• Korean Journal of Environment and Ecology
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• v.22 no.3
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• pp.241-248
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• 2008

We studied concentrations of trace elements such as iron, zinc, copper, lead and cadmium in three shorebird species from Saemankeum mudflat, Korea$(1999{\sim}2000)$, and also analysed correlations between elements in livers. Iron(ANOVA, p=0.018), copper(ANOVA, p=0.043), lead(ANOVA, p=<0.001) and cadmium (ANOVA, p=0.016) concentrations significantly differed among shorebird species, but zinc concentrations wasn't different among species. We suggested that iron, zinc, and copper concentrations were within a range for normal and are maintained by normal homeostatic mechanisms for wild birds. Lead concentrations in Great Knots Calidris tenuirostris$(5.76{\pm}2.14{\mu}g/dry\;g)$ were at the background level but Red-necked Stints Calidris ruficollis$(29.4{\pm}10.6{\mu}g/dry\;g)$ and Terek Sandpipers Xenus sinereus$(15.9{\pm}11.9{\mu}g/dry\;g)$ were within the exposed level for wild birds. In particular, Red-necked Stints were nearly poisoned level. Cadmium concentrations in Terek Sandpipers and Great Knots were at the background concentration, but Red-necked Stints were greater than the poisoned level$(3{\mu}g/dry\;g)$. We found significantly correlations between lead and cadmium concentrations, but other elements didn't find.

• Journal of the Korea Concrete Institute
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• v.19 no.4
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• pp.449-456
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• 2007

This research was conducted to analyze the features of the critical tensile stresses at the top and bottom of the concrete slab in the jointed concrete pavement (JCP) when subjected to both the environmental and vehicle loads. First, the stress distribution in JCP was analyzed when the system was subjected to only the environmental loads or the vehicle loads by using the finite element model of JCP. Then, the stresses were analyzed when the system was subjected to the environmental and vehicle loads at the same time. From this study, it was found that the critical tensile stresses at the slab bottom under the vehicle loads were almost constant regardless of the loading positions once the loads were applied at the positions having some distance from the transverse joint. The critical tensile stresses at the slab bottom could be obtained using the model consisting of normal springs for underlying layers by adding the critical stresses due to the environmental loads and the vehicle loads for the curled-down slab, and by subtracting the critical stress due to the environmental loads from that due to the vehicle loads for the curled-up slab. The critical tensile stresses at the top of the slab could be obtained using the model consisting of tensionless springs for underlying layers by adding the critical stress due to the environmental loads and the stress at the middle of the slab under the vehicle loads applied at the joint for the curled-up slab. An alternative to obtain the critical stresses at the top of the slab for the curled-up slab was to use the critical stresses under only the environmental loads obtained from the model having normal springs for underlying layers.

• Toxicological Research
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• v.21 no.4
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• pp.347-353
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• 2005

Eukaryotic initiation factor 4E (elF4E) is a key element for cap-dependent protein translation controlled by affinity between elF4E and 4E-binding protein 1 (4E-BP1). Rapamycin can also affect protein translation by regulating 4E-BP1 phosphorylation. Tobacco-specific nitrosamine, 4(N-methyl-N-nitrosamino )-1-(3-pyridyl)-1-butanone (NNK) is a strong lung carcinogen, but its precise lung cancer induction mechanism remains unknown. Relative roles of cap-dependent and -independent protein translation in terms of NNK-induced lung carcinogenesis were elucidated using normal human bronchial epithelial cells. NNK concentrations applied in this study did not decrease cell viability. Addition of NNK restored rapamycin-induced decrease of protein synthesis and rapamycin-induced phosphorylation of 4E-BP1, and increased expression levels of mTOR, ERK1/2, p70S6K, and Raf-1 in a concentration-dependent manner. NNK also caused perturbation of normal cell cycle progression. Taken together, NNK might cause toxicity through the combination of restoration of 4E-BP1 phosphorylation and increase of elF4E as well as mTOR protein expression, interruption of Raf1/ERK as well as the cyclin G-associated p53 network. Our data could be applied towards elucidation of the molecular basis for lung cancer treatment.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.15 no.3
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• pp.103-119
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• 2020

This study aimed to derive theoretical and practical implications by analyzing the relationship between adversity quotient, entrepreneurial orientation, and customer orientation, which are the internal competency of start-up entrepreneurs affecting the performance of a small business CEO. As in previous domestic studies, we deviated from analyzing internal competency as a single-dimensional functional relationship to business performance, and attempted to explain the relationship between the internal competences of start-up entrepreneurs. Empirical analysis was conducted by setting the adversity quotient as an independent variable, the entrepreneurial orientation as a parameter, and the customer orientation as a dependent variable. As a result of the analysis, first, it was found that control and ownership, which are sub-elements of adversity quotient, have a positive effect on entrepreneurial orientation and customer orientation. Second, entrepreneurial orientation was found to have a positive effect on customer orientation. Third, it was found that only the ownership of the adversity quotient had a positive effect on customer orientation through the mediating effect of entrepreneurial orientation. In other words, it was found that the entrepreneur's ownership influences customer orientation through entrepreneurial orientation. On the other hand, endurance, sub-element of adversity quotient, was found to have no significant effect on entrepreneurial orientation and customer orientation. This means that in the rapidly changing New Normal era, endurance of entrepreneur can no longer have a large impact on entrepreneurial orientation and customer orientation. This study gives implications for the entrepreneur's competencies that must be developed first and the tendency to be developed together. Furthermore, it can be helpful in policy designing start-up support programs and guidelines for investors' investment standards.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.2
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• pp.169-177
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• 2017

In this paper, classification of spall and crack faults of gear teeth is studied by applying the ensemble empirical mode decomposition(EEMD) for the gear transmission error(TE). Finite element models of the gears with the two faults are built, and TE is obtained by simulation of the gears under loaded contact. EEMD is applied to the residuals of the TE which are the difference between the normal and faulty signal. From the result, the difference of spall and crack faults are clearly identified by the intrinsic mode functions(IMF). A simple test bed is installed to illustrate the approach, which consists of motor, brake and a pair of spur gears. Two gears are employed to obtain the TE for the normal, spalled, and cracked gears, and the type of the faults are separated by the same EEMD application process. In order to quantify the results, crest factors are applied to each IMF. Characteristics of spall and crack are well represented by the crest factors of the first and the third IMF, which are used as the feature signals. The classification is carried out using the Bayes decision theory using the feature signals acquired through the experiments.

• Korean Journal of Plant Tissue Culture
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• v.26 no.2
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• pp.127-132
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• 1999

Protoplasts were isolated from the leaf mesophyll tissue of in vitro 4-weeks-old Arabidopsis thaliana and cultured in MS liquid medium supplemented with 2.0 mg/L NAA, 0.5 mg/L BAP and 9% mannitol in the dark at $25^{\circ}C$. When protoplast-derived microcolonies were dehydrated, the frequency of callus induction enhanced approximately 7-fold higher compared with non-dehydrated microcolonies in CP medium. Fifty callus lines were selected from dehydrated microcolonies. Shoots were efficiently initiated from the green spots of the selected shoot forming calli cultured on MS regeneration medium supplemented with 0.05 mg/L IAA, 7.0 mg/L 2-iP and 30 g/L sucrose under continous illumination for 4 weeks. Shoot regeneration frequencies (calli regenerating at least one shoot) were 3.5%~56%. Histological observations of shoot forming callus revealed that tracheary elements initiated from inner compact cells, and that meristemoids developed to shoot primordia and shoots. Roots were induced from these regenerating shoots on MS medium without phytohormones. These regenerants were successfully transplanted into potting soil. Morphological characterization of 50 protoplast-derived plants showed that the frequency of normal type was 78%.

• Journal of the Korean Institute of Gas
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• v.11 no.4
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• pp.79-84
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• 2007

In this paper, the finite element analysis of a valve screw for a LPG cylinder has been presented on the leakage safety and strength one, which are computed and investigated by a contact normal stress and von Mises stress between a female screw of a valve and a male screw of a neck ring in a LPG bombe. The LP gas charging pressure of a LPG bombe is $8{\sim}9kg/cm^2$, which is pressurized to the screw sealing contact areas between a valve and a LP gas cylinder. The peak failures of the screw tooth height due to a scratch wear and chipping loss of the contact area may decrease screw tooth strength and increase a leakage of a LP gas. These are strongly affect to the contact normal and von Mises stresses of the valve screws. The FEM computed results show that the tooth height loss due to a wear and chipping failure of the screw peak does not affect to the LP gas leak and strength of a valve screw theoretically. But if the tooth wear of the screw height of a brass valve overpasses the critical strength safety of the valve, the valve screw may be failed in fastening the valve and a LP gas bombe suddenly.

• The Journal of the Petrological Society of Korea
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• v.6 no.1
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• pp.1-18
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• 1997

Andesitic pyroclastics and lava flows are deposited as a part of composite volcanoes by Cretaceous volcanic activity in Geojae Island, off the coast of Korea. The andesitic pyroclastics are composed of tuff breccia and lapilli tuff minor intercalated tuff. Lava flows are divided into dense and porphyritic andesite containing phenocrysts of plagioclase, pyroxene, and/or hornblende. The andesitic rocks represent charactersitcs of carc-alkaline BAR association with basalt, basaltic andesite, andesite, and dacite to rhyolite. Major element variations of the volcanic rocks show that $Al_2O_3$, total FeO, CaO, MgO and $TiO_2$ decrease with increasing $SiO_2$ but $K_2O$ and total alkalis increase, and represent differntiation trend of calc-alkaline rock series. In spider diagram, contents of Sr, K, Rb, Ba, and Th are relatively high, but contents of Nb, P, Ti and Cr are low. These petrochemcial characteristics are similar to those of rocks from island arc or continental margein related to plate subduction. Chondrite-normalized REE patterns of volcanic rocks are paralle to subparallel, with LREE enriched than HREE, and show gradual increase of negative Eu anomaly from basalt to dacite and rhyolite, suggesting comagmatic fractional crystallization with minor effects of assimilation and magma mixing. Andesitic rocks are assumed medium-K orogenic andesites that formed in the tectomagmatic environment of subduction zone under normal continental margin arc.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.3
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• pp.105-113
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• 2010

This study is for the preservation plan of the tradition space which is performed by the damage status analysis through performing the value assessment. Especially, it is an experimental study for finding the process and methods by analyzing the major element for the value assessment of the selected object's damage status through the expert group who are systematized in their interest to conserve the traditional structure in traditional space. For that purpose, this study should be performed by the fundamental understanding of the physical property of the Supyo-bridge and the condition of the selected site's environment. Meanwhile, this study has been done that 'map of the damage status distribution' for making records of damage status of the Supyo-bridge on the property utilized field measurement adapted by photogrammetry and assessment guidelines, which are for investigation on damage status of objects that are standardized 'Raccomandazioni Normal' which could be said construction culture assets management guidelines of Italian government. As the result of investigation, damage status of each part in the Supyo-bridge was mostly composed of damage by sediment and corrosion and in case of 9 damage types including corrosion, in consideration of physical and chemical properties and distribution status of those elements, it is made an judgement that is not working as a threatened factor regarding security of the Supyo-bridge. On the contrary, for the improvement landscape, in case of 'Thermoclastism' phenomenon observed in 'upper floor', 'Myungae stone' and 'bridge pier' is that when taking it into consideration that is widely distributed concentrated on the bridge pier, surface reinforcement job along with elimination of damage part will be judged to be requested for earliest treatment.

• Molecules and Cells
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• v.40 no.5
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• pp.346-354
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• 2017

Long interspersed nuclear element-1 (LINE-1) is a retrotransposon that contains a CpG island in its 5'-untranslated region. The CpG island of LINE-1 is often heavily methylated in normal somatic cells, which is associated with poor prognosis in various cancers. DNA methylation can differ between formalin-fixed paraffin-embedded (FFPE) and frozen tissues. Therefore, this study aimed to compare the LINE-1 methylation status between the two tissue-storage conditions in gastric cancer (GC) clinical samples and to evaluate whether LINE-1 can be used as an independent prognostic marker for each tissue-storage type. We analyzed four CpG sites of LINE-1 and examined the methylation levels at these sites in 25 FFPE and 41 frozen GC tissues by quantitative bisulfite pyrosequencing. The LINE-1 methylation status was significantly different between the FFPE and frozen GC tissues (p < 0.001). We further analyzed the clinicopathological features in the two groups separately. In the frozen GC tissues, LINE-1 was significantly hypomethylated in GC tissues compared to their corresponding normal gastric mucosa tissues (p < 0.001), and its methylation status was associated with gender, differentiation state, and lymphatic and venous invasion of GC. In the FFPE GC tissues, the methylation levels of LINE-1 differed according to tumor location and venous invasion of GC. In conclusion, LINE-1 can be used as a useful methylation marker for venous invasion in both FFPE and frozen tumor tissues of GC.