• Nuclear Engineering and Technology
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• 제9권3호
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• pp.151-163
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• 1977

CANDU-PHWR형 원자로인 월성 1호기의 Zircaloy-4 피복 핵연료 설계치를 중심으로 Segel method에 의하며 FACOM 230 OS$_2$/VS 콤퓨터 시스템을 사용하여 핵연료비를 계산하였다. 아울러 핵연료 제조공장의 수덩, 가동을, 곧장시설 낑산규모 증대, 건설지 및 운전비기 변동, 이자율의 변화, 원광가격의 물가상승을, 기술개발인자 등이 핵연료비 계산에 미치는 효과에 패한 민감도를 분석하였다.

• Nuclear Engineering and Technology
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• 제52권1호
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• pp.87-100
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• 2020

Performance shaping factors (PSFs) in a human reliability analysis (HRA) are one that may influence human performance in a task. Most currently applicable HRA methods for nuclear power plants (NPPs) use PSFs to highlight human error contributors and to adjust basic human error probabilities (HEPs) that assume nominal conditions of NPPs. Thus far, the effects of PSFs have been treated independently. However, many studies in the fields of psychology and human factors revealed that there may be relationships between PSFs. Therefore, the inter-relationships between PSFs need to be studied to better reflect their effects on operator errors. This study investigates these inter-relationships using two data sources and also suggests a context-based approach to treat the inter-relationships between PSFs. Correlation and factor analyses are performed to investigate the relationship between PSFs. The data sources are event reports of unexpected reactor trips in Korea and an experiment conducted in a simulator featuring a digital control room. Thereafter, context-based approaches based on the result of factor analysis are suggested and the feasibility of the grouped PSFs being treated as a new factor to estimate HEPs is examined using the experimental data.

• BMB Reports
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• 제32권5호
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• pp.468-473
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• 1999

Nuclear Factor 1 (NF1) proteins are a family of transcriptional factors consisting of four different types: NF1-A, -B, -C, and -X. Some NF1 transcription factors contain a heptasequence motif, SPTSPSY, which is found as a repeat sequence in the carboxy terminal domain (CTD) of the largest subunit of RNA polymerase II. A similar heptasequence, SPTSPTY, is contained in rat liver NF1-A at a position between residues 469 and 475. In order to investigate the roles of the individual amino acids of the heptasequence of rat liver NF1-A in transcriptional activation, we systematically substituted single and multiple amino acid residues with alanine residue(s) and evaluated the transcriptional activities of the mutated NF1-A. Substitution of a single amino acid reduced transcriptional activity by 10 to 30%, except for the proline residue at position 473, whose substitution with alanine did not affect transcriptional activity. However, changes of all four serine and threonine residues to alanine or of the tyrosine residue along with the serine residue at position 469 to alanine reduced the activity to almost background levels. Our results indicate that multiple serine and threonine residues, rather than a single residue, may be involved in the modulation of the transcriptional activities of the factor. Involvement of the tyrosine residue is also implicated.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2005년도 제44차 추계학술대회 및 총회
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• pp.339.1-339.1
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• 2005

• Nuclear Engineering and Technology
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• 제55권11호
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• pp.4282-4286
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• 2023

Nuclear energy is estimated by the machine learning method as the mathematical quantifications where neural networking is the major algorithm of the data propagations from input to output. As the aspect of nuclear energy, the other energy sources of the traditional carbon emission-characterized oil and coal are compared. The artificial intelligence (AI) oriented algorithm like the intelligence of a robot is applied to the modeling in which the mimicking of biological neurons is utilized in the mathematical calculations. There are graphs for nuclear priority weighted by climate factor and for carbon dioxide mitigation weighted by climate factor in which the carbon dioxide quantities are divided by the weighting that produces some results. Nuclear Priority and CO2 Mitigation values give the dimensionless values that are the comparative quantities with the normalization in 2010. The values are 1.0 in 2010 of the graphs which are changed to 24.318 and 0.0657 in 2040, respectively. So, the carbon dioxide emissions could be reduced in this study.

• 한국가축번식학회지
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• 제21권2호
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• pp.177-183
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• 1997

The present study examined the effects of epidermal growth factor(EGF) and transforming growth factor-$\alpha$(TGF-$\alpha$) on in vitro maturation of porcine follicular oocytes. Basic medium used TCM-HEPES, and oocytes cultured for 42 hours in vitro. The results obtained are as follows; 1. The nuclear maturation rates of EGF-treated groups(10ng/ml, 75.9% ; 30ng/ml, 69.2% ; 50ng/ml, 67.2% ; 100ng/ml, 71.0%) on the porcine oocytes cultured in medium without pFF in vitro were significantly(P<0.01) higher than those of non-treated group(57.1%). When the oocytes were cultured in media with 10%(v/v) pFF, the nuclear maturation rates of 30ng EGF/ml(77.1%) treated group were significantly(P<0.01) higher than those of non-(59.2%) and EGF-treated groups(10ng/ml, 65.4% ; 50ng/ml, 65.5% ; 100ng/ml, 70.4%). 2. The nuclear maturation rates of 30ng TGF-$\alpha$/ml treated group(71.9%) in media without pFF in vitro were significatnly(P<0.01) higher than those of non-(57.1%) and TGF-$\alpha$ treated groups(10ng/ml, 60.4% ; 50ng/ml, 65.4% ; 100ng/ml, 60.0%). When the oocytes were cultured in media with 10%(v/v) pFF, the nuclear maturation rates of 30 and 50ng TGF-$\alpha$/ml(77.4% and 79.6%) treated groups(10ng/ml, 64.2% ; 100ng/ml, 61.6%). 3. On the effect of EGF(30ng/ml) and/or TGF-$\alpha$(30ng/ml) treated groups in medium without pFF in vitro, the nuclear maturation rates indicated 57.3, 60.4, 75.9 and 79.7% in media with no EGF & TFG-$\alpha$, TGF-$\alpha$ only, EGF only nad EGF＋TGF-$\alpha$ treated groups, respectively. The nuclear maturation rates in medium with EGF only or EGF＋TGF-$\alpha$ were significantly(P<0.01) higher than those non- and TGF-$\alpha$ treated groups. When the oocytes were cultured in media with 10%(v/v) pFF, the nuclear maturation ratesof EGF＋TGF-$\alpha$ treated group(75.9%) were significantly(P<0.01) higher than those of non-(59.2%), TGF-$\alpha$ only (64.2%) and EGF only(69.4%) treated groups.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권2호
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• pp.63-69
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• 2017

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in $Nfic^{-/-}$ mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-${\beta}1$, $Kr{\ddot{u}}ppel$-like factor 4, and ${\beta}$-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.

• 한국지진공학회논문집
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• 제24권3호
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• pp.123-128
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• 2020

Analysis of the 2016 Gyeongju earthquake and the 2017 Pohang earthquake showed the characteristics of a typical high-frequency earthquake with many high-frequency components, short time strong motion duration, and large peak ground acceleration relative to the magnitude of the earthquake. Domestic nuclear power plants were designed and evaluated based on NRC's Regulatory Guide 1.60 design response spectrum, which had a great deal of energy in the low-frequency range. Therefore, nuclear power plants should carry out seismic verification and seismic performance evaluation of systems, structures, and components by reflecting the domestic characteristics of earthquakes. In this study, high-frequency amplification factors that can be used for seismic verification and seismic performance evaluation of nuclear power plant systems, structures, and equipment were analyzed. In order to analyze the high-frequency amplification factor, five sets of seismic time history were generated, which were matched with the uniform hazard response spectrum to reflect the characteristics of domestic earthquake motion. The nuclear power plant was subjected to seismic analysis for the construction of the Korean standard nuclear power plant, OPR1000, which is a reactor building, an auxiliary building assembly, a component cooling water heat exchanger building, and an essential service water building. Based on the results of the seismic analysis, a high-frequency amplification factor was derived upon the calculation of the floor response spectrum of the important locations of nuclear power plants. The high-frequency amplification factor can be effectively used for the seismic verification and seismic performance evaluation of electric equipment which are sensitive to high-frequency earthquakes.

• Journal of Ginseng Research
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• 제44권6호
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• pp.790-798
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• 2020

Background: Beneficial effects of Korean Red Ginseng (KRG) on polycystic ovarian syndrome (PCOS) remains unclear. Methods: We examined whether pretreatment (daily from 2 hours before PCOS induction) with KRG extract in water (KRGE; 75 and 150 mg/kg/day, p.o.) could exert a favorable effect in a dehydroepian-drosterone (DHEA)-induced PCOS rat model. Results: Pretreatment with KRGE significantly inhibited the elevation of body and ovary weights, the increase in number and size of ovarian cysts, and the elevation of serum testosterone and estradiol levels induced by DHEA. Pretreatment with KRGE also inhibited macrophage infiltration and enhanced mRNA expression levels of chemokines [interleukin (IL)-8, monocyte chemoattractant protein-1), proinflammatory cytokines (IL-1β, IL-6), and inducible nitric oxide synthase in ovaries induced by DHEA. It also prevented the reduction in mRNA expression of growth factors (epidermal growth factor, transforming growth factor-beta (EGF, TGF-β)) related to inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cell pathway and stimulation of the nuclear factor erythroid-derived 2-related factor 2 pathway. Interestingly, KRGE or representative ginsenosides (Rb1, Rg1, and Rg3(s)) inhibited the activity of inflammatory enzymes cyclooxygenase-2 and iNOS, cytosolic p-IκB, and nuclear p-nuclear factor kappa-light-chain-enhancer of activated B in lipopolysaccharide-induced RAW264.7 cells, whereas they increased nuclear factor erythroid-derived 2-related factor 2 nuclear translocation. Conclusion: These results provide that KRGE could prevent DHEA-induced PCOS via antiinflammatory and antioxidant activities. Thus, KRGE may be used in preventive and therapeutic strategies for PCOS-like symptoms.

• Nuclear Engineering and Technology
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• 제54권12호
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• pp.4731-4742
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• 2022

RBMK fuel assemblies differ from other LWR FA due to a specific arrangement of the fuel rods, the low enrichment, and the used burnable absorber - erbium. Therefore, there is a challenge to adapt modeling tools, developed for other LWR types, to solve RBMK problems. A set of 10 different depletion simulation schemes were tested to estimate the impact on reactivity and spent fuel composition of possible SCALE code options for the neutron transport modelling and the use of different nuclear data libraries. The simulations were performed using cross-section libraries based on both, VII.0 and VII.1, versions of ENDF/B nuclear data, and assuming continuous energy and multigroup simulation modes, standard and user-defined Dancoff factor values, and employing deterministic and Monte Carlo methods. The criticality analysis with burn-up credit was performed for the SFP loaded with RBMK-1500 FA. Spent fuel compositions were taken from each of 10 performed depletion simulations. The criticality of SFP is found to be overestimated by up to 0.08% in simulation cases using user-defined Dancoff factors comparing the results obtained using the continuous energy library (VII.1 version of ENDF/B nuclear data). It was shown that such discrepancy is determined by the higher U-235 and Pu-239 isotopes concentrations calculated.