• Journal of Korean Medicine Rehabilitation
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• v.32 no.2
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• pp.19-36
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• 2022

Objectives This study is to investigate the effects and mechanisms of Imyo-san (IMS) on the obese mice model induced by high-fat diet. Methods Antioxidative capacity was measured by in vitro method. C57BL/6 mice were randomly assigned into 5 groups (n=7). Normal group was fed general diet (Normal). The other 4 groups were fed high fat diet (HFD) with water (Control), with Garcinia gummi-gutta (GG, Garcinia gummi-gutta 200 mg/kg), with low-dose IMS (IMSL, Imyo-san 0.54 g/kg) and with high-dose IMS (IMSH, Imyo-san 1.08 g/kg). Results IMS showed high radical scavenging activity. After 6 week experiment, body weight, food intake, food efficiency ratio (FER), epididymal fat and liver weight, triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol, sterol regulatory element-binding protein-1 (SREBP-1), phospho-acetyl-CoA carboxylase (p-ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1), SREBP-2, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), phospho-liver kinase B1 (p-LKB1), phospho-AMP-activated protein kinase (p-AMPK), peroxisome proliferator-activated receptor 𝛼 (PPAR𝛼), peroxisome proliferator-activated receptor 𝛾 coactivator-1𝛼 (PGC-1𝛼), uncoupling protein-2 (UCP-2), carnitine palmitoyltransferase 1A (CPT-1A), and histology of liver and epididymal fat were measured and analysed. Body weight gain, FER, liver and epididymal fat weight of IMS groups were significantly decreased. There were significant improvements in blood lipids with less TG, TC, LDL-cholesterol, VLDL-cholesterol and more HDL-cholesterol. Proteins associated with lipid synthesis (SREBP-1, p-ACC, FAS, SCD-1) and cholesterol (SREBP-2, HMGCR) was improved. Factors regulating lipid synthesis and lipid catabolism (p-LKBI, p-AMPK, PPARα, PGC-1α, UCP-2, CPT-1A) were increased. In histological examinations, IMS group had smaller fat droplets than control group. All results increased depending on concentration. Conclusions It can be suggested that IMS has anti-obesity effects with improving lipid metabolism.

• Journal of the Korean Geosynthetics Society
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• v.22 no.2
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• pp.1-12
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• 2023

Research on the causes of landslides and prediction of vulnerable areas is being conducted globally. This study aims to predict the effective soil depth, a critical element in analyzing and forecasting landslide disasters, using topographic information. Topographic data from various institutions were collected and assigned as attribute information to a 100 m × 100 m grid, which was then reduced through data grading. The study predicted effective soil depth for two cases: three depths (shallow, normal, deep) and five depths (very shallow, shallow, normal, deep, very deep). Three classification models, including K-Nearest Neighbor, Random Forest, and Deep Artificial Neural Network, were used, and their performance was evaluated by calculating accuracy, precision, recall, and F1-score. Results showed that the performance was in the high 50% to early 70% range, with the accuracy of the three classification criteria being about 5% higher than the five criteria. Although the grading criteria and classification model's performance presented in this study are still insufficient, the application of the classification model is possible in predicting the effective soil depth. This study suggests the possibility of predicting more reliable values than the current effective soil depth, which assumes a large area uniformly.

• The Korea Journal of Herbology
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• v.37 no.2
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• pp.1-11
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• 2022

Objectives : Although the anti-obesity effect of Schizandrae Fructus water extract has been demonstrated, its underlying mechanism is still unclear. Therefore, we aimed to evaluate the anti-obesity effect of Schizandrae Fructus water extract through the p-AMP-activated protein kinase (p-AMPK), sirtuin1 (Sirt1), and peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling in 60% high-fat diet (HFD)-induced obese mouse model. Methods : Male C57BL/6 mice were divided into four groups. The Normal group was fed a normal diet and the obese groups were fed 60% HFD. Except for the Control group, the GG group was supplemented with 0.5% Garcinia gummigutta and the SCW group was supplemented with 0.5% Schizandrae Fructus water extract. After 6 weeks, obesity-related biomarkers in serum were measured and the expressions of protein for lipid-related factors in liver tissue were analyzed by western blot. Results : Treatment with SCW significantly down-regulated body weight compared to the Control group. SCW down-regulated levels of triglyceride and total cholesterol in serum and significantly increased p-AMPK, Sirt1, and PGC-1α in liver tissue. In addition, the expressions of fatty acid oxidation-related proteins such as peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase 1A (CPT-1A), uncoupling protein 1 (UCP1), and uncoupling protein 3 (UCP3) were significantly up-regulated. However, fatty acid synthesis-related proteins including sterol regulatory element-binding protein-1 (SREBP-1), phospho-Acetyl-CoA Carboxylase (p-ACC), and fatty acid synthase (FAS) were significantly down-regulated. Conclusions : Taken together, SCW treatment showed anti-obesity effect by regulating both fatty acid oxidation-related and fatty acid synthesis-related proteins through AMPK/Sirt1/PGC-1α signaling in 60% HFD-induced obese mice.

• Progress in Medical Physics
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• v.25 no.3
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• pp.176-184
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• 2014

In this study, we compared dose distributions from simultaneously integrated boost (SIB) method versus the RTOG 0631 protocol for spine radiosurgery. Spine radiosurgery plans were performed in five patients with localized spinal metastases from hepatocellular carcinoma. The computed tomography (CT) and T1- and T2-weighted magnetic resonance imaging (MRI) were fused for delineating of GTV and spinal cord. In SIB plan, the clinical target volume (CTV1) was included the whole compartments of the involved spine, while RTOG 0631 protocol defines the CTV2 as the involved vertebral body and both left and right pedicles. The CTV2 includes transverse process and posterior element according to the extent of GTV. The doses were prescribed 18 Gy to GTV and 10 Gy to CTV1 in SIB plan, while the prescription of RTOG 0631 protocol was applied 18 Gy to CTV2. The results of dose-volume histogram (DVH) showed that there were competitive in target coverage, while the doses of spinal cord and other normal organs were lower in SIB method than in RTOG 0631 protocol. The 85% irradiated volume of VB in RTOG 0631 protocol was similar to that in the SIB plan. However, the dose to normal organs in RTOG 0631 had a tendency to higher than that in SIB plan. The SIB plan might be an alternative method in case of predictive serious complications of surrounded normal organs. In conclusion, although both approaches of SIB or RTOG 0631 showed competitive planning results, tumor control probability (TCP) and normal tissue complication probability (NTCP) through diverse clinical researches should be analyzed in the future.

• The Journal of the Korean Society for Microbiology
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• v.20 no.1
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• pp.65-72
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• 1985

Vitamin C is known as an integral element for the formation and maintenance of intercellular supporting structures. Ascorbic acid has been used for the treatment of certain poisonings and hypovitaminosis(scurvy) but also known as a powerful reducing agent, and can kill a variety of bacteria and detoxify bacterial exotoxins including various clostridial exotoxins in vitro. For viruses, vitamin C inactivates herpes virus, vaccinia virus and influenza virus and has been used for the prevention and treatment of the common cold. Thus ascorbic acid plays an important role in antimicrobial action. Scurvy also promotes the development of tubercles in experimentally infected guinea pig and the tuberculosis patients require more vitamin C than normal persons. However there is no reports that ascorbic acid could inhibit the growh of M. tuberculosis. In this paper, antibacterial effects of ascorbic acid against M. tuberculosis were studied. The results are as follows: 1. The single use of the ascorbic acid exhibited antibacterial effect in vitro against $5{\times}10^3/ml$ of M. tuberculosis $H_{37}$ Rv at the concentration of ascorbic acid 0.625mg/ml over 3 hours exposure and 0.05mg/ml over 9 hours exposure. 2. In vivo mice administered with ascorbic acid 50mg/day for 5, 10 and 15 days respectively were protected from M. tuberculosis $2LD_{50}$, $3LD_{50}$, $4LD_{50}$ and $5LD_{50}$ given intravenously.

• Journal of the Korea Computer Industry Society
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• v.9 no.1
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• pp.21-28
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• 2008

In this paper, the edge parameters were drawn from speaking image around lip and effective automatic lip reading system to recognize the Korean 'a/e/i/o/u' 5 owels were constructed using the parameter. Speaking images around lip were divided into $5{\times}5$ pane. In each pane the number of digital edge element using Sobel operator were evaluated. The observational error between samples was corrected by using normalization method and the normalized value is used for parameter In the experiment to convince the strength of parameter, 50 normal persons were sampled. The images of 10 persons were analyzed and the images of another 40 persons were experimented for recognition. 500 data are gathered and analyzed. Based on this analysis, the neural net system is constructed and the recognition experiments are performed for 400 data. The neural net system gave the best recognition result of 91.1%.

• Journal of the Korean Electrochemical Society
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• v.11 no.2
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• pp.115-119
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• 2008

Single particle of nickel hydroxide and the surface-treated one with cobalt element were performed to review the effect of LiOH additive in alkaline electrolyte for Ni-MH batteries using microelectrode test system. As a result of cyclic voltammetry, the electrochemical behaviors such as the oxidation/reduction and oxygen evolution reaction are clearly observed for a single particle of nickel hydroxide, respectively. Furthermore, the reduction current peak of nickel hydroxide added with LiOH in electrolyte was very low and broad compared with the normal nickel hydroxide without an additive LiOH, which had a bad effect to the crystallization structure of nickel hydroxide. However, it was found that capacity and cycle properties of the nickel hydroxide treated with cobalt greatly increased by the addition of LiOH.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.680-689
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• 2011

A dynamic analysis procedure is developed to provide a comprehensive estimation of the dynamic response spectrum for locomotive's wheels running over a Pre-Stressed Concrete (PSC) box girder bridge on the Korea high speed railway. The wheel force spectrum with the bridge behavior are analyzed as the dynamic procedure for various running speeds (50~450km/h). The high-speed railway locomotive (KTX) is used as 38-degree of freedom system. Three displacements(vertical, lateral, and longitudinal) and three rotational components (pitching, rolling, and yawing). For one car-body and two bogies as well as five movements except pitching rotation components for four wheel axes forces are considered in the 38-degree of freedom model. Three dimensional frame element is used to model of the PSC box girder bridges, simply supported span length of 40m. The irregulation of rail-way is derived using the exponential spectrum density function under assumption of twelve level tracks conditions based on the normal probability procedure. The dynamic responses of bridge passing through the railway locomotive with high-speed analyzed by Newmark-${\beta}$ method and Runge-Kutta method are compared and contrasted considering the developed models of bridge, track and locomotive comprehensively. The dynamic analyses of wheel forces by Runge-Kutta method which are able to analyze the forces with high frequency running on the bridge and ground rail-way are conducted. Additionally, wheel forces spectrum and three rotational components of vehicle body for three typical running speeds is also presented.

• Smart Structures and Systems
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• v.9 no.3
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• pp.287-301
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• 2012

It is well known that overloaded vehicles may cause severe damages to bridges, and how to estimate and evaluate the status of the overloaded vehicles passing through bridges become a challenging problem. Therefore, based on the monitored strain data from a structural health monitoring system (SHM) installed on a bridge, a method is recommended to identify and analyze the probability of overloaded vehicles. Overloaded vehicle loads can cause abnormity in the monitored strains, though the abnormal strains may be small in a concrete continuous rigid frame bridge. Firstly, the abnormal strains are identified from the abundant strains in time sequence by taking the advantage of wavelet transform in abnormal signal identification; secondly, the abnormal strains induced by heavy vehicles are picked up by the comparison between the identified abnormal strains and the strain threshold gotten by finite element analysis of the normal heavy vehicle; finally, according to the determined abnormal strains induced by overloaded vehicles, the statistics of the overloaded vehicles passing through the bridge are summarized and the whole probability of the overloaded vehicles is analyzed. The research shows the feasibility of using the monitored strains from a long-term SHM to identify the information of overloaded vehicles passing through a bridge, which can help the traffic department to master the heavy truck information and do the damage analysis of bridges further.

• Journal of the Korean Society of Clothing and Textiles
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• v.38 no.6
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• pp.887-895
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• 2014

The study provides baseline data on developing ready-to-wear clothes for adult females in their twenties who have finished shaping their bodies and have realized an ideal shape. We analyzed the data from females aged from 20 to 29 in "The $5^{th}$ Size Korea Survey" and "The $6^{th}$ Size Korea Survey", and sorted body shapes into several types according to drop values before analyzing and comparing the characteristics among groups. We also referred to the change by year in the size of upper inner wear. To classify body shapes, three drop values were assigned for bust girth - waist girth, hip girth - waist girth, hip girth - bust girth; through cluster analysis all data were classified into three body types. Type 1 is more like normal body shapes with small drop values at the bust girth - waist girth and well-build lower body. Type 2 is X-shaped body shaped like a fiddle with big drop values at all parts. Type 3 is Y-shaped body with a big drop value at the bust girth - waist girth and well-build upper body. Type 2, X-shaped body, has the majority of distribution in every year, which proved to be the most idealistic body shape. There was a change in the brassiere cup size. Korean ladies in their twenties have larger breasts. The body shapes of Korean females in their twenties are increasingly like those of westerners. Bust girth is a very critical element to set measurements and design patterns for upper wear; consequently, a change in the size of breasts should be considered.