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Effects of Ethanol Extract of Sargassum horneri on Adipocyte Differentiation and Adipogenesis in 3T3-L1 Preadipocytes (괭생이모자반 에탄올 추출물이 3T3-L1 지방전구세포의 분화 및 adipogenesis에 미치는 영향)

  • Kwon, Da Hye;Choi, Yung Hyun;Kim, Byung Woo;Hwang, Hye Jin
    • Journal of Life Science
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    • v.29 no.2
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    • pp.209-214
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    • 2019
  • Sargassum horneri (Turner) C. Agardh is a marine brown algae widely distributed in the North Pacific Ocean. It is known for its anti-inflammatory and anti-atopic effects. In this study, we determined the effects of ethanol extract of Sargassum horneri (Turner) C. Agardh (EESH) on anti-obesity activities in 3T3-L1 preadipocytes. Our results indicated that treatment with EESH decreased the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner, as confirmed by a decrease in lipid droplet content observed by oil red O staining. The concentrations of cellular triglycerides were also reduced in 3T3-L1 cells after treatment with EESH. Triglyceride content was inhibited by 13%, 16%, and 23% after treatment with 250, 500, and $1,000{\mu}g/ml$ of EESH in 3T3-L1 cells, respectively. Western blotting analysis showed that EESH suppressed adipogenic transcription factor expression in a dose dependent manner. Specifically, it suppressed cytidine-cytidine-adinosine-adenosine-thymidine (CCAAT) /enhancer binding proteins $(C/EBP){\alpha}$, $C/EBP{\beta}$ and peroxisome proliferator-activated receptor $(PPAR){\gamma}$. This indicated that EESH could control the expression of adipogenic transcription factors and inhibit the differentiation of adipocytes. Taken together, these findings demonstrated that EESH showed anti-obesity effects and could have potential uses in the field of nutraceuticals.

A Study on the Migration Phenomena of Korean Repatriates just after Liberation -Focus on Illegal Moving Back to Manchuria and Japan, 1946~1947- (해방 직후 남한 귀환자의 해외 재이주 현상에 관한 연구 -만주 '재이민'과 일본 '재밀항' 실태의 원인과 전개과정을 중심으로, 1946~1947-)

  • Yi, Yeon-Sik
    • The Journal of Korean-Japanese National Studies
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    • no.34
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    • pp.77-123
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    • 2018
  • The liberated korea has the estimated population 16 million in 1945, and added 2.5 million just after an year. The korean repatriates returned by way of 2 main routes. The returnees, Wol-Nam-Min(former residents in north korea), and repatriates from Manchuria came into south korea over the 38th division line. The other repatriates from japanese islands and pacific areas came into Busan port and the vicinity. The repatriates who returned from the China and the Japanese islands made up about 80% of the total added population. However, the influx of overseas repatriates who explosively increased between 1945 and 1946, declined abruptly in April of 1946, and at last illegal re-emigration group to Manchuria and Japan Appeared, who had repatriated from those areas. This study deals with the "re-migration phenomenon of 1946" in korea, mainly focuses on 1) the motivation for those who decided to remigrate, their prospects of resettlement in Manchuria and post war japan after re-migration, 2) the structural problems of the Korean society in 1946-1947, and 3) the social recognition for the people who letf for Manchuria and Japan. This study proved the cause and background of re-migration phenomenon. The Manchuria case, the local authorities wanted farmers and peasants who could cultivate the abandoned land which had been originally pioneered and reclaimed by korean poor peasants, who repatriated to korean peninsula. On the other hand, the korean repatriates had a hard time in tenanting farmland, and so much difficulty in getting farming tools including fertilizer. That's why they left korea for Manchuria again. The Japanese case, the korean repatriates had a tough life owing to the restriction of properties left in japan, while the inflation and food shortage in korea got worse and worst. Accordingly, many koreans tried illegal entrance into post war japan. This study is a part of clarifying the universality and specificity of post war repatriation and migration issues developed in the south Korea. Through this study, we can find how difficult it is for newly liberated areas to accommodate repatriates and make them ordinary nationals in harmonic way with successful social integration. and we can observe the social aspect and administrative ability of newly liberated south korea in detail, Because the present korea has faced with so many problems connected with immigration workers and re-setting with korean communities abroad, we should introspect these historical experience of our own.

One-to-All and All-to-all Broadcasting Algorithms of Matrix Hypercube (매트릭스 하이퍼큐브의 일-대-다 방송과 다-대-다 방송 알고리즘)

  • Kim, Jongseok;Lee, Heongok
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.8 no.8
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    • pp.825-834
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    • 2018
  • Broadcasting is a basic data communication method for interconnection networks. There are two types of broadcasting. One-to-all broadcasting is to transmit a message from one node to all other nodes and all-to-all broadcasting is to transmit a message from all the nodes that have messages to other nodes. And by the using way of the transmission port per unit time, there are two schemes of broadcasting. Single port telecommunication(SLA) is to transmit messages from one node that contains the messages to one adjacent node only and all port telecommunication(MLA) is to transmit messages from one node to all adjacent nodes within a time of unit. Matrix hypercube is that an interconnection network has improved network cost than that of hypercube with the same number of nodes. In this paper, we analyze broadcasting scheme of matirx hypercube. First, we propose one-to-all and all-to-all broadcasting algorithms of matrix hypercube. And we prove that one-to-all broadcasting times are 2n+1 and $2{\lceil}{\frac{n}{2}}{\rceil}+1$ based on the SLA and MLA models, respectively. Also, we show all-to-all broadcasting time using SLA model is $5{\times}2^{\frac{n}{2}}-2$ when n=even, and is $5{\times}2^{\frac{n-1}{2}}+2$ when n=odd.

Evaluation of Extreme Rainfall based on Typhoon using Nonparametric Monte Carlo Simulation and Locally Weighted Polynomial Regression (비매개변수적 모의발생기법과 지역가중다항식을 이용한 태풍의 극치강우량 평가)

  • Oh, Tae-Suk;Moon, Young-Il;Chun, Si-Young;Kwon, Hyun-Han
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.29 no.2B
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    • pp.193-205
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    • 2009
  • Typhoons occurred in the tropical Pacific region, these might be affected the Korea moving toward north. The strong winds and the heavy rains by the typhoons caused a natural disaster in Korea. In the research, the heavy rainfall events based on typhoons were evaluated quantitative through various statistical techniques. First, probability precipitation and typhoon probability precipitation were compared using frequency analysis. Second, EST probability precipitation was calculated by Empirical Simulation Techniques (EST). Third, NL probability precipitation was estimated by coupled Nonparametric monte carlo simulation and Locally weighted polynomial regression. At the analysis results, the typhoons can be effected Gangneung and Mokpo stations more than other stations. Conversely, the typhoons can be effected Seoul and Inchen stations less than other stations. Also, EST and NL probability precipitation were estimated by the long-term simulation using observed data. Consequently, major hydrologic structures and regions where received the big typhoons impact should be review necessary. Also, EST and NL techniques can be used for climate change by the global warming. Because, these techniques used the relationship between the heavy rainfall events and the typhoons characteristics.

Genetic Similarity-dissimilarity Among Korea Chum Salmons of Each Stream and Their Relationship with Japan salmons (한국 연어의 소상하천간 유전적 유사성과 차이점 및 일본 연어와 유전적 관계)

  • Kim, Go-Eun;Kim, Choong-Gon;Lee, Youn-Ho
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.12 no.2
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    • pp.94-101
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    • 2007
  • Analysis of population structure of Oncorhynchus keta, the most abundant salmon in the East Sea of Korea, has not been much carried out despite its importance as a fishery resource in the North Pacific. Currently, molecular methods are being applied to stock identification and a method of using single nucleotide polymorphisms (SNPs) is getting more popular. In this study, we analyzed the 720 bp long sequence of the mtDNA COIII-ND3-ND4L region in order to examine genetic similarity-dissimilarity among the Korea chum salmons of each stream and their relationship with the Japan chum salmons. A total of 152 individuals were analyzed, 108 from 3 locations of Korea and 44 from 2 locations of japan, which resulted in as many as 29 different haplotypes. Pairwise $F_{ST}$ and AMOVA tests of the populations show that there is no significant population-level genetic difference among the chum salmons analyzed ($F_{ST}<0.07$). On the other hand, haplotype relationships among the individuals reveal that approximately 25% of the Korea salmons consist genetic lineages independent of Japan salmons and also that a genetic lineage exists in the Puk river and the Namdae river salmons independent of the Wangpi river salmons of Korea.

Petrogenesis of Early Cretaceous Magmatism in Eastern China and the Gyeongsang Basin, Korean Peninsula (동중국과 한반도 경상분지의 백악기초기 화성활동의 성인 고찰)

  • Choi, Sung Hi
    • The Journal of the Petrological Society of Korea
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    • v.25 no.1
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    • pp.51-67
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    • 2016
  • Geochemical characteristics of the Early Cretaceous igneous rocks from eastern China and the Gyeongsang Basin, Korean Peninsula has been summarized. They have wide range of lithological variation with extrusive picrite-basalt-andesite-trachyte-rhyolite and lamprophyre, and intrusive gabbro-diorite-monzonite-syenite-granite and diabase in eastern China, mostly belonging to the high-K calc-alkaline or shoshonitic series. The volcanic rocks intercalated with the Hayang Group sedimentary assemblages in the Gyeongsang basin are high-K to shoshonitic basaltic trachyandesites. The Early Cretaceous basaltic rocks studied mostly fall within the field of within-plate basalts on the Zr/Y-Zr and Nb-Zr-Y tectonic discrimination diagrams. On a Sr-Nd isotope correlation diagram, basaltic rocks from the North China block (NCB) and the continent-continent collision zone (CZ) between the North and South China blocks plot into the enriched lower right quadrant along the extension of the mantle array. The initial $^{87}Sr/^{86}Sr$ ratios of basaltic rocks from the South China block (SCB) are indistinguishable from those of the NCB and CZ basaltic rocks, but their ${\varepsilon}_{Nd}$ (t) values are relatively more elevated, plotting in right side of the mantle array. Basaltic rocks from the NCB and CZ are characterized by low $^{206}Pb/^{204}Pb(t)$ ratios, lying to the left of the Geochron on the $^{207}Pb/^{204}Pb(t)$ vs. $^{206}Pb/^{204}Pb(t)$ correlation. Meanwhile, the SCB basaltic rocks have relatively radiogenic Pb isotopic compositions compared with those of the NCB and CZ basaltic rocks. Basaltic rocks from the Hayang Group plot within the field of the NCB basaltic rocks in Sr-Nd and Pb-Pb isotope spaces. Metasomatically enriched subcontinental lithospheric mantle (SCLM) is likely to have been the dominant source for the early Cretaceous magmatism. Asthenospheric upwelling under an early Cretaceous extensional tectonic setting in eastern China and the Korean Peninsula might be a heat source for melting of the enriched SCLM. Metasomatic agents proposed include partial melts of lower continental crust delaminated and foundered into the mantle or subducted Yangtze continental crust, or fluid/melt derived from the subducted paleo-Pacific plate.

A Study on Seeking a Multilateral Cooperation Framework for the Inter-Korean Exchange of Intangible Cultural Heritage - Through a Multinational Nomination of a Representative List of Intangible Cultural Heritage of Humanity - (남북 무형유산 교류 협력의 다자간 협력 틀 모색 - 유네스코 인류무형문화유산 남북 공동 등재 사례 -)

  • Kim, Deoksoon
    • Korean Journal of Heritage: History & Science
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    • v.52 no.3
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    • pp.252-269
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    • 2019
  • Since the inauguration of the Kim Jong-un regime in 2012, the safeguarding and management system of cultural heritage in the Democratic People's Republic of Korea (DPRK) has been changing to a form similar to that of a democratic country's legal system. In addition, the National Authority for the Protection of Cultural Heritage (NAPCH) has continuously recorded and cataloged intangible cultural heritage elements in the DPRK, listing Arirang, kimchi-making, and ssireum on the UNESCO Intangible Cultural Heritage Representative List. In particular, the multinational nomination of ssireum in October 2018 is symbolic in terms of inter-Korean exchanges and cooperation for peace and reconciliation, raising expectations for the further multinational nomination of the two Koreas' intangible cultural heritage. Currently, South Korea lists 20 items on its Representative List of the Intangible Cultural Heritage of Humanity, three of which are shared by various countries with multinational nominations such as falconry, tug-of-war, and ssireum. However, when comparing the process of applying for multinational nomination in the three elements that follow, it is necessary to discuss whether these cases reflect the nature of multinational nomination. In particular, in the case of ssireum, without a working-level consultation between the two Koreas to prepare an application for a multinational nomination, each applied for a single registration; these applications were approved exceptionally as a multinational nomination by the Intergovernmental Committee under the leadership of the Secretary-General of UNESCO, and no bilateral exchanges have taken place until now. This is symbolic, formal, and substantially similar to the individual listings in terms of the spirit of co-listing on the premise of mutual exchange and cooperation. Therefore, the only way to strengthen the effectiveness of the multinational nomination between the two Koreas and to guarantee the spirit of multinational nomination is to request multilateral co-registration, including the two Koreas. For this, the Korean government needs a strategic approach, such as finding elements for multilateral co-listing; accumulating expertise, capabilities, and experience as a leading country in multilateral co-listing; and building cooperative governance with stakeholders. Besides, to reduce the volatility of inter-Korean cultural exchanges and cooperation depending on political situations and the special nature of inter-Korean relations, measures should be taken toward achieving inter-Korean cultural heritage exchanges and cooperation under a multilateral cooperation system using UNESCO, an international organization.

8q24 rs4242382 Polymorphism is a Risk Factor for Prostate Cancer among Multi-Ethnic Populations: Evidence from Clinical Detection in China and a Meta-analysis

  • Zhao, Cheng-Xiao;Liu, Ming;Xu, Yong;Yang, Kuo;Wei, Dong;Shi, Xiao-Hong;Yang, Fan;Zhang, Yao-Guang;Wang, Xin;Liang, Si-Ying;Zhao, Fan;Zhang, Yu-Rong;Wang, Na-Na;Chen, Xin;Sun, Liang;Zhu, Xiao-Quan;Yuan, Hui-Ping;Zhu, Ling;Yang, Yi-Ge;Tang, Lei;Jiao, Hai-Yan;Huo, Zheng-Hao;Wang, Jian-Ye;Yang, Ze
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8311-8317
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    • 2014
  • Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations. Materials and Methods: Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype. Results: The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, $P=7.3{\times}10^{-5}$), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, $Padj=1.1{\times}10^{-4}$). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ${\geq}65$ years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype ($P=4.6{\times}10^{-5}-3.0{\times}10^{-2}$). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, $P=1.0{\times}10^{-5}$) across Asian, Caucasian and African American populations. Conclusions: The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.

Multilateral Approach to forming Air Logistics Hub on North East Asia Region (동북아 항공물류허브을 구축하기 위한 다자적 접근방안)

  • Hong, Seock-Jin
    • The Korean Journal of Air & Space Law and Policy
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    • v.19 no.2
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    • pp.97-136
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    • 2004
  • The Northeast Asian air cargo market has expanded tremendously as a result of the opening up of the Chinese market. The importance of the Asia-Pacific region in the global air transport has also increased. The exchange of human and material resources, services, and information in Northeast Asia, which is expected to increase in the near future, requires that the airlines operating within this region adopt a more liberalized approach. This paper introduced alternatives which can be applied to the Northeast Asian airlines industry so as to bring about the integration of regional air transport: First, this paper found a need for individual Northeast Asian nations to alter their policies towards the airlines industry. Second, each country should further liberalize their respective domestic air transport. Third, there is a need for freer air service agreements to be signed between the nations of Northeast Asia. Fourth, the strategic alliances between the airlines operating in Northeast Asia should be further strengthened. Fifth, this liberalization process should be carried out in an incremental manner, beginning with more competitive airports and routes, or with less-in-demand routes. Sixth, there is a need for a shuttle system to be put into place between the main airports in China, Korea, and Japan. Seventh, these three nations jointly develop aviation safety and security systems that are in accordance with international standards. Eighth, the liberalization process of the aviation industry should be undertaken in conjunction with other related fields. Ninth, organizations linking together civil aviation organization in the Asia-Pacific area should be formed, as should each government linking together. By doing so, these countries will be able to establish regular venues through which to exchange opinions on the integration and liberalization of the air cargo market so as to induce the gradual liberalization of the actual market. The liberalization of the air transport in Northeast Asia will prove to be a daunting task in the short term. However, if the Chinese airlines continue to exhibit continuous growth and Japanese airlines are able to complete their move towards a low-cost structure, this process could be completed earlier than expected. Over the last twenty five years the air transport has undergone tremendous changes. The most important factor behind these changes has been the increased liberalization of the market. As a result, rates have decreased while demand has increased. This has resulted in turning the air transport industry, which was long perceived as an industry in decline, into a high-growth industry. The only method of increasing regional exchanges in the air transport is to pursue further liberalization. The country which implements this liberalization process at the earliest date may very well emerge as a leading force within the air transport industry.

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Geochemical Study of the Cretaceous Granitic Rocks in Southwestern Part of the Korean Peninsula (한반도 남서부지역에 분포하는 백악기 화강암류에 대한 지화학적 연구)

  • Wee Soo Meen;Park Se Mi;Choi Seon Cyu;Ryu In Chang
    • Economic and Environmental Geology
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    • v.38 no.2 s.171
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    • pp.113-127
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    • 2005
  • Cretaceous intrusive and extrusive rocks are widely distributed in the southwestern part of the Korean peninsula, possibly the result of intensive magmatism which occurred in response to subduction of the western proto-Pacific plate beneath the north-eastern part of the Eurasian plate. Geochemical and petrological study on the Cretaceous granitic rocks were carried out in order to constrain the petrogenesis of the granitic magma and to establish the paleotectonic environment of the area. Whole rock chemical data of the granitic rocks from the study area indicate that the all the rocks have characteristics of calc-alkaline series in the subalkaline field. The overall geochemical features show systematic variations in each granitic body, but the source materials of each granitic body are thought to have been different in their chemical composition. Higher values of $Fe_2O_3/FeO$ of the granitic rocks in the western area suggest that the granitoids had been solidified under highly oxidizing environment. The granitic bodies in the eastern area also show higher contents of Li, Ni, Co, Sr, Cr, Sc and lower Rb and Nb compared to the those of the western area. Chondrite normalized REE patterns show generally enriched LREE and strong negative Eu anomalies in the western wet while slight to flat Eu anomalies in the east-ern area. The REE and $(La/Lu)_{CN}$ of the granites are $60{\~}499ppm$ and $8.9{\~}66$ correspond to the range of the continental margin granite. On the ANK vs. ACNK and tectonic discrimination diagrams, parental magma type of the granites corresponds to I-type, VAG and syn-collision granite. Interpretations of the chemical characteristics of the granitic rocks favor their emplacement in a compressional tectonic regime at continental margin during the subduction of proto-Pacific plate.