• Journal of Preventive Medicine and Public Health
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• 제32권1호
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• pp.9-16
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• 1999

Objectives. Few studies have attempted to explain the association between socioeconomic status (SES) and obesity in Korea Especially the studies on same race with different SES at same time are good for SES influence estimation. The present study highlights the influence of SES of parents on adolescent obesity. The subjects are the same race, but live in different areas, with different SES, Seoul and Yangpung in Korea, and Yanbian in China. Methods. The cross-sectional study was conducted in Mar-Jun 1996. We carried out anthropometry, 24 hour-recall diet survey, self-reported questionnaire about sociodemographic characteristics and physical activity. For SES indicators, we used income and education of parents. Results. The relationship between SES of parents, defined as educational status, and obesity in boys in Korea and China is direct, but not significant. The relationship is inverse and nonsignificant among Korean girls, However, for the Korean girls in severe obesity, the relationship is significant. For the Korean-Chinese girls, there is an inverse relationship between the education level and obesity but a direct relationship between the income level of parents and obesity. For the Korean adolescent, there are a direct association between the SES of parents and the nutrients factors such as energy, protein, and fat intake. The energy expenditure of adolescent has no relationship with SES of parents. Conclusion. Among boys, the higher the SES, the greater the risk of obese. Among girls in Korea and Korean-Chinese, on the other hand, the lower the educational status of parents, the greater the risk of obese.

• 한국비블리아학회지
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• 제22권2호
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• pp.63-79
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• 2011

본 연구는 대학도서관시스템의 MyLibrary 기능을 CRM개념을 적용하여 이용자들에게 맞춤서비스를 제공 하고자 하였다. 연구방법은 문헌조사, 홈페이지조사를 통하여 1차 자료를 수집하였으며, 국내외 대학도서관의 사례조사를 실시하고, 대학도서관시스템 중 3개의 시스템을 선정하고 해당 대학도서관 사서와 이용자를 대상으로 설문조사를 실시하였다. 수집된 자료를 분석한 결과 서비스의 각 기능을 담당하는 사서들이 MyLibrary 기능에서 생성되는 이용자들의 정보데이터를 체계적으로 활용하고 있는 사례가 많지 않다는 것을 파악하였다. 개선방안으로는 MyLibrary에서 생성되는 데이터를 토대로 이용자들에게 맞춤정보서비스 제공과 질적으로 높은 서비스를 제공하기 위하여 CRM에 대한 인식제고와 feedback 자료로 활용하기 위한 체계적 관리가 필요하다고 제시하였다.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2006년도 춘계학술발표회
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• pp.47-52
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• 2006

연안 김 양식장의 효과적 관리를 위해서는 실제 시설량의 조사가 필요하며, 인공위성을 이용한 방법이 가장 효과적이다. 본 연구에서는 10m의 해상도를 갖고 있는 SPOT-5 다중분광영상을 사용하였으며, 김 양식장의 자동탐지알고리듬의 개발을 위하여 경기도 화성시 제부도 남방해역에 대한 2005년도 영상을 사용하였다. 김 양식장을 추출하기 위하여 우선 3밴드 영상의 분광특성을 이용한 밴드차(Band difference) 영상을 작성하여, 두 가지 방법 (형태학적 처리기법 및 Canny 에지 탐지기법)으로 처리를 한 후, 두 결과를 합성하여 라벨링함으로써 탐지율을 극대화하였다. 마지막으로 2005년 우리나라 연안의 김 양식장에 대한 인공위성 조사 결과, 실제 시설량은 676,749 책(柵)으로, 면허시설량 572,745 책보다 다소 많은 것으로 나타났다. 양식장 시설 현황 조사 결과는, 정부에서 전체 생산량을 조절할 수 있게 하며, 양식업자가 좋은 수확을 달성하는데 도움이 될 수 있을 것이다.

• Journal of Microbiology and Biotechnology
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• 제25권10호
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• pp.1599-1605
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• 2015

The development of rapid and efficient genome sequencing methods has enabled us to study the evolutionary background of bacterial genetic information. Here, we present comparative genomic analysis of 17 Streptomyces species, for which the genome has been completely sequenced, using the pan-genome approach. The analysis revealed that 34,592 ortholog clusters constituted the pan-genome of these Streptomyces species, including 2,018 in the core genome, 11,743 in the dispensable genome, and 20,831 in the unique genome. The core genome was converged to a smaller number of genes than reported previously, with 3,096 gene families. Functional enrichment analysis showed that genes involved in transcription were most abundant in the Streptomyces pan-genome. Finally, we investigated core genes for the sigma factors, mycothiol biosynthesis pathway, and secondary metabolism pathways; our data showed that many genes involved in stress response and morphological differentiation were commonly expressed in Streptomyces species. Elucidation of the core genome offers a basis for understanding the functional evolution of Streptomyces species and provides insights into target selection for the construction of industrial strains.

• 한국미생물·생명공학회지
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• 제48권3호
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• pp.296-302
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• 2020

Rapamycin, derived from Streptomyces rapamycinicus, is an important bioactive compound having a therapeutic value in managing Parkinson's disease, rheumatoid arthritis, cancer, and AIDS. Because of its pharmaceutical activity, studies over the past decade have focused on the biosynthesis of rapamycin to enhance its yield. In this study, the effect of rapG on rapamycin production was investigated. The rapG expression vector was constructed by utilizing the integration vector pSET152 under the control of the erythromycin resistance gene (ermE^⁎), a strong constitutive promoter. The rapamycin yield of wild type (WT) and WT/rapG overexpression mutant strains, under fermentation conditions, was analyzed by high-performance liquid chromatography (HPLC). Our results revealed that overexpression of rapG increased rapamycin production by approximately 4.9-fold (211.4 mg/l) in MD1 containing 15 g/l of glycerol, compared to that of the WT strain. It was also found that Illicium verum powder (10 g/l), containing shikimic acid, enhanced rapamycin production in both WT and WT/rapG strains. Moreover, the amount of rapamycin produced by the WT/rapG strain was statistically higher than that produced by the WT strain. In conclusion, the addition 15 g/l glycerol and 15 g/l I. verum powder produced the optimal conditions for rapamycin production by WT and WT/rapG strains.

• 대한임상독성학회지
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• 제9권2호
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• pp.71-76
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• 2011

Purpose: The Rumack-Matthew nomogram cannot be applied in managing overdose by extended release (ER) preparation acetaminophen (AAP). This study analyzed the clinical characteristics of ER preparation AAP overdose in order to develop a treatment recommendation. Methods: We retrospectively reviewed the medical records of patients presented to the emergency department as a result of AAP overdose from Jan 2008 to Dec 2010. Only those patients who ingested an ER preparation of AAP were included in the study. Their blood AAP concentrations were measured at 4 and 8 hours after ingestion. Clinical variables related to AAP intoxication were analyzed. Results: Of the total 108 AAP overdose patients identified during the 3-year period, 20 suffered specifically with ER preparation AAP overdose. The mean estimated ingestion amount was 167.5 mg/kg. Treatments including gastric lavage, activated charcoal, and N-acetyl cysteine (NAC) were performed on 10, 14, and 11 patients, respectively. Hepatotoxicity was diagnosed in only one patient who was then successfully treated with NAC. In another case, blood AAP concentration continued to increase until at least 11-hours after ingestion. Conclusion: This study suggested that blood AAP concentrations associated with ingestion of ER formulations of AAP, may increase in an extended manner. Therefore, multiple sampling and longer periods between samples assessing AAP blood concentration may be required for incidences of extended release overdose.

• 한국약용작물학회지
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• 제20권5호
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• pp.315-319
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• 2012

This study was conducted to select plant growth regulators effective at ginseng berry set inhibition to help root growth in Korean ginseng (Panax ginseng C. A. Meyer). PGRs (ethephon, gibberellic acid, maleic hydrazide, coumarin) were applied to field grown 5-year-old Korean ginseng between one and two times, before and during bloom in 2009, 2010. The number of treatment was more effective in ginseng berry set inhibition when used two times compared with one time in GA 1,000 ppm, MH (5,000, 10,000 ppm), coumarin (5,000, 10,000 ppm) treatment. According to treatment period of plant growth regulator, ginseng berry set inhibition rate from 20days before flowering date to 5days after blooming was the highest in MH 5000 ppm showing 99.9% and the lowest in GA 100 ppm showing 32.8%. The spray treatments of Ethephon (50, 150 ppm) and MH (5,000, 10,000 ppm) from 20 days before the flowering bloom up to 5 days before, and coumarin (5,000, 10,000 ppm) from 20 days to 6 days and before blooming that induced the inhibitory effect more than 90% after 12 weeks. Considering ginseng berry set inhibition characteristics and treatment period ethephon and coumarin was important about applied period but, MH treatment appeared to effective ginseng berry set inhibition regardless of treatment period.

• 천문학회보
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• 제39권2호
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• pp.95-95
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• 2014

The mass measurement of neutron stars or black holes is of fundamental importance in our understanding of the evolution of massive stars and core-collapse supernova explosions as well as some exotic physics of the extreme conditions. Despite the importance, however, it's very difficult to measure mass of these objects directly. One way to do this, if they are in binary systems, to measure their binary motions (i.e., Doppler shifts) which can give us direct information on their mass. Recently many new highly-obscured massive X-ray binaries have been discovered by new hard X-ray satellites such as INTEGRAL and NuSTAR. The new highly-obscured massive X-ray binaries are faint in the optical, but bright in the infrared with many emission lines. Based on the near-infrared spectroscopy, one can first understand the nature of stellar companions to the compact objects, determining its spectral types and luminosity classes as well as mass losses and conditions of (potential) circumstellar material. Next, spectroscopic monitoring of these objects can be used to estimate the mass of compact objects via measuring the Doppler shifts of the lines. For the former, broad-band spectroscopy is essential; for the latter, high-resolution spectroscopy is critical. Therefore, IGRINS appears to be an ideal instrument to study them. An IGRINS survey of these new highly-obscured massive X-ray binaries can give us a rare opportunity to carry out population analyses for understanding the evolution of massive binary systems and formation of compact objects and their mass ranges. In this talk, we will present a sample near-infrared high resolution spectra of HMXB, IGR J19140+0951 and discuss about its spectral feature. These spectra are obtained on 13th July, 2014 from IGRINS commissioning run at McDonald 2.7m telescope. And at final, we will introduce the upgrade plan of IGRINS Operation Software (IGOS), to gather the input from IGRINS observer.

• 한국임상약학회지
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• 제25권3호
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• pp.187-199
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• 2015

Background: Singapore has the stable healthcare system with utilizing pharmacist manpower in proper positions by demand of populations' health among Asian countries. Objective: This study aims to systematically review (1) the pharmacists' role and (2) the pharmacy education system of Singapore in comparison with Korea. Method: We searched for information about academic, medical and governmental institutions related to professional pharmacists' practice in Singapore by primarily using database such as DBpia, KISS, Google Scholar and ProQuest and the official website of the Singapore Ministry of Health. We contacted and arranged the visit schedules with National University of Singapore, National Health Group's polyclinics, Agency for Integrated Care, National University Hospital, and community chain pharmacies. During onsite visits, we interviewed pharmacists working in each institution and obtained additional documents and materials relevant to this manuscript work. Results: To become a registered pharmacist in Singapore, the pharmacy curriculum requires four full-time academic years and six additional months allotted for pre-registration training. Pharm.D. course is offered for pharmacy graduate students with additional two full-time years of study. Team teaching and inter professional education program seem the most significant method in pharmacy education. Pharmacists working at hospitals, polyclinics, and community pharmacies in Singapore take broader roles and offer more cognitive services such as smoking cessation program and medication reconciliation. Especially, pharmacists in Agency for Integrated Care fill the role of primary care providers for the continuing care of the community through the governmental support toward the patients-centered integrated care. Conclusion: Singaporean pharmacists take significant and active roles in collaboration with other healthcare providers. Efforts such as interprofessional pharmacy education and governmental endorsement of the systematic and interactive care between pharmacists and other medical providers in Singapore are needed to be urgently applied to Korea healthcare system for the promotion of population health.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2004년도 춘계학술발표회
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• pp.483-490
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• 2004

Nakdong River Plain and its adjoining sea arc unusually covered by very thick soft clay sediments which were caned Pusan clays, sometimes reaching 40-70m. Since early 1990s a large number of geotechnical investigations have been carried out for land reclamation works in the area, including Busan city and its neighboring cities. Nevertheless, geotechnical engineers have paid little attention to studying geological characteristics on the clays, except some researches related to mineralogy, geo-chemistry, benthic foraminiferal fauna etc. The purpose of reserach is the knowledge of the correlation between engineering properties and mineralogy of clay sediments. The correlation analysis carry out multiple regression that have independent variables (Engineering properties) and dependent variables (mineralogy, geochemistry). Engineering properties of clay are correlated with the mineral compositions and geochemical characteristics. The result of the analysis is Wn = -0,6Feldspar + 1.1pH + 0.01TDS + 27.5, Ip = 0.36Clay + 1.44Vermiculite + 0.94clay mineral - 22.118, PI. = 0.005TDS - 0.31Feldspar + 22.43, eo = 0.02Vermiculite - 0.01Quartz + TDS + 0.93, ${\nu}$t = 0.009Quartz - 0.06Conductivity + 1.67, E50 = 1.94Vermicuhte - 0.96Kaohnite -0.53silt + 49.64, SR = -0.25Kaolinite + 1.5pH -2.3Conductivity, Cc = 0.03pH + TDS -0.2, LL = 0.5Clay + 1.3Vermiculite + 5.5Conductivity + 0.8Caly mineral -20.48