• The Journal of Korean Medicine
• /
• v.37 no.1
• /
• pp.77-89
• /
• 2016

Objectives: The present study was conducted to examine whether Haedoksamul-tang (HS), a traditional oriental herbal medicine, have beneficail effects on anti-inflammation and dyslipidemia in lipopolysaccharide (LPS)-induced ICR mouse. Methods: Twenty four 8-week old male ICR mouse were divided into four groups: normal untreated; LPS treatment only; HS 10 mg/kg plus LPS treatment; and HS 30 mg/kg plus LPS treatment. HS was orally administered per day for 2days. Twenty-four hours after LPS injection (10 mg/kg/day, i.p.), all the mice were sacrificed, and serological changes were evaluated. The levels of nuclear factor-${\kappa}B$ (NF-${\kappa}B$), sterol regulatory element-binding transcription protein 1 (SREBP-1) activity and cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor a (TNF-a), monocyte chemotactic protein 1 (MCP-1), acetyl-CoA carboxylase a (ACCa) expression were analyzed in Western blot analysis. Results: HS inhibited oxidative stress in the liver of LPS-induced ICR mice. The LPS-induced ICR mice exhibited the increase of NF-${\kappa}B$ activity and COX-2, iNOS, TNF-a, MCP-1 expressions in the liver, while HS treatment significantly inhibited them. Moreover, The administration of HS significantly decreased the elevated serum triglyceride and down-regulated the levels of SREBP-1, ACCa in the liver of LPS-induced ICR mice. Conclusions: In conclusion, HS could have hepato-protective effects against the oxidative stress-related inflammation and abnormal lipid metabolism.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.41 no.8
• /
• pp.665-672
• /
• 2013

One of the major causes of stiffness and strength degradations in laminated composite structures is the delamination between composite layers. In most engineering applications, laminated composite structures have certain curvatures. If the curved composite structure is subjected to bending that tends to flatten the composite structures, through the thickness stresses can be generated in the thickness direction of the composites. Under normal operation open mode delamination could occur at the sites of peak interlaminar stress. This paper describes a technique to determine radial direction stress of a laminated composite structure using a curved beam. Stacking sequence effects of interlaminar stress were studied. The radial location and intensity of the open mode delamination stress were calculated and compared with the results obtained from the analytical solution and finite element method.

• Korean Institute of Interior Design Journal
• /
• v.24 no.6
• /
• pp.145-153
• /
• 2015

For this research with the objects of spaces in two department stores which can be referred to as representative facility of commercial space, observation test has carried out to estimate how much visitors rivet their eyes to the display of shops. In addition, to find out what effect the difference among the department types has on the selective attention to space element, the observation time was applied as a medium for estimation. The followings are the result from analyzing the observation frequency and the observation intensity feature of each section where the characteristics of design could be found at attention. First, both images of A and B had concentrative dominant-observation at left shops. In case of Image A, Customers began to observe the right shops very attentively after 25 seconds, and with Image B, the attentive observation at right and left took place alternatively after 35 seconds. In other words, regardless of the characteristics of shop displays, the left shops were observed first while in case of the observation after the early and middle time-frame the characteristics of shops were found to have effects on observation. Second, the normal observation showed some difference among attention sections over time while on the whole both images of A and B had the same highly attentive observation at the middle space. Accordingly, it could be concluded that the middle space was playing a faithful role as background for commercial spaces. Third, the ignorant observation, which is the opposite to the attentive observation, was found different between the images of A and B. When the ignorant observation is considered to have intentionality, it will be possible to set up the display which may attract the attention aggressively by the process of figuring out the characteristics of ignored shops.

• Journal of the Korean Society for Precision Engineering
• /
• v.29 no.5
• /
• pp.584-590
• /
• 2012

The structural and functional disorder of a detrusor induces a bladder hypertrophy and degenerates a bladder muscle gradually by preventing normal urination. Thus, the thickness of the bladder wall has been increased in proportion to the degree of bladder outlet obstruction. In this study, the mechanical characteristics of the detrusor is analyzed for the physical properties and the thickness changes of the bladder muscle using a mathematically analytic method. In order to obtain the mechanical property of the bladder muscle, the tensile test of porcine bladder tissue is performed because its property is similar to that of human. The result of tensile test is applied to the mathematically model as Mooney Rivlin coefficients which represent the hyperelastic material. The model of the bladder is defined as the spherical shape with the initial volume of 50ml. The principal stress and strain according to the thickness are analyzed. Also, computer simulations for three types of the material property for the model of the bladder are performed based on the fact that the stiffness of the bladder is weakened as the progress of the benign prostatic hyperplasia. As a result, the principal stress is 341kPa at the initial thickness of 2.2mm, and is 249kPa at 6.5mm. As the bladder wall thickness increases, the principal stress decreases. The principal stress and strain decrease as the stiffness of the bladder decreases under the same thinkness.

• Earthquakes and Structures
• /
• v.9 no.4
• /
• pp.831-849
• /
• 2015

Seismic-design procedures for walls require that the confinement in the critical (plastic hinge) regions should extend over a length in the compression zone of the cross section at the wall base where concrete strains in the Ultimate Limit State (ULS) exceed the limit of 0.0035. In a performance-based framework, confinement is linked to required curvature ductility so that the drift demand at the performance point of the structure for the design earthquake may be met. However, performance of flexural walls in the recent earthquakes in Chile (2010) and Christchurch (2011) indicates that the actual compression strains in the critical regions of many structural walls were higher than estimated, being responsible for several of the reported failures by toe crushing. In this study, the method of estimating the confined region and magnitude of compression strain demands in slender walls are revisited. The objective is to account for a newly identified kinematic interaction between the normal strains that arise in the compression zone, and the lumped rotations that occur at the other end of the wall base due to penetration of bar tension yielding into the supporting anchorage. Design charts estimating the amount of yield penetration in terms of the resulting lumped rotation at the wall base are used to quantify the increased demands for compression strain in the critical section. The estimated strain increase may exceed by more than 30% the base value estimated from the existing design expressions, which explains the frequently reported occurrence of toe crushing even in well confined slender walls under high drift demands. Example cases are included in the presentation to illustrate the behavioral parametric trends and implications in seismic design of walls.

• International Journal of Automotive Technology
• /
• v.7 no.5
• /
• pp.571-577
• /
• 2006

This paper deals with dynamic tensile characteristics for the polypropylene used in an IP(Instrument Panel). The polypropylene is adopted in the dash board of a car, especially PAB(Passenger Air Bag) module. Its dynamic tensile characteristics are important because the PAB module undergoes high speed deformation during the airbag expansion. Since the operating temperature of a car varies from $-40^{\circ}C$ to $90^{\circ}C$ according to the specification, the dynamic tensile tests are performed at a low temperature($-30^{\circ}C$), the room temperature($21^{\circ}C$) and a high temperature($85^{\circ}C$). The tensile tests are carried out at strain rates of six intervals ranged from 0.001/sec to 100/sec in order to obtain the strain rate sensitivity. The flow stress decreases at the high temperature while the strain rate sensitivity increases. Tensile tests of polymers are rather tricky since polymer does not elongate uniformly right after the onset of yielding unlike the conventional steel. A new method is suggested to obtain the stress-strain curve accurately. A true stress-strain curve was estimated from modification of the nominal stress-strain curves obtained from the experiment. The modification was carried out with the help of an optimization scheme accompanied with finite element analysis of the tensile test with a special specimen. The optimization method provided excellent true stress-strain curves by enforcing the load response coincident with the experimental result. The material properties obtained from this paper will be useful to simulate the airbag expansion at the normal and harsh operating conditions.

• Journal of Satellite, Information and Communications
• /
• v.8 no.4
• /
• pp.142-149
• /
• 2013

As we, human expand its everyday life boundary to the geosynchronous orbit, we have experienced frequent chance of the atmospheric re-entry and surface impact of space objects(satellite and space debris). Recently a satellite re-entry monitoring room in Korea has been operated to predict the time and the location of the re-entry of space objects. However, we do not have a domestic version of a numerical re-entry model for normal operation using TLE (Two line Element) information from the United States Strategic Command yet. The space information from the several space operation centers has been used to analyse the re-entry situations. In this paper, the re-entry time is calculated with TLE based on the several atmosphere models, the result is comprehensively analyzed, a new re-entry case model fitted from the result of the predicted satellite re-entry times by a new Rubber Sheet Shift Method used by the domestic satellite re-entry room is suggested.

• Journal of the Korean Mathematical Society
• /
• v.53 no.3
• /
• pp.709-723
• /
• 2016

Let C[0, t] denote a generalized Wiener space, the space of real-valued continuous functions on the interval [0, t] and define a random vector $Z_n:C[0,t]{\rightarrow}{\mathbb{R}}^n$ by $Zn(x)=(\int_{0}^{t_1}h(s)dx(s),{\cdots},\int_{0}^{t_n}h(s)dx(s))$, where 0 < $t_1$ < ${\cdots}$ < $t_n$ < t is a partition of [0, t] and $h{\in}L_2[0,t]$ with $h{\neq}0$ a.e. In this paper we will introduce a simple formula for a generalized conditional Wiener integral on C[0, t] with the conditioning function $Z_n$ and then evaluate the generalized analytic conditional Wiener and Feynman integrals of the cylinder function $F(x)=f(\int_{0}^{t}e(s)dx(s))$ for $x{\in}C[0,t]$, where $f{\in}L_p(\mathbb{R})(1{\leq}p{\leq}{\infty})$ and e is a unit element in $L_2[0,t]$. Finally we express the generalized analytic conditional Feynman integral of F as two kinds of limits of non-conditional generalized Wiener integrals of polygonal functions and of cylinder functions using a change of scale transformation for which a normal density is the kernel. The choice of a complete orthonormal subset of $L_2[0,t]$ used in the transformation is independent of e and the conditioning function $Z_n$ does not contain the present positions of the generalized Wiener paths.

• Earthquakes and Structures
• /
• v.8 no.5
• /
• pp.1255-1276
• /
• 2015

The importance of considering soil-structure interaction effect in the analysis and design of RC frame buildings is increasingly recognized but still not penetrated to the grass root level owing to various complexities involved. It is well established fact that the soil-structure interaction effect considerably influence the design of multi-storey buildings subjected to lateral seismic loads. The shear walls are often provided in such buildings to increase the lateral stability to resist seismic lateral loads. In the present work, the linear soil-structure analysis of a G+5 storey RC shear wall building frame resting on isolated column footings and supported by deformable soil is presented. The finite element modelling and analysis is carried out using ANSYS software under normal loads as well as under seismic loads. Various load combinations are considered as per IS-1893 (Part-1):2002. The interaction analysis is carried out with and without shear wall to investigate the effect of inclusion of shear wall on the total and differential settlements in the footings due to deformations in the soil mass. The frame and soil mass both are considered to behave in linear elastic manner. It is observed that the soil-structure interaction effect causes significant total and differential settlements in the footings. Maximum total settlement in footings occurs under vertical loads and inner footings settle more than outer footings creating a saucer shaped settlement profile of the footings. Each combination of seismic loads causes maximum differential settlement in one or more footings. Presence of shear wall decreases pulling/pushing effect of seismic forces on footings resulting in more stability to the structures.

• Journal of Microbiology and Biotechnology
• /
• v.25 no.12
• /
• pp.2116-2124
• /
• 2015

To understand the effects of physicochemical factors on nitrite transformation by microalgae, a lipid-rich Chlorella with high nitrite tolerance was cultured with 8 mmol/l sodium nitrite as sole nitrogen source under different conditions. The results showed that nitrite transformation was mainly dependent on the metabolic activities of algal cells rather than oxidation of nitrite by dissolved oxygen. Light intensity, temperature, pH, NaHCO₃ concentrations, and initial cell densities had significant effects on the rate of nitrite transformation. Single-factor experiments revealed that the optimum conditions for nitrite transformation were light intensity: 300 μmol/m²/s; temperature: 30℃ pH: 7-8; NaHCO₃ concentration: 2.0 g/l; and initial cell density: 0.15 g/l; and the highest nitrite transformation rate of 1.36 mmol/l/d was achieved. There was a positive correlation between nitrite transformation rate and the growth of Chlorella. The relationship between nitrite transformation rate (mg/l/d) and biomass productivity (g/l/d) could be described by the regression equation y = 61.3x (R² = 0.9665), meaning that 61.3 mg N element was assimilated by 1.0 g dry biomass on average, which indicated that the nitrite transformation is a process of consuming nitrite as nitrogen source by Chlorella. The results demonstrated that the Chlorella suspension was able to assimilate nitrite efficiently, which implied the feasibility of using flue gas for mass production of Chlorella without preliminary removal of NO_X.