• 대한한방소아과학회지
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• 제15권1호
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• pp.77-104
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• 2001

The effects of the oriental herbal medicine Saenghyetang(SHT, 生慧湯), which consists of Rehmanniae Radix (熟地黃 九蒸: was made by 9th steam) 40g, Corni Fructus(山茱黃) 16g, Polygalae Radix(遠志) 8g, Zizyphi Spinosae Semen(酸棗仁) 2g, Biotae Semen(柏子仁 去油: oil ingredient was removed) 20g, Poria Cocos(茯笭) 12g, Ginseng Radix(人蔘) 12g, Acori Graminei Rhizoma(石菖蒲) 2g, Sinapis Semen(白芥子) 8g, on learning ability and memory were investigated. Hot water extract(HWE) and ethanol extract(EE) from SHT were used for the studies. Learning ability and memory are related to modifications of synaptic strength among neurons that interactive. Enhanced synaptic coincidence detection leads to improved learning ability and memory. If the NMDA receptor, a synaptic coincidence detector, acts as a graded switch for memory formations, enhanced signal detection by NMDA receptors should enhance learning ability and memory. It was shown that NR2B was increased in the forebrains of oriental medicine-administrated mice, leading to enhanced activation of NMDA receptors and facilitating synaptic potentiation in response to stimulation at 10-100 Hz. These HWE-SHT treated mice exhibited that superior ability in learning and memory when performing various behavioral tasks, showing that NR2B is enhanced by HWE-SHT treatment and also is critical in gating the age-dependent threshold for plasticity and memory formation. NMDA receptor-dependent modifications, which were mediated in part by HWE administration, of synaptic efficacy, therefore, represent a mechanism for associative learning ability and memory. Results suggest that oriental medical enhancement of NR2B contributes to increase intelligence and memory in mammals On the other hand, to examine the effects of EE-SHT on the learning ability and memory in experimental mice, EE-SHT was tested on passive and active avoidance responses. The EE-SHT ameliorated the memory retrieval deficit induced by ethanol in mice, but not other memory impairments. EE-SHT(10, 20mg/100 g, p.o.) did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests and the ambulatory activity of normal mice in a normal condition. However, EE-SHT at 20 mg/kg significantly decrease the spontaneous motor activity during the shuttle box test, and also to extend the sleeping time induced by pentobarbital in mice. These results suggest that SHT has an ameliorating effect on memory retrieval impairments and a weak tranquilizing action.

• 대한의용생체공학회:의공학회지
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• 제43권4호
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• pp.185-192
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• 2022

Early detection of mild cognitive impairment can help prevent the progression of dementia. The purpose of this study was to design and validate a machine learning model that automatically differential diagnosed patients with mild cognitive impairment and identified cognitive decline characteristics compared to a control group with normal cognition using resting-state quantitative electroencephalogram (qEEG) with eyes closed. In the first step, a rectified signal was obtained through a preprocessing process that receives a quantitative EEG signal as an input and removes noise through a filter and independent component analysis (ICA). Frequency analysis and non-linear features were extracted from the rectified signal, and the 3067 extracted features were used as input of a linear support vector machine (SVM), a representative algorithm among machine learning algorithms, and classified into mild cognitive impairment patients and normal cognitive adults. As a result of classification analysis of 58 normal cognitive group and 80 patients in mild cognitive impairment, the accuracy of SVM was 86.2%. In patients with mild cognitive impairment, alpha band power was decreased in the frontal lobe, and high beta band power was increased in the frontal lobe compared to the normal cognitive group. Also, the gamma band power of the occipital-parietal lobe was decreased in mild cognitive impairment. These results represented that quantitative EEG can be used as a meaningful biomarker to discriminate cognitive decline.

• Clinical and Experimental Pediatrics
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• 제51권9호
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• pp.911-921
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• 2008

Learning disabilities (LD) are heterogeneous group of disorders with evidences of genetic or familial trait, intrinsic to the individual and presume to be due to central nervous dysfunction. Learning disabilities and attention deficit hyperactivity disorder (ADHD) are the two of the most common disorders in the population of school-age children. Typically academic achievements in children with learning disabilities are significantly lower than expected by their normal or above normal range of IQ. Although academic and cognitive deficits are hallmarks of children with LD, those children are also at risk for a broad range of behavioral and emotional problems. Almost all cases meet criteria for at least one additional diagnosis such as ADHD, developmental coordination disorder, depression, anxiety, obsessive compulsive disorder, tic disorder, among which ADHD is particularly predominant. Because of the response to the therapeutic intervention program is promising and positive when applied early, it is critical to recognize patients as early as possible. Pediatricians often are the first to hear from parents worried about a childs academic progress. It is not the responsibility of pediatrician to make a diagnosis, referring children for a diagnostic evaluation of LD is a reasonable first step. Pediatricians can make early referral of suspicious children by asking some serial short questions about basic and processing skills. With a basic knowledge about the clinical characteristics, diagnostic and therapeutic procedures of LD, pediatricians also can provide primary counseling and education for parents at their outpatient clinical settings.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제24권1호
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• pp.177-193
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• 2010

본 연구는 고등학교 통계 영역의 확률분포에 제시되어 있는 정규분포를 이항분포에서 정규분포로의 근사, 정규분포곡선의 탐구, Monte Carlo 방법에 의한 정규분포곡선의 넓이 탐구, 정규분포곡선의 선형변환, 그리고 여러 형태의 정규분포곡선 탐구 등의 내용을 중심으로 CAS 계산기를 활용하여 탐구해보고자 한다. CAS 계산기의 도구적 기능인 사소화, 실험, 시각화, 집중의 측면에서 볼 때 지필로서는 교육과정에 제시된 확률분포의 목표를 달성하기 불가능하다고 판단된다. 따라서 본 연구에서는 CAS 계산기를 활용하여 정규분포곡선의 다양한 성질을 탐구하고 이러한 과정과 결과로부터 정규분포곡선에 대한 교수학적 시사점을 도출하고자 한다.

• International Journal of Contents
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• 제15권1호
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• pp.39-51
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• 2019

Spontaneous speech provides rich information defining the linguistic characteristics of individuals. As such, computational analysis of speech would enhance the efficiency involved in evaluating patients' speech. This study aims to provide a method to differentiate the persons with and without aphasia based on language usage. Ten aphasic patients and their counterpart normal controls participated, and they were all tasked to describe a set of given words. Their utterances were linguistically processed and compared to each other. Computational analyses from PCA (Principle Component Analysis) to machine learning were conducted to select the relevant linguistic features, and consequently to classify the two groups based on the features selected. It was found that functional words, not content words, were the main differentiator of the two groups. The most viable discriminators were demonstratives, function words, sentence final endings, and postpositions. The machine learning classification model was found to be quite accurate (90%), and to impressively be stable. This study is noteworthy as it is the first attempt that uses computational analysis to characterize the word usage patterns in Korean aphasic patients, thereby discriminating from the normal group.

• 한국수학교육학회지시리즈D:수학교육연구
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• 제25권4호
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• pp.267-284
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• 2022

In response to the current educational situation of students' heavy workload, the author constructs the precision-targeted classroom based on Precision Teaching (PT), Network Pharmacology, and Treatment Based on Syndrome Differentiation. The precision-targeted classroom can solve the current problems of PT and the phenomenon of the heavy academic burden on students, achieve the reduction of the burden and increase the efficiency of education. The precision-targeted classroom includes five key points: targeted goals, childlike thinking, precise intervention, intelligent homework, and stereoscopic evaluation, and the implementation process of the precision-targeted classroom is built from three aspects: before, during and after class. In addition, the author applied it to the actual mathematics classroom to test its teaching effect, and the experimental results showed that: the precision-targeted classroom significantly improved students' academic performance and thinking level; considerably improved students' classroom learning status, and facilitated teaching personalization and realized homework quantity control and quality improvement.

• 한국정보통신학회논문지
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• 제26권1호
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• pp.30-40
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• 2022

심전도 신호는 개인에 따라 형태와 특징이 다양하므로, 하나의 신경망으로는 분류하기가 어렵다. 주어진 데이터를 직접적으로 분류하는 것은 어려우나, 대응되는 정상 데이터가 있을 경우, 이를 비교하여 정상 및 비정상을 분류하는 것은 상대적으로 쉽고 정확하다. 본 논문에서는 템플릿 군을 이용하여 대표정상심박 정보를 획득하고, 이를 입력 심박에 결합함으로써 심박을 분류한다. 결합된 심박을 영상화한 후, 학습 및 분류를 진행하여, 하나의 신경망으로도 다양한 레코드의 비정상심박을 검출이 가능하였다. 특히, GoogLeNet, ResNet, DarkNet 등 다양한 신경망에 대해서도 비교학습 기법을 적용한 결과, 모두 우수한 검출성능을 가졌으며, GoogLeNet의 경우 99.72%의 민감도로, 실험에 사용된 신경망 중 가장 우수한 성능을 가졌음을 확인하였다.

• 한국인터넷방송통신학회논문지
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• 제22권4호
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• pp.157-163
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• 2022

최근 산업 분야 자동화의 발전에 따라 이상 징후 검출에 대한 연구가 활발하게 진행 중이다. 공장 자동화에 사용되는 이상 징후 검출의 응용분야로 카메라를 사용한 결함 검사가 있다. 비전 카메라 검사는 공장 자동화에서 높은 성능과 효율성을 보이지만, 조명과 환경조건의 불안정성을 극복하기가 어렵다. 딥러닝을 이용한 카메라 검사가 훨씬 더 높은 성능을 보이면서 비전 카메라 검사의 문제를 해결할 수 있지만 학습을 위해 엄청난 양의 정상 데이터 및 비정상 데이터를 요구하기 때문에 실제 산업 분야에 적용하기가 어렵다. 따라서 본 연구는 정상 데이터만을 사용한 72개의 기하학적 변환 딥러닝 방법으로 비정상 데이터 수집 문제를 극복하고, 성능 개선을 위한 특이치 노출 방법을 추가한 네트워크를 제안한다. 이를 자동차 부품 데이터 및 이상치 검출용 데이터베이스인 MVTec 데이터 셋에 적용하고 검증함에 의해 실제 산업 현장에서 적용할 수 있음을 보인다.

• 한국초지조사료학회지
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• 제43권3호
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• pp.190-198
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• 2023

This study was conducted to calculate the damage of Italian ryegrass (IRG) by abnormal climate using machine learning and present the damage through the map. The IRG data collected 1,384. The climate data was collected from the Korea Meteorological Administration Meteorological data open portal.The machine learning model called xDeepFM was used to detect IRG damage. The damage was calculated using climate data from the Automated Synoptic Observing System (95 sites) by machine learning. The calculation of damage was the difference between the Dry matter yield (DMY)_normal and DMY_abnormal. The normal climate was set as the 40-year of climate data according to the year of IRG data (1986~2020). The level of abnormal climate was set as a multiple of the standard deviation applying the World Meteorological Organization (WMO) standard. The DMY_normal was ranged from 5,678 to 15,188 kg/ha. The damage of IRG differed according to region and level of abnormal climate with abnormal temperature, precipitation, and wind speed from -1,380 to 1,176, -3 to 2,465, and -830 to 962 kg/ha, respectively. The maximum damage was 1,176 kg/ha when the abnormal temperature was -2 level (+1.04℃), 2,465 kg/ha when the abnormal precipitation was all level and 962 kg/ha when the abnormal wind speed was -2 level (+1.60 ㎧). The damage calculated through the WMO method was presented as an map using QGIS. There was some blank area because there was no climate data. In order to calculate the damage of blank area, it would be possible to use the automatic weather system (AWS), which provides data from more sites than the automated synoptic observing system (ASOS).

• 한국수학교육학회지시리즈D:수학교육연구
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• 제12권1호
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• pp.67-83
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• 2008

Promoting students' mathematics understanding is an important research theme in mathematics education. According to general theories of learning, mathematics understanding is close to active learning or significant learning. Thus, if a teacher wants to promote his/her students' mathematics understanding, he/she should pay attention to the students so that the students' thinking is in active situation. In the first part of this paper, some mathematics teachers' ideas about paying attention to their students in Chinese high school are given by questionnaire and interview. In the second part of this paper, we give some teaching episodes about how experienced mathematics teachers promote their students' mathematics understanding based on paying attention on them.