• Title/Summary/Keyword: Nuclear Reaction

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Indigenous Radiosynthesis of [131I]Iodobenzylguanidine ([131I]mIBG) for Neuroblastoma Imaging

  • Nadeem Ahmed Lodhi;Muhammad Irfan;Muhammad Nasir Saddique;Kahkshan Bashir Mir;Naseer Ahmed;Shazia Fatima;Mumtaz Khan;Muhammad Wasim;Samina Roohi
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.8 no.2
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    • pp.71-76
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    • 2022

  • Indigenous diagnostic dose of 131I-labeled meta-iodobenzylguanidine ([131I]mIBG) was prepared via Cu+ catalyzed isotope exchange reaction generated in situ by sodium metabisulfite for imaging of neuroblastoma tumor. [131I]mIBG was produced in overall 85-90% radiochemical yield. The average amount of radioactivity of [131I]mIBG was 2164 MBq (1998-2331MBq) with an average specific activity > 1000 MBq/mg at the end of synthesis. The radiochemical purity was ≥ 99.9% after purification through Dowex-1 × 8 ion exchange resin (100-150 mesh) at the date of preparation. The stability of [131I]mIBG at concentration 480-555 MBq/mL was > 97% at 4 ℃ after 4 days. The room temperature (25 ℃) stability of [131I]mIBG was > 98% after 24 h. Biodistribution of [131I]mIBG in patient showed uptake in salivary glands, liver, spleen and excreted though urinary bladder. Neuroendocrine medicated uptake into tumor lesion and metastatic sites were noted which strongly correlate with the morphological abnormalities of patient.

  • https://doi.org/10.22643/JRMP.2002.8.71 인용 PDF KSCI