• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2023년도 제68차 하계학술대회논문집 31권2호
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• pp.283-285
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• 2023

이상 탐지는 데이터에서 일반적인 범주에서 크게 벗어나는 인스턴스 또는 패턴을 식별하는 중요한 작업이다. 본 연구에서는 시계열 데이터의 특징 추출을 위한 비지도 학습 기반 방법과 정규화 흐름의 결합을 통한 이상 탐지 프레임워크를 제안한다. 특징 추출기는 1차원 합성곱 신경망 기반의 오토인코더로 구성되며, 정상적인 시퀀스로만 구성된 훈련 데이터를 압축하고 복원하는 과정을 통해 최적화된다. 추출된 시계열 데이터의 특징 맵은 가능도를 최대화하도록 훈련된 정규화 흐름의 입력으로 사용된다. 이와 같은 방식으로 훈련된 이상 탐지 시스템은 테스트 샘플에 대한 이상치를 계산하며, 최종적으로 임계값과의 비교를 통해 이상 여부를 예측한다. 성능 평가를 위해 시계열 이상 탐지를 위한 공개 데이터셋을 이용하여 공정하게 이상 탐지 성능을 비교하였으며, 실험 결과는 제안하는 정규화 흐름 기법이 시계열 이상 탐지 시스템에 활용될수 있는 잠재성을 시사한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권6호
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• pp.1516-1529
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• 2023

In this paper, a motor gearbox fault-detection system based on a hierarchical flow-based model is proposed. The proposed system is used for the anomaly detection of a motion sound-based actuator module. The proposed flow-based model, which is a generative model, learns by directly modeling a data distribution function. As the objective function is the maximum likelihood value of the input data, the training is stable and simple to use for anomaly detection. The operation sound of a car's side-view mirror motor is converted into a Mel-spectrogram image, consisting of a folding signal and an unfolding signal, and used as training data in this experiment. The proposed system is composed of an encoder and a decoder. The data extracted from the layer of the pretrained feature extractor are used as the decoder input data in the encoder. This information is used in the decoder by performing an interlayer cross-scale convolution operation. The experimental results indicate that the context information of various dimensions extracted from the interlayer hierarchical data improves the defect detection accuracy. This paper is notable because it uses acoustic data and a normalizing flow model to detect outliers based on the features of experimental data.

• Journal of Advanced Research in Ocean Engineering
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• 제2권4호
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• pp.169-178
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• 2016

Recently, artificial reefs (ARs) have been frequently used primarily owing to the development in AR materials and projects for relatively complicated, large ARs. Among several engineering issues of ARs, wake region of an AR has been characterized because these regions have a high probability of recruiting seaweed spores, providing an energy saving zone, and facilitating deposition of sediments, nutrients, and bio-deposits. To characterize an efficiency index of an AR wake region and its dependency on the prevailing water flow directions, this study proposes a so-called efficiency index diagram. This characterization is done by normalizing the wake volumes with respect to the real AR volume and illustrating how efficiency indices vary with respect to the inlet flow directions. As a result, according to the diagram characteristics such as an averaged efficiency index, fundamental symmetric angle, secure angles, and principal directions, we can easily figure out how a target AR should be aligned along the main water flows to maximize the wake region around the AR. In addition, six ARs are considered and their efficiency index diagrams are illustrated to pinpoint the physical characteristics.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.283-289
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• 2013

This study was designed to evaluate the protective effect of Korean red ginseng (KRG) against ischemia/reperfusion (I/R) injury in isolated guinea pig heart. KRG has been shown to possess various ginsenosides, which are the major components of Panax ginseng. These components are known naturally occurring compounds with beneficial effects and free radical scavenging activity. The heart was induced to ischemia for 60 min, followed by 120 min reperfusion. The hearts were randomly allocated into five groups (n=8 for each group): normal control (N/C), KRG control, I/R control, 250 mg/kg KRG group and 500 mg/kg KRG group. KRG significantly increased hemodynamics parameters such as aortic flow, coronary flow and cardiac output. Moreover, KRG significantly increased left ventricular systolic pressure (LVSP), the maximal rate of contraction (+dP/$dt_{max}$) and maximal rate of relaxation (-dP/$dt_{max}$). Also, treatment of KRG ameliorated electrocardiographic index such as the QRS, QT and RR intervals. Moreover, KRG significantly suppressed the lactate dehydrogenase, creatine kinase-MB fraction and cardiac troponin I and ameliorated the oxidative stress markers such as malondialdehyde and glutathione. KRG was standardized through ultra performance liquid chromatograph analysis for its major ginsenosides. Taken together, KRG has been shown to prevent cardiac injury by normalizing the biochemical and oxidative stress.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2447-2451
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• 2013

Objective: To study changes of tumor associated carbohydrate antigen (TACAs) expression and mRNA levels for tumor associated glycosyltransferases, and assess subcellular localizations of N-acetyl galactosyltransferases (GalNAc-Ts) in the K562 leukemia cell line after imatinib treatment. Methods: RT-PCR was performed to analyze the expression of glycosyltransferases which synthesize O-glycan in tumor-associated carbohydrate antigens (TCTAs). The expression of Tn antigen, T antigen and sialyl T antigen on K562 cell membranes was measured by flow cytometry after treatment with different concentrations of imatinib. Co-localization of GalNAc-Ts and ER (endoplasmic reticulum) was determined by confocal laser scanning microcopy. Results: Transcript expression levels of several glycosyltransferases related to TCTAs were decreased after imatinib ($0-0.3{\mu}M$) treatment. Expression of Tn antigen and T antigen was increased while that of sialyl T antigen was decreased. Co-localization of GalNAc-Ts and ER was reduced by $0.2{\mu}M$ of imatinib. Conclusion: Imatinib inhibited the expression of O-glycan related TACAs and several related glycosyltransferases, while decreasing the co-localization of GalNAc-Ts and ER and normalizing O-glycosylation in the K562 human leukemia cell.

• 한국항공우주학회지
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• 제30권5호
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• pp.71-78
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• 2002

동축공기 수소확산 화염에서 세 가지 동축공기 조건과 화염의 유무에 따라 실험조건을 분류하고, 이에 대해 PIV를 이용하여 실험을 수행하였다. PIV를 통해 얻은 속도장을 이용하여 평균속도, 난류강도, Reynolds stress 등을 구하여 유동장을 분석하였다. 우선 단순제트에 대해 상사성을 살펴본 결과 이전의 다른 연구자의 실험결과와 일치하였다. 동축공기가 있는 경우 중심축 속도 감쇠는 $x^{-1}$에 비례하여 감소하는 것을 확인하였다. 축방향 길이를 유효밀도에 의해 정의된 유효 제트 지름으로 무차원화한 값으로 중심축 속도를 도시한 결과 하나의 선분에 떨어지는 것을 확인하였다. 평균속도 분포를 살펴보면 일정한 연료유량에 동축공기 유량을 증가시킨 경우 동축공기가 증가함에 따라 속도 분포의 형태가 바뀌게 되어 자기상사성이 유지되지 않는 것으로 보인다. 난류강도는 평균속도 분포의 경우보다 후류에서 자기상사성이 나타난다.

• Journal of Ginseng Research
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• 제48권2호
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• pp.190-201
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• 2024

Background: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive. Methods: Female MRL/lpr mice were administered CK (40 mg/kg) intragastrically for 10 weeks, followed by measurements of anti-dsDNA antibodies, inflammatory chemokines, and metabolite profiles on renal samples. Podocyte function and ultrastructure were detected. Publicly available single-cell RNA sequencing data and flow cytometry analysis were employed to investigate B cell subpopulations. Metabolomics analysis was adopted. SIRT1 and AMPK expression were analyzed by immunoblotting and immunofluorescence assays. Results: CK reduced proteinuria and protected podocyte ultrastructure in MRL/lpr mice by suppressing circulating anti-dsDNA antibodies and mitigating systemic inflammation. It activated B cell-specific SIRT1 and AMPK with Rhamnose accumulation, hindering the conversion of renal B cells into plasma cells. This cascade facilitated the resolution of local renal inflammation. CK facilitated the clearance of deposited immune complexes, thus reinstating podocyte morphology and mobility by normalizing the expression of nephrin and SYNPO. Conclusions: Our study reveals the synergistic interplay between SIRT1 and AMPK, orchestrating the restoration of renal B cell subsets. This process effectively mitigates immune complex deposition and preserves podocyte function. Accordingly, CK emerges as a promising therapeutic agent, potentially alleviating the hyperactivity of renal B cell subsets during LN.

• 대한한의학원전학회지
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• 제37권2호
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• pp.11-30
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• 2024

Objectives : Not many studies have been done on the mechanism of the Gangeum or Gangpyoeum method which treats the Soyang Exterior Pattern, nor on which collective or individual roles the Gangeum medicinals play. Therefore in this study, four medicinals categorized as Gangpyoeum which are Jingjie, Fangfeng, Qianghuo, Duhuo, were analyzed in terms of their individual and collective effects. Methods : Content analysis based on the verses in the Donguisusebowon, and medicinal analysis on contents from the Donguibogam, Bencaogangmu, and Benjingshuzheng were carried out followed by a medicinal combination analysis using the InSAm 1.1 program. Results : The four medicinals Jingjie, Fangfeng, Qianghuo, Duhuo had the common effect of normalizing the Wei qi, allowing for unobstructed Qi flow to prevent production of dampness and phlegm, which ultimately lowers Yin[降陰, gangeum] and helps to preserve the Kidney Yin Qi. Jingjie works at the highest position of the upper body; Fangfeng, the most basic medicinal of the Soyangin pattern, works mostly at the upper body although it defends the entire body from wind-dampness. Qianghuo and Duhuo are more or less similar. The difference is that Qianghuo mostly pulls Yang qi upwards while eliminating pathological byproducts, and Duhuo stabilizes the lower body that pulls Wei qi upwards. Conclusions : Analysis on the relationship between Gangpyoeum of the Soyangin pattern and Wei qi, the individual and collective effects of the four Gangpyoeum medicinals were carried out. Further research on other major Soyangin medicinals, along with those of other constitution patterns is anticipated.

• 한국수자원학회논문집
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• 제54권8호
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• pp.629-641
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• 2021

본 연구에서는 2차원 수치모형(Nays2DH)을 적용하여 금강에 건설된 세종보를 중심으로 보 개방 후에 홍수량 변화에 의한 하도의 지형변화 과정을 분석하였다. 이를 위해 부등류, 부정류(단일사상), 연속홍수사상을 수문특성을 반영한 흐름조건으로 수치모의를 수행하였다. 부등류 수치모의 조건은 유황에 따른 정상유량으로 상류단 경계조건을 가정하였다. 부정류와 연속홍수사상의 경우에는 실제 홍수사상들로부터 정규 수문곡선 (normalized hydrograph)을 산정 한 후, 시나리오에 따른 첨두유량으로 정규 수문곡선을 재구성하여 상류단 유량으로 가정하였다. 본 연구에서는 지형학적 변화를 정량적으로 평가하기 위해 하상기복지수(BRI)를 산정하여 시간에 따른 하상변동을 분석하였으며, 연구지역의 항공사진과 수치모의 결과를 정성적으로 비교하였다. 부등류 수치모의 결과, 각 유황별 유량이 증가하면 하폭 대 수심의 비는 감소하고, 사주의 이동속도는 증가하였다. 하상기복지수는 초기에는 증가하지만, 시간이 증가함에 따라 변화량이 작아졌다. 또한 유량이 증가하면 하상기 복지수가 증가했다. 부정류 수치모의 결과 사주의 이동속도는 유량의 변화에 따라 감소했다. 또한 첨두홍수에 대한 지형적 반응에서 시간지체(time lag)가 발생했다. 즉, 부정류에서는 하상고의 변화는 수리학적 조건에 대하여 위상지연(Phase lag) 이 나타났다. 연속홍수사상 발생에 의한 부정류 수치모의 결과에서는 각각 첨두홍수 발생에 따른 사주의 이동속도는 홍수발생이 반복됨에도 불구하고 급격하게 감소했다. 또한 부정류 수치모의 결과와 마찬가지로 위상지연이 나타났으며 사주의 이동속도는 지수적으로 감소하는 특성을 보였다. 하상기복지수는 시간경과에 따라 증가하였으나, 첨두홍수가 연속으로 발생하였음에도 불구하고 하상기복지수의 증가율은 완만하였다. 본 연구를 통해 하천의 수문특성을 반영한 지형변화 과정을 수치모의를 수행하여 분석하였으며, 이를 통해 흐름특성에 따른 하상변동의 정량적인 예측모의를 현장에 적용할 수 있는 방법을 제시할 수 있을 것으로 판단된다.

• 한국수정란이식학회지
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• 제24권3호
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• pp.225-230
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• 2009

Sex-sorting of sperm is an assisted reproductive technology (ART) used by the livestock industry for the mass production of animals of a desired sex. The standard method for sorting sperm is the detection of DNA content differences between X and Y chromosome-bearing sperm by flow cytometry. However, this method has variable efficiency and therefore requires verification by a second method. We have developed a sex determination method based on quantitative real-time polymerase chain reaction (qPCR) of the porcine amelogenin (AMEL) gene. The AMEL gene is present on both the X and the Y chromosome, but the length and sequence of its noncoding regions differ between the X and Y chromosomes. By measuring the threshold cycle (Ct) of qPCR, we were able to calculate the relative frequency of X chromosome. Two sets of AMEL primers were used in these studies. One set (AME) targeted AMEL gene sequences present in both X and Y chromosome, but produced PCR products of different lengths for each chromosome. The other set (AXR) bound to AMEL gene sequences present on the X chromosome but absent esholthe Y-chromosome. Relative product levels were calculated by normalizing the AXR fluorescence to the AME fluorescence. The AMEL method accurately predicted the sex ratios of boar sperm, demonstrating that it has potential value as a sex determination method.