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한국어판 부부 만족도 측정도구 및 단축형의 타당도와 신뢰도 (Validity and Reliability of the Korean Version of the Couple Satisfaction Index)

  • 김석선;길민지;김다은;김선해;허다연;문난영
    • 대한간호학회지
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    • 제52권2호
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    • pp.228-243
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    • 2022
  • Purpose: The study aimed to translate the Couple Satisfaction Index (CSI 32) into Korean, to evaluate the reliability and validity of CSI 32 and short-form (CSI 16, 4) in the Korean context, and to determine a cut-off score for Korean couples. Methods: Korean Versions of the Couple Satisfaction Index (K-CSI) 32 was translated, back-translated, and reviewed by five bilingual experts. Confirmatory factor analysis (CFA) was conducted with data from a sample of 218 couples (N = 436) to test construct validity. Validity and reliability were evaluated. The receiver's operating characteristics curve analysis was used to obtain the cut-off score. Results: The construct validities of K-CSI 32, 16, and 4 were verified using one-factor structures. The results of CFA showed a slightly better fit for K-CSI 16 and 4 than for K-CSI 32. Convergent validity was supported by significant positive correlations of K-CSI with Kansas Marital Satisfaction Scale, Dyadic Adjustment Scale, and Family Relationship Assessment Scale. Moreover, the significant differences in K-CSI between normal and depressive group demonstrated known-group validity. Cut-off scores of 105.5 on K-CSI 32, 50.25 on K-CSI 16, and 13.25 on K-CSI 4 were validated to identify distressed couple relationships. Conclusion: For clinical practice, the reliable and valid K-CSI 32 has the potential to measure changes in couple satisfaction after couple therapy or interventions. Applying K-CSI 32 may facilitate research on couple and family relationships in nursing and contribute to the discussion on the role of couple satisfaction in mental health.

일제강점기 교사 윤재천이 본 조선의 초등 과학교육 (Elementary School Science Education in Joseon as viewed by Yun Jae-Cheon during the Japanese Colonial Period)

  • 이면우
    • 한국초등과학교육학회지:초등과학교육
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    • 제41권2호
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    • pp.236-249
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    • 2022
  • 이 연구는 일제강점기의 교사 윤재천(尹在千)이 언급한 조선의 초등 과학교육에 대한 내용을 분석한 것이다. 윤재천은 대한제국 말에 태어나 일제강점기와 광복을 직접 경험한 사람이었다. 일제강점기에 경성사범학교 교사였던 윤재천은 <조선의 교육 연구(朝鮮の敎育硏究)>라는 교육 전문 잡지에 과학교육에 관련된 글을 많이 게재했다. 특히 그가 1939년에 저술한 "조선의 이과교육(朝鮮の理科敎育)"은 조선인 교사가 평가한 당시의 과학교육 전반을 분석하여 보고한 기사였다. 이 연구에서는 일제강점기에 조선인 교사의 눈으로 본 조선의 과학교육의 전반적인 상황을 추적했다. 일제가 강제 점령한 식민지 상황의 조선에서 윤재천이 생각했던 과학교육의 관점은 친일적인 색채를 드러내지 않을 수 없었던 한계가 있었다.

Energy-efficient intrusion detection system for secure acoustic communication in under water sensor networks

  • N. Nithiyanandam;C. Mahesh;S.P. Raja;S. Jeyapriyanga;T. Selva Banu Priya
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제17권6호
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    • pp.1706-1727
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    • 2023
  • Under Water Sensor Networks (UWSN) has gained attraction among various communities for its potential applications like acoustic monitoring, 3D mapping, tsunami detection, oil spill monitoring, and target tracking. Unlike terrestrial sensor networks, it performs an acoustic mode of communication to carry out collaborative tasks. Typically, surface sink nodes are deployed for aggregating acoustic phenomena collected from the underwater sensors through the multi-hop path. In this context, UWSN is constrained by factors such as lower bandwidth, high propagation delay, and limited battery power. Also, the vulnerabilities to compromise the aquatic environment are in growing numbers. The paper proposes an Energy-Efficient standalone Intrusion Detection System (EEIDS) to entail the acoustic environment against malicious attacks and improve the network lifetime. In EEIDS, attributes such as node ID, residual energy, and depth value are verified for forwarding the data packets in a secured path and stabilizing the nodes' energy levels. Initially, for each node, three agents are modeled to perform the assigned responsibilities. For instance, ID agent verifies the node's authentication of the node, EN agent checks for the residual energy of the node, and D agent substantiates the depth value of each node. Next, the classification of normal and malevolent nodes is performed by determining the score for each node. Furthermore, the proposed system utilizes the sheep-flock heredity algorithm to validate the input attributes using the optimized probability values stored in the training dataset. This assists in finding out the best-fit motes in the UWSN. Significantly, the proposed system detects and isolates the malicious nodes with tampered credentials and nodes with lower residual energy in minimal time. The parameters such as the time taken for malicious node detection, network lifetime, energy consumption, and delivery ratio are investigated using simulation tools. Comparison results show that the proposed EEIDS outperforms the existing acoustic security systems.

Expression of anoctamin 7 (ANO7) is associated with poor prognosis and mucin 2 (MUC2) in colon adenocarcinoma: a study based on TCGA data

  • Chen, Chen;Siripat Aluksanasuwan;Keerakarn Somsuan
    • Genomics & Informatics
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    • 제21권4호
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    • pp.46.1-46.10
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    • 2023
  • Colon adenocarcinoma (COAD) is the predominant type of colorectal cancer. Early diagnosis and treatment can significantly improve the prognosis of COAD patients. Anoctamin 7 (ANO7), an anion channel protein, has been implicated in prostate cancer and other types of cancer. In this study, we analyzed the expression of ANO7 and its correlation with clinicopathological characteristics among COAD patients using the Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and the University of Alabama at Birmingham CANcer (UALCAN) databases. The GEPIA2, Kaplan-Meier plotter, and the Survival Genie platform were employed for survival analysis. The co-expression network and potential function of ANO7 in COAD were analyzed using GeneFriends, the Database for Annotation, Visualization and Integrated Discovery (DAVID), GeneMANIA, and Pathway Studio. Our data analysis revealed a significant reduction in ANO7 expression levels within COAD tissues compared to normal tissues. Additionally, ANO7 expression was found to be associated with race and histological subtype. The COAD patients exhibiting low ANO7 expression had lower survival rates compared to those with high ANO7 expression. The genes correlated with ANO7 were significantly enriched in proteolysis and mucin type O-glycan biosynthesis pathway. Furthermore, ANO7 demonstrated a direct interaction and a positive co-expression correlation with mucin 2 (MUC2). In conclusion, our findings suggest that ANO7 might serve as a potential prognostic biomarker and potentially plays a role in proteolysis and mucin biosynthesis in the context of COAD.

Curvature ductility of confined HSC beams

  • Bouzid Haytham;Idriss Rouaz;Sahnoune Ahmed;Benferhat Rabia;Tahar Hassaine Daouadji
    • Structural Engineering and Mechanics
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    • 제89권6호
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    • pp.579-588
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    • 2024
  • The present paper investigates the curvature ductility of confined reinforced concrete (RC) beams with normal (NSC) and high strength concrete (HSC). For the purpose of predicting the curvature ductility factor, an analytical model was developed based on the equilibrium of internal forces of confined concrete and reinforcement. In this context, the curvatures were calculated at first yielding of tension reinforcement and at ultimate when the confined concrete strain reaches the ultimate value. To best simulate the situation of confined RC beams in flexure, a modified version of an ancient confined concrete model was adopted for this study. In order to show the accuracy of the proposed model, an experimental database was collected from the literature. The statistical comparison between experimental and predicted results showed that the proposed model has a good performance. Then, the data generated from the validated theoretical model were used to train the artificial neural network (ANN) prediction model. The R2 values for theoretical and experimental results are equal to 0.98 and 0.95, respectively which proves the high performance of the ANN model. Finally, a parametric study was implemented to analyze the effect of different parameters on the curvature ductility factor using theoretical and ANN models. The results are similar to those extracted from experiments, where the concrete strength, the compression reinforcement ratio, the yield strength, and the volumetric ratio of transverse reinforcement have a positive effect. In contrast, the ratio and the yield strength of tension reinforcement have a negative effect.

Harnessing the Power of Voice: A Deep Neural Network Model for Alzheimer's Disease Detection

  • Chan-Young Park;Minsoo Kim;YongSoo Shim;Nayoung Ryoo;Hyunjoo Choi;Ho Tae Jeong;Gihyun Yun;Hunboc Lee;Hyungryul Kim;SangYun Kim;Young Chul Youn
    • 대한치매학회지
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    • 제23권1호
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    • pp.1-10
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    • 2024
  • Background and Purpose: Voice, reflecting cerebral functions, holds potential for analyzing and understanding brain function, especially in the context of cognitive impairment (CI) and Alzheimer's disease (AD). This study used voice data to distinguish between normal cognition and CI or Alzheimer's disease dementia (ADD). Methods: This study enrolled 3 groups of subjects: 1) 52 subjects with subjective cognitive decline; 2) 110 subjects with mild CI; and 3) 59 subjects with ADD. Voice features were extracted using Mel-frequency cepstral coefficients and Chroma. Results: A deep neural network (DNN) model showed promising performance, with an accuracy of roughly 81% in 10 trials in predicting ADD, which increased to an average value of about 82.0%±1.6% when evaluated against unseen test dataset. Conclusions: Although results did not demonstrate the level of accuracy necessary for a definitive clinical tool, they provided a compelling proof-of-concept for the potential use of voice data in cognitive status assessment. DNN algorithms using voice offer a promising approach to early detection of AD. They could improve the accuracy and accessibility of diagnosis, ultimately leading to better outcomes for patients.

호스피스와 종교적 죽음이해

  • 신민선;김문수
    • 호스피스학술지
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    • 제6권1호
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    • pp.1-11
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    • 2006
  • There are various understandings how to define death. In the context of medicine, death is defined as the irreversible change of the tissue according to the cessation of circulation and respiration. According to the psychologists, a person need to accept the finiteness as a human being and remain conscious that the death is not avoidable. And they say if a person doesn't regard death as unavoidable reality of life he or she will not confront the humanistic death and after all will die like animals. In philosophy, death is viewed as an unwelcome reality in the end of the journey of life. Sociologists usually understand that the society is the organization composed with living persons and human beings which construct and transmit the culture from generation to generation between the both ends of life and death. In society, the generation is changed, maintained, and developed through the phenomenon of death. Although death of human being is natural event in society, the death of a specific person brings a sense of loss, crisis, and anxiety to the communities like family, regional society, nation, and the world. In this context, death is not confined to personal dimension and it can be regarded as a social problem. It is valuable to summarize the religious perspectives on the meaning of death for the better hospice care. In shamanism, there are basic idea that although the flesh of human being disappears, soul never die. If human dies, the flesh of human being disappears but soul never disappear and come back to the origin of soul as it is called chaos. So in shamanism, it is said that shaman can solve the mortified feeling, restore the broken harmony, send the soul to comfortable space- the origin, and guarantee the blessing of descendents. Buddhists regard the death as an essential component through the cycles of life. Through this cycle, human being exits as an endlessly transmigrating being and the death is just a restoration to the original status. In Confucianism, the view on the death based on the philosophy of the "Yin and Yang" and "Five elements". In Buddhist tradition, many believers said the philosophy of "Death is the same as life". Unlike usual thoughts that a god governs "life and death" and "fortune and misfortune", Confucianists deny the governance of a god and emphasize the natural orders in which every phenomenon in the world moves according to the principle. Confucianists understand the death as a natural order with this principle. In Confucianists' belief, the essence of human being remains in their own descendent's lives after the death of ancestor, so in Confucianism there is no concept of immortality of the soul. In the history of Christianity, death has been defined generally as the separation of the immortal soul from the mortal body. In the earlier days of Old Testament, the death is regarded as a disappearance of just a flesh and human never disappear and always live in the relationship with God. Later days in Old Testament, we can find the growing concern for the life after the death because of the entrance of the theodicy. In the New Testament, the death is not regarded as the normal process of the human life and regarded as the abnormal status in which death come to human because of sin as a decisive factor and it should be conquered. In fact, the most of us afraid death because not of the fear of death itself but of the sense of the emptiness and regrets. so many people often make the monument hoping to live forever. But Christian usually regard this behavior as a sinful act because human being usually think themselves as a master of their life and attempt to become immortal in this kind of trial mortal. But if we live with God, we cannot confront such a condition because we aware limits as a mortal human being and entrust everything on Him and want to live according to His guidance. Therefore, in the Christian tradition, the death is regarded as accomplishment of life, fruits of life, invitation to the eternal life, and the last stage of human growth. For human being, the death is the great step of maturation as a human in the final stage of life.

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후생유전학 (Epigenetics)과 DNA methylation의 이해 (UNDERSTANDING OF EPIGENETICS AND DNA METHYLATION)

  • 오정환;권용대;윤병욱;최병준
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제30권3호
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    • pp.302-309
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    • 2008
  • DNA 메틸화는 histone modification과 함께 DNA의 염기서열이 유지되면서 유전기능이 변화되고 자손까지 전달 될 수 있는 후생 유전의 중요한 한 부분이다. DNA 메틸화는 크로마틴의 구조를 변경시키는 과정을 통하여 유전자와 repetitive sequence의 표현을 억제시킬 수 있다. DNA 메틸화는 X-불활성화, 유전체 각인, 유전자 발현조절, 암 생성 등에 중요한 역할을 하는 것으로 밝혀졌고, DNA 메틸화 표지자 (DNA methylation marker)들은 종양의 진단과 치료에 대한 반응을 예측하는 지표로 활용되고 있다. 지금까지 많은 연구 성과에도 불구하고 DNA메틸화, 메틸화에 의한 gene silencing, DNA 메틸화의 표적부위 등에 대한 명확한 기전이 아직도 밝혀지지 않고 있어 향후 더 많은 기초적 연구가 필요할 것이다. 최근에는 후생 유전적 변화는 가역적이기 때문에 종양억제유전자를 억압하는 후생 유전적 변화를 제거한다면 그 종양억제유전자를 다시 활성화시킬 수 있다는 개념의 후생유전 치료법 연구로 DNA 메틸화 억제제와 histone deacetyaltion에 관여하는 HDAC의 억제제들이 항암제로서 개발되어 사용되고 있는데 향후 더 많은 약제 개발과 임상적 연구가 진행되어야 할 것이다.

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

  • Abbasi, Mehran Mesgari;Khiavi, Monir Moradzadeh;Monfaredan, Amir;Hamishehkar, Hamed;Seidi, Khaled;Jahanban-Esfahlan, Rana
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권19호
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    • pp.8377-8382
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    • 2014
  • Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

50,000 DWT 유조선의 밸러스트 흘수에서 우현 전타시 과도상태가 프로펠러축 거동에 미치는 영향 연구 (Effect of Transient Condition on Propeller Shaft Movement during Starboard Turning under Ballast Draught Condition for the 50,000 DWT Oil Tanker)

  • 이재웅
    • 해양환경안전학회지
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    • 제26권4호
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    • pp.412-418
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    • 2020
  • 선박 축계를 구성하는 프로펠러축은 엔진출력, 프로펠러 하중 및 편심추력의 영향으로 인해 거동의 양상이 달라져 선미관 후부베어링의 국부하중 변화를 일으킴으로써 선미관 베어링 손상의 위험을 증가시킨다. 이를 방지하기 위해 수행된 추진축계 정렬연구는 선급강선규칙을 중심으로 주로 축과 지지베어링간의 상대적 경사각과 유막유지를 최적화 하는데 중점을 두어 진행 되어왔다. 그러나 보다 상세한 평가를 통한 추진축계의 안정성 확보를 위해서는 전타와 같은 급격한 선미유동장 변화에 기인한 과도상태를 포함한 동적상태의 고려가 필요하다. 이러한 관점에서, 본 연구는 50,000 DWT 선박을 대상으로 스트레인 게이지법을 이용하여 밸러스트 흘수 상태에서 정격회전수로 운전 중 대표적 동적 과도상태인 우현 전타상태에서의 프로펠러 축 거동이 추진축계에 미치는 영향을 분석하였다. 그 결과 변동된 프로펠러 편심추력은 프로펠러축을 일시적으로 강하게 내려 누르는 힘으로 작용하여 선미관 베어링의 국부하중을 증가시켜 축계 안정성에 부정적 영향을 미침을 증명하였다.