characteristics in the dry period, and the risk of postpartum SCE. Methods: Multiparous Holstein dairy cows (n = 25, raised in a tied stall) were used. Endometrial cytological analysis was performed around 30 days post-partum, with 5% to 14% polymorphonuclear (PMN) as a cut-off point to define SCE. Serum levels of glucose, non-esterified fatty acids, β-hydroxybutyric acid (BHBA), blood urea nitrogen, total cholesterol, aspartate aminotransferase, γ-glutamyl transpeptidase, calcium, phosphorus, and magnesium were measured in the cows at the dry period to evaluate energy status, protein metabolism, and mineral metabolism. Results: The incidence of SCE in the cows was 60.0% (n = 15/25) and the mean PMN% in postpartum cows diagnosed as SCE was 8.05%±2.6%. Overall, 17 and 8 samples were collected from the cows in the far-off and close-up periods, respectively. The serum concentration of BHBA in the far-off period and serum glucose concentration in the closeup period were correlated with postpartum PMN% (r = 0.62, p<0.01; r = -0.74, p<0.05, respectively). Serum levels of calcium and magnesium in the dry period were associated with the incidence of postpartum SCE (healthy vs SCE cows, p<0.05). Conclusion: Blood levels of glucose, BHBA, calcium, and magnesium in dry periods could be useful parameters for predicting the risk of postpartum SCE. The present study also suggests that management in the close-up period is essential for promoting recovery from calving fatigue.

• 한국식생활문화학회지
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• 제13권3호
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• pp.159-168
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• 1998

This survey was carried out to obtain the information concerning nutritional status, including factors of food intake and health condition of elderly living in Ulsan area. Main results were as follows. 1) Average height of subjects was close to Korean reference, while weight was below Korean reference, average obesity rate and body mass index were +6.93% and 21.9. 2) In health related factors, 41% of subjects exercised regularly, 31.6% of subjects drank alcoholic beverage, and 41.4% of subjects smoked currently. 3) Mean food habits score was 32.1(ranging from 10 to 50) and milk and lipid food intake were decreased. 4) Dietary intake data showed the average daily intake of all nutrients except phosphorus, were lower than RDA, especially vitamin A, calcium and zinc were lower than other nutrients. According to the percentage of RDA, vitamin A was the nutrient found to be least sufficient. 5) Among the various influential factors resident type, pocket money, exercise and smoking influenced on nutrient intake considerably

• 한국식품조리과학회지
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• 제16권1호
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• pp.9-16
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• 2000

The purpose of this study was to investigate the intake of the health food among the salary men. The subjects consisted of 517 men in Seoul. This study used a constructed questionnaire as instrument tool. The results obtained were summarized as follow : The subjects who consumed lactobacillus were 40.2% and those who consumed drinks of solution type were 32.3%. The subjects who purchase health food by a recommendation from family, relative or acquaintance were 47.3% and those who purchase it by advertisement were 16.9%. The subjects who took the health food for relieving easily fatigue were 36.1% and for the prevention of disease were 25.6%. Most of the subjects took lactobacillus regardless of age, educational levels and income. However, the subjects who were educated below college were tended to take dog-soju more frequently compared to the other subjects. The subjects who felt their health condition good were significantly(p<0.05) consumed the health food more than those who felt their health condition bad. The subjects who had low nutritional knowledge score were significantly(p<0.05)consumed the health food more frequently than those who had high nutritional knowledge score.

• 한국제4기학회지
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• 제21권1호
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• pp.37-45
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• 2007

머리뼈 밑면의 높이는 영양상태와 건강조건에 크게 영향을 받는다. 귀밑점-으뜸점(Porion-basion)의 길이로 알려진 머리뼈 밑면의 높이는 캘리퍼(coordinate caliper)나 머리깊이(subtraction)를 계산하는 방법 등으로 쉽게 측정된다. 이 연구에서는 조선후기(17-18세기)와 6.25전쟁을 수행한 한국인의 영양상태와 건강상태를 알고자 하였다. 이를 위해 6.25전사자와 조선후기(17-18세기) 인골을 자료로 머리뼈 밑면높이의 변화정도를 살펴보고 변화에 영향을 끼친 요인이 무엇인지를 밝히고자 한다. 17-18세기 조선시대 회곽묘에서 출토된 인골모음과 6.25전사자 유해모음을 자료로 하였으며 비교는 미국에서 시기를 달리한 테리 인골모음과 법의학 인골모음을 사용하였다. 한국 인골모음의 경우 백인들과 비슷하거나 약간 낮으나 흑인보다는 건강상태가 좋은 것으로 관찰되는데 이는 민간계층가정에서 어린아이 성장에 필요한 영양을 효과적으로 공급하는 민간 재래적 방법 때문인 것으로 가늠된다. 그러나 조선 후기시대후기 인골의 영양상태는 일제하에서 성장한 6.25전사자와 별로 차이가 없다.

• 농업과학연구
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• 제45권2호
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• pp.258-264
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• 2018

A study was performed to analyze the biochemical composition (moisture, protein, fat, ash, salt value, iron, calcium and phosphorus) of raw and salted hilsa. Pure (with less than 1% impurities) and clean dry salt was used (fish weight : salt weight = 3 : 1) for salting the hilsa. The nutrients values of the hilsa from two different regions were significantly (p < 0.05) varied. The biochemical compositions were also different before and after the processing of the hilsa. Riverine hilsa contains relatively more moisture ($57.79{\pm}0.51%$) and protein ($15.65{\pm}0.50%$) than marine hilsa. Fat ($16.39{\pm}0.51%$) and salt ($1.80{\pm}0.14%$) contents are higher in marine hilsa; whereas the ash ($7.88{\pm}0.35%$) content was higher in the riverine hilsa. Minerals like iron ($4.92{\pm}0.32mg/100g$) and calcium ($480.02{\pm}6.73mg/100g$) remain in large amounts in the marine hilsa, but the phosphorus ($112.36{\pm}4.40mg/100g$) content remains at a high level in the riverine hilsa. In addition, the protein (raw condition, $18.54{\pm}0.46%$, riverine; $17.12{\pm}0.42%$, marine and salted condition, $32.54{\pm}0.5%$, riverine; $27.31{\pm}0.48%$, marine) and fat (raw condition, $15.41{\pm}0.46%$, riverine; $19.07{\pm}0.51%$, marine and salted condition, $11.58{\pm}0.39%$, riverine; $13.6{\pm}0.55%$, marine) contents were higher in the abdominal region of the riverine and marine hilsa both in the raw and salted conditions than in the head and caudal region.

• 생명과학회지
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• 제5권3호
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• pp.145-150
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• 1995

Alcoholic liver disease is defined by the development of three types of liver damage following chronic heavy alcohol consumption, namely, alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis, The clinical features and laboratory tests often do not distinguish among these types of liver injuries. In addition, a considerable number of the patients who have clinical and laboratory features compatible with alcoholic liver disease are diagnosed on liver biopsy to have chronic viral hepatitis or other lesion. Because of these factors, liver biopsy is frequently needed to arrive a definite diagnosis of the disease, its activity, and its chronicity. Fatty liver is usually a benign and reverible condition that disappears on abstinence from alcohol. However, alcoholic hepatitis is usually regarded as a precursor of cirrhosis. The principle factors in the development of alcoholic hepatitis and cirrhosis are the quantity and length of ingestion of alcohol. women are much more susceptible than men to hepatic injuries. Since only 10 - 20% of alcoholics develop cirrhosis, however, it is conceivable that other factors, either genetic, environmental, or nutritional may contribute in the genesis of liver injuries. The most important factor in the treatment of alcoholic liver disease is prolonzed abstinence from alcohol, since abstinence by itself improves clinical status and survival, Nutritional support in patients with nutritional deficiency, and specific drug therapies such as corticosteroid or anabolic steroids for hospitaliged patients with severe alcoholic hepatitis also play an important role in devreasing morbidity and improving survival. Liver transplantation is a newer treatment modality in the patients with advanced cirrhosis, not responsible to medical treatment.

• Mycobiology
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• 제43권1호
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• pp.14-23
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• 2015

The influences of temperature and nutritional conditions on the mycelium growth of oyster mushroom Pleurotus ostreatus (PO) and Pleurotus cystidiosus (PC) were investigated in laboratory experiment during the summer season of 2014. The results of the experiment indicated that potato dextrose agar (PDA) and yam dextrose agar (YDA) were the most suitable media for the mycelium growth of oyster mushroom PO while four media (PDA, YDA, sweet potato dextrose agar, and malt extract agar medium) were not significantly different in supporting mycelium growth of oyster mushroom PC. The optimal temperature for mycelium growth of both oyster mushroom species was obtained at $28^{\circ}C$. Mycelium growth of oyster mushroom PO was improved by carbon sources such as glucose, molasses, and at 1~5% sucrose concentration, mycelium colony diameter of mushroom PO was achieved the highest value. Whereas glucose, dextrose, and sucrose as carbon sources gave the good mycelium growth of oyster mushroom PC, and at 1~3% sucrose concentration, mycelium colony diameter of PC was achieved the maximum value. Ammonium chloride concentrations at 0.03~0.09% and 0.03~0.05% also gave the greatest values in mycelium colony diameter of mushroom PO and PC. Brown rice was found to be the most favourable for mycelium growth of two oyster mushroom species. In addition, sugarcane residue, acasia sawdust and corn cob were selected as favourable lignocellulosic substrate sources for mycelium growth of both oyster mushrooms.

• Journal of Nutrition and Health
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• 제22권6호
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• pp.547-556
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• 1989

This survey was carried out to investigate the nutritional status of 102 rural pregnant women after the 2nd trimester and the effect of pregnant nutritional status on newborn infant's anthropometric measurements. 102 rural pregant women's age was distributed 20 to 34. Pregnant height and prepregnant weight were 157.7$\pm$3.2cm and 50.7$\pm$5.4kg, respectively, which were similar to Korean standard, and pregnant weight gain per week after the 2nd trimester was 0.35$\pm$0.13kg, which was showed normal weight gain. Pregnant blood pressure were 112.6$\pm$12.7mmHg (systolic pressure) and 71.8$\pm$10.6(diastolic pressure), and energy and protein intake were 83.8$\pm$34.3% and 72.2$\pm$24.2% of RDA, respectively. Hemoglobin and blood protein level of 17 pregnant women who selected among total pregnant women were 11.8$\pm$1.0g / dl, 6.5$\pm$0.9g / dl, respectively. Height, weight, and head circumference of 17 newborn infants who delivered from 17 pregnant women were 50.1$\pm$1.9cm, 3.4$\pm$0.6kg, and 31.4$\pm$1.2cm, respectively, which were similar to Korean standard. Infant height, weight, and head circumference at birth were significantly correlated with pregnant higher than dietary intakes and weight gain per week during midpregnancy.