• Journal of Biosystems Engineering
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• 제1권1호
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• pp.64-72
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• 1976

This experimental work was carried out to investigate the fatigue bending strength on various shapes and sizes of notches of the domestically manufactured steel plate. The notch types tested were a circular hole, U-and V-notches. The S-N diagram for different notch shapes were discussed in relation to plan bending strength and stress concentration factor of notches .The results of the experiments are summarized as follows : (1) The difference between stress concentration factor and notch factor was greater as the radium of notch root became smaller, and these values approached to an identical value as the radium of notch root increased. (2) It was shown that the plane bending fatigue limit of bar without notch for the hotrolled steel having the tensile strength of 33.1kg/$mm^2$was 17.0kg/$mm^2$. (3) U-and V-notch had a greater effect of stress concentration factor on the endurance limit, but O-hole showed the same effect only for $\o\pm2mm$. (4) For the same radius of notch root, U-notch showed a lower value of fatigue limit compared to V-notch and O-hole.

• KCI Concrete Journal
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• 제14권1호
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• pp.43-50
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• 2002

In this study, size effect tests were conducted on axial compressive strength of concrete members. An experiment of Mode I failure, which is one of two representative compressive failure modes, was carried out by using dimensionally proportional cylindrical specimens (CS). An adequate notch length was taken from the experimental results obtained from the compressive strength experiment of various initial notch lengths. Utilizing the notch length, specimen sizes were then varied. In addition, new parameters for the modified size effect law (MSEL) were suggested using Levenberg-Marquardt's least square method (LSM). The test results show that size effect was apparent for axial compressive strength of cracked specimens. Namely, the effect of initial notch length on axial compressive strength size effect was apparent.

• Journal of Welding and Joining
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• 제23권6호
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• pp.87-92
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• 2005

It has been well hewn that ductile fracture of steels is accelerated by triaxial stresses. The characteristics of ductile crack initiation in steels are evaluated quantitatively using a two-parameters criterion based on equivalent plastic strain and stress triaxiality. The present study focuses on the effects of strength mismatch, which can elevate plastic constraint due to heterogeneous plastic straining, on the critical condition for ductile fracture initiation usinga two-parameter criterion. Fracture initiation testing has been conducted under static loading using notched round bar specimens which had different notch locations. This study provides the fundamental clarification of the effect of strength mismatching and effect of notch location on the critical condition to ductile crack initiation from notch root using fuite element method and ultrasonic-mechatronics system. The critical condition of ductile crack initiation from notch root of strength mismatched tensile specimens under static loading appeared to be almost the same as those of homogeneous tensile specimens with circumferential sharp notch specimen. Also, the effect of notch location in mismatched specimens was estimated using finite element(FE) analyses.

• 한국과학예술포럼
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• 제25권
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• pp.379-388
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• 2016

인체연속절단 영상은 관상면, 시상면 영상으로 재구성할 경우 절단무늬가 발생한다. 이러한 문제는 FFT(Fast Fourier Transform)와 놋치필터를 이용하여 제거할 수 있었지만 놋치필터의 사용으로 급격한 주파수 변화에 따른 파문현상의 발생은 여전히 문제로 남아 있다. 따라서 본 연구는 놋치필터의 다양한 형태와 효과를 알아보고 인체연속절단면 영상에 적합한 놋치필터 설계를 제안하고자 한다. 연구의 결과는 다음과 같다. 첫째, 방사형-놋치필터를 사용할 경우 상대적으로 절단무늬를 자연스럽게 보정할 수 있다. 둘째, 방사형-놋치 필터를 사용으로 파문현상이 상대적으로 줄어들었다. 향후 이러한 연구 결과와 더욱 진전된 후속 연구를 통해 파문현상을 완전히 제거하고, 실제 인체 정보에 근접한 데이터를 재현할 수 있을 것으로 기대한다.

• 콘크리트학회논문집
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• 제12권6호
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• pp.99-108
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• 2000

The size effect on axial compressive strength in notched concrete specimens was experimentally investigated. Based on the concept of the fracture mechanics and size effect law, theoretical studies for axial compressive failure of concrete were reviewed, and two failure modes of concrete specimens under compression were discussed. In this study, experiments of axial compressive failure, which is one of the two failure modes, was carried out by using cylindrical specimens. Adequate notch length was taken from the experimental result of strength variation based on the notch length. And, by taking various sizes of specimens the size effect on axial compressive strength of concrete was investigated. Also, model equations were suggested by modified size effect law (MSEL). The test results show that size effect appears conspicuously for all series of specimens. Additionally, the effect of initial notch length on axial compressive strength was also apparent.

• Journal of Korean Neurosurgical Society
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• 제64권5호
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• pp.716-725
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• 2021

Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity in glioblastoma is not well-evaluated. The Notch-Hes pathway is known to regulate cell differentiation, proliferation, and apoptosis. We investigated the effect of propranolol to human glioblastoma cell lines, and the role of Notch and Hes signaling in this process. Methods : We performed immunohistochemical staining on 31 surgically resected primary human glioblastoma tissues. We also used glioblastoma cell lines of U87-MG, LN229, and neuroblastoma cell line of SH-SY5Y in this study. The effect of propranolol and isoproterenol on cell proliferation was evaluated using the MTT assay (absorbance 570 nm). The impact of propranolol on gene expression (Notch and Hes) was evaluated using real-time polymerase chain reaction (RT-PCR, whereas protein levels of Notch1 and Hes1 were measured using Western blotting (WB), simultaneously. Small interfering RNA (siRNA) was used to suppress the Notch gene to investigate its role in the proliferation of glioblastoma. Results : Propranolol and isoproterenol caused a dose-dependent decrease in cell proliferation (MTT assay). RT-PCR showed an increase in Notch1 and Hes1 expression by propranolol, whereas WB demonstrated increase in Notch1 protein, but a decrease in Hes1 by propranolol. The proliferation of U87-MG and LN229 was not significantly suppressed after transfection with Notch siRNA. Conclusion : These results demonstrated that propranolol suppressed the proliferation of glioblastoma cell lines and neuroblastoma cell line, and Hes1 was more closely involved than Notch1 was in glioblastoma proliferation.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.795-798
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• 1997

This study is about the dynamic behavior of steel(SM45C). Dynamic tests were performed using SHPB(Split Hopkinson Pressure Bar) which is designed and modified to be used in both tensile and compressive modes. Quasi-static compression tests were also carried out for the comparison to the dynamic results. Not only the dynamic mechanical properties but also the effect of the notch of the specimen on stress-strain curve were investigated. The dynamic test results reveal that strain and stress are sensitively affected by the notch. The depth and the number of notch increase the stress and decrease the strain.

• 생약학회지
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• 제49권4호
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• pp.285-290
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• 2018

Harmine, a beta-carboline alkaloid isolated from the seeds of Peganum harmala has been reported as a promising drug candidate for cancer therapy. However, the effect of harmine on breast cancer remains still unclear. In this study, the effect of harmine on the cell proliferation, migration, and invasion of breast cancer MDA-MB231 cells and the underlying mechanism were investigated. The results indicated that harmine inhibited the proliferation MDA-MB231 cells in a dose-dependent manner and markedly suppressed migration and invasion of MDA-MB231 cells. The mechanism involved in part through Notch signaling. The Notch activity was significantly inhibited by harmine treatment and harmine suppressed the expression of Jagged1 which is a key ligand to activate Notch signaling. These findings suggest a novel mechanism of harmine on anti-cancer activity and harmine may act as a potential therapeutic drug for breast cancer treatment.

• 전기학회논문지
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• 제66권11호
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• pp.1568-1574
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• 2017

This paper studied cogging torque reduction effect for sloping notch applied two notches on stator teeth. We have confirmed accuracy of FEM(Finite Element Method) through comparison previous model using asymmetric notch for experiment and 3D FEM results, and then cogging torque comparison of previous model and sloping notch model. Also the sloping notch model has been modified to step-sloping notch model to consider manufactur. The modification method of sloping notch changed the degree of slope of notch (a)(Notch(a) sloping Deg) and the degree of Slope of notch (b)(Notch(b) Sloping Deg). When Cogging torque is case of minimum, Notch (a) Sloping Deg is $-12[^{\circ}]$ and Notch(b) Sloping Deg $12[^{\circ}]$. In this case, cogging torque was about 23.9[mNm]. Cogging torque of previous model is about 40.8[mNm], so sloping notch model is less than previous model by 41.42[%]. Also, if sloping notch model is changed to step-sloping notch model, cogging torque of step-sloping notch model is about 24.82[mNm], Therefore the difference between the two cogging torque is about 3.85[%], so step-sloping notch model can be applied when considering manufacture.

• 한국해양공학회지
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• 제2권2호
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• pp.61-70
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• 1988

In order to consider the concept of the fitness for purpose'in fatigue design of offshore structure, fracture mechanics is applied to evaluate initial or weld defects. Generally, linear elastic fracture mechanics has been applied to tstimate initial fatigue crack propagation rate as well as long fatigue crack propagation rate. But, initial fatigue crack propagation rate in elasto-plastic notch field may not be characterized by application of stress intensity factor range .DELTA. K, because plastic effect due to stress concentration of notch may contribute to initial crack propagation. Therefore, to introduce the plastic effect into fatigue crack driving force, in this studty, the evaluating method of J-integral range .DELTA. J, was developed by willson was modified for application to notch field. In calculation of .DELTA. J obtained from the modified J-integral, stress gradient and crack closure behavior in the notch field were considered. The initial crack propagation rates in the notch fields of mild steels and high tensile strength steels were correlated to .DELTA. J. As the result, it was cleared that the present .DELTA. J is applicable to charachterize the fatigue crack propagation rates in both the elastic and elasto-plastic notch fields.