• 한국자기공명학회논문지
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• 제22권4호
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• pp.149-157
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• 2018

Diabetes is known to be one of common causes for several types of peripheral nerve damage. Diabetic neuropathy (DN) is a significant complication lowering the quality of life that can be frequently found in diabetes patients. In this study, the metabolomic characteristic of DN and Diabetes was investigated with NMR spectroscopy. The sera samples were collected from DN patients, Diabetes patients, and healthy volunteers. Based on the pair-wise comparison, three metabolites were found to be noticeable: glucose, obviously, was upregulated both in DN patients (DNP) and Diabetes. Citrate is also increased in both diseases. However, the dietary nutrient and biosynthesized metabolite from glucose, ascorbate, was elevated only in DNP, compared to healthy control. The multivariate model of OPLS-DA clearly showed the group separation between healthy control-DNP and healthy control-Diabetes. The most significant metabolites that contributed the group separation included glucose, citrate, ascorbate, and lactate. Lactate did not show the statistical significance of change in t-test while it tends to down-regulated both in DNP and Diabetes. We also conducted the ROC curve analysis to make a multivariate model for discrimination of healthy control and diseases with the identified three metabolites. As a result, the discrimination model between healthy control and DNP (or Diabetes) was successful while the model between DNP and Diabetes was not satisfactory for discrimination. In addition, multiple combinations of lactate and citrate in the OPLS-DA model of healthy control and diabetes group (DNP + Diabetes patients) gave good ROC value of 0.952, which imply these two metabolites could be used for diagnosis of Diabetes without glucose information.

• Nutrition Research and Practice
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• 제15권4호
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• pp.504-515
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• 2021

BACKGROUND/OBJECTIVES: Malnutrition risk and malnutrition among the elderly is a public health concern. In combating this health-related problem, it is critically important to evaluate the risk factors in a multidimensional way and to apply appropriate nutrition intervention based on the results. SUBJECTS/METHODS: A cross-sectional study was conducted on 215 elderly patients (32.6% male, 67.4% female) in a geriatric outpatient clinic of a hospital in Turkey. Nutritional questionnaires that incorporated the 24-h recall method were applied to determine general characteristics of patients, their health status, nutritional habits, and daily energy and nutrient intakes. Mini Nutritional Assessment was used to determine nutritional status. Relevant anthropometric measurements were obtained. RESULTS: The subjects' mean age was 76.1 ± 7.0 years, and the prevalence of malnutrition (n = 7) and risk of malnutrition (n = 53) among the 215 subjects was 3.2% and 24.7%, respectively. Patients with malnutrition or risk of malnutrition were found to be single, have a depression diagnosis, in an older age group, have less appetite, more tooth loss, have more frequent swallowing/chewing difficulty, and have more frequent meal skipping. In addition, mean daily energy, carbohydrate, fat, fiber, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin C, folates, potassium, magnesium, phosphorus, iron intake, and water consumption were found to be statistically significantly low in subjects with malnutrition or risk of malnutrition. After performing regression analysis to determine confounding factors, malnutrition risk was significantly associated with marital status, loss of teeth, appetite status, and depression. CONCLUSIONS: Routine nutritional screening and assessment of the elderly should be performed. If nutritional deficiencies cannot be diagnosed early and treated, self-sufficiency in the elderly may deteriorate, resulting in increased institutionalization.

• 한국산림과학회지
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• 제105권2호
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• pp.177-185
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• 2016

시비는 고정포지에서 연속적인 묘목 생산에 의해 발생할 수 있는 양분 부족을 예방하고 건전한 묘목 생산을 위해 필수적이다. 본 연구에서는 물푸레나무, 들메나무, 잣나무, 전나무 묘목을 대상으로 무처리인 대조구를 포함하여, 단일원소비료 질소(N $13.8g{\cdot}m^{-2}$), 인(P $6.1g{\cdot}m^{-2}$), 칼륨(K $7.5g{\cdot}m^{-2}$) 처리와 NPK복합비료 1x(N $6.9g{\cdot}m^{-2}$, P $3.05g{\cdot}m^{-2}$, K $3.75g{\cdot}m^{-2}$), 2x(1x의 2배량), 4x(1x의 4배량) 처리가 묘목의 생장과 양분 변화에 미치는 영향을 양분벡터분석법(Vector diagnosis method)으로 정량화하였다. 토양 pH는 시비량이 증가할수록 감소하는 경향을 보였으며, 치환성 칼슘과 마그네슘은 질소와 복합비료 처리에서 감소하였다. 물푸레나무와 들메나무는 질소와 복합비료 시비에서 수고와 근원경이 유의하게 증가하였고, 잣나무와 전나무는 처리에 따른 차이가 없었다. 물푸레나무와 들메나무는 대조구에 비해 복합비료 처리에서 약 2배의 물질량 증가를 보였다. 양분벡터반응은 수종과 시비처리에 따라 상이한 경향을 보였는데, 물푸레나무는 식물체 내 질소 농도와 함께 질소함량이 감소되는 "양분희석" 현상이 나타났고, 식물체 인과 칼륨은 4x처리에서 식물체 농도 변동 없이 함량이 증가하는 "양분최적" 현상을 보였다. 들메나무는 질소, 인, 칼륨의 단일원소비료 처리에서 건중량의 변화 없이 질소 함량을 감소시키는 "체내이동" 현상을 보였으며, 복합비료 처리는 정도는 다르지만 "양분희석" 현상을 보였다. 본 연구는 양묘과정에서 물푸레나무와 들메나무는 적절한 시비가 요구되지만, 잣나무와 전나무는 시비가 필수적이지 않음을 보여주고 있다.

• 한국토양비료학회지
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• 제34권4호
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• pp.265-272
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• 2001

토양비옥도와 토성이 서로 다른 논토양에서 수도 생산성과 환경을 고려한 가축분퇴비의 적정시용기준량을 확립하기 위하여 남계 사양토, 용지 양토, 화동 식양토에서 돈분퇴비를 0, 5, 10, 20 톤 $ha^{-1}$을 시용하고 추청벼를 공시 품종으로 하여 포장시험을 1년간 수행하여 다음과 같은 결과를 얻었다. 토양검정에 의한 화학비료 시용시 돈분퇴비 적정시용량은 사양토 4.0, 양토와 식양토 7.0 톤 $ha^{-1}$ 이었으며, 이때의 정조 수량은 사양토 7.440, 양토 7.000 식양토 6.020 톤 $ha^{-1}$이었다. 사양토와 양토에서 NPK와 함께 돈분퇴비를 15 톤 $ha^{-1}$ 이상 시용시에는 도복에 의한 수량 감소가 발생되었다. 수확기 식물체의 양분흡수량은 돈분 퇴비 시용량이 증가할수록 많아지는 경향이었으며, 시험 후 토양의 인산과 칼리의 함량은 돈분퇴비 시용량의 증가에 따라 높아지는 경향을 보였으며, 그 외의 성분은 처리구간 큰 차이가 없었다.

• 생태와환경
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• 제40권4호
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• pp.503-510
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• 2007

The purposes of the study were to analyze the seasonal effects on the fish fauna and compositions including trophic guilds and tolerance guilds. For the study, we collected fish samples twice in June as premonsoon period and early September 2007 as monsoon periods in five sampling sites of the Gap Stream, and then biological oxygen demand (BOD), nutrients (TN, TP) and suspended solids (SS) were compared with the guild data along the gradient of upstream-to-downstream. Chemical water quality, based on BOD, TP, and TN degraded gradually from the upstream to downstream reach and there were about 3 fold difference between S1 and S5. Water quality was worse in the premonsoon than the monsoon, and the heavy monsoon resulted in a dilution of the polluted river by rain water, especially, in the downstream reach. Total number of fish species, based on the catch per unit effort (CPUE), showed a distinct difference between the two seasons; 30 species were sampled in premonsoon, but 23 species were sampled in the monsoon, indicating a seasonal difference in the fish fauna. Tolerant species dominated the fish community (48.3%) in the stream, and the proportions prior to physical disturbance by the monsoon rain were evidently greater in the downstream reach than the upstream. This reflected the characteristics of urban stream polluted by nutrient enrichment as shown in the BOD and TP values. Sensitive species in the premonsoon decreased from the gradient of upstream-to-downstream reach. Such seasonal modifications in the trophic and tolerance guilds were evident. In the analysis of trophic guild and habitat guild, during the premonsoon the proportion of insectivore and riffle-benthic species were largely greater in the upstream reach than the downstream, whereas the proportions were opposite along the gradient of the stream in monsoon. Thus, the patterns of chemical water quality along the longitudinal gradients reflected the premonsoon conditions of insectivores and tolerant species, indicating that summer monsoon data of fish may not match with water quality due to large physical disturbance by flow regime. Seasonal monsoon in this region as well as the chemical pollution may act as a key role influencing the fish compositions of trophic and tolerance guilds and fauna. The data collected during the premonsoon rather than the monsoon, thus, may be better predictor for a diagnosis of stream health conditions.

• Journal of Community Nutrition
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• 제4권1호
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• pp.3-11
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• 2002

The purpose of this study is to evaluate the iron nutritional status by investigating dietary intake and analyzing the hematological iron status indices including serum transferrin receptor (sTfR) in 8 to 28 month old infants md young children taking supplementary foods. The nutrient intake of 60 healthy infants and young children from 8 to 24 months of age was investigated by means of a 24-hour recall method, and the subjects were divided into 2 groups (8- 12 months and 13-28 months) according to age. Venous blood samples from these groups were collected and measured for the following : hemoglobin(Hb), hematocrit(Hct) , mean corpuscular volume (MCV), mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration (MCHC), serum ferritin, serum iron, total iron binding capacity (TIBC), and sTfR. Anemia is defined as hemoglobin < 11g /dl , serum ferritin level < 10ng1m1 for iron deficiency , serum transferring receptor(sTfR) > 4.5mg / 1 for iron deficient erythropoiesis. Total daily calorie intake was 934.6 ${\pm}$ 284.5kcal (98.32% of RDA) on average. Average daily iron intake in infants aged 8 to 12 months was 8.92 ${\pm}$ 3.32mg. The mean daily iron intake in infants aged 13 to 28 months was 7.15 ${\pm}$ 3.35mg (90% of Recommended Dietary Allowance, RDA). Mean values for Hb, Hct sew ferritin and sTfR were 12.10 ${\pm}$ 0.77g141,36.02 ${\pm}$ 2.31%,20.91 ${\pm}$ 11.58ng/m1 and 3.78 ${\pm}$ 1.47mg /1, respectively. In the young children from 13 to 28 months of age, the prevalence of anemia was 5.6%. The prevalence of iron deficiency was 9.5% in those from 8 to 12 months of age, and 27.8% in those from 13 to 28 months of age. The prevalence of iron deficient erythropoiesis was 16.7% in infants aged 8 to 12 months and 44.4% in those aged 13 to 28 months. The prevalence of both serum ferritin level < 10ng/m1 sTfR > 4.5mg/1 was 22% in the young children aged 13 to 28 months. The measureand ment of sTfR may be a promising new tool in diagnosis of iron deficiency in early childhood when the iron deficiency is prevalent. It seems appropriate to emphasize nutritional education and evaluation to promote the iron nutritional status of infants and young children.

• 대한지역사회영양학회지
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• 제19권2호
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• pp.163-175
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• 2014

Objectives: We aimed to evaluate dietary intake among female breast cancer survivors in a cross-sectional study. Methods: A total of 127 women who had breast cancer surgery at least 6 months before baseline were included. Dietary intake of female breast cancer survivors was assessed through self-reported 3 day-dietary records. To compare dietary intake between breast cancer survivors and general female population without cancer, we selected the 1:4 age matched women from the 2011 Korean National Health and Nutrition Examination Survey (KNHANES). In the KNHANES, participants were asked about their dietary intake using the 24-hour dietary recalls. We also examined whether dietary intake varied by age group, cancer stage, or time since surgery among breast cancer survivors. We used the generalized linear model to compare their dietary intakes. Results: Intakes of total energy, beta-carotene, folate, vitamin C, plant iron and fruits were lower among breast cancer survivors with longer time since surgery compared to those with shorter time (p<0.05). Breast cancer patients with higher stage at diagnosis tended to consume less legumes (p=0.01) than those with lower stage. When we compared dietary intake between breast cancer survivors and the general female population without cancer, breast cancer survivors were more likely to consume most of macro- and micro-nutrients in larger quantity (p<0.05) and adhere to healthier diet characterized by higher intakes of legumes, seed and nuts, vegetables and fishes and shells than the general female population who never had been diagnosed with cancer (p<0.05). Conclusions: Our study results suggested that the intakes of nutrients and foods varied by time since surgery and cancer stage among breast cancer survivors and dietary intakes among breast cancer survivors differed from that in the general population. Further prospective studies are warranted to explore the association between dietary intakes of specific food items and survival among Korean breast cancer survivors.

• 한국토양비료학회지
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• 제9권1호
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• pp.39-45
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• 1976

농가포장(農家圃場)에 실시(實施)한 대맥(大麥) 삼요소(三要素) 시험(試驗)(1967/68)지(地)를 대상(對象)으로 생육시기별(生育時期別) N.P.K.Ca.Mg 농도(濃度), NPK와 수량(收量)과의 상관(相關) 및 NPK 이용율(利用率)을 조사(調査)하여 다음과 같은 결과(結果)를 얻었다. 1. 생육시기별(生育時期別) 농도(濃度)의 변화량(變化量)으로 보아 N와 K가 유이(類似)하고 P, Mg, Ca가 유이(類似)하였다. 2. 수량(收量)은 해빙직후(解氷直後) N농도(濃度)와 가장 유의성(有意性)이 깊고 북부(北部) 즉(卽) 강원(江原)과 충남(忠南)에서는 동결직전(凍結直前)의 P및 N농도(濃度)와 고도(高度)의 유의성(有意性)을 보였다. 기타(其他)의 시기(時期)는 P, K에서 부(負)의 관련경향(關聯傾向)을 보였는데 K에서 더욱 그러했다. 3. 시비량(施肥量)이 증가(增加)할수록 N.P.K 농도(濃度)가 증가(增加)하는 경향(傾向)은 초기(初期)일수록 뚜렷하고 N에서 더욱 뚜렷하며 P와 K가 생육후기(生育後期)에 상대적(相對的)으로 많은 반면 N가 적은 것을 잘 보였으며 N와 K간(間)의 길항관계(拮抗關係)도 잘 보였다. 4. 이용율(利用率)은 N(55)>K(27)>P(12)의 순(順)이었으며 N이용율(利用率)은 수량(收量)이 증가(增加)할수록 증가(增加)하는 경향(傾向)이다. 5. 수량(收量)과 관련(關聯)된 영양진단(營養診斷)은 해빙직후(解氷直後) 또는 직전(直前)이 가장 좋을 것으로 나타났고 생육시기별(生育時期別) 영양(營養) 기준(基準)을 제시(提示)하였다.

• 한국토양비료학회지
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• 제48권4호
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• pp.295-304
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• 2015

To develop a technique for efficient management of fertility for cucumber in greenhouse, a quick test method to quantify nitrate ($NO_3{^-}$) content in soil solution and leaf petiole juice using a simple instrument that are easy to use for farmers was investigated. N fertilizer (urea) was applied at 0, 50, 100 and 200% levels of the recommended application rate from 30 days after transplanting to harvest by soil fertigation treatments. Stable results were obtained from analysis of nitrate ($NO_3{^-}$) using top $10^{th}$ or $11^{th}$ leaf petioles collected between 10 to 11 am in the morning. Under the semiforcing culture, $NO_3{^-}$ content of leaf petiole juice was highest at 60 days after transplanting (DAT) at all fertigation treatments. Appropriate $NO_3{^-}$content of leaf petiole juice was $2,418{\pm}78{\sim}2,668{\pm}118$ at 45 DAT, $3,032{\pm}90{\sim}3,332{\pm}63$ at 60 DAT, $2,709{\pm}50{\sim}3,158{\pm}155$ at 75 DAT, $2,535{\pm}49{\sim}2,907{\pm}83$ at 90 DAT, and $2,242{\pm}48mg\;L^{-1}$ at 105 DAT. In addition, appropriate $NO_3{^-}$ content of soil solution was $167{\pm}9{\sim}212{\pm}15$ at 45 DAT, $83{\pm}10{\sim}112{\pm}12$ at 60 DAT, $49{\pm}3{\sim}92{\pm}6$ at 75 DAT, $71{\pm}9{\sim}103{\pm}9$ at 90 DAT, and $73{\pm}9mg\;L^{-1}$ at 105 DAT. The cucumber yield at 100% N level of fertigation was $7,770kg\;10a^{-1}$ and no difference in yield was found at 200% N level of fertigation. However, there was 12% decrease in yield at 50% N fertigation and, 17% decrease at 0% N fertigation. Under retarding culture, $NO_3{^-}$ concentration of leaf petiole juice was highest at 55 days after transplanting (DAT) at all fertigation treatments. Appropriate $NO_3{^-}$ content of leaf petiole juice was $2,464{\pm}102{\sim}2,651{\pm}33$ at 45 DAT, $3,025{\pm}71{\sim}3,314{\pm}84$ at 55 DAT and $2,488{\pm}92mg\;L^{-1}$ at 65 DAT, respectively. Appropriate $NO_3{^-}$ content of soil solution was $111{\pm}10{\sim}155{\pm}14$ at 45 DAT, $93{\pm}7{\sim}147{\pm}14$ at 55 DAT, $67{\pm}4mg\;L^{-1}$at 65 DAT, respectively. The cucumber yield at 50% N fertigation was not different from $1,697kg\;10a^{-1}$ of 100% N fertigation level and even with that of the 200% N fertigation. However, there was 21% decrease in yield at 0% N fertigation.

• Journal of Nutrition and Health
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• 제56권2호
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• pp.184-202
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• 2023

본 연구는 식품알레르기 경험이 있는 미취학아동의 양육자를 대상으로 양육자가 식품알레르기 관리를 위해 필요한 교육이 무엇인지 파악하고자 하였다. 양육자 400명을 대상으로 2022년 7월 온라인 업체를 통해 설문조사를 진행하였으며, 모든 데이터는 SPSS 통계 (ver. 25)를 사용하여 분석되었다. 미취학아동의 식품알레르기 경험에도 불구하고 양육자의 식품알레르기 지식수준은 낮았다. 특히 '원인식품' (74.2%)과 '식품반응' (65.2%) 관련된 문항의 오답률이 높았다. 또한, 식품알레르기 지식수준을 '상', '중', '하'로 구분하여 평가한 결과 미취학아동의 연령에 따라 아동의 나이가 어릴수록 지식수준이 유의하게 높았다 (p < 0.05). 양육자의 식품알레르기 관리여부를 4가지 문항으로 측정한 결과, '식재료 및 조리기기 분리사용' (50.5%), '식품알레르기 유발표시 확인' (34.0%) 관리율이 낮았다. 식품알레기 진단여부에 따라 식재료 및 조리기기를 분리사용 관리에 유의적인 차이가 있었으며, 의사진단을 받은 미취학아동의 양육자 중 59.4%가 분리사용 관리를 하고 있었다 (p < 0.01). 또한, 식품알레르기 지식이 높아질수록 관리의 총점이 높아졌다 (r = 0.137, p < 0.01). 본 연구결과를 바탕으로 살펴볼 때 지식수준이 낮거나, 자녀가 만 4세 이상, 자가진단을 하는 양육자의 경우 식품알레르기 관리율이 낮았다. 따라서 해당 양육자의 지식수준을 높일 수 있는 '유발식품제한', '식품알레르기 유발표시 확인', '식재료 및 조리기기 분리사용' 하는 방법 등 맞춤 교육이 필요하다고 사료된다.