• KSBB Journal
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• 제29권1호
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• pp.42-49
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• 2014

The aim of this study was to develop a composite human skin equivalent for wound healing. Collagen type1 and acellular dermal matrix powder were utilized as the scaffold with dermal fibroblasts and keratinocytes for the development of a composite human skin equivalent. Fibroblast maintained the volume of composite skin equivalent and also induced keratinocytes to attach and proliferate on the surface of composite skin equivalent. The composite human skin equivalent had a structure and curvature similar to those of real skin. Balb-C nu/nu mice were used for the evaluation of full-thickness wound healing effect of the composite human skin equivalent. Graft of composite skin equivalent on full-thickness wound promoted re-epithelialization and granulation tissue formation at 9 days. Given the average wound-healing time (14 days), the wound in the developed composite skin equivalent healed quickly. The overall results indicated that this three-dimensional composite human skin equivalent can be used to effectively enhance wound healing.

• 대한기계학회논문집
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• 제12권5호
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• pp.1138-1149
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• 1988

본 연구에서는 논란의 여지가 많은 문제점을 구간별 특성 척도 분석으로 보다 명확히 하고, 매질이 물과 공기인 경우 실험을 통하여 난류 열대류 구조를 분석하여 척도분석 및 Kraichnan등의 분석을 통해 확인된 바 있는 지수법칙층의 존재를 확인하 고자 한다.

• Bulletin of the Korean Chemical Society
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• 제5권1호
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• pp.44-49
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• 1984

The ionic association constant (K) of N-methyl pyridinium iodide (NMPI) ion in several ethanol-water mixtures were determined by the combination of UV spectroscopy and conductance measurements using the Shedlovsky function as a correction factor. The measurement of electrical conductance and UV absorption were performed in 95, 90, 80 and 60 volume percentages of ethanol in the solvent mixture at 15, 25, 35 and 45 $({\pm}0.1)^{\circ}C$. The ion size parameter $(r_A+_D-)$ and the dipole moment $({\mu}_A+_D-)$ of NMPI ion were obtained from he linear plots of ln K vs. (1/D) and (D-1)/(2D+1), respectively. These ${\mu}_A+_D-$ values were in good agreement with the values of transition moment calculated from the equation, ${\mu}_{nm}=6.5168{\times}10^{-2}{\times}({\varepsilon}_{max}{\frac{\bar{\nu}_{\frac{1}{2}}}{\bar{\nu}_{max}})^{\frac{1}{2}}$ (Debye) which we have derived. The thermodynamic parameters indicate (1) that the water dipoles have an ordered rearrangement around the dipolar NMPI ions rather than the configuration existing in bulk free waters; and (2) that the equilibrium state between NMPI ion and its component ions are controlled by entropy.

• 천문학회보
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• 제40권2호
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• pp.30.1-30.1
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• 2015

Radio relics are diffuse radio sources found in the outskirts of galaxy clusters and they are thought to trace synchrotron-emitting relativistic electrons accelerated at shocks. We explore a diffusive shock acceleration (DSA) model for radio relics in which a spherical shock with the parameters relevant for the Sausage radio relic in cluster CIZA J2242.8+5301 impinges on a magnetized cloud containing fossil relativistic electrons. This model is expected to explain some observed characteristics of giant radio relics such as the relative rareness, uniform surface brightness along the length of thin arc-like radio structure, and spectral curvature in the integrated radio spectrum. We find that the observed surface brightness profile of the Sausage relic can be explained reasonably well by shocks with speed $u_s{\sim}3{\times}10^3km/s$ and sonic Mach number $M_s{\sim}3$. These shocks also produce curved radio spectra that steepen gradually over $(0.1-10){\nu}_{br}$ with a break frequency ${\nu}_{br}{\sim}1GHz$, if the duration of electron acceleration is ~60-80 Myr. However, the abrupt increase in the spectral index above ~1.5 GHz observed in the Sausage relic seems to indicate that additional physical processes, other than radiative losses, operate for electrons with the Lorentz factor, ${\gamma}_e$ > $10^4$.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.199-207
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• 1998

Ginseng saponin (G5) purified from Panax ginseng, increase renal blood flow in rats. Nitric oxide (NO) is thought to be a substance endogenously released by G5 in preconstricted lungs and cultured endothelial cells. The present study aims to determine whether G5 could stimulate endogenous 1'elease of NO in rat kidney and urine levels of the stable NO metabolites, nitrite (NO,) and nitrate (NO,) and urinary COMP levels were measured 8 hr after a single intraperitoneal injection of GS (200 mg/kg) Into rats. The effects of the WO synthesis inhibitor, Nu-nitro-L-arginine methyl ester, .1nd the NO precursor, L-arginine, on the G5-induced changes were also determined. The activity of NO synthase, as determined by conversion of ('"C)-L-arginine to ('"C)-L-citrulline, in whole kidney, glomeruli and cortical tubules were also investigated. A single injection of GS resulted in endogenous production of NO as reflected by increase in serum and urine levels of N021N03 and urinary cGMP levels, which were inhibited by the addition o ( N-nitro-L-arginine methyl ester and restored fly L-arginine. GS also stimulated the activity of NO synthase in whole kidney as well as glomeruli and cortical tubules, and Nu-nitro-L-arginine methyl tilter significantly prevented this increase. In conclusion, GS stimulates endogenous NO production and thus, may play a protective role 1 11 the kidney by modulating renal blood flow.

• Journal of Pharmaceutical Investigation
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• 제20권2호
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• pp.79-88
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• 1990

A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of ${\nu}$ parameter: ${\nu}$ value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.

• 천문학회지
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• 제54권1호
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• pp.1-8
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• 2021

We report X-ray timing and spectral properties of the pulsar PSR J0205+6449 measured using NuSTAR and Chandra observatories. We measure the pulsar's rotation frequency ν = 15.20102357(9) s-1 and its derivative $\dot{\nu}=-4.5(1){\times}10^{-11}\;s^{-2}$ during the observation period, and model the 2-30 keV on-pulse spectrum of the pulsar with a power law having a photon index Γpsr = 1.07 ± 0.16 and a 2-30 keV flux F2-30 keV = 7.3±0.6 × 10-13 erg cm-2 s-1. The Chandra 0.5-10 keV data are analyzed for an investigation of the pulsar's thermal emission properties. We use thermal and non-thermal emission models to fit the Chandra spectra and infer the surface temperature T∞ and luminosity Lth of the neutron star to be T∞ = 0.5 - 0.8 MK and Lth = 1 - 5 × 1032 erg s-1. This agrees with previous results which indicated that PSR J0205+6449 has a low surface temperature and luminosity for its age of 800-5600 yrs.

• 대한한방내과학회지
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• 제43권2호
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• pp.144-151
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• 2022

Objective: The purpose of this study is to report the effects of Shihogayonggolmoryo-tang on elderly delirium. Methods: A patient suffering from delirium was treated with Shihogayonggolmoryo-tang herbal therapy for 35 days. To evaluate the therapeutic effects, the Korean version of the Mini Mental State Examination (MMSE-K) and the Korean Nursing Delirium Screening Scale (nu-DESC) were used twice a week. Results: After treatment, the patient's MMSE-K score increased from 0 to 12, and the nu-DESC results decreased 4 to 0. Conclusion: These scores suggest that therapy with Shihogayonggolmoryo-tang has a positive effect on elderly delirium.

• 한국지반공학회논문집
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• 제23권11호
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• pp.67-76
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• 2007

낙석에 영향을 주는 요소로는 기울기, 높이, 표면 거칠기 등의 비탈면 형태, 식생, 퇴적물질 등의 사면 구성재료 및 낙석 형상, 무게 등이 있다. 이들 영향요소 중 낙석의 크기 즉, 무게는 낙석시뮬레이션 결과에 큰 영향을 미침에도 불구하고 낙석무게에 대한 연구는 많이 이루어지고 있지 않다. 또한, 낙석의 크기는 현장의 절리간격에 의해서 영향을 많이 받으며, 현장의 발생 가능한 낙석무게분포는 절리간격을 이용하여 산정할 수 있다. 따라서 본 연구에서는 절리간격을 이용하는 체적절리개수(volumetric Joint count, $J_{\nu}$) 및 $RQD-J_{\nu}$ 관계를 이용하여 낙석무게분포를 산정하였으며, 이는 연구부지에 대한 직접적인 현장낙석 조사결과 및 기존 문헌자료를 이용하여 비교 검증을 수행하였다. 낙석무게 추정결과 분석방법에 따라서 유사한 결과를 보이는 것으로 분석되었으며, 200kg 이하는 $75.3{\sim}76.7%,\;200{\sim}400kg$은 $15.0{\sim}16.6%$, 400kg 이상은 $6.7{\sim}9.7%$의 분포를 보이는 것으로 나타났다. 또한, 현장의 낙석무게분포와 비교한 결과 유사한 분포를 보이는 것으로 나타났다. 따라서 본 연구에서 제시한 방법으로 산정한 낙석무게분포는 낙석시뮬레이션의 입력 자료로 사용할 수 있을 것으로 판단되며, 그 추정 결과를 본 현장사면의 낙석 검토시 사용할 경우 경제적인 검토결과를 보이는 것으로 나타났다.

• 대한설비공학회지:설비저널
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• 제17권6호
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• pp.708-716
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• 1988

Local heat transfer coefficients were measured on semi-cylinders on which a circular water jet impinged in crossflow. The ratio of the semi-cylinder's diameter and the nozzle outlet diameter were varied parametrically, as were the Reynolds number and the supplementary water heights. The measurements showed that the circumferential distribution of the heat transfer coefficient peaked at the stagnation point. For a fixed supplementary water height, the peak heat transfer coefficient was not depend on the curvature of test specimen(d/D). Optimum height of supplementary water which brought about the augmentation of heat transfer at the stagnation point was S/D=1. The Nusselt number decreased as the circumferential distance or angle increased. The circumferential distribution of dimensionless heat transfer (Nu/Nus) was independent of d/D ($d/D{\geq}8.33$), but for the d/D<8.33, it was depended on d/D. At a fixed angle of specimen, dimensionless heat transfer (Nu/Nus) decreased as the ratio d/D increased. The extent of the decrease between d/D=6.67 and 8.33 was markedly greater than that between d/D=8.33 and 10, or d/D=10 and 11.67.