• Molecules and Cells
• /
• v.28 no.6
• /
• pp.589-593
• /
• 2009

In this study, the roles of the p38 MAPK, ERK1/2 and JNK signaling pathway in IGF-I-induced AR induction and activation were examined. C2C12 cells were treated with IGF-I in the absence or presence of various inhibitors of p38 MAPK (SB203580), ERK1/2 (PD98059), and JNK (SP600125). Inhibition of the MAPK pathway with SB203580, PD98059, or SP600125 significantly decreased IGF-I-induced AR phosphorylation and total AR protein expression. IGF-I-induced nuclear fraction of total AR and phosphorylated AR were significantly inhibited by SB203580, PD98059, or SP600125. Furthermore, IGF-I-induced AR mRNA and skeletal ${\alpha}-actin$ mRNA were blocked by those inhibitors in dose-dependent manner. Confocal images showed that IGF-I-induced AR nuclear translocation from cytosol was significantly blocked by SB203580, PD98059, or SP600125, suggesting that the MAPK pathway regulates IGF-I-induced AR nuclear localization in skeletal muscle cells. The present results suggest that the MAPK pathways are required for the ligand-independent activation of AR by IGF-I in C2C12 skeletal muscle cells.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.43 no.2
• /
• pp.63-69
• /
• 2017

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in $Nfic^{-/-}$ mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-${\beta}1$, $Kr{\ddot{u}}ppel$-like factor 4, and ${\beta}$-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

• Proceedings of the KIEE Conference
• /
• 2004.07d
• /
• pp.2200-2202
• /
• 2004

This paper deals with the design of the Control Cabinet in Control Rod Control System(CRCS), using a domestic Distributed Control System(DCS) developed to localize the instrumentation and control(I&C) system for nuclear power plant(NPP). There are many parts developed by domestic skill and being operated successfully in NPP, but the development of I&C system as an essential part has been slow in progress. We will show the great possibility of developing our own I&C system by applying this domestic DCS to nuclear I&C system and confirming its successful operation, in this paper.

• The Korean Journal of Nuclear Medicine
• /
• v.29 no.3
• /
• pp.332-342
• /
• 1995

This study was designed to evaluate the effects of various factors on the therapeutic effect of the I-131 labeled anti-carcinoembryonic antigen monoclonal antibody(anti-CEA antibody). Tetrazolium-based colorimetric assay (MTT) was used to compare in vitro cytotoxicity of 3 Korean colon cancer cell lines (SNU-C2A, SNU-C4, SNU-C5) for selection of proper 2 cell lines in this study. The changes of the size of tumor which was xenografted to nude mice (balb/c nu/nu) were compared in 4 groups (group treated I-131 labeled anti-CEA antibody, group treated with non-radiolabeled anti-CEA antibody, group treated with I-131 labeled anti-human chorionic gonadotropin monoclonal antibody (anti-hCG antibody) as nonspecific antibody, and group injected with normal saline as a control). Immunohistochemical staining and in vivo autoradiography were performed after excision of the xenografted tumor. The results were as below mentioned. The in vitro cytotoxic effect of I-131 labeled anti-CEA antibody is most prominent in SNU-C5 cell line between 3 cancer cell lines. The changes of xenografted tumor size in both SNU-C4 and SNU-5S cell tumors at the thirteenth day after injection of the antibodies were smallest in the group treated with I-131 labeled anti-CEA antibody (SNU-C4/SNU-C5; 324/342%) comparing with other groups, group treated with anti-CEA antibody (622/660%), group treated with I-131 anti-hCG antibody (538/546%), and control group(1030/724%)(P<0.02 in SNU-C4 and P<0.1 in SNU-C5 at the 13th day after injection of antibodies). On the thirteenth day after injection of the antibodies nude mice were sacreficed to count the radiouptake of tumor and to check the changes of tumor size. Correlations between radiouptake and change of tumor size were calculated in each groups and significant negative correlation was only obtained in the group treated with I-131 anti-CEA antibody (p<0.05). There were no correlations between antigenic expression of carcinoembryonic antigen and distribution of anti-CEA antibody in both SNU-C4 and SNU-C5 cell tumors on immunoperoxidase staining. On in vivo autoradiography the distributions of anti-CEA antibody were heterogeneous and the intensities of binding were various in SNU-C4 and SNU-C5 cell tumors. It is concluded that I-131 labeled tumor-specific monoclonal antibody, anti-CEA antibody is effective in suppressing the xenografted tumor growth and the effect is influenced by sensitivity of tumor cell itself to the radiolabeled antibody and other local factors instead of specificity of antibody.

• The Korean Journal of Nuclear Medicine
• /
• v.19 no.1
• /
• pp.53-55
• /
• 1985

• Journal of the Ergonomics Society of Korea
• /
• v.33 no.1
• /
• pp.49-58
• /
• 2014

Objective: The aim of this study is to enhance the efficiency of education and training through application and management of 'Transfer of Training' in nuclear power plants. Background: Despite the sophistication and standardization of job-related skills and techniques of workers, accidents/incidents keep taking place due to human errors and unsafe actions and behaviors, which translates into the necessity to review and examine the effectiveness and influence of education and training on the workers of nuclear power plants. Method/Results: This study drew the factors of 'Transfer of Training' through a review on the preceding studies and document research. In addition, through expert examination, this study explored the expected effects and possibility of application when managing the influencing factors of 'Transfer of Training' in nuclear power plants. And lastly, management priority order for nuclear power plants was drawn through an AHP analysis. Conclusion: Among the 'Transfer of Training' factors, the training design factor was the most important. In addition, the design of the training and transfer and goal setting showed a high degree of importance among the influencing factors. Application: The management of 'Transfer of Training' in nuclear power plants enhances the capability of workers and improves the operational integrity of nuclear power plants.

• Nuclear Engineering and Technology
• /
• v.55 no.1
• /
• pp.25-36
• /
• 2023

Nuclear power plants have recognized the importance of nuclear cybersecurity. Based on regulatory guidelines and security-related standards issued by regulatory agencies around the world including IAEA, NRC, and KINAC, nuclear operating organizations and related systems manufacturing organizations, design companies, and regulatory agencies are considering methods to prepare for nuclear cybersecurity. Cryptographic algorithms have to be developed and applied in order to meet nuclear cybersecurity requirements. This paper presents methodologies for validating cryptographic algorithms that should be continuously applied at the critical control system of I&C in NPPs. Through the proposed schemes, validation programs are developed in the PLC, which is a critical system of a NPP's I&C, and the validation program is verified through simulation results. Since the development of a cryptographic algorithm validation program for critical digital systems of NPPs has not been carried out, the methodologies proposed in this paper could provide guidelines for Cryptographic Module Validation Modeling for Control Systems in NPPs. In particular, among several CMVP, specific testing techniques for ECB mode-based block ciphers are introduced with program codes and validation models.

• Proceedings of the Korean Nuclear Society Conference
• /
• 2005.05a
• /
• pp.1329-1330
• /
• 2005

• Journal of dental hygiene science
• /
• v.9 no.4
• /
• pp.427-433
• /
• 2009

Nuclear factor I-C (NFI-C) null mice demonstrated aberrant odontoblast differentiation and abnormal dentin formation. In order to elucidate the mechanisms responsible for these changes, we evaluated the expression of dentin matrix gene after over-expression and inactivation of NFI-C in MDPC-23 cells by reverse transcription-polymerase chain reaction (RT-PCR) analysis. Collagen type I (Col I), osteocalcin (OC), and dentin sialophosphoprotein (DSPP) expression was decreased after inactivation of NFI-C. However, bone sialoprotein (BSP) expression was dramatically increased after inactivation of NFI-C. ALP and DMP4 expression was not changed after inactivation of NFI-C. The expression of alkaline phoshatase (ALP) and dentin matrix protein 4 (DMP4) was increased after over-expression of NFI-C, while Col I, OC, DSPP, and BSP expression was decreased. These findings suggest that odontoblasts after loss of NFI-C lost the phenotype of odontoblasts and acquired those of osteoblasts.

• Proceedings of the Korean Nuclear Society Conference
• /
• 2004.10a
• /
• pp.575-576
• /
• 2004