• Smart Structures and Systems
• /
• v.23 no.5
• /
• pp.479-493
• /
• 2019

In this paper, the interaction between notch and micro pore under uniaxial compression has been performed experimentally and numerically. Firstly calibration of PFC2D was performed using Brazilian tensile strength, uniaxial tensile strength and biaxial tensile strength. Secondly uniaxial compression test consisting internal notch and micro pore was performed experimentally and numerically. 9 models consisting notch and micro pore were built, experimentally and numerically. Dimension of these models are 10 cm*1 cm*5 cm. the length of joint is 2 cm. the angularities of joint are $30^{\circ}$, $45^{\circ}$ and $60^{\circ}$. For each joint angularity, micro pore was situated 2 cm above the lower tip of the joint, 2 cm above the middle of the joint and 2 cm above the upper of the joint, separately. Dimension of numerical models are 5.4 cm*10.8 cm. The size of the cracks was 2 cm and its orientation was $30^{\circ}$, $45^{\circ}$ and $60^{\circ}$. Diameter of pore was 1cm which situated at the upper of the notch i.e., 2 cm above the upper notch tip, 2 cm above the middle of the notch and 2 cm above the lower of the notch tip. The results show that failure pattern was affected by notch orientation and pore position while uniaxial compressive strength is affected by failure pattern.

• Journal of the Korean Society of Manufacturing Technology Engineers
• /
• v.4 no.2
• /
• pp.46-53
• /
• 1995

In this study, Wear of a ceramic cutting tool for hardened STD11 steel was investigated. Under the finish machining condition. DOC notch wear of a ceramic cutting tool was mostly occurred earlier than flank and crater wear were proceeded. The relations of DOC notch wear, which was characteristically produced at the beginning of cutting. to cutting speed, feed, depth of cut, and nose radius of a ceramic cutting tool were examined. Effective approach angle, which is a function of cutting conditions, and boundary area were suggested, and then the influence of those was investigated, The following conclusions were obtained: (1)as cutting speed was increasing. DOC notch wear was decreasing (2) the cutting condition that magnitude of slendermess ratio was made small, was favorable for DOC notch wear, (3) as depth of cut was smaller, the influence of feed on DOC notch wear was also smaller, (4) DOC notch wear was mainly influenced by effective approach angle, but by boundary area in the range of low feed.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2002.10a
• /
• pp.58-63
• /
• 2002

This study has performed rotary bending fatigue testing that smooth specimen using SM45C materials and notched specimen whose radii were R6, R4 and R2, were processed in 3% NaCl aqueous solutions or in the air. The results are as followed; 1. In the air fatigue limit at 10$^{7}$ cycles remarkably reduced as notch radius goes small. 2. In 3% NaCl aqueous solution fatigue strength at 10$^{6}$ cycles also had large range of reduction as notch radius goes small. 3. Comparing fatigue strength in the air, fatigue strength at 10$^{6}$ cycles in 3% NaCl aqueous solution reduced by 46.2% at smooth specimen, 55.3% at R6 notch radius, 45.8% at R4 and 39.7% at R2 respectively. 4. The reason that fatigue strength reduced in the reduction of notch radius sire was because the surface of notch exposed in corrosion was small and consequently it was less corroded.

• Korean Journal of Pharmacognosy
• /
• v.49 no.4
• /
• pp.285-290
• /
• 2018

Harmine, a beta-carboline alkaloid isolated from the seeds of Peganum harmala has been reported as a promising drug candidate for cancer therapy. However, the effect of harmine on breast cancer remains still unclear. In this study, the effect of harmine on the cell proliferation, migration, and invasion of breast cancer MDA-MB231 cells and the underlying mechanism were investigated. The results indicated that harmine inhibited the proliferation MDA-MB231 cells in a dose-dependent manner and markedly suppressed migration and invasion of MDA-MB231 cells. The mechanism involved in part through Notch signaling. The Notch activity was significantly inhibited by harmine treatment and harmine suppressed the expression of Jagged1 which is a key ligand to activate Notch signaling. These findings suggest a novel mechanism of harmine on anti-cancer activity and harmine may act as a potential therapeutic drug for breast cancer treatment.

• Journal of information and communication convergence engineering
• /
• v.1 no.4
• /
• pp.189-193
• /
• 2003

A new algorithm is presented for adaptive notch filtering of narrow band or sine signals for embedded among broad band noise. The notch filter is implemented as a constrained infinite impulse response filter with a minimal number of parameters, Based on the recursive prediction error (RPE) method, the algorithm has the advantages of the fast convergence, accurate results and initial estimate of filter coefficient and its covariance is revealed. A convergence criterion is also developed. By using the information of the noise-to-signal power, the algorithm can self-adjust its initial filter coefficient estimate and its covariance to ensure convergence.

• Development and Reproduction
• /
• v.15 no.3
• /
• pp.215-221
• /
• 2011

Endocytosis of the Notch ligand, DeltaD, by mind bomb1 is indispensable for activation of Notch in cell fate determination, proliferation, and differentiation during zebrafish neurogenesis. Loss of mind bomb1 activity as an E3 Ubiquitin ligase causes the accumulation of deltaD at the plasma membrane and results in the ectopic neurogenic phenotype by activation of Notch in early zebrafish embryogenesis. However, the regulatory mechanism of deltaD during neurogenesis is not identified yet. This study aims to analyze the pathway of mib1 and deltaD after endocytosis in vivo during zebrafish embryogenesis. Mind bomb1 and deltaD are co-localized into autophagosome and mutant form of mind bomb1 fails to cargo deltaD into autophagosomes. These findings suggest that mind bomb I mediates deltaD regulation by autophagy in an ubiquitin-dependent manner during zebrafish embryogenesis.

• Journal of the Korean Society of Safety
• /
• v.9 no.1
• /
• pp.3-8
• /
• 1994

This paper has described the analysis of the Stress Intensity Factor behaviour of a short crack Initiated from notch tip. The model for finite element analysis is a double edge notched specimen. The parameters used in this study are crack length and notch root curvature radius.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.9 no.4
• /
• pp.43-49
• /
• 2013

In this paper, it is designed inverted triangle structural planar monopole antenna with edge and rectangle slot for UWB(Ultra Wide Band) communication (3.1~10.6 GHz) and researched in about 5.8 GHz notch structure to prevent interference between UWB systems and existing wireless systems for using Wi-Fi service. The antenna have broadband property structurally through inverted triangle structural planar monopole which have edge. and rectangle form addition planned notch slot of 1 mm and height 0.1 mm. Monopole and ground of proposed antenna exist on coplanar plane, and excite as CPW. It used FR4 epoxy dielectric substrate of ${\varepsilon}r$=4.4, and the size is $20{\times}20{\times}1.6$ mm dimension. The measured results that are obtained return loss under -10 dB through 3.1~10.6 GHz(7.5 GHz) without Wi-Fi bandwidth and maximum gain of 8.44 dBi at E-plane. Radiation pattern is about the same that of dipole antenna at all frequency. And using notch slot and it will be able to confirm the quality which becomes notch from 5.8 GHz which are a radio LAN frequency range.

• Bulletin of the Society of Naval Architects of Korea
• /
• v.4 no.1
• /
• pp.55-58
• /
• 1967

It is investigated that in what shape the stress concentration factor of a notched strip under pure bending changes due to unsymmetrically varying notch angle. Four models made of CR-39, having parameters of r/d-0.225, h/r=4; r/d=0.225, h/r=2; r/d=0.4, h/r=4 and r/d=0.4, h/r=2 respectively as shown in Fig.1, Fig.2 and Table are tested with the use of polariscope. For each model, notch angle is unsymmetrically varied from $0^{\circ}$ to $180^{\circ}$ at intervals of $15^{\circ}$ as shown in Fig. 1 and Fig. 2. The results of this experiment are Fig. 7 and Fig. 8 and the following are deduced. As notch angle increases 1) from $0^{\circ}$ to $50^{\circ}$, the decrement of concentration factor is slight. 2) from $50^{\circ}$ to 90, the decrement of concentration factor is a little steeper. 3) from $30^{\circ}$ to $140^{\circ}$, the decrement of concentration factor is slight. 4) from $140^{\circ}$ to $180^{\circ}$, the decrement is very steep with an abrupt with an abrupt change in the neighborhood of $140^{\circ}$.

• The Journal of the Korean dental association
• /
• v.45 no.8 s.459
• /
• pp.483-490
• /
• 2007

The aim of this study was to investigate the relationship between the mandibular antegonial notch and the mandibular morphology, and the curve of Spee in anteroposterior skeletal relationship. Pre-treatment lateral cephalograms were obtained from 80(male 34, female 46) adult orthodontic patients and the samples were classified into 3 categories by ANB angle($0^{\circ}$$\leq$ANB< $4^{\circ}$ Class I, $4^{\circ}$$\leq$ANB Class II, ANB< $0^{\circ}$ Class III). The curve of Spee was measured directly from the pre-treatment mandibular study cast of each patient included in this study. Pearson correlation coefficient test and multiple regression analysis in each group revealed the following results; 1. Antegonial notch depth was positively correlated with hoth lower anterior facial height(ANS-Me) in skeletal Class I, II and III groups and Id-Me height in skeletal Class I and II groups. 2. A statistically significant negative correlation was found between the depth of the antegonial notch and the curve of Spee in the Class III group. 3. Significant relationship was not found between the antegonial notch depth and any of the other cephalometric variables such as mandibular body length(Go-Gn) and ramus height(Co-Go). As antegonial notch depth increased, more vertical growth of the mandible was observed. Antegonial notch can be used as a predictor of vertical mandibular growth in the diagnosis and treatment planning of malocclusion.