• Journal of rehabilitation welfare engineering & assistive technology
• /
• v.11 no.2
• /
• pp.179-186
• /
• 2017

Because facial asymmetry is caused by various causes, the cause analysis is important and quantitative index is needed to the evaluation. In this study, we applied the Nottingham Grading System that was used as a quantitative index to evaluate the facial paralysis by tracking the markers through the image processing and calculating the distance between the markers with images obtained by using the webcam, to evaluate facial asymmetry. The existing Nottingham Grading System has a problem of causing a measurement error in the specific case because the left and right are compared by summing the distance change between the feature points of the face part according to the change of the facial expression. We compared the case of the facial asymmetry and case of normal subject by using the existing Nottingham Grading System and the improved Nottingham grading system. In the existing Nottingham Grading System, case of facial asymmetry and case of facial symmetry were 99.0% and 95.0% respectively in the normal range, but the improved Nottingham Grading System showed facial asymmetry case was 74.0% and facial symmetrical case was 93.2%. The results of experiment show that the improved Nottingham Grading System allows detailed evaluation of each site and improved the problem of the Nottingham Grading System for specific cases.

• The Journal of the Society of Korean Medicine Diagnostics
• /
• v.17 no.3
• /
• pp.233-240
• /
• 2013

Objectives The objective and universal grading system for the facial nerve palsy is needed to the objectification of treatment in Oriental medicine. In this study, the facial nerve palsy grading was developed with combination of image processing technique and Nottingham scale. Methods The developed system is composed of measurement part, image processing part, facial nerve palsy evaluation part, and display part. With the video data recorded by webcam at measurement part, the positions of marker were measured at image processing part. In evaluation part, Nottingham scales were calculated in four different facial expressions with measured marker position. The video of facial movement, time history of marker position, and Nottingham scale were displayed in display part. Results & Conclusion The developed system was applied to a normal subject and a abnormal subject with facial nerve palsy. The left-right difference of Nottingham scores was large in the abnormal compared with the normal. In normal case, the change of the length between supraorbital point and infraorbital point was larger than that of the length between lateral canthus and angle of mouth. The abnormal case showed an opposite result. The developed system showed the possibilities of the objective and universal grading system for the facial nerve palsy.

• Journal of rehabilitation welfare engineering & assistive technology
• /
• v.9 no.2
• /
• pp.129-135
• /
• 2015

The objective grading system for the facial palsy is needed. In this study, the facial palsy grading system was developed with combination of three dimensional image processing and Nottingham scale. The developed system is composed of 4 parts; measurement part, image processing part, computational part, facial palsy evaluation & display part. Two web cam were used to get images. The 8 marker on face were recognized at image processing part. The absolute three dimensional positions of markers were calculated at computational part. Finally, Nottingham scale was calculated and displayed at facial palsy evaluation & display part. The effects of measurement method and position of subject on Nottingham scale were tested. The markers were measured with 2-dimension and 3-dimension. The subject was look at the camera with $0^{\circ}$ and $11^{\circ}$ rotation. The change of Scale was large in the case of $11^{\circ}$ rotation with 2-dimension measurement. So, the developed system with 3-dimension measurement is robust to the orientation change of subject. The developed system showed the robustness of grading error originated from subject posture.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.20 no.3
• /
• pp.147-160
• /
• 2007

Background and Objective : The facial nerve grading system proposed by House and Brackmann is most widely accepted for the clinical assessment of facial nerve injury. Because of the limitations and subjectivity of the House-Brackmann scale, several new scales of varying degrees of objectivity and ease of use have been introduced. To assess methods of evaluating the function of the facial nerve that have been introduced over the past 20 years, We compared with the House-Brackmann scale. Method : We referred to the information through Entrez Pubmed and Korean studies information(KSI) from 1985 to 2006 about methods of evaluating facial nerve function. We choose 7 scales that focused on objective and easy of use. Result and conclusion : Sunnybrook scale is a weighted, subjective scale with incorporation of secondary defects into a single composite score. Sunnybrook scale can be recommended over House-Brackmann scale.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.3
• /
• pp.1313-1320
• /
• 2014

Introduction: Although most prostate cancers initially respond to castration with luteinizing hormonereleasing analogues or bilateral orchiectomy, progression eventually occurs. Based on the exciting results of several randomized controlled trials (RCTs), it seems that patients with metastatic castration-resistant prostate cancer (mCRPC) might benefit more from treatment withabiraterone. Therefore we conducted a systematic review to evaluate the efficacy and toxicity of abiraterone in the treatment of mCRPC. Methods: Literature was searched from Embase, PubMed, Web of Science, and Cochrane Library up to July, 2013. Quality of the study was evaluated according to the Cochrane's risk of bias of randomized controlled trial (RCT) tool, then the Grading of Recommendations Assessment, Development and Evaluation (GRADE) System was used to rate the level of evidence. Stata 12.0 was used for statistical analysis. Summary data from RCTs comparing abiraterone plus prednisone versus placebo plus prednisone for mCRPC were meta-analyzed. Pooled hazard ratios (HRs) for overall survival (OS), radiographic progression-free survival (RPFS) and time to PSA progression (TTPP); Pooled risk ratios (RR) for PSA response rate, objective response rate and adverse event were calculated. Results: Ten trials were included in the systematic review; Data of 2,283 patients (1,343 abiraterone; 940 placebo) from two phase 3 trials: COU-AA-301 and COU-AA-302 were meta-analyzed. Compared with placebo, abiraterone significantly prolonged OS (HR, 0.74; 95% confidence interval [CI], 0.66 to 0.84), RPFS (HR, 0.59; 95% CI, 0.48 to 0.74) and time to PSA progression (HR, 0.55; 95% CI, 0.43 to 0.70); it also significantly increased PSA response rate (RR, 3.63; 95% CI, 1.72 to 7.65) and objective response rate (RR, 3.05; 95% CI, 1.51 to 6.15). This meta-analysis suggested that the adverse events caused by abiraterone are acceptable and can be controlled. Conclutios: Abiraterone significantly prolonged OS, RPFS and time to progression patients with mCRPC, regardless of prior chemotherapy or whether chemotherapy-na$\ddot{i}$ve, and no unexpected toxicity was evident. Abiraterone can serve as a new standard therapy for mCRPC.