• Environmental Mutagens and Carcinogens
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• v.22 no.4
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• pp.289-295
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• 2002

This study was conducted to quantify of micronucleus frequencies in human umbilical cord blood by supravital staining method with acridine orange, and to find some factors that affected on micronucleus frequncies in humans. In this study, we used umbilical cord blood of new born infants that have sufficient reticulocytes compared with adult peripheral blood. The cord bloods were taken after childbirth from 60 normal infants in industrial and coastal region in Korea. The total of 3 ${mu}ell$ cord blood was applied to slide coated with acridine orange, and micronuclei were observed under fluorescent microscopy. Demographic factors and independent variables were collected from mothers by questionnaire. The frequencies of micronuclei in umbilical cord blood of new born infants were 0-5 per 2,000 reticulocytes by supravital staining method, and mean value and standard deviation were 1.75$\pm$0.97. There were no significant difference by the regions, smoking habits of father or mother. However, age of mother showed significant positive correlation with frequencies of micronuclei (p<0.05). Smoking at home by fathers also was found as a significant variable by muliple regression analysis. Therefore, further studies would be needed for genotoxicological evaluation of new born infants by microneuli test using supravital staining method.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.11
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• pp.2086-2094
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• 2008

Finding a planar surface on 3D space is very important for efficient and safe operation of a mobile robot. In this paper, we propose a method using a plane detection cell (PDC) and iterative randomized Hough transform (IRHT) for finding the planar region from a 3D range image. First, the local planar region is detected by a PDC from the target area of the range image. Each plane is then segmented by analyzing the accumulated peaks from voting the local direction and position information of the local PDC in Hough space to reduce effect of noises and outliers and improve the efficiency of the HT. When segmenting each plane region, the IRHT repeatedly decreases the size of the planar region used for voting in the Hough parameter space in order to reduce the effect of noise and solve the local maxima problem in the parameter space. In general, range images have many planes of different normal directions. Hence, we first detected the largest plane region and then the remained region is again processed. Through this procedure, we can segment all planar regions of interest in the range image.

• Annals of Clinical Neurophysiology
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• v.19 no.2
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• pp.93-100
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• 2017

In this article, we review the differences of the brain morphology according to age, sex, and handedness. Age is a well-known factor affecting brain morphology. With aging, progressive reduction of brain volume is driven. Sex also has great effects on brain morphology. Although there are some reports that the differences of brain morphology may originate from the differences of weight between the 2 sexes, studies have demonstrated that there are regional differences even after the correction for weight. Handedness has long been regarded as a behavioral marker of functional asymmetry. Although there have been debates about the effect of handedness on brain morphology, previous well-established studies suggest there are differences in some regions according to handedness. Even with the studies done so far, normal brain morphology is not fully understood. Therefore, studies specific for the each ethnic group and standardized methods are needed to establish a more reliable database of healthy subjects' brain morphology.

• Journal of Biomedical Engineering Research
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• v.29 no.2
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• pp.122-131
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• 2008

For B-mode ultrasound images, we propose an image enhancement algorithm based on a multi-resolution approach, which consists of edge enhancing and noise reducing procedures. Edge enhancement processing is applied sequentially to coarse-to-fine resolution images obtained from wavelet-transformed data. In each resolution, the structural features of each pixel are examined through eigen analysis. Then, if a pixel belongs to an edge region, we perform two-step filtering: that is, directional smoothing is conducted along the tangential direction of the edge to improve continuity and directional sharpening is conducted along the normal direction to enhance the contrast. In addition, speckle noise is alleviated by proper attenuation of the wavelet coefficients of the homogeneous regions at each band. This region-based speckle-reduction scheme is differentiated from other methods that are based on the magnitude statistics of the wavelet coefficients. The proposed algorithm enhances edges regardless of changes in the resolution of an image, and the algorithm efficiently reduces speckle noise without affecting the sharpness of the edge. Hence, compared with existing algorithms, the proposed algorithm considerably improves the subjective image quality without providing any noticeable artifacts.

• Korean Journal of Human Ecology
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• v.16 no.6
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• pp.1211-1221
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• 2007

To provide the basic information of the brassiere development for women with poor breast, we performed the survey on their wearing habits for brassieres by comparing the poor breast type women and the normal breast type women. Also, to suggest the advanced design methods for the mould brassiere for the poor breast women, we conducted the subjective wear test of commercial mould brassieres and measured the local thickness for mould cup under various loads. As the results, the good fitness of cup and wire, the natural wear silhouette, and the adaptation of soft and stretchy material for mould cup were very important to design the comfortable brassiere for the poor breast type. The good-fitness of upper cup was the key factor for the satisfactory wear appearance of brassiere and the cup should be designed not too thick at the upper and the bust point regions.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9557-9565
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• 2014

MiRNAs are endogenous, single stranded ~22-nucleotide non-coding RNAs (ncRNAs) which are transcribed by RNA polymerase II and mediate negative post-transcriptional gene regulation through binding to 3'untranslated regions (UTR), possibly open reading frames (ORFs) or 5'UTRs of target mRNAs. MiRNAs are involved in the normal physiology of eukaryotic cells, so dysregulation may be associated with diseases like cancer, and neurodegenerative, heart and other disorders. Among all cancers, lung cancer, with high incidence and mortality worldwide, is classified into two main groups: non-small cell lung cancer and small cell lung cancer. Recent promising studies suggest that gene expression profiles and miRNA signatures could be a useful step in a noninvasive, low-cost and repeatable screening process of lung cancer. Similarly, every stage of lung development during fetal life is associated with specific miRNAs. Since lung development and lung cancer phenomena share the same physiological, biological and molecular processes like cell proliferation, development and shared mRNA or expression regulation pathways, and according to data adopted from various studies, they may have partially shared miRNA signature. Thus, focusing on lung cancer in relation to lung development in miRNA studies might provide clues for lung cancer diagnosis and prognosis.

• Journal of Korea Multimedia Society
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• v.19 no.1
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• pp.1-9
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• 2016

In this paper, we propose a method of measuring bone mineral density in a peripheral-type clinical X-ray CT using a phantom, and we propose a method of classifying osteoporosis using bone mineral density and bone structure parameters together. It segments the trabecular bone region and cortical bone region for the six sections of the phantom and calculates the average HU value of the segmented regions. By using these values, it derives an expression converting HU value to bone mineral density. It segments trabecular bone of 1 cm region in the end part of distal radius and extracts the bone mineral density and structural parameters for the trabecular bone region. We extracted bone mineral density and structural parameters for the 18 subjects each of normal and osteoporotic group. We carried out classification experiments using three classification methods; SAD, SVM, ANN. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, likelihood ratio of the classification was improved in the order of ANN, SVM and SAD. Also, The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, likelihood ratio of the classification was improved when we use the bone mineral density and structural parameters together.

• Proceedings of the KSR Conference
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• 2004.06a
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• pp.1297-1302
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• 2004

In DC power distribution system for urban rail transits potential relay, 64P, is used to detect the ground faults. The problem with this 64P is that though it detects the ground fault it cannot identify the faulted region. Therefore the faulted region cannot be isolated properly. It could results in power loss of the trains on the healthy regions and the safety of the passengers in the trains could be affected adversely. A new ground fault protective relaying scheme that can identify the faulted region is presented in this paper. The new concept uses the current differential scheme and the permissive scheme to identify the faulted region correctly. A device with similar characteristic to the arrestor is adapted to use the current relay for the ground fault detection. The role of the device is to block the ground leakage current in normal operating condition and enable the ground fault current to flow in ground fault condition. The algorithm of the new relay and the effect of the newly adapted device in the new relaying scheme are discussed.

• Journal of the Korean Geophysical Society
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• v.7 no.1
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• pp.1-10
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• 2004

Gravity, magnetic and high-resolution seismic surveys were carried out in the Powell Basin to examine tectonic structure and recent sedimentation on Dec. 2002. The trend of negative gravity anomalies along the spreading axis of the Powell Basin changes from northwest to east-west toward south. Both boundaries of the basin with the Antarctic Peninsula and the South Orkey micro-continent show negative magnetic anomalies, which indicates that the boundaries were continental rift areas in the initial stage of spreading. Magnitude of the magnetic anomalies corresponding to the axis of the basin is rather small compared to those of normal spreading axises in other regions. Such small anomalies would be caused by reduction of magnetic strength of oceanic crust below thick sediments due to thermal alternation. High-resolution (3.5 kHz) seismic profiles reveal that top of the South Scotia Ridge is a flat terrain coverd with thin coarse sediments by glacial erosion. Thick oceanic sediments are deposited in the central part of the basin. Little deformation in the oceanic sediments indicates that the Powell Basin has been in stable tectonic environment after spreading of the basin stopped.

• The korean journal of orthodontics
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• v.23 no.1 s.40
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• pp.123-136
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• 1993

The purpose of this report is to present the successful improvement of occlusal relationship and facial esthetics in class II division 1 malocclusion with severe labioversion of upper anterior teeth and severe overjet, and in class II malocclusion with infraversion of bilateral maxillary canines by MEAW mechanics, which enables us to get effective distal on mass movement of maxillary dentition, with upper second molar extraction. After treatment, there were natural contact points at canine and premolar regions, normal occlusal relation-ship and treatment results, satisfied the gnathologic concept, in this 2 cases. Compared with the routine treatment with premolar extraction, the treatment time and patients' discomfort were reduced. And the MEAW mechanics, which enables us to get effective distal on mass movement of maxillary dentition, resulted in reduction of the treatment time and getting the good treatment results. Consequently, the majot concerns in orthodontic treatment are appropriate diagnosis and treatment plan, so, the application of second molar extraction with appropriate case analysis and diagnosis is very helpful to orthodontic treatment.