• The Journal of Korean Medicine
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• v.31 no.4
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• pp.63-78
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• 2010

Objectives: This study was carried out to know the effects of Gwan-Jul-Bang-7 (hereafter referred to GJB-7) on the inhibition of arthritis induced by collagen on the mouse. Methods: To assess the effects of GJB-7 on mouse with arthritis induced by collagen II, we conducted several experiments such as analysis of cytotoxicity, hepatotoxicity, arthritis index, total cell number of draining lymph nodes and paw joints, value of immunocyte in PBMC (peripheral blood mononuclear cell), DLN (draining lymph node) and paw joint, measurement of cytokine and anti-collagen II, observation of the histological changes of joint. Results: 1. Cytotoxicity against HFC (human fibroblast cells) was not observed in any concentration and hepatotoxicity was not observed in the GJB-7 treated group. 2. The incidence of arthritis significantly decreased. 3. Total cell number of draining lymph nodes significantly increased and total cell number of paw joints significantly decreased. 4. The percentage of $CD8^+$ cells in PBMC (peripheral blood mononuclear cell) significantly increased. The percentage of $CD3^+/CD69^+$, and $CD3^+/CD49b^+$ cells in PBMC significantly decreased. 5. The percentage of $CD19^+,\;CD3^+$, and $CD4^+/CD25^+$ cells in DLN (draining lymph nodes) significantly increased. The percentage of $B220^+/CD23^+$ cells in DLN significantly decreased. 6. The percentage of $CD3^+,\;CD4^+$, and $CD11b^+/Gr-1^+$ cells in paw joints significantly decreased. 7. The production of TNF-$\alpha$, IL-6, and MCP-1 significantly decreased. 8. Anti-collagen II in serum significantly decreased. 9. With the hematoxylin and eosin stain, inflammation of joint decreased. Under Masson's trichrome stain, the cartilage destruction and synovial cell proliferation and the expression of collagen fibers decreased. Conclusions: Comparison of the results for this study showed that GJB-7 had immunomodulatory effects. So we expect that GJB-7 could be used as an effective drug for not only rheumatoid arthritis but also another auto-immune diseases.

• Earthquakes and Structures
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• v.15 no.2
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• pp.113-122
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• 2018

This study presents a new beam-column model comprising material nonlinearity and joint flexibility to predict the nonlinear response of reinforced concrete structures. The nonlinear behavior of connections has an outstanding role on the nonlinear response of reinforced concrete structures. In presented research, the joint flexibility is considered applying a rotational spring at each end of the member. To derive the moment-rotation behavior of beam-column connections, the relative rotations produced by the relative slip of flexural reinforcement in the joint and the flexural cracking of the beam end are taken into consideration. Furthermore, the considered spread plasticity model, unlike the previous models that have been developed based on the linear moment distribution subjected to lateral loads includes both lateral and gravity load effects, simultaneously. To confirm the accuracy of the proposed methodology, a simply-supported test beam and three reinforced concrete frames are considered. Pushover and nonlinear dynamic analysis of three numerical examples are performed. In these examples the nonlinear behavior of connections and the material nonlinearity using the proposed methodology and also linear flexibility model with different number of elements for each member and fiber based distributed plasticity model with different number of integration points are simulated. Comparing the results of the proposed methodology with those of the aforementioned models describes that suggested model that only uses one element for each member can appropriately estimate the nonlinear behavior of reinforced concrete structures.

• The Journal of Korean Medicine
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• v.40 no.1
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• pp.86-98
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• 2019

Objectives: This study analyzes the electronic medical record (EMR) data of the spine specialist oriental hospital and clinic in various regions, and reports the actual number and used cases of Chuna therapy. Methods: 2,470,772 data was extracted retrospectively from electronic medical records of all inpatients and outpatients who were treated chuna therapy at 21 Korean medicine hospitals and clinics from January 1, 2018 to December 31, 2018. The characteristics of medical treatment using chuna therapy reflect the minimum, maximum and average values of the number of hospitalized patients, length of hospitalization, frequency of hospitalization, number of outpatients, frequency of treatment and frequency of visit. Diseases were classified in the proportion of Chuna treatment according to the KCD, 7th edition. The chuna and blindness charts were derived accordingly from illness and disease of each part of the body. Results: During the study period, a total 1,342,022 inpatients and outpatients visited the study sites. The male proportion was a little higher than the females' (male: 53.7%, female: 46.3%). According to age, the 30s and 40s were more than half the total(30s: 33.0% and 40s: 20.1%). Chuna therapy was treated to more outpatients than hospitalized patients (outpatient: 83.6%, hospitalization: 16.4%), and most treatments were related to musculoskeletal illness(99.06%). Conclusions: As a result of this study, 1,342,389 chuna therapy was performed in 21 hospitals for one year. As highly demanded by the public, we look forward to ensuring national health care options and medical access when health insurance for chuna therapy is applied beginning March 2019.

• Geomechanics and Engineering
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• v.29 no.4
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• pp.471-486
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• 2022

The effect of segmental joints is one of main importance for the segmental lining design when tunnels are excavated by a mechanized process. In this paper, segmental tunnel linings are analyzed by two numerical methods, namely the Beam-Spring Method (BSM) and the Solid-Interface Method (SIM). For this purpose, the Tehran Subway Line 6 Tunnel is considered to be the reference case. Comprehensive 2D numerical simulations are performed considering the soil's calibrated plastic hardening model (PH). Also, an advanced 3D numerical model was used to obtain the stress relaxation value. The SIM numerical model is conducted to calculate the average rotational stiffness of the longitudinal joints considering the joints bending moment distribution and joints openings. Then, based on the BSM, a sensitivity analysis was performed to investigate the influence of the ground rigidity, depth to diameter ratios, slippage between the segment and ground, segment thickness, number of segments and pattern of joints. The findings indicate that when the longitudinal joints are flexible, the soil-segment interaction effect is significant. The joint rotational stiffness effect becomes remarkable with increasing the segment thickness, segment number, and tunnel depth. The pattern of longitudinal joints, in addition to the joint stiffness ratio and number of segments, also depends on the placement of longitudinal joints of the key segment in the tunnel crown (similar to patterns B and B').

• Journal of Technology Innovation
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• v.23 no.4
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• pp.63-87
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• 2015

As the important factors to improve research performance, the researchers' capacity and the input of resources like research funds have been pointed out. As joint researches are recently vitalized, however, the scientific knowledge is produced by forming continuous mutual relations through the structural characteristics between researchers. Since the support of research funds becomes a foothold to perform researches as multiple institutions cooperate with each other, it can be considered to have influence on research performance. In other words, it can be estimated that the support of research funds has influence on research performance by generating differences in the connecting structure of joint researches. In the results of analyzing the relation between network structure and research performance in accordance with the matter of supporting research funds, targeting the joint research theses in the culture technology(CT) area for five years from 2009 to 2013 in SCIE DB, when multiple research institutes are connected to each other, the number of thesis is increased. When the betweenness centrality is increased, the number of thesis is decreased. Also, the matter of supporting research funds has influence on network structure and research performance.

• Journal of the Microelectronics and Packaging Society
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• v.16 no.1
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• pp.7-11
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• 2009

In this study, solder joints were made with Sn-3.5Ag (wt%) solder ball. Electroless nickel / immersion gold (ENIG) printed circuit board (PCB) substrates were employed in this work. The mechanical and electrical properties were measured as a function of the number of reflow. Die shear strength was measured with increasing reflow number. Until the forth or fifth reflow, shear force increased and after the fifth reflow the shear force of die decreased. The electrical resistivity of solder joint linearly increased with increasing reflow number.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.5
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• pp.1199-1206
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• 2015

This paper introduces an algorithm for computing similarity between two poses in the motion capture data with different scale of skeleton, different number of joints and different joint names. The proposed algorithm first performs the topological analysis on the skeleton hierarchy for classifying the joints into more meaningful groups. The global joints positions of each joint group then are aggregated into a point cloud. The number of joints and their positions are automatically adjusted in this process. Once we have two point clouds, the algorithm finds an optimal 2D transform matrix that transforms one point cloud to the other as closely as possible. Then, the similarity can be obtained by summing up all distance values between two points clouds after applying the 2D transform matrix. After some experiment, we found that the proposed algorithm is able to compute the similarity between two poses regardless of their scale, joint name and the number of joints.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.8 no.1
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• pp.37-42
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• 2010

Purpose : This study will recognize about the influences that stretching exercise with ultrasound and microwave application has on a knee joint position sense after induction to muscle fatigue. Methods : The object by each ten people divided at random thirty physical healthy adult men to constant group 1, group 2, group 3 to the objects. Treadmill exercised for induction to muscle fatigue, and let an exercise intensity decided on 85% of the maximum heart beat number with the goal heart beat number, and you exercise. Goal heart beat number measured as used heat rate monitor, and measured a oneself at the scale in order to recognize own physical state after end treadmill exercise to all objects to criteria to evaluate an ability shown in case of sports. Knee joint position sense used a N-K table, and experimenter did so as adaptation got passively arbitrary three angle done, and to order an original position. The object carried in person out one angle that experimenter designated, and measured repeatedly an error along him to this three times after being so. Rear before induction to muscle fatigue a position sense and measured after stretching exercise application, and played. Stretching exercise after induction applied stretching exercise, stretching exercise with ultrasound, stretching exercise with microwave, and applied to each group 1, group 2 and group 3 to muscle fatigue. Results : The result each group the difference which considers does not come out it was not but, improvement of the position sense is the possibility of knowing was from group 1, group 2 and group 3. Conclusion : These findings stretching exercise and stretching exercise with ultrasound and microwave after induct ion give help to a position sense elevation, and execute stretching exercise, and be effective against damage prevention by physical insecurity to muscle fatigue, and look.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2603-2609
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• 2014

Reliability analysis of mechanical systems requires statistical modeling of input random variables such as distribution function types and statistical parameters that affect the performance of the mechanical systems. Some random variables are correlated, but considered as independent variables or wrong assumptions on input random variables have been used. In this paper, joint distributions were modeled using copulas and Bayesian method from limited number of data. To verify the proposed method, statistical simulation tests were carried out for various number of samples and correlation coefficients. As a result, the Bayesian method selected the most probable copula types among candidate copulas even though the candidate copula shapes are similar for low correlations or the number of data is limited. The most probable copulas also yielded similar reliabilities with the true reliability obtained from a true copula, so that it can be concluded that the Bayesian method provides accurate statistical modeling for the reliability analysis.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.1
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• pp.873-880
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• 2021

The purpose of this study is to investigate the impact of internal control on credit risk of joint stock commercial banks in Vietnam from 2007 to 2018. Furthermore, we specify bank-specific characteristics and macroeconomic conditions, and analyze how these factors affect credit risk of banks: the number of board members, the number of board members with banking or finance background as ratio of total board members, loans to total assets ratio, loans to deposit ratio, the number of days between the year-end and the publication of the financial statements, and the use of top four auditing firms proxy for five elements of internal control. By using the dataset of 30 Vietnamese joint stock commercial banks and Bayesian linear regression via Random-walk Metropolis Hastings algorithm, the results of this study show that five elements of internal control have a impact on bank credit risk, namely, control environment, risk assessment, control activities, information and communication, and monitoring activities. For factors of banks' characteristics, bank size and financial leverage have a negative impact on banks' credit risk, and bank age has a positive effect. For macroeconomic factors, inflation has a positive impact and economic growth has a negative impact on banks' credit risk.